LOCUS       NM_001035006             614 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ribosomal protein L17 (RPL17), transcript variant 2,
            mRNA.
ACCESSION   NM_001035006 XM_001713653
VERSION     NM_001035006.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 614)
  AUTHORS   Fellmann,F., Saunders,C., O'Donohue,M.F., Reid,D.W., McFadden,K.A.,
            Montel-Lehry,N., Yu,C., Fang,M., Zhang,J., Royer-Bertrand,B.,
            Farinelli,P., Karboul,N., Willer,J.R., Fievet,L., Bhuiyan,Z.A.,
            Kleinhenz,A.L., Jadeau,J., Fulbright,J., Rivolta,C., Renella,R.,
            Katsanis,N., Beckmann,J.S., Nicchitta,C.V., Da Costa,L., Davis,E.E.
            and Gleizes,P.E.
  TITLE     An atypical form of 60S ribosomal subunit in Diamond-Blackfan
            anemia linked to RPL17 variants
  JOURNAL   JCI Insight 9 (17), e172475 (2024)
   PUBMED   39088281
  REMARK    GeneRIF: An atypical form of 60S ribosomal subunit in
            Diamond-Blackfan anemia linked to RPL17 variants.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 614)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 614)
  AUTHORS   Hori,H., Nakamura,S., Yoshida,F., Teraishi,T., Sasayama,D., Ota,M.,
            Hattori,K., Kim,Y., Higuchi,T. and Kunugi,H.
  TITLE     Integrated profiling of phenotype and blood transcriptome for
            stress vulnerability and depression
  JOURNAL   J Psychiatr Res 104, 202-210 (2018)
   PUBMED   30103068
  REMARK    GeneRIF: The present study combines an individual-based phenotypic
            profiling with a transdiagnostic approach and shows that several
            ribosomal genes including RPL17 is involved in stress vulnerability
            across nonclinical and clinical conditions.
REFERENCE   4  (bases 1 to 614)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   5  (bases 1 to 614)
  AUTHORS   Jefferson,M., Donaszi-Ivanov,A., Pollen,S., Dalmay,T., Saalbach,G.
            and Powell,P.P.
  TITLE     Host factors that interact with the pestivirus N-terminal protease,
            Npro, are components of the ribonucleoprotein complex
  JOURNAL   J Virol 88 (18), 10340-10353 (2014)
   PUBMED   24965446
REFERENCE   6  (bases 1 to 614)
  AUTHORS   Odintsova,T.I., Muller,E.C., Ivanov,A.V., Egorov,T.A., Bienert,R.,
            Vladimirov,S.N., Kostka,S., Otto,A., Wittmann-Liebold,B. and
            Karpova,G.G.
  TITLE     Characterization and analysis of posttranslational modifications of
            the human large cytoplasmic ribosomal subunit proteins by mass
            spectrometry and Edman sequencing
  JOURNAL   J Protein Chem 22 (3), 249-258 (2003)
   PUBMED   12962325
REFERENCE   7  (bases 1 to 614)
  AUTHORS   Yoshihama,M., Uechi,T., Asakawa,S., Kawasaki,K., Kato,S., Higa,S.,
            Maeda,N., Minoshima,S., Tanaka,T., Shimizu,N. and Kenmochi,N.
  TITLE     The human ribosomal protein genes: sequencing and comparative
            analysis of 73 genes
  JOURNAL   Genome Res 12 (3), 379-390 (2002)
   PUBMED   11875025
REFERENCE   8  (bases 1 to 614)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   9  (bases 1 to 614)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   10 (bases 1 to 614)
  AUTHORS   Mager,D.L. and Freeman,J.D.
  TITLE     A human gene related to the ribosomal protein L23 gene of
            Halobacterium marismortui
  JOURNAL   Nucleic Acids Res 18 (17), 5301 (1990)
   PUBMED   2402465
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AC100778.5.
