LOCUS       NM_015272               7935 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens RPGRIP1 like (RPGRIP1L), transcript variant 1, mRNA.
ACCESSION   NM_015272 XM_051197
VERSION     NM_015272.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7935)
  AUTHORS   Zhang,P., Wu,B., Wang,Y., Ren,Y., Li,G., Qan,Y., Lei,C. and Wang,H.
  TITLE     Identification of Pathogenic Variants in RPGRIP1L with Meckel
            Syndrome and Preimplantation Genetic Testing in a Chinese Family
  JOURNAL   Reprod Sci 29 (8), 2200-2207 (2022)
   PUBMED   35233738
  REMARK    GeneRIF: Identification of Pathogenic Variants in RPGRIP1L with
            Meckel Syndrome and Preimplantation Genetic Testing in a Chinese
            Family.
REFERENCE   2  (bases 1 to 7935)
  AUTHORS   Wiegering,A., Dildrop,R., Vesque,C., Khanna,H.,
            Schneider-Maunoury,S. and Gerhardt,C.
  TITLE     Rpgrip1l controls ciliary gating by ensuring the proper amount of
            Cep290 at the vertebrate transition zone
  JOURNAL   Mol Biol Cell 32 (8), 675-689 (2021)
   PUBMED   33625872
  REMARK    GeneRIF: Rpgrip1l controls ciliary gating by ensuring the proper
            amount of Cep290 at the vertebrate transition zone.
REFERENCE   3  (bases 1 to 7935)
  AUTHORS   Vossing,C., Atigbire,P., Eilers,J., Markus,F., Stieger,K., Song,F.
            and Neidhardt,J.
  TITLE     The Major Ciliary Isoforms of RPGR Build Different Interaction
            Complexes with INPP5E and RPGRIP1L
  JOURNAL   Int J Mol Sci 22 (7), 3583 (2021)
   PUBMED   33808286
  REMARK    GeneRIF: The Major Ciliary Isoforms of RPGR Build Different
            Interaction Complexes with INPP5E and RPGRIP1L.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7935)
  AUTHORS   Choi,Y.J., Laclef,C., Yang,N., Andreu-Cervera,A., Lewis,J., Mao,X.,
            Li,L., Snedecor,E.R., Takemaru,K.I., Qin,C., Schneider-Maunoury,S.,
            Shroyer,K.R., Hannun,Y.A., Koch,P.J., Clark,R.A., Payne,A.S.,
            Kowalczyk,A.P. and Chen,J.
  TITLE     RPGRIP1L is required for stabilizing epidermal keratinocyte
            adhesion through regulating desmoglein endocytosis
  JOURNAL   PLoS Genet 15 (1), e1007914 (2019)
   PUBMED   30689641
  REMARK    GeneRIF: Biotinylation assays on cell surface proteins not only
            reinforced the role of RPGRIP1L in desmoglein endocytosis, but also
            suggested that RPGRIP1L may be more broadly involved in
            endocytosis. Thus, data obtained from this study advanced our
            understanding of the biological functions of RPGRIP1L by
            identifying its role in the cellular endocytic pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7935)
  AUTHORS   Delous,M., Baala,L., Salomon,R., Laclef,C., Vierkotten,J., Tory,K.,
            Golzio,C., Lacoste,T., Besse,L., Ozilou,C., Moutkine,I.,
            Hellman,N.E., Anselme,I., Silbermann,F., Vesque,C., Gerhardt,C.,
            Rattenberry,E., Wolf,M.T., Gubler,M.C., Martinovic,J.,
            Encha-Razavi,F., Boddaert,N., Gonzales,M., Macher,M.A., Nivet,H.,
            Champion,G., Bertheleme,J.P., Niaudet,P., McDonald,F.,
            Hildebrandt,F., Johnson,C.A., Vekemans,M., Antignac,C., Ruther,U.,
            Schneider-Maunoury,S., Attie-Bitach,T. and Saunier,S.
