LOCUS       NM_006013               2164 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ribosomal protein L10 (RPL10), transcript variant 1,
            mRNA.
ACCESSION   NM_006013 NM_032241
VERSION     NM_006013.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2164)
  AUTHORS   Wang,K., Chen,S., Wu,Y., Wang,Y., Lu,Y., Sun,Y. and Chen,Y.
  TITLE     The ufmylation modification of ribosomal protein L10 in the
            development of pancreatic adenocarcinoma
  JOURNAL   Cell Death Dis 14 (6), 350 (2023)
   PUBMED   37280198
  REMARK    GeneRIF: The ufmylation modification of ribosomal protein L10 in
            the development of pancreatic adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2164)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2164)
  AUTHORS   Yang,J., Chen,Z., Liu,N. and Chen,Y.
  TITLE     Ribosomal protein L10 in mitochondria serves as a regulator for ROS
            level in pancreatic cancer cells
  JOURNAL   Redox Biol 19, 158-165 (2018)
   PUBMED   30172100
  REMARK    GeneRIF: The regulation of reactive oxygen species level by
            mitochondrial RPL10 is one of the major extra-ribosomal functions
            in pancreatic cancer cells, which could be used as an indicator for
            the tumorigenesis of pancreatic cancer.
REFERENCE   4  (bases 1 to 2164)
  AUTHORS   Farmer,A.A., Johnsen,J.I., Loftus,T.M., Smith,K.P. and
            Stanbridge,E.J.
  TITLE     Isolation and characterization of the QM promoter
  JOURNAL   Nucleic Acids Res 24 (11), 2158-2165 (1996)
   PUBMED   8668549
REFERENCE   5  (bases 1 to 2164)
  AUTHORS   Farmer,A.A., Loftus,T.M., Mills,A.A., Sato,K.Y., Neill,J.D.,
            Tron,T., Yang,M., Trumpower,B.L. and Stanbridge,E.J.
  TITLE     Extreme evolutionary conservation of QM, a novel c-Jun associated
            transcription factor
  JOURNAL   Hum Mol Genet 3 (5), 723-728 (1994)
   PUBMED   8081358
REFERENCE   6  (bases 1 to 2164)
  AUTHORS   Kaneko,K., Kobayashi,H., Onodera,O., Miyatake,T. and Tsuji,S.
  TITLE     Genomic organization of a cDNA (QM) demonstrating an altered mRNA
            level in nontumorigenic Wilms' microcell hybrid cells and its
            localization to Xq28
  JOURNAL   Hum Mol Genet 1 (7), 529-533 (1992)
   PUBMED   1339145
REFERENCE   7  (bases 1 to 2164)
  AUTHORS   van den Ouweland,A.M., Verdijk,M., Mannens,M.M. and van Oost,B.A.
  TITLE     The QM gene is X-linked and therefore not involved in suppression
            of tumorigenesis in Wilms' tumor
  JOURNAL   Hum Genet 90 (1-2), 144-146 (1992)
   PUBMED   1330878
REFERENCE   8  (bases 1 to 2164)
  AUTHORS   van den Ouweland,A.M., Kioschis,P., Verdijk,M., Tamanini,F.,
            Toniolo,D., Poustka,A. and van Oost,B.A.
  TITLE     Identification and characterization of a new gene in the human Xq28
            region
  JOURNAL   Hum Mol Genet 1 (4), 269-273 (1992)
   PUBMED   1303197
REFERENCE   9  (bases 1 to 2164)
  AUTHORS   Bignon,C., Roux-Dosseto,M., Zeigler,M.E., Wicha,M.S. and
            Martin,P.M.
  TITLE     cDNA cloning and genomic analysis of a new multigene family sharing
            common phylogenetic and expression profiles with the laminin
            receptor gene
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1165-1172 (1992)
   PUBMED   1534224
REFERENCE   10 (bases 1 to 2164)
  AUTHORS   Dowdy,S.F., Lai,K.M., Weissman,B.E., Matsui,Y., Hogan,B.L. and
            Stanbridge,E.J.
  TITLE     The isolation and characterization of a novel cDNA demonstrating an
            altered mRNA level in nontumorigenic Wilms' microcell hybrid cells
  JOURNAL   Nucleic Acids Res 19 (20), 5763-5769 (1991)
   PUBMED   1658743
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AK130582.1 and AC245140.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 13, 2019 this sequence version replaced NM_006013.4.