            
            On Sep 16, 2020 this sequence version replaced NM_001035006.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L22P family of ribosomal proteins. It is located in the
            cytoplasm. This gene has been referred to as rpL23 because the
            encoded protein shares amino acid identity with ribosomal protein
            L23 from Halobacterium marismortui; however, its official symbol is
            RPL17. As is typical for genes encoding ribosomal proteins, there
            are multiple processed pseudogenes of this gene dispersed through
            the genome. Alternative splicing results in multiple transcript
            variants. Read-through transcription also exists between this gene
            and the neighboring downstream C18orf32 (chromosome 18 open reading
            frame 32) gene. [provided by RefSeq, Dec 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ949854.1, BU153842.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000580261.6/ ENSP00000462385.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC100778.5         7382-7389
            9-61                AC100778.5         8263-8315
            62-102              AC100778.5         8402-8442
            103-237             AC100778.5         8920-9054
            238-336             AC100778.5         9295-9393
            337-528             AC100778.5         10297-10488
            529-614             AC100778.5         11281-11366
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..614
                     /gene="RPL17"
                     /gene_synonym="L17; PD-1; RPL23; uL22"
                     /note="ribosomal protein L17"
                     /db_xref="GeneID:6139"
                     /db_xref="HGNC:HGNC:10307"
                     /db_xref="MIM:603661"
     exon            1..8
                     /gene="RPL17"
                     /gene_synonym="L17; PD-1; RPL23; uL22"
                     /inference="alignment:Splign:2.1.0"
     exon            9..61
                     /gene="RPL17"
                     /gene_synonym="L17; PD-1; RPL23; uL22"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..576
                     /gene="RPL17"
                     /gene_synonym="L17; PD-1; RPL23; uL22"
                     /note="isoform a is encoded by transcript variant 2; 60S
                     ribosomal protein L17; large ribosomal subunit protein
                     uL22; gene encoding putative NFkB activating protein; 60S
                     ribosomal protein L23"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL22 isoform a"
                     /protein_id="NP_001030178.1"
                     /db_xref="CCDS:CCDS45865.1"
                     /db_xref="GeneID:6139"
                     /db_xref="HGNC:HGNC:10307"
                     /db_xref="MIM:603661"
                     /translation="MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKA
                     TKYLKDVTLQKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNA
                     ELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKP
                     EEEVAQKKKISQKKLKKQKLMARE"
     exon            62..102
                     /gene="RPL17"
                     /gene_synonym="L17; PD-1; RPL23; uL22"
                     /inference="alignment:Splign:2.1.0"
     exon            103..237
                     /gene="RPL17"
                     /gene_synonym="L17; PD-1; RPL23; uL22"
                     /inference="alignment:Splign:2.1.0"
     exon            238..336
                     /gene="RPL17"
                     /gene_synonym="L17; PD-1; RPL23; uL22"
                     /inference="alignment:Splign:2.1.0"
     exon            337..528
                     /gene="RPL17"
                     /gene_synonym="L17; PD-1; RPL23; uL22"
                     /inference="alignment:Splign:2.1.0"
     exon            529..614
                     /gene="RPL17"
                     /gene_synonym="L17; PD-1; RPL23; uL22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      589..594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL17"
                     /gene_synonym="L17; PD-1; RPL23; uL22"
                     /note="hexamer: AATAAA"
     polyA_site      614
                     /gene="RPL17"
                     /gene_synonym="L17; PD-1; RPL23; uL22"
                     /note="major polyA site"
ORIGIN      
        1 agcctgaggt gatctgtgaa aatggttcgc tattcacttg acccggagaa ccccacgaaa
       61 tcatgcaaat caagaggttc caatcttcgt gttcacttta agaacactcg tgaaactgct
      121 caggccatca agggtatgca tatacgaaaa gccacgaagt atctgaaaga tgtcacttta
      181 cagaaacagt gtgtaccatt ccgacgttac aatggtggag ttggcaggtg tgcgcaggcc
      241 aagcaatggg gctggacaca aggtcggtgg cccaaaaaga gtgctgaatt tttgctgcac
      301 atgcttaaaa acgcagagag taatgctgaa cttaagggtt tagatgtaga ttctctggtc
      361 attgagcata tccaagtgaa caaagcacct aagatgcgcc gccggaccta cagagctcat
      421 ggtcggatta acccatacat gagctctccc tgccacattg agatgatcct tacggaaaag
      481 gaacagattg ttcctaaacc agaagaggag gttgcccaga agaaaaagat atcccagaag
      541 aaactgaaga aacaaaaact tatggcacgg gagtaaattc agcattaaaa taaatgtaat
      601 taaaaggaaa agaa
//
