LOCUS       NM_002948               2155 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens ribosomal protein L15 (RPL15), transcript variant 1,
            mRNA.
ACCESSION   NM_002948
VERSION     NM_002948.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2155)
  AUTHORS   Wang,G., Qin,M., Zhang,B., Yan,Y., Yang,F., Chen,Q., Liu,Y.,
            Qiao,F. and Ni,Y.
  TITLE     Decreased expression of RPL15 and RPL18 exacerbated the
            calcification of valve interstitial cells during aortic valve
            calcification
  JOURNAL   Cell Biol Int 47 (10), 1749-1759 (2023)
   PUBMED   37431269
  REMARK    GeneRIF: Decreased expression of RPL15 and RPL18 exacerbated the
            calcification of valve interstitial cells during aortic valve
            calcification.
REFERENCE   2  (bases 1 to 2155)
  AUTHORS   Xu,C., He,X.Y., Ren,X.H., Han,D. and Cheng,S.X.
  TITLE     Detection of mRNAs of Ribosomal Protein L15 and E-Cadherin in
            Living Circulating Tumor Cells at Single Cell Resolution To Study
            Tumor Heterogeneity
  JOURNAL   Anal Chem 94 (30), 10610-10616 (2022)
   PUBMED   35856393
  REMARK    GeneRIF: Detection of mRNAs of Ribosomal Protein L15 and E-Cadherin
            in Living Circulating Tumor Cells at Single Cell Resolution To
            Study Tumor Heterogeneity.
REFERENCE   3  (bases 1 to 2155)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2155)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2155)
  AUTHORS   Yoshihama,M., Uechi,T., Asakawa,S., Kawasaki,K., Kato,S., Higa,S.,
            Maeda,N., Minoshima,S., Tanaka,T., Shimizu,N. and Kenmochi,N.
  TITLE     The human ribosomal protein genes: sequencing and comparative
            analysis of 73 genes
  JOURNAL   Genome Res 12 (3), 379-390 (2002)
   PUBMED   11875025
REFERENCE   6  (bases 1 to 2155)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   7  (bases 1 to 2155)
  AUTHORS   Wang,Q., Yang,C., Zhou,J., Wang,X., Wu,M. and Liu,Z.
  TITLE     Cloning and characterization of full-length human ribosomal protein
            L15 cDNA which was overexpressed in esophageal cancer
  JOURNAL   Gene 263 (1-2), 205-209 (2001)
   PUBMED   11223259
REFERENCE   8  (bases 1 to 2155)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   9  (bases 1 to 2155)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   10 (bases 1 to 2155)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AC124914.3.
            
            On Oct 16, 2019 this sequence version replaced NM_002948.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of four RNA species and approximately
            80 structurally distinct proteins. This gene encodes a member of
            the L15E family of ribosomal proteins and a component of the 60S
            subunit. This gene shares sequence similarity with the yeast
            ribosomal protein YL10 gene. Elevated expression of this gene has
            been observed in esophageal tumors and gastric cancer tissues, and
            deletion of this gene has been observed in a Diamond-Blackfan
            anemia (DBA) patient. As is typical for genes encoding ribosomal
            proteins, there are multiple processed pseudogenes of this gene
            dispersed through the genome. [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1-5 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014837.1, AF283772.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307839.10/ ENSP00000309334.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC124914.3         62309-62350
            43-224              AC124914.3         63027-63208
            225-361             AC124914.3         63617-63753
            362-2155            AC124914.3         64373-66166
FEATURES             Location/Qualifiers
     source          1..2155
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.2"
     gene            1..2155
                     /gene="RPL15"
                     /gene_synonym="DBA12; EC45; eL15; L15; RPL10; RPLY10;
                     RPYL10"
                     /note="ribosomal protein L15"
                     /db_xref="GeneID:6138"
                     /db_xref="HGNC:HGNC:10306"
                     /db_xref="MIM:604174"
     exon            1..42
                     /gene="RPL15"
                     /gene_synonym="DBA12; EC45; eL15; L15; RPL10; RPLY10;
                     RPYL10"
                     /inference="alignment:Splign:2.1.0"
     exon            43..224
                     /gene="RPL15"
                     /gene_synonym="DBA12; EC45; eL15; L15; RPL10; RPLY10;
                     RPYL10"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..667
                     /gene="RPL15"
                     /gene_synonym="DBA12; EC45; eL15; L15; RPL10; RPLY10;
                     RPYL10"
                     /note="isoform 1 is encoded by transcript variant 1; 60S
                     ribosomal protein L15; large ribosomal subunit protein
                     eL15"
                     /codon_start=1
                     /product="large ribosomal subunit protein eL15 isoform 1"
                     /protein_id="NP_002939.2"
                     /db_xref="CCDS:CCDS2640.1"
                     /db_xref="GeneID:6138"
