LOCUS       NM_000975               1017 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens ribosomal protein L11 (RPL11), transcript variant 1,
            mRNA.
ACCESSION   NM_000975
VERSION     NM_000975.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1017)
  AUTHORS   Chen,J., Lei,C., Zhang,H., Huang,X., Yang,Y., Liu,J., Jia,Y.,
            Shi,H., Zhang,Y., Zhang,J. and Du,J.
  TITLE     RPL11 promotes non-small cell lung cancer cell proliferation by
            regulating endoplasmic reticulum stress and cell autophagy
  JOURNAL   BMC Mol Cell Biol 24 (1), 7 (2023)
   PUBMED   36869281
  REMARK    GeneRIF: RPL11 promotes non-small cell lung cancer cell
            proliferation by regulating endoplasmic reticulum stress and cell
            autophagy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1017)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1017)
  AUTHORS   Babaylova,E.S., Gopanenko,A.V., Tupikin,A.E., Kabilov,M.R.,
            Malygin,A.A. and Karpova,G.G.
  TITLE     Deficiency of the Ribosomal Protein uL5 Leads to Significant
            Rearrangements of the Transcriptional and Translational Landscapes
            in Mammalian Cells
  JOURNAL   Int J Mol Sci 22 (24), 13485 (2021)
   PUBMED   34948282
  REMARK    GeneRIF: Deficiency of the Ribosomal Protein uL5 Leads to
            Significant Rearrangements of the Transcriptional and Translational
            Landscapes in Mammalian Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1017)
  AUTHORS   Panici,B., Nakajima,H., Carlston,C.M., Ozadam,H., Cenik,C. and
            Cenik,E.S.
  TITLE     Loss of coordinated expression between ribosomal and mitochondrial
            genes revealed by comprehensive characterization of a large family
            with a rare Mendelian disorder
  JOURNAL   Genomics 113 (4), 1895-1905 (2021)
   PUBMED   33862179
  REMARK    GeneRIF: Loss of coordinated expression between ribosomal and
            mitochondrial genes revealed by comprehensive characterization of a
            large family with a rare Mendelian disorder.
REFERENCE   5  (bases 1 to 1017)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1017)
  AUTHORS   Graphodatsky,A.S., Vorobieva,N.V., Filipenko,M.L., Voronina,E.V.,
            Frengen,E. and Prydz,H.
  TITLE     Assignment of the L11 ribosomal protein gene (RPL11) to human
            chromosome 1p36.1-->p35 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 84 (1-2), 97-98 (1999)
   PUBMED   10343117
REFERENCE   7  (bases 1 to 1017)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   8  (bases 1 to 1017)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (bases 1 to 1017)
  AUTHORS   Mishin,V.P., Filipenko,M.L., Muravlev,A.I., Karpova,G.G. and
            Mertvetsov,N.P.
  TITLE     [Cloning and determination of the primary structure of DNA
            complementary to the mRNA of human ribosomal protein L11]
  JOURNAL   Bioorg Khim 21 (2), 158-160 (1995)
   PUBMED   7748210
REFERENCE   10 (bases 1 to 1017)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BU954396.1, CA335141.1, BX118515.1, AL451000.16 and
            AA748897.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 8, 2018 this sequence version replaced NM_000975.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L5P family of ribosomal proteins. It is located in the
            cytoplasm. The protein probably associates with the 5S rRNA.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. As is typical for genes
            encoding ribosomal proteins, there are multiple processed
            pseudogenes of this gene dispersed through the genome. [provided by
            RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM740317.1, DA529750.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000643754.2/ ENSP00000496250.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               BU954396.1         21-580
            561-607             CA335141.1         562-608
            608-819             BX118515.1         246-457
            820-867             AL451000.16        109342-109389
            868-1017            AA748897.1         13-162              c
FEATURES             Location/Qualifiers
     source          1..1017