  TITLE     The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal
            syndrome (Joubert syndrome type B) and Meckel syndrome
  JOURNAL   Nat Genet 39 (7), 875-881 (2007)
   PUBMED   17558409
  REMARK    GeneRIF: Mutations can cause the multiorgan phenotypic
            abnormalities found in cerebello-oculo-renal syndrome or Meckel
            syndrome.
REFERENCE   6  (bases 1 to 7935)
  AUTHORS   Arts,H.H., Doherty,D., van Beersum,S.E., Parisi,M.A.,
            Letteboer,S.J., Gorden,N.T., Peters,T.A., Marker,T., Voesenek,K.,
            Kartono,A., Ozyurek,H., Farin,F.M., Kroes,H.Y., Wolfrum,U.,
            Brunner,H.G., Cremers,F.P., Glass,I.A., Knoers,N.V. and Roepman,R.
  TITLE     Mutations in the gene encoding the basal body protein RPGRIP1L, a
            nephrocystin-4 interactor, cause Joubert syndrome
  JOURNAL   Nat Genet 39 (7), 882-888 (2007)
   PUBMED   17558407
  REMARK    GeneRIF: Responsible for Joubert syndrome, affecting cilia and
            basal bodies.
REFERENCE   7  (bases 1 to 7935)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7935)
  AUTHORS   Stokman,M., Lilien,M. and Knoers,N.
  TITLE     Nephronophthisis-Related Ciliopathies
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27336129
REFERENCE   9  (bases 1 to 7935)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
REFERENCE   10 (bases 1 to 7935)
  AUTHORS   Parisi,M. and Glass,I.
  TITLE     Joubert Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007909.8, CR749645.1 and
            AC007497.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015272.4.
            
            Summary: The protein encoded by this gene can localize to the basal
            body-centrosome complex or to primary cilia and centrosomes in
            ciliated cells. The encoded protein has been found to interact with
            nephrocystin-4. Defects in this gene are a cause of Joubert
            syndrome type 7 (JBTS7) and Meckel syndrome type 5 (MKS5).
            [provided by RefSeq, Jun 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749645.1, SRR1803611.128861.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000647211.2/ ENSP00000493946.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC007909.8         153505-153517
            14-1787             CR749645.1         1-1774
            1788-1848           AC007497.6         1496-1556
            1849-3038           CR749645.1         1836-3025
            3039-3039           AC007497.6         16064-16064
            3040-3491           CR749645.1         3027-3478
            3492-3492           AC007497.6         32236-32236
            3493-4066           CR749645.1         3480-4053
            4067-7935           AC007497.6         52438-56306
FEATURES             Location/Qualifiers
     source          1..7935
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..7935
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /note="RPGRIP1 like"
                     /db_xref="GeneID:23322"
                     /db_xref="HGNC:HGNC:29168"
                     /db_xref="MIM:610937"
     exon            1..57
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            58..149
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..4012
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /note="isoform a is encoded by transcript variant 1;
                     protein phosphatase 1, regulatory subunit 134; fantom
                     homolog; protein fantom; RPGR-interacting protein 1-like
                     protein; nephrocystin-8"
                     /codon_start=1
                     /product="protein fantom isoform a"