                     /db_xref="HGNC:HGNC:10306"
                     /db_xref="MIM:604174"
                     /translation="MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTR
                     PDKARRLGYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVA
                     EERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHRE
                     MRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLHRYR"
     exon            225..361
                     /gene="RPL15"
                     /gene_synonym="DBA12; EC45; eL15; L15; RPL10; RPLY10;
                     RPYL10"
                     /inference="alignment:Splign:2.1.0"
     exon            362..2155
                     /gene="RPL15"
                     /gene_synonym="DBA12; EC45; eL15; L15; RPL10; RPLY10;
                     RPYL10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      697..702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL15"
                     /gene_synonym="DBA12; EC45; eL15; L15; RPL10; RPLY10;
                     RPYL10"
                     /note="hexamer: AATAAA"
     polyA_site      718
                     /gene="RPL15"
                     /gene_synonym="DBA12; EC45; eL15; L15; RPL10; RPLY10;
                     RPYL10"
                     /note="major polyA site"
     regulatory      1987..1992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL15"
                     /gene_synonym="DBA12; EC45; eL15; L15; RPL10; RPLY10;
                     RPYL10"
                     /note="hexamer: AATAAA"
     polyA_site      2009
                     /gene="RPL15"
                     /gene_synonym="DBA12; EC45; eL15; L15; RPL10; RPLY10;
                     RPYL10"
     regulatory      2116..2121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL15"
                     /gene_synonym="DBA12; EC45; eL15; L15; RPL10; RPLY10;
                     RPYL10"
                     /note="hexamer: AATATA"
     regulatory      2133..2138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL15"
                     /gene_synonym="DBA12; EC45; eL15; L15; RPL10; RPLY10;
                     RPYL10"
                     /note="hexamer: CATAAA"
     polyA_site      2143
                     /gene="RPL15"
                     /gene_synonym="DBA12; EC45; eL15; L15; RPL10; RPLY10;
                     RPYL10"
     polyA_site      2155
                     /gene="RPL15"
                     /gene_synonym="DBA12; EC45; eL15; L15; RPL10; RPLY10;
                     RPYL10"
ORIGIN      
        1 gggagtacag ctctttcctt tccgtctggc ggcagccatc aggtaagcca agatgggtgc
       61 atacaagtac atccaggagc tatggagaaa gaagcagtct gatgtcatgc gctttcttct
      121 gagggtccgc tgctggcagt accgccagct ctctgctctc cacagggctc cccgccccac
      181 ccggcctgat aaagcgcgcc gactgggcta caaggccaag caaggttacg ttatatatag
      241 gattcgtgtt cgccgtggtg gccgaaaacg cccagttcct aagggtgcaa cttacggcaa
      301 gcctgtccat catggtgtta accagctaaa gtttgctcga agccttcagt ccgttgcaga
      361 ggagcgagct ggacgccact gtggggctct gagagtcctg aattcttact gggttggtga
      421 agattccaca tacaaatttt ttgaggttat cctcattgat ccattccata aagctatcag
      481 aagaaatcct gacacccagt ggatcaccaa accagtccac aagcacaggg agatgcgtgg
      541 gctgacatct gcaggccgaa agagccgtgg ccttggaaag ggccacaagt tccaccacac
      601 tattggtggc tctcgccggg cagcttggag aaggcgcaat actctccagc tccaccgtta
      661 ccgctaatat aagtaaagtt tgtaaaattc atacttaata aacaatttag gacagtcatg
      721 tctgcttaca ggtgttattt gtctgttaaa actagtctgc agatgtttct tgaatgcttt
      781 gtcaaattaa gaaagttaaa gtgcaataat gtttgaagac aataagtggt ggtgtatctt
      841 gtttctaata agataaactt ttttgtcttt gctttatctt attagggagt tgtatgtcag
      901 tgtataaaac atactgtgtg gtataacagg cttaataaat tctttaaaag gagagaactg
      961 aaactagccc tgtagatttg tctggtgcat gtgatgaaac ctgcagcttt atcggagtga
     1021 tggcaatgct ctgctggttt attttcaagt ggctgcgttt tttttagttt ggcaggtgta
     1081 gactttttaa gttgggcttt agaaaatctg ggttagcctg aagaaaattg cctcagcctc
     1141 cacagtacca ttttaaattc acataaaagg tgaaagctcc tggttcagtg ccatggcttc
     1201 atggcattca gtgattagtg gtaatggtaa acactggtgt gttttgaagt tgaatgtgcg
     1261 ataaaattat tagccttaag attggtaagc tagcaatgaa tgctagggtg ggaagctggt
     1321 gagccagtgg ccattagata aatacctttc aagtgtgagc ttagacgtca accctaaaat
     1381 acttaaccgt aatgctaatt gtgatcatta tgaatccctt cagtcacatt agggggaaag
     1441 tagttggcta taagtacgtc attcttagtc cagtcagtct taaaaacatc ttgggttacc
     1501 cactctgtcc actcccatag gctacagaaa aagtcacaag cgcatggttt ccaaccatat
     1561 gtgttttctg cagttatttc tcttgttctg gccaaacaac cctaaaaatc cttaccattc
     1621 cacaaagttg gaccatcact tgtgcaccca ctttgactat gagtatacca ccacattgca
     1681 tttctgtttg caccatgtct tccaggagac tagactactg ttgtccaggg tcaatttgag
     1741 tgtaaagaaa atgtagacaa ggaattgccc aattttaaat tctgactttg ctgacttaat
     1801 ttaaatgctc gttctgaacc aattttctcc tatcttctct aggggtttca aaagactcag
     1861 ttaattgatt tccaggaagt actcatagca agttcataaa agttcttgag acctaaattt
     1921 cttcacaaaa aaagaaaaga tcttaagtca tacattttaa ttgtgtagag gttgttcaac
     1981 tgaaggaata aatgtctatt aaactaaaac aaatggacct tctgttattt tttgtcatct
     2041 tacagtgcta atgtacttta aagcaaacca aatgccctaa ccagcaaaaa ggcatcaaaa
     2101 tgtgattata gaaataatat aatttgagat agcataaaat gtacttattc tctca
//
