LOCUS       NM_007104                718 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribosomal protein L10a (RPL10A), mRNA.
ACCESSION   NM_007104
VERSION     NM_007104.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 718)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 718)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 718)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 718)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 718)
  AUTHORS   Lee,J.H., Han,J.H., Kim,H., Park,S.M., Joe,E.H. and Jou,I.
  TITLE     Parkinson's disease-associated LRRK2-G2019S mutant acts through
            regulation of SERCA activity to control ER stress in astrocytes
  JOURNAL   Acta Neuropathol Commun 7 (1), 68 (2019)
   PUBMED   31046837
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 718)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   7  (bases 1 to 718)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   8  (bases 1 to 718)
  AUTHORS   Olvera,J. and Wool,I.G.
  TITLE     The primary structure of rat ribosomal protein L10a
  JOURNAL   Biochem Biophys Res Commun 220 (3), 954-957 (1996)
   PUBMED   8607874
REFERENCE   9  (bases 1 to 718)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   10 (bases 1 to 718)
  AUTHORS   Fisicaro,N., Katerelos,M., Williams,J., Power,D., D'Apice,A. and
            Pearse,M.
  TITLE     Identification of genes downregulated in the thymus by
            cyclosporin-A: preliminary characterization of clone CSA-19
  JOURNAL   Mol Immunol 32 (8), 565-572 (1995)
   PUBMED   7609734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BP318268.1 and BC006791.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007104.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 60S subunit. The protein belongs
            to the L1P family of ribosomal proteins. It is located in the
            cytoplasm. The expression of this gene is downregulated in the
            thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies
            in mice have shown that the expression of the ribosomal protein
            L10a gene is downregulated in neural precursor cells during
            development. This gene previously was referred to as NEDD6 (neural
            precursor cell expressed, developmentally downregulated 6), but it
            has been renamed RPL10A (ribosomal protein 10a). As is typical for
            genes encoding ribosomal proteins, there are multiple processed
            pseudogenes of this gene dispersed through the genome. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.467930.1,
                                           SRR5189652.58832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322203.7/ ENSP00000363018.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BP318268.1         1-19
            20-718              BC006791.1         1-699
FEATURES             Location/Qualifiers
     source          1..718
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..718
                     /gene="RPL10A"
                     /gene_synonym="Csa-19; CSA19; L10A; NEDD6; uL1"
                     /note="ribosomal protein L10a"
                     /db_xref="GeneID:4736"
                     /db_xref="HGNC:HGNC:10299"
                     /db_xref="MIM:615660"
     exon            1..39
                     /gene="RPL10A"
                     /gene_synonym="Csa-19; CSA19; L10A; NEDD6; uL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..688
                     /gene="RPL10A"
                     /gene_synonym="Csa-19; CSA19; L10A; NEDD6; uL1"
                     /EC_number="3.6.5.3"
                     /note="60S ribosomal protein L10a; NEDD-6; neural
                     precursor cell expressed developmentally down-regulated
                     protein 6"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL1"
                     /protein_id="NP_009035.3"
                     /db_xref="CCDS:CCDS4806.1"
                     /db_xref="GeneID:4736"
                     /db_xref="HGNC:HGNC:10299"
                     /db_xref="MIM:615660"
                     /translation="MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQ
                     KDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKK
                     LAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMK
                     KVLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY"
     exon            40..114
                     /gene="RPL10A"
                     /gene_synonym="Csa-19; CSA19; L10A; NEDD6; uL1"
                     /inference="alignment:Splign:2.1.0"
     exon            115..195
                     /gene="RPL10A"
                     /gene_synonym="Csa-19; CSA19; L10A; NEDD6; uL1"
                     /inference="alignment:Splign:2.1.0"
     exon            196..344
                     /gene="RPL10A"
                     /gene_synonym="Csa-19; CSA19; L10A; NEDD6; uL1"
                     /inference="alignment:Splign:2.1.0"
     exon            345..517
                     /gene="RPL10A"
                     /gene_synonym="Csa-19; CSA19; L10A; NEDD6; uL1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..718
                     /gene="RPL10A"
                     /gene_synonym="Csa-19; CSA19; L10A; NEDD6; uL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      699..704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL10A"
                     /gene_synonym="Csa-19; CSA19; L10A; NEDD6; uL1"
                     /note="hexamer: AATAAA"
     polyA_site      718
                     /gene="RPL10A"
                     /gene_synonym="Csa-19; CSA19; L10A; NEDD6; uL1"
                     /note="major polyA site"
ORIGIN      
        1 agtctctttt ccggttagcg cggcgtgaga agccatgagc agcaaagtct ctcgcgacac
       61 cctgtacgag gcggtgcggg aagtcctgca cgggaaccag cgcaagcgcc gcaagttcct
      121 ggagacggtg gagttgcaga tcagcttgaa gaactatgat ccccagaagg acaagcgctt
      181 ctcgggcacc gtcaggctta agtccactcc ccgccctaag ttctctgtgt gtgtcctggg
      241 ggaccagcag cactgtgacg aggctaaggc cgtggatatc ccccacatgg acatcgaggc
      301 gctgaaaaaa ctcaacaaga ataaaaaact ggtcaagaag ctggccaaga agtatgatgc
      361 gtttttggcc tcagagtctc tgatcaagca gattccacga atcctcggcc caggtttaaa
      421 taaggcagga aagttccctt ccctgctcac acacaacgaa aacatggtgg ccaaagtgga
      481 tgaggtgaag tccacaatca agttccaaat gaagaaggtg ttatgtctgg ctgtagctgt
      541 tggtcacgtg aagatgacag acgatgagct tgtgtataac attcacctgg ctgtcaactt
      601 cttggtgtca ttgctcaaga aaaactggca gaatgtccgg gccttatata tcaagagcac
      661 catgggcaag ccccagcgcc tatattaagg cacatttgaa taaattctat taccagtt
//
