LOCUS       NM_001330538            7833 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens RPGRIP1 like (RPGRIP1L), transcript variant 6, mRNA.
ACCESSION   NM_001330538 XM_005255867
VERSION     NM_001330538.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7833)
  AUTHORS   Zhang,P., Wu,B., Wang,Y., Ren,Y., Li,G., Qan,Y., Lei,C. and Wang,H.
  TITLE     Identification of Pathogenic Variants in RPGRIP1L with Meckel
            Syndrome and Preimplantation Genetic Testing in a Chinese Family
  JOURNAL   Reprod Sci 29 (8), 2200-2207 (2022)
   PUBMED   35233738
  REMARK    GeneRIF: Identification of Pathogenic Variants in RPGRIP1L with
            Meckel Syndrome and Preimplantation Genetic Testing in a Chinese
            Family.
REFERENCE   2  (bases 1 to 7833)
  AUTHORS   Wiegering,A., Dildrop,R., Vesque,C., Khanna,H.,
            Schneider-Maunoury,S. and Gerhardt,C.
  TITLE     Rpgrip1l controls ciliary gating by ensuring the proper amount of
            Cep290 at the vertebrate transition zone
  JOURNAL   Mol Biol Cell 32 (8), 675-689 (2021)
   PUBMED   33625872
  REMARK    GeneRIF: Rpgrip1l controls ciliary gating by ensuring the proper
            amount of Cep290 at the vertebrate transition zone.
REFERENCE   3  (bases 1 to 7833)
  AUTHORS   Vossing,C., Atigbire,P., Eilers,J., Markus,F., Stieger,K., Song,F.
            and Neidhardt,J.
  TITLE     The Major Ciliary Isoforms of RPGR Build Different Interaction
            Complexes with INPP5E and RPGRIP1L
  JOURNAL   Int J Mol Sci 22 (7), 3583 (2021)
   PUBMED   33808286
  REMARK    GeneRIF: The Major Ciliary Isoforms of RPGR Build Different
            Interaction Complexes with INPP5E and RPGRIP1L.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7833)
  AUTHORS   Choi,Y.J., Laclef,C., Yang,N., Andreu-Cervera,A., Lewis,J., Mao,X.,
            Li,L., Snedecor,E.R., Takemaru,K.I., Qin,C., Schneider-Maunoury,S.,
            Shroyer,K.R., Hannun,Y.A., Koch,P.J., Clark,R.A., Payne,A.S.,
            Kowalczyk,A.P. and Chen,J.
  TITLE     RPGRIP1L is required for stabilizing epidermal keratinocyte
            adhesion through regulating desmoglein endocytosis
  JOURNAL   PLoS Genet 15 (1), e1007914 (2019)
   PUBMED   30689641
  REMARK    GeneRIF: Biotinylation assays on cell surface proteins not only
            reinforced the role of RPGRIP1L in desmoglein endocytosis, but also
            suggested that RPGRIP1L may be more broadly involved in
            endocytosis. Thus, data obtained from this study advanced our
            understanding of the biological functions of RPGRIP1L by
            identifying its role in the cellular endocytic pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7833)
  AUTHORS   Delous,M., Baala,L., Salomon,R., Laclef,C., Vierkotten,J., Tory,K.,
            Golzio,C., Lacoste,T., Besse,L., Ozilou,C., Moutkine,I.,
            Hellman,N.E., Anselme,I., Silbermann,F., Vesque,C., Gerhardt,C.,
            Rattenberry,E., Wolf,M.T., Gubler,M.C., Martinovic,J.,
            Encha-Razavi,F., Boddaert,N., Gonzales,M., Macher,M.A., Nivet,H.,
            Champion,G., Bertheleme,J.P., Niaudet,P., McDonald,F.,
            Hildebrandt,F., Johnson,C.A., Vekemans,M., Antignac,C., Ruther,U.,
            Schneider-Maunoury,S., Attie-Bitach,T. and Saunier,S.
