LOCUS       NM_012423               1127 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal protein L13a (RPL13A), transcript variant 1,
            mRNA.
ACCESSION   NM_012423
VERSION     NM_012423.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1127)
  AUTHORS   Molavi,G., Samadi,N., Hashemzadeh,S., Halimi,M. and
            Hosseingholi,E.Z.
  TITLE     Moonlight human ribosomal protein L13a downregulation is associated
            with p53 and HER2/neu expression in breast cancer
  JOURNAL   J Appl Biomed 18 (2-3), 46-53 (2020)
   PUBMED   34907725
  REMARK    GeneRIF: Moonlight human ribosomal protein L13a downregulation is
            associated with p53 and HER2/neu expression in breast cancer.
REFERENCE   2  (bases 1 to 1127)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1127)
  AUTHORS   Kour,R., Komar,A.A. and Mazumder,B.
  TITLE     Mutually exclusive amino acid residues of L13a are responsible for
            its ribosomal incorporation and translational silencing leading to
            resolution of inflammation
  JOURNAL   RNA 25 (10), 1377-1392 (2019)
   PUBMED   31308261
  REMARK    GeneRIF: show through cellular immunofluorescence experiments that
            nuclear but not nucleolar localization of L13a is resistant to
            extensive amino acid alterations, suggesting that multiple complex
            nuclear import signals are present within this protein
REFERENCE   4  (bases 1 to 1127)
  AUTHORS   Gentile,A.M., Lhamyani,S., Coin-Araguez,L., Oliva-Olivera,W.,
            Zayed,H., Vega-Rioja,A., Monteseirin,J., Romero-Zerbo,S.Y.,
            Tinahones,F.J., Bermudez-Silva,F.J. and El Bekay,R.
  TITLE     RPL13A and EEF1A1 Are Suitable Reference Genes for qPCR during
            Adipocyte Differentiation of Vascular Stromal Cells from Patients
            with Different BMI and HOMA-IR
  JOURNAL   PLoS One 11 (6), e0157002 (2016)
   PUBMED   27304673
  REMARK    GeneRIF: The expression of RPL13A and EEF1A1 was not affected by
            differentiation, thus being these genes the most stable candidates
            as reference genes for RT-PCR.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1127)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   6  (bases 1 to 1127)
  AUTHORS   Yoshihama,M., Uechi,T., Asakawa,S., Kawasaki,K., Kato,S., Higa,S.,
            Maeda,N., Minoshima,S., Tanaka,T., Shimizu,N. and Kenmochi,N.
  TITLE     The human ribosomal protein genes: sequencing and comparative
            analysis of 73 genes
  JOURNAL   Genome Res 12 (3), 379-390 (2002)
   PUBMED   11875025
REFERENCE   7  (bases 1 to 1127)
  AUTHORS   Nicoloso,M., Qu,L.H., Michot,B. and Bachellerie,J.P.
  TITLE     Intron-encoded, antisense small nucleolar RNAs: the
            characterization of nine novel species points to their direct role
            as guides for the 2'-O-ribose methylation of rRNAs
  JOURNAL   J Mol Biol 260 (2), 178-195 (1996)
   PUBMED   8764399
REFERENCE   8  (bases 1 to 1127)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (bases 1 to 1127)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   10 (bases 1 to 1127)
  AUTHORS   Price,S.R., Nightingale,M.S., Bobak,D.A., Tsuchiya,M., Moss,J. and
            Vaughan,M.
