LOCUS       NM_000979                643 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens ribosomal protein L18 (RPL18), transcript variant 1,
            mRNA.
ACCESSION   NM_000979
VERSION     NM_000979.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 643)
  AUTHORS   Wang,G., Qin,M., Zhang,B., Yan,Y., Yang,F., Chen,Q., Liu,Y.,
            Qiao,F. and Ni,Y.
  TITLE     Decreased expression of RPL15 and RPL18 exacerbated the
            calcification of valve interstitial cells during aortic valve
            calcification
  JOURNAL   Cell Biol Int 47 (10), 1749-1759 (2023)
   PUBMED   37431269
  REMARK    GeneRIF: Decreased expression of RPL15 and RPL18 exacerbated the
            calcification of valve interstitial cells during aortic valve
            calcification.
REFERENCE   2  (bases 1 to 643)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 643)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 643)
  AUTHORS   Odintsova,T.I., Muller,E.C., Ivanov,A.V., Egorov,T.A., Bienert,R.,
            Vladimirov,S.N., Kostka,S., Otto,A., Wittmann-Liebold,B. and
            Karpova,G.G.
  TITLE     Characterization and analysis of posttranslational modifications of
            the human large cytoplasmic ribosomal subunit proteins by mass
            spectrometry and Edman sequencing
  JOURNAL   J Protein Chem 22 (3), 249-258 (2003)
   PUBMED   12962325
REFERENCE   5  (bases 1 to 643)
  AUTHORS   Yoshihama,M., Uechi,T., Asakawa,S., Kawasaki,K., Kato,S., Higa,S.,
            Maeda,N., Minoshima,S., Tanaka,T., Shimizu,N. and Kenmochi,N.
  TITLE     The human ribosomal protein genes: sequencing and comparative
            analysis of 73 genes
  JOURNAL   Genome Res 12 (3), 379-390 (2002)
   PUBMED   11875025
REFERENCE   6  (bases 1 to 643)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   7  (bases 1 to 643)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   8  (bases 1 to 643)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (bases 1 to 643)
  AUTHORS   Puder,M., Barnard,G.F., Staniunas,R.J., Steele,G.D. Jr. and
            Chen,L.B.
  TITLE     Nucleotide and deduced amino acid sequence of human ribosomal
            protein L18
  JOURNAL   Biochim Biophys Acta 1216 (1), 134-136 (1993)
   PUBMED   8218404
REFERENCE   10 (bases 1 to 643)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BM764512.1 and AK026558.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000979.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a member of the
            L18E family of ribosomal proteins that is a component of the 60S
            subunit. As is typical for genes encoding ribosomal proteins, there
            are multiple processed pseudogenes of this gene dispersed through
            the genome. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.247865.1,
                                           SRR1163657.51232.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000549920.6/ ENSP00000447001.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BM764512.1         359-360
            3-643               AK026558.1         1-641
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..643
                     /gene="RPL18"
                     /gene_synonym="DBA18; eL18; L18"
                     /note="ribosomal protein L18"
                     /db_xref="GeneID:6141"
                     /db_xref="HGNC:HGNC:10310"
                     /db_xref="MIM:604179"
     exon            1..38
                     /gene="RPL18"
                     /gene_synonym="DBA18; eL18; L18"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..602
                     /gene="RPL18"
                     /gene_synonym="DBA18; eL18; L18"
                     /note="isoform 1 is encoded by transcript variant 1; 60S
                     ribosomal protein L18; large ribosomal subunit protein
                     eL18"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL18 isoform 1"
                     /protein_id="NP_000970.1"
                     /db_xref="CCDS:CCDS12726.1"
                     /db_xref="GeneID:6141"
                     /db_xref="HGNC:HGNC:10310"
                     /db_xref="MIM:604179"
                     /translation="MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFN
                     QVVLKRLFMSRTNRPPLSLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPKLKVCA
                     LRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPH
                     SHTKPYVRSKGRKFERARGRRASRGYKN"
     exon            39..125
                     /gene="RPL18"
                     /gene_synonym="DBA18; eL18; L18"
                     /inference="alignment:Splign:2.1.0"
     exon            126..233
                     /gene="RPL18"
                     /gene_synonym="DBA18; eL18; L18"
                     /inference="alignment:Splign:2.1.0"
     exon            234..332
                     /gene="RPL18"
                     /gene_synonym="DBA18; eL18; L18"
                     /inference="alignment:Splign:2.1.0"
     exon            333..456
                     /gene="RPL18"
                     /gene_synonym="DBA18; eL18; L18"
                     /inference="alignment:Splign:2.1.0"
     exon            457..526
                     /gene="RPL18"
                     /gene_synonym="DBA18; eL18; L18"
                     /inference="alignment:Splign:2.1.0"
     exon            527..643
                     /gene="RPL18"
                     /gene_synonym="DBA18; eL18; L18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      622..627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL18"
                     /gene_synonym="DBA18; eL18; L18"
                     /note="hexamer: ATTAAA"
     polyA_site      643
                     /gene="RPL18"
                     /gene_synonym="DBA18; eL18; L18"
                     /note="major polyA site"
ORIGIN      
        1 ctctttccgg acctggccga gcaggaggcg ccatcatggg agtggacatc cgccataaca
       61 aggaccgaaa ggttcggcgc aaggagccca agagccagga tatctacctg aggctgttgg
      121 tcaagttata caggtttctg gccagaagaa ccaactccac attcaaccag gttgtgttga
      181 agaggttgtt tatgagtcgc accaaccggc cgcctctgtc cctttcccgg atgatccgga
      241 agatgaagct tcctggccgg gaaaacaaga cggccgtggt tgtggggacc ataactgatg
      301 atgtgcgggt tcaggaggta cccaaactga aggtatgtgc actgcgcgtg accagccggg
      361 cccgcagccg catcctcagg gcagggggca agatcctcac tttcgaccag ctggccctgg
      421 actcccctaa gggctgtggc actgtcctgc tctccggtcc tcgcaagggc cgagaggtgt
      481 accggcattt cggcaaggcc ccaggaaccc cgcacagcca caccaaaccc tacgtccgct
      541 ccaagggccg gaagttcgag cgtgccagag gccgacgggc cagccgaggc tacaaaaact
      601 aaccctggat cctactctct tattaaaaag atttttgctg aca
//