  TITLE     The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal
            syndrome (Joubert syndrome type B) and Meckel syndrome
  JOURNAL   Nat Genet 39 (7), 875-881 (2007)
   PUBMED   17558409
  REMARK    GeneRIF: Mutations can cause the multiorgan phenotypic
            abnormalities found in cerebello-oculo-renal syndrome or Meckel
            syndrome.
REFERENCE   6  (bases 1 to 7833)
  AUTHORS   Arts,H.H., Doherty,D., van Beersum,S.E., Parisi,M.A.,
            Letteboer,S.J., Gorden,N.T., Peters,T.A., Marker,T., Voesenek,K.,
            Kartono,A., Ozyurek,H., Farin,F.M., Kroes,H.Y., Wolfrum,U.,
            Brunner,H.G., Cremers,F.P., Glass,I.A., Knoers,N.V. and Roepman,R.
  TITLE     Mutations in the gene encoding the basal body protein RPGRIP1L, a
            nephrocystin-4 interactor, cause Joubert syndrome
  JOURNAL   Nat Genet 39 (7), 882-888 (2007)
   PUBMED   17558407
  REMARK    GeneRIF: Responsible for Joubert syndrome, affecting cilia and
            basal bodies.
REFERENCE   7  (bases 1 to 7833)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7833)
  AUTHORS   Stokman,M., Lilien,M. and Knoers,N.
  TITLE     Nephronophthisis-Related Ciliopathies
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27336129
REFERENCE   9  (bases 1 to 7833)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
REFERENCE   10 (bases 1 to 7833)
  AUTHORS   Parisi,M. and Glass,I.
  TITLE     Joubert Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX340768.2, AK307929.1,
            AC084795.5, AC007497.6 and R45454.1.
            
            On May 31, 2019 this sequence version replaced NM_001330538.1.
            
            Summary: The protein encoded by this gene can localize to the basal
            body-centrosome complex or to primary cilia and centrosomes in
            ciliated cells. The encoded protein has been found to interact with
            nephrocystin-4. Defects in this gene are a cause of Joubert
            syndrome type 7 (JBTS7) and Meckel syndrome type 5 (MKS5).
            [provided by RefSeq, Jun 2016].
            
            Transcript Variant: This variant (6) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 1. The encoded
            isoform (f) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK307929.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BX340768.2         80-91
            13-885              AK307929.1         1-873
            886-886             AC084795.5         88957-88957
            887-1477            AK307929.1         875-1465
            1478-1478           AC084795.5         106414-106414
            1479-4205           AK307929.1         1467-4193
            4206-6563           AC007497.6         52679-55036
            6564-6747           R45454.1           21-204              c
            6748-7833           AC007497.6         55221-56306
FEATURES             Location/Qualifiers
     source          1..7833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..7833
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /note="RPGRIP1 like"
                     /db_xref="GeneID:23322"
                     /db_xref="HGNC:HGNC:29168"
                     /db_xref="MIM:610937"
     exon            1..57
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            58..149
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..3910
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /note="isoform f is encoded by transcript variant 6;
                     protein phosphatase 1, regulatory subunit 134; fantom
                     homolog; protein fantom; RPGR-interacting protein 1-like
                     protein; nephrocystin-8"
                     /codon_start=1
                     /product="protein fantom isoform f"
                     /protein_id="NP_001317467.1"
                     /db_xref="CCDS:CCDS81980.1"
                     /db_xref="GeneID:23322"
                     /db_xref="HGNC:HGNC:29168"
                     /db_xref="MIM:610937"
                     /translation="MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSR