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..1017
                     /gene="RPL11"
                     /gene_synonym="DBA7; GIG34; L11; uL5"
                     /note="ribosomal protein L11"
                     /db_xref="GeneID:6135"
                     /db_xref="HGNC:HGNC:10301"
                     /db_xref="MIM:604175"
     exon            1..24
                     /gene="RPL11"
                     /gene_synonym="DBA7; GIG34; L11; uL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..555
                     /gene="RPL11"
                     /gene_synonym="DBA7; GIG34; L11; uL5"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     growth-inhibiting protein 34; 60S ribosomal protein L11;
                     CLL-associated antigen KW-12; large ribosomal subunit
                     protein uL5"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL5 isoform 1"
                     /protein_id="NP_000966.2"
                     /db_xref="CCDS:CCDS238.1"
                     /db_xref="GeneID:6135"
                     /db_xref="HGNC:HGNC:10301"
                     /db_xref="MIM:604175"
                     /translation="MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLT
                     GQTPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDT
                     GNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKE
                     EAMRWFQQKYDGIILPGK"
     exon            25..175
                     /gene="RPL11"
                     /gene_synonym="DBA7; GIG34; L11; uL5"
                     /inference="alignment:Splign:2.1.0"
     exon            176..282
                     /gene="RPL11"
                     /gene_synonym="DBA7; GIG34; L11; uL5"
                     /inference="alignment:Splign:2.1.0"
     exon            283..414
                     /gene="RPL11"
                     /gene_synonym="DBA7; GIG34; L11; uL5"
                     /inference="alignment:Splign:2.1.0"
     exon            415..525
                     /gene="RPL11"
                     /gene_synonym="DBA7; GIG34; L11; uL5"
                     /inference="alignment:Splign:2.1.0"
     exon            526..1017
                     /gene="RPL11"
                     /gene_synonym="DBA7; GIG34; L11; uL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      580..585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL11"
                     /gene_synonym="DBA7; GIG34; L11; uL5"
                     /note="hexamer: AATAAA"
     polyA_site      600
                     /gene="RPL11"
                     /gene_synonym="DBA7; GIG34; L11; uL5"
                     /note="major polyA site"
     regulatory      996..1001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL11"
                     /gene_synonym="DBA7; GIG34; L11; uL5"
                     /note="hexamer: ATTAAA"
     polyA_site      1017
                     /gene="RPL11"
                     /gene_synonym="DBA7; GIG34; L11; uL5"
ORIGIN      
        1 ctcttcctgc tctccatcat ggcgcaggat caaggtgaaa aggagaaccc catgcgggaa
       61 cttcgcatcc gcaaactctg tctcaacatc tgtgttgggg agagtggaga cagactgacg
      121 cgagcagcca aggtgttgga gcagctcaca gggcagaccc ctgtgttttc caaagctaga
      181 tacactgtca gatcctttgg catccggaga aatgaaaaga ttgctgtcca ctgcacagtt
      241 cgaggggcca aggcagaaga aatcttggag aagggtctaa aggtgcggga gtatgagtta
      301 agaaaaaaca acttctcaga tactggaaac tttggttttg ggatccagga acacatcgat
      361 ctgggtatca aatatgaccc aagcattggt atctacggcc tggacttcta tgtggtgctg
      421 ggtaggccag gtttcagcat cgcagacaag aagcgcagga caggctgcat tggggccaaa
      481 cacagaatca gcaaagagga ggccatgcgc tggttccagc agaagtatga tgggatcatc
      541 cttcctggca aataaattcc cgtttctatc caaaagagca ataaaaagtt ttcagtgaaa
      601 tgtgcaattc tgttgtgtgt tctgtgaaag gatcctggcc atattcaagt ccttggacct
      661 caagccactt aaagcttcga tgggagtagc tggtaacaac cccgtcatcc tctgattgga
      721 tgccagtatt tcctggcaga tccaagtcca agcttcatag cattcattgc ctgtgcttgc
      781 cacaccttgg ttgatgtgct gtggtgcagt agccccattt ggaggggagg gtttggttga
      841 tgttggggtt tgaatttaga gccttggtta agcagggtgc agtgctcctg tgttccagga
      901 ggccccctgc tattcagtga ttctgttctg tactagaaat tttatcagca ttgatgcgtc
      961 atgaaggaat gacaggcttt ggtgtgatgg ttgagattaa atttagactt aactgtt
//