                     /protein_id="NP_056087.2"
                     /db_xref="CCDS:CCDS32447.1"
                     /db_xref="GeneID:23322"
                     /db_xref="HGNC:HGNC:29168"
                     /db_xref="MIM:610937"
                     /translation="MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSR
                     VSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRL
                     GRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTG
                     RRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQ
                     RGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLV
                     EKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSM
                     KFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQL
                     ETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQ
                     ENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQE
                     LEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLE
                     AQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQAS
                     GDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQYLVHVNDLFLQYIQKNTITLEV
                     HQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTKGDIPNFGTVEYWFRLRVPMD
                     QAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLSSTDSTDGNLNELHITIRC
                     CNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDDHMYFPVPMNMDLDRYL
                     KSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELTDHQKHPAGTIHVIL
                     KWKFAYLPPSGSITTEDLGNFIRSEEPEVVQRLPPASSVSTLVLAPRPKPRQRLTPVD
                     KKVSFVDIMPHQSDETSPPPEDRKEISPEVEHIPEIEINMLTVPHVPKVSQEGSVDEV
                     KENTEKMQQGKDDVSLLSEGQLAEQSLASSEDETEITEDLEPEVEEDMSASDSDDCII
                     PGPISKNIKQSLALSPGLGCSSAISAHCNFRLPGSSDFPASASQVDGITGACHHTQPS
                     EKIRIEIIALSLNDSQVTMDDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVYYNYS
                     NVIYVDKENNKAKRDILKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHVDL
                     ADMFQEGRDLIEQNIDVFDARADGEGIGKLRVTVEALHALQSVYKQYRDDLEA"
     exon            150..294
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            295..593
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            594..696
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            697..840
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            841..946
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1093
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1167
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1307
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1414
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1465
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1645
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1763
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..2216
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2368
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2747
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2938
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3022
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3124
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3284
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3358
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3496
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3680
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            3681..3765
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            3766..3899