                     VSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRL
                     GRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTG
                     RRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQ
                     RGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLV
                     EKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSM
                     KFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQL
                     ETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQ
                     ENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQE
                     LEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLE
                     AQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQAS
                     GDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQYLVHVNDLFLQYIQKNTITLEV
                     HQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTKGDIPNFGTVEYWFRLRVPMD
                     QAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLSSTDSTDGNLNELHITIRC
                     CNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDDHMYFPVPMNMDLDRYL
                     KSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELTDHQKHPAGTIHVIL
                     KWKFAYLPPSGSITTEDLGNFIRSEEPEVVQRLPPASSVSTLVLAPRPKPRQRLTPVD
                     KKVSFVDIMPHQSDVSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAEQSLASSEDET
                     EITEDLEPEVEEDMSASDSDDCIIPGPISKNIKQSLALSPGLGCSSAISAHCNFRLPG
                     SSDFPASASQVDGITGACHHTQPSEKIRIEIIALSLNDSQVTMDDTIQRLFVECRFYS
                     LPAEETPVSLPKPKSGQWVYYNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRFT
                     VVSDPPEDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVFDARADGEGIGKLRVTV
                     EALHALQSVYKQYRDDLEA"
     exon            150..294
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            295..593
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            594..696
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            697..840
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            841..946
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1093
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1167
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1307
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1414
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1465
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1645
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1763
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..2216
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2368
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2747
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2938
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3022
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3182
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3256
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            3257..3394
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            3395..3578
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3663
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3797
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     exon            3798..7833
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4515..4520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /note="hexamer: AATGAA"
     polyA_site      4536
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /note="major polyA site"
     regulatory      6733..6738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /note="hexamer: AAGAAA"
     polyA_site      6751
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
     regulatory      7086..7091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /note="hexamer: AATAAA"
     polyA_site      7118
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
     regulatory      7808..7813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
                     /note="hexamer: AATAAA"
     polyA_site      7833