            
            Summary: This gene encodes a ribosomal protein that is a component
            of the 60S ribosome subunit. The related protein in chicken can
            bind to c-Jun and can repress c-Jun-mediated transcriptional
            activation. Some studies have detected an association between
            variation in this gene and autism spectrum disorders, though others
            do not detect this relationship. There are multiple pseudogenes of
            this gene dispersed throughout the genome. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jan
            2015].
            
            Transcript Variant: This variant (1) encodes isoform a. Variants 1,
            4, and 5 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK130582.1, M64241.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369817.7/ ENSP00000358832.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-744               AK130582.1         1-744
            745-2164            AC245140.2         18616-20035         c
FEATURES             Location/Qualifiers
     source          1..2164
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..2164
                     /gene="RPL10"
                     /gene_synonym="AUTSX5; DXS648; DXS648E; L10; MRXS35; NOV;
                     QM; uL16"
                     /note="ribosomal protein L10"
                     /db_xref="GeneID:6134"
                     /db_xref="HGNC:HGNC:10298"
                     /db_xref="MIM:312173"
     exon            1..18
                     /gene="RPL10"
                     /gene_synonym="AUTSX5; DXS648; DXS648E; L10; MRXS35; NOV;
                     QM; uL16"
                     /inference="alignment:Splign:2.1.0"
     exon            19..64
                     /gene="RPL10"
                     /gene_synonym="AUTSX5; DXS648; DXS648E; L10; MRXS35; NOV;
                     QM; uL16"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..686
                     /gene="RPL10"
                     /gene_synonym="AUTSX5; DXS648; DXS648E; L10; MRXS35; NOV;
                     QM; uL16"
                     /EC_number="3.6.5.3"
                     /note="isoform a is encoded by transcript variant 1; 60S
                     ribosomal protein L10; tumor suppressor QM; Wilms
                     tumor-related protein; laminin receptor homolog; large
                     ribosomal subunit protein uL16"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL16 isoform a"
                     /protein_id="NP_006004.3"
                     /db_xref="CCDS:CCDS14746.1"
                     /db_xref="GeneID:6134"
                     /db_xref="HGNC:HGNC:10298"
                     /db_xref="MIM:312173"
                     /translation="MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVD
                     EFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKM
                     LSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFP
                     GRQKIHISKKWGFTKFNADEFEDMVAEKRLIPDGCGVKYIPSRGPLDKWRALHS"
     exon            65..123
                     /gene="RPL10"
                     /gene_synonym="AUTSX5; DXS648; DXS648E; L10; MRXS35; NOV;
                     QM; uL16"
                     /inference="alignment:Splign:2.1.0"
     exon            124..231
                     /gene="RPL10"
                     /gene_synonym="AUTSX5; DXS648; DXS648E; L10; MRXS35; NOV;
                     QM; uL16"
                     /inference="alignment:Splign:2.1.0"
     exon            232..370
                     /gene="RPL10"
                     /gene_synonym="AUTSX5; DXS648; DXS648E; L10; MRXS35; NOV;
                     QM; uL16"
                     /inference="alignment:Splign:2.1.0"
     exon            371..533
                     /gene="RPL10"
                     /gene_synonym="AUTSX5; DXS648; DXS648E; L10; MRXS35; NOV;
                     QM; uL16"