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            3900..7935
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4617..4622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /note="hexamer: AATGAA"
     polyA_site      4638
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /note="major polyA site"
     regulatory      6835..6840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /note="hexamer: AAGAAA"
     polyA_site      6853
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
     regulatory      7188..7193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /note="hexamer: AATAAA"
     polyA_site      7220
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
     regulatory      7910..7915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /note="hexamer: AATAAA"
     polyA_site      7935
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
ORIGIN      
        1 gcccgccacg ctgtcggcgc tatagcaacg gtagctagct gcagggccag tggcacgcta
       61 ggccatgtct ggtccaactg atgagactgc aggagacttg cctgtgaaag atacaggtct
      121 aaacctcttt ggaatgggag ggttacaaga aacttcaaca acacggacaa tgaagtctcg
      181 ccaggcagtg tcacgtgtca gtcgtgagga actggaagac agatttttgc gtttgcatga
      241 tgagaacatt ttacttaaac agcatgcccg caagcaggag gataaaatta aaagaatggc
      301 caccaagtta atacggctag ttaatgacaa gaaaagatat gagcgggttg gtggcggccc
      361 caagcggctg ggacgagatg tggaaatgga agaaatgatt gagcagctgc aagagaaagt
      421 tcatgagctt gaaaaacaaa atgaaaccct caaaaacaga ctgatttcag ccaaacagca
      481 acttcaaacc cagggttaca ggcaaactcc atacaataat gtacaatctc gtattaacac
      541 tgggcgtaga aaagcaaatg aaaatgctgg tttacaggaa tgccccagga aaggtataaa
      601 attccaagat gcagatgtag cagaaactcc acatcccatg tttacaaaat atggcaacag
      661 tttacttgaa gaagccagag gagaaataag aaatttagaa aacgttattc agtcacaaag
      721 aggccagata gaggagttag agcacttggc tgagatcctg aaaactcagt tgaggagaaa
      781 agaaaatgaa attgagttat ctcttcttca gcttcgagaa cagcaagcta cagatcaaag
      841 gtcaaatatt cgggacaatg tagaaatgat taagcttcat aaacagctag tagagaaaag
      901 caatgctctt tcagcaatgg aaggaaaatt tattcagctt caagagaagc aaagaactct
      961 cagaatcagc cacgatgctt tgatggcaaa tggggatgaa ttaaacatgc aacttaaaga
     1021 gcagcgttta aaatgctgca gtcttgagaa acaattacat tctatgaagt tttctgaaag
     1081 aagaatagaa gagctgcagg atagaattaa tgatttagaa aaggaacggg aacttttaaa
     1141 ggaaaactat gataaacttt atgacagtgc cttcagtgct gcccatgaag agcaatggaa
     1201 gttaaaggag caacagctga aagtgcagat tgctcagctc gagactgcct tgaagtctga
     1261 cttaacagac aaaactgaaa tccttgacag attaaaaact gaaagagatc aaaatgaaaa
     1321 actcgttcaa gagaatagag aactacagtt acagtatctg gaacaaaagc aacaacttga
     1381 tgaacttaaa aaacgcataa aattgtacaa ccaggagaat gatattaatg ctgatgaatt
     1441 gagtgaagct ctcctactta taaaggctca aaaagaacaa aaaaatggag acctttcctt
     1501 tttagtgaaa gtagatagtg aaattaataa agatctagaa cgctctatga gagagctgca
     1561 agcaactcat gcagaaacgg tgcaagagct ggaaaagaca agaaacatgc taattatgca
     1621 acacaaaatt aataaagatt atcagatgga ggttgaggca gtgacccgta agatggaaaa
     1681 tttgcagcaa gattatgaac tcaaagtgga acagtatgtt catcttcttg atatcagggc
     1741 tgcacgtatc cataaactag aagcccaatt aaaggatatt gcctatggca ccaagcagta
     1801 caaatttaaa ccagaaatca tgccagatga ctctgttgat gaatttgatg aaaccatcca
     1861 cttagaacga ggcgaaaatc tatttgaaat ccatatcaac aaagtaacct tttcttctga
     1921 agttttacag gcatctggag ataaagagcc tgtcactttc tgtacctatg ctttctatga
     1981 ttttgaacta cagacaactc ccgtagtgcg aggccttcat cccgaatata acttcacttc
     2041 tcaatatctt gttcatgtta atgacttatt tttgcaatat attcagaaga atactatcac
     2101 ccttgaggtc caccaggctt atagcacaga atatgaaaca attgcagcat gtcaattaaa