  TITLE     Conservation of a 23-kDa human transplantation antigen in mammalian
            species
  JOURNAL   Genomics 14 (4), 959-964 (1992)
   PUBMED   1282492
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AK291120.1 and BC062537.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012423.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a member of the
            L13P family of ribosomal proteins that is a component of the 60S
            subunit. The encoded protein also plays a role in the repression of
            inflammatory genes as a component of the IFN-gamma-activated
            inhibitor of translation (GAIT) complex. This gene is
            co-transcribed with the small nucleolar RNA genes U32, U33, U34,
            and U35, which are located in the second, fourth, fifth, and sixth
            introns, respectively. As is typical for genes encoding ribosomal
            proteins, there are multiple processed pseudogenes of this gene
            dispersed throughout the genome. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070223.1, SRR1660805.176507.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391857.9/ ENSP00000375730.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1124              AK291120.1         1-1124
            1125-1127           BC062537.1         1105-1107
FEATURES             Location/Qualifiers
     source          1..1127
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1127
                     /gene="RPL13A"
                     /gene_synonym="L13A; TSTA1; uL13"
                     /note="ribosomal protein L13a"
                     /db_xref="GeneID:23521"
                     /db_xref="HGNC:HGNC:10304"
                     /db_xref="MIM:619225"
     exon            1..37
                     /gene="RPL13A"
                     /gene_synonym="L13A; TSTA1; uL13"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..634
                     /gene="RPL13A"
                     /gene_synonym="L13A; TSTA1; uL13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tissue specific transplantation antigen 1; 60S ribosomal
                     protein L13a; 23 kDa highly basic protein; large ribosomal
                     subunit protein uL13; epididymis secretory sperm binding
                     protein; highly basic protein 23 kDa"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL13 isoform 1"
                     /protein_id="NP_036555.1"
                     /db_xref="CCDS:CCDS12768.1"
                     /db_xref="GeneID:23521"
                     /db_xref="HGNC:HGNC:10304"
                     /db_xref="MIM:619225"
                     /translation="MAEVQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINIS
                     GNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALDRL
                     KVFDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKR
                     KEKAKIHYRKKKQLMRLRKQAEKNVEKKIDKYTEVLKTHGLLV"
     exon            38..110
                     /gene="RPL13A"
                     /gene_synonym="L13A; TSTA1; uL13"
                     /inference="alignment:Splign:2.1.0"
     exon            111..176
                     /gene="RPL13A"
                     /gene_synonym="L13A; TSTA1; uL13"
                     /inference="alignment:Splign:2.1.0"
     exon            177..278
                     /gene="RPL13A"
                     /gene_synonym="L13A; TSTA1; uL13"
                     /inference="alignment:Splign:2.1.0"
     exon            279..364
                     /gene="RPL13A"
                     /gene_synonym="L13A; TSTA1; uL13"
                     /inference="alignment:Splign:2.1.0"
     exon            365..424
                     /gene="RPL13A"
                     /gene_synonym="L13A; TSTA1; uL13"
                     /inference="alignment:Splign:2.1.0"
     exon            425..547
                     /gene="RPL13A"
                     /gene_synonym="L13A; TSTA1; uL13"
                     /inference="alignment:Splign:2.1.0"
     exon            548..1127
                     /gene="RPL13A"
                     /gene_synonym="L13A; TSTA1; uL13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1107..1112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL13A"
                     /gene_synonym="L13A; TSTA1; uL13"
                     /note="hexamer: AATAAA"
     polyA_site      1127
                     /gene="RPL13A"
                     /gene_synonym="L13A; TSTA1; uL13"
                     /note="major polyA site"
ORIGIN      
        1 cttttccaag cggctgccga agatggcgga ggtgcaggtc ctggtgcttg atggtcgagg
       61 ccatctcctg ggccgcctgg cggccatcgt ggctaaacag gtactgctgg gccggaaggt
      121 ggtggtcgta cgctgtgaag gcatcaacat ttctggcaat ttctacagaa acaagttgaa
      181 gtacctggct ttcctccgca agcggatgaa caccaaccct tcccgaggcc cctaccactt
      241 ccgggccccc agccgcatct tctggcggac cgtgcgaggt atgctgcccc acaaaaccaa
      301 gcgaggccag gccgctctgg accgtctcaa ggtgtttgac ggcatcccac cgccctacga
      361 caagaaaaag cggatggtgg ttcctgctgc cctcaaggtc gtgcgtctga agcctacaag
      421 aaagtttgcc tatctggggc gcctggctca cgaggttggc tggaagtacc aggcagtgac
      481 agccaccctg gaggagaaga ggaaagagaa agccaagatc cactaccgga agaagaaaca
      541 gctcatgagg ctacggaaac aggccgagaa gaacgtggag aagaaaattg acaaatacac
      601 agaggtcctc aagacccacg gactcctggt ctgagcccaa taaagactgt taattcctca
      661 tgcgttgcct gcccttcctc cattgttgcc ctggaatgta cgggacccag gggcagcagc
      721 agtccaggtg ccacaggcag ccctgggaca taggaagctg ggagcaagga aagggtctta
      781 gtcactgcct cccgaagttg cttgaaagca ctcggagaat tgtgcaggtg tcatttatct
      841 atgaccaata ggaagagcaa ccagttacta tgagtgaaag ggagccagaa gactgattgg
      901 agggccctat cttgtgagtg gggcatctgt tggactttcc acctggtcat atactctgca
      961 gctgttagaa tgtgcaagca cttggggaca gcatgagctt gctgttgtac acagggtatt
     1021 tctagaagca gaaatagact gggaagatgc acaaccaagg ggttacaggc atcgcccatg
     1081 ctcctcacct gtattttgta atcagaaata aattgctttt aaagaaa
//