                     /inference="alignment:Splign:2.1.0"
     exon            534..2164
                     /gene="RPL10"
                     /gene_synonym="AUTSX5; DXS648; DXS648E; L10; MRXS35; NOV;
                     QM; uL16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      724..729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL10"
                     /gene_synonym="AUTSX5; DXS648; DXS648E; L10; MRXS35; NOV;
                     QM; uL16"
                     /note="hexamer: AATAAA"
     polyA_site      745
                     /gene="RPL10"
                     /gene_synonym="AUTSX5; DXS648; DXS648E; L10; MRXS35; NOV;
                     QM; uL16"
                     /note="major polyA site"
     regulatory      2144..2149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPL10"
                     /gene_synonym="AUTSX5; DXS648; DXS648E; L10; MRXS35; NOV;
                     QM; uL16"
                     /note="hexamer: AATAAA"
     polyA_site      2164
                     /gene="RPL10"
                     /gene_synonym="AUTSX5; DXS648; DXS648E; L10; MRXS35; NOV;
                     QM; uL16"
ORIGIN      
        1 ctctttccct tcggtgtgcc actgaagatc ctggtgtcgc catgggccgc cgccccgccc
       61 gttgttaccg gtattgtaag aacaagccgt acccaaagtc tcgcttctgc cgaggtgtcc
      121 ctgatgccaa gattcgcatt tttgacctgg ggcggaaaaa ggcaaaagtg gatgagtttc
      181 cgctttgtgg ccacatggtg tcagatgaat atgagcagct gtcctctgaa gccctggagg
      241 ctgcccgaat ttgtgccaat aagtacatgg taaaaagttg tggcaaagat ggcttccata
      301 tccgggtgcg gctccacccc ttccacgtca tccgcatcaa caagatgttg tcctgtgctg
      361 gggctgacag gctccaaaca ggcatgcgag gtgcctttgg aaagccccag ggcactgtgg
      421 ccagggttca cattggccaa gttatcatgt ccatccgcac caagctgcag aacaaggagc
      481 atgtgattga ggccctgcgc agggccaagt tcaagtttcc tggccgccag aagatccaca
      541 tctcaaagaa gtggggcttc accaagttca atgctgatga atttgaagac atggtggctg
      601 aaaagcggct catcccagat ggctgtgggg tcaagtacat ccccagtcgt ggccctctgg
      661 acaagtggcg ggccctgcac tcatgagggc ttccaatgtg ctgcccccct cttaatactc
      721 accaataaat tctacttcct gtccacctat gtctttgtat ctacattctt gacggggaag
      781 gaacttcctc tgggaacctt tgggtcattg ccctttcact tcagaaacag gttgacaact
      841 cagccctgct catgaggcag caaaccctgc aaagggctgg gactggtggc cttatgtcag
      901 ttgtctactc tggagcttga cttggacctc cccaggtcct aggcagtagg ttgaaaaaca
      961 ctgaagtgct tttcatgaag cacagctgca gcaaagcctt gcaatcccag gctggggtca
     1021 gcctacagtt gtgttgctta ttacaacaca tgcggaccaa gaggggcttg tgggctagag
     1081 gctgaccagc agcgtttatt tagcaagggt aggtgtgcat cacattgggc ttgttctcac
     1141 ccatctggtt tggccattcc tccttggtgg gaatcatcca ggtactgctg aggtcacctg
     1201 cgatttgccc catttcctat ctctagcaac ctcctgggcc ccatgccccc accccttcta
     1261 gaacctgcat tcccagggcc ttcaccacct gaccaaaggt ctaggctaac ctttggtcat
     1321 ttgtaacaag acctcggaac agacacgtgt gtggcatggt ttggcctggg gatcttagat
     1381 gtctgacctg aactattgta gaacagcgct ggcttttggg ggagcagcaa aaatgagagg
     1441 agtgctaggt gggtggcctg agcatctgta tccagggaca ggactccaaa ggcttttggt
     1501 cccagagctg gggtatgttg gccccagccc ccagcctgtg gctcccaaaa ggcctctggt
     1561 tttttgtaat ctcagtttac agccatttct taggttttta attaccttta ttttattttg
     1621 ccaaacatac ctgggaatac cttttatttt ttttttacct tggggtgatg gttccaaacc
     1681 ataaatgtga ttatagttaa cacatgaccc ttctagcgtc ccagccagtg tttttcctga
     1741 cctctcttct ttggagagga ggatggaagg gaggggtccg gcatgctgct ggcattttgc
     1801 tgtgtcctgc agcccctttc cgggacacct gggttcacac agctttttag cttacataac
     1861 tggtgcagat tttctgtgtg gagatgttgc cttgaccagc cttggctgga ctttaccagg
     1921 catgcagaag cctgtaccaa cacagactac agcacccagg aggtgcgagt gtggctgctc
     1981 agcggttata acaggcctga ctgcattgtt caccggatta taatgagcca aaatgtttcc
     2041 cggtgtttgc tggtttcagg gaaggagttt gatatagcag attaaccacc ctccttgtag
     2101 ctattggggc ttaatggttt cctggtgatt cttaccaatc cacaataaac atggcccatt
     2161 ggca
//