     2161 atttcacgaa attcttgaaa aaagcggccg aatattttgt acagcaagtt tgattggaac
     2221 aaaaggagac atcccaaatt ttggcacagt ggaatactgg ttccgattaa gagttcccat
     2281 ggatcaagca attcgacttt atcgagaaag ggcaaaggct ttggggtata taacatcaaa
     2341 ttttaagggg ccagagcata tgcagtcgtt aagtcagcaa gcacccaaaa ctgctcaact
     2401 cagttctaca gattccacag atggcaactt aaatgaactt cacattacaa taagatgttg
     2461 caaccacctg cagtcccgag caagccacct gcagccacac ccatatgttg tgtacaagtt
     2521 ttttgatttt gcagaccatg atacagctat cattcccagt agcaatgatc cacagtttga
     2581 tgatcatatg tatttcccag tgccaatgaa tatggacttg gatcgatacc ttaagtcaga
     2641 gtctctgagt ttttatgttt ttgatgatag tgatacccag gagaatattt acataggaaa
     2701 agtcaatgtg cctctgattt cgttggcaca tgacaggtgt atctcaggaa tatttgagtt
     2761 aacagaccat caaaagcatc ctgctggcac catccatgtt atattgaaat ggaaatttgc
     2821 ttaccttcca ccaagtggat caataacaac tgaagactta ggaaatttca ttcgcagcga
     2881 agagccagaa gttgttcaaa gacttcctcc agcatcctct gttagcacac tagttttagc
     2941 accaagacct aaaccaagac aacgtttaac acctgtagat aagaaggtat ctttcgtgga
     3001 tatcatgcca catcagagtg atgagacttc tcctcctcct gaagatagga aggaaatttc
     3061 accagaggta gagcatatac cagaaataga aattaatatg ctgactgttc cacatgttcc
     3121 caaggtttca caagaaggca gtgtagatga ggtaaaagag aatactgaga aaatgcagca
     3181 aggaaaagat gatgtgtctt tactatctga aggtcagctt gcagaacaaa gcttggcatc
     3241 ttctgaagat gaaacagaaa taacagagga cttggaacca gaagttgaag aggacatgtc
     3301 agcttctgac agtgatgact gtattattcc aggtcctatc tccaagaata tcaaacagag
     3361 tctcgcattg tctcccgggc tggggtgcag tagcgcgatc tcagctcact gcaacttccg
     3421 cctcccgggt tccagcgatt ttcctgcctc agcctcccaa gtagatggga ttacaggtgc
     3481 ctgccaccac acccagccat cagaaaaaat tcggattgag atcatagctc taagccttaa
     3541 tgattctcaa gtaaccatgg atgacactat ccaacggctg tttgttgagt gtcgattcta
     3601 cagtcttcct gctgaagaga cacccgtgtc acttccaaaa cccaagagtg ggcagtgggt
     3661 ctactataac tatagcaatg tgatctacgt ggataaagaa aacaacaaag caaagagaga
     3721 catcttaaaa gctatactac aaaaacaaga gatgcctaat agaagccttc gcttcaccgt
     3781 ggtcagtgac cctccagagg acgagcagga cctggagtgt gaggacattg gcgtggctca
     3841 cgtcgacctt gccgacatgt ttcaggaagg gagggacctc attgagcaaa atatcgatgt
     3901 ttttgatgca cgagcagatg gtgaaggtat tggcaagctc agggtaacag tcgaagctct
     3961 ccatgccctc cagtctgtct acaagcaata cagagatgac ttggaggctt gaaagcaaat
     4021 gctccagagg catctcctac tcctcagtaa atgctcacat gaaagttcct acatgagatt
     4081 tttgtaatta ctctggtgta tataatctat aattcatggg aagctgggag cggggagacc
     4141 tgggtttgaa gtgttgaagt tttgtatact ttttcatttg tttatttctc tattccctcc
     4201 ttctcataac tgccacccct caggacttaa gttctccata atgggcagta ccttctcaat
     4261 aatttatacc tacgtgatag cgtgagaaag tctatttgca ttttcaacat tttcttagga
     4321 agaaccgaaa tgcaattccc atttttattt ttaataagca aaagcataaa tcttagaaaa
     4381 cctatgaaaa agaaatactt ttatgttatc cctaatcgtc ccactaaatg gaatgcctat
     4441 gattagcttc attaagagtt ttatactgtg aagattttat tagaagcaat atatgaaaat
     4501 tacttggatt aatgtgttaa tcttcctctt taaaatgcta atatccattt tatgcacatt
     4561 aaagctcagt atgcattttc tttgatgcat gcagtttcta tcaattaaat ataaagaatg
     4621 aaacttagca ccaacttatt caatgactgc aagttttttg tctttctttc ttaaaagttc
     4681 attctatttg tattattttc atacatttgt aatggtgacc cagggatgta tatataaaaa
     4741 ggagatagtt atatagatag atgtgaaatt tacacgttga aaacttagta tatgacacag
     4801 aaagaaatta tgaaaagtat aactcaaatt ctgatatgct tagttagacg tgaaaggagt
     4861 atctttttat cattttttaa atttacatca agccagtaca gtgccagggt gtatctgggt
     4921 aaccagatcc tcgaaaagca gctctgaaag ttaattttct agcttttacc caatctcact
     4981 gaaggattta attgatattt ttaatggagc tgtgaatcaa tgctgcaaag gaattgtctc
     5041 tagaggtcta ggatataatg catttcattt tttaatttac ttttttattt gtcattttct
     5101 tcaaaggatt tttataggct gtgggttttc actgtttgca aacaggctat gttccttctt
     5161 aagcatatgt aaagtattca gggagataag taatttatta aaatctacct aatttgccgt
     5221 gatatattaa atctctgctt cagtgatcac agaccatttc atttagagaa ttaggcattc
     5281 cctctttgtg tgattaaagc tctggaaaat gagttctttg ctcctatttg tgaacattca
     5341 aagcctgcta atggcaagaa gatggaatag attatgagac aattcattac agttcaatag
     5401 aaaaaaaaag cagctataat gcaaaaatgc aagtatgaat atctgcatat agtttgaacc
     5461 atctgtgctc taatggcttc aataatgact ctcgtcttta gaaggctttg aaatgacatc
     5521 cgtacaatat taatttgttg atgtacattg tgggaccagt agagtatgat ctgaccacag
     5581 aaatctataa attctgtcta taccactggg cctccctgtc ctggggcctg ccatctccga
     5641 gaagaatctt gctctcatcc aactctgcaa atcttcataa caactcgttc ctctggaacc
     5701 ttctggagac cacaaacatc tgcagactaa acctctccag tcctagtaaa caaccacatg
     5761 tttgttgtca cttcggctgg ctctgagctc atttttttgg cccctttttc tagctttctt
     5821 tggctttatg cagttacagt gtcattaagg cccataatat tccctgcagt aatttaaaac
     5881 agccagatta taccctggga ttaactgagt ggtttttgag acatttattg tggtattctc
     5941 ccaggaggtt tgtattattg ttgtaaaatg ttacatccca aactaaataa cccttctgca
     6001 gggagaagaa ccagattgca ctgacttctt aggatcatta agtggaaagg aaaagttttt
     6061 cttagaaaac ttatgggacc cagtcacctg tatggaatgt atatctcaga caagatgaga
     6121 gaaacagcca tgtttctgtc acattgttta ctgtcatatt aaagatatct agttttaaaa
     6181 tattcagttt caaactattg cgaattttca caacactcat tttcatagct aattgctgct
     6241 gacacatttt gaagtggcga ggtagtattg aacgctgtca tgtggatact tcagttgggt
     6301 ttcataatct gtttgagaat tttgtttgtt ttatcttgtg gtaactggag gccattgaaa
     6361 agcttaccac cttttgggtt aaagagcagt ggatttctct tggtgagcca aactggatcc
     6421 attgaagagg gcttggcgtc aggggccacc agcagtggcc ttgccacaca gataccagct
     6481 taaggtgttg ctggtgtgaa catacacttc ttggtgtaac tagaccagtg cacgcagcac
     6541 ttttttgggc tgtaatgctt ttagtttgga aatacaaata gagatgtgat gtggtatgtg
     6601 ggagagtgta ttttacatgt atttttgcct actgtagtag aaatgtcaaa ttcccagcca
     6661 ctgtcatgaa aagcagttga caaaaataag ttttatggtt tacagtgtgg tttacgtaaa
     6721 gaacatttct cttcactctc agtttcacca tgttttctaa attatcatgg tttactgcca
     6781 tttaacttaa attagttttt ttaaaaatac ataaagaata tgtttaatca aataaagaaa
     6841 ggccacactg aaattctgct gttcctgcca ttcattcgtt accacaaaac acaaataatt
     6901 tctatgtgtt atgaagacat gtgggctgag aagtggtcat gtgattggag aggttttgcg
     6961 tgcactcatg ttcccacaac aaaacataaa ttattttagt aatctgacat caagagctgt
     7021 gaaaatgaaa accagttctt acacatgttc taacaagaat ctgattaaca tttttgtgga
     7081 tatggaaaat ttttttttta gtcaaactgg cactattgct gaatgtagaa tgatttcctt
     7141 atgcactaga tagaaaaatg tgaatcatgt ctgtgaacaa atatgagaat aaaatgtcat
     7201 ctttgtgtag gacaaaacaa ccaggagaga gattttggga taaaaattat caagtgattg
     7261 acaatatcag gatgataatt catccccaac tatcagagta cattttaata agtcactcat
     7321 gcctgaaggc ctctgactac cttaacaaag aaaaactaaa cccgtgattt attagagatt
     7381 gggcaacatg cctaattaaa tccatgaatg ggaacaaaca gatttacatc ccctttgttc
     7441 agaacaaaaa caacctctag gtcaaccaga aagctagaaa atatcaaagc aagagaaaca
     7501 agtgttttta aaactaaaaa tatagaatta gaaaacatct cctcatccta atctctttta
     7561 tcttacaagg tagaattttc acttccattt caaagtgcca ccagtggact gcaccctcca
     7621 gcctgaccgc ctggaaaatt ggacccatat tactggtatt cttatacctt ttgttcttgc
     7681 cctttcattt tccatatgac attcactaat atatcaagct atgtttttcc ttcaggcttt
     7741 tggaagtgca atctggtact cttagacttc gatcatgacc tgttttctga ggtagatgct
     7801 gtttgacttt tctgcttttt gcctcttctc actctattga gagtcacctt tttcatccct
     7861 agaacagcat tacctctgtc ttcactgtgc accatttgtt ttctttttaa ataaaattta
     7921 acatcttgat tttta
//