                     /gene="RPGRIP1L"
                     /gene_synonym="COACH3; CORS3; FTM; JBTS7; MKS5; NPHP8;
                     PPP1R134"
ORIGIN      
        1 gcccgccacg ctgtcggcgc tatagcaacg gtagctagct gcagggccag tggcacgcta
       61 ggccatgtct ggtccaactg atgagactgc aggagacttg cctgtgaaag atacaggtct
      121 aaacctcttt ggaatgggag ggttacaaga aacttcaaca acacggacaa tgaagtctcg
      181 ccaggcagtg tcacgtgtca gtcgtgagga actggaagac agatttttgc gtttgcatga
      241 tgagaacatt ttacttaaac agcatgcccg caagcaggag gataaaatta aaagaatggc
      301 caccaagtta atacggctag ttaatgacaa gaaaagatat gagcgggttg gtggcggccc
      361 caagcggctg ggacgagatg tggaaatgga agaaatgatt gagcagctgc aagagaaagt
      421 tcatgagctt gaaaaacaaa atgaaaccct caaaaacaga ctgatttcag ccaaacagca
      481 acttcaaacc cagggttaca ggcaaactcc atacaataat gtacaatctc gtattaacac
      541 tgggcgtaga aaagcaaatg aaaatgctgg tttacaggaa tgccccagga aaggtataaa
      601 attccaagat gcagatgtag cagaaactcc acatcccatg tttacaaaat atggcaacag
      661 tttacttgaa gaagccagag gagaaataag aaatttagaa aacgttattc agtcacaaag
      721 aggccagata gaggagttag agcacttggc tgagatcctg aaaactcagt tgaggagaaa
      781 agaaaatgaa attgagttat ctcttcttca gcttcgagaa cagcaagcta cagatcaaag
      841 gtcaaatatt cgggacaatg tagaaatgat taagcttcat aaacagctag tagagaaaag
      901 caatgctctt tcagcaatgg aaggaaaatt tattcagctt caagagaagc aaagaactct
      961 cagaatcagc cacgatgctt tgatggcaaa tggggatgaa ttaaacatgc aacttaaaga
     1021 gcagcgttta aaatgctgca gtcttgagaa acaattacat tctatgaagt tttctgaaag
     1081 aagaatagaa gagctgcagg atagaattaa tgatttagaa aaggaacggg aacttttaaa
     1141 ggaaaactat gataaacttt atgacagtgc cttcagtgct gcccatgaag agcaatggaa
     1201 gttaaaggag caacagctga aagtgcagat tgctcagctc gagactgcct tgaagtctga
     1261 cttaacagac aaaactgaaa tccttgacag attaaaaact gaaagagatc aaaatgaaaa
     1321 actcgttcaa gagaatagag aactacagtt acagtatctg gaacaaaagc aacaacttga
     1381 tgaacttaaa aaacgcataa aattgtacaa ccaggagaat gatattaatg ctgatgaatt
     1441 gagtgaagct ctcctactta taaaggctca aaaagaacaa aaaaatggag acctttcctt
     1501 tttagtgaaa gtagatagtg aaattaataa agatctagaa cgctctatga gagagctgca
     1561 agcaactcat gcagaaacgg tgcaagagct ggaaaagaca agaaacatgc taattatgca
     1621 acacaaaatt aataaagatt atcagatgga ggttgaggca gtgacccgta agatggaaaa
     1681 tttgcagcaa gattatgaac tcaaagtgga acagtatgtt catcttcttg atatcagggc
     1741 tgcacgtatc cataaactag aagcccaatt aaaggatatt gcctatggca ccaagcagta
     1801 caaatttaaa ccagaaatca tgccagatga ctctgttgat gaatttgatg aaaccatcca
     1861 cttagaacga ggcgaaaatc tatttgaaat ccatatcaac aaagtaacct tttcttctga
     1921 agttttacag gcatctggag ataaagagcc tgtcactttc tgtacctatg ctttctatga
     1981 ttttgaacta cagacaactc ccgtagtgcg aggccttcat cccgaatata acttcacttc
     2041 tcaatatctt gttcatgtta atgacttatt tttgcaatat attcagaaga atactatcac
     2101 ccttgaggtc caccaggctt atagcacaga atatgaaaca attgcagcat gtcaattaaa
     2161 atttcacgaa attcttgaaa aaagcggccg aatattttgt acagcaagtt tgattggaac
     2221 aaaaggagac atcccaaatt ttggcacagt ggaatactgg ttccgattaa gagttcccat
     2281 ggatcaagca attcgacttt atcgagaaag ggcaaaggct ttggggtata taacatcaaa
     2341 ttttaagggg ccagagcata tgcagtcgtt aagtcagcaa gcacccaaaa ctgctcaact
     2401 cagttctaca gattccacag atggcaactt aaatgaactt cacattacaa taagatgttg
     2461 caaccacctg cagtcccgag caagccacct gcagccacac ccatatgttg tgtacaagtt
     2521 ttttgatttt gcagaccatg atacagctat cattcccagt agcaatgatc cacagtttga
     2581 tgatcatatg tatttcccag tgccaatgaa tatggacttg gatcgatacc ttaagtcaga
     2641 gtctctgagt ttttatgttt ttgatgatag tgatacccag gagaatattt acataggaaa
     2701 agtcaatgtg cctctgattt cgttggcaca tgacaggtgt atctcaggaa tatttgagtt
     2761 aacagaccat caaaagcatc ctgctggcac catccatgtt atattgaaat ggaaatttgc
     2821 ttaccttcca ccaagtggat caataacaac tgaagactta ggaaatttca ttcgcagcga
     2881 agagccagaa gttgttcaaa gacttcctcc agcatcctct gttagcacac tagttttagc
     2941 accaagacct aaaccaagac aacgtttaac acctgtagat aagaaggtat ctttcgtgga
     3001 tatcatgcca catcagagtg atgtttcaca agaaggcagt gtagatgagg taaaagagaa
     3061 tactgagaaa atgcagcaag gaaaagatga tgtgtcttta ctatctgaag gtcagcttgc
     3121 agaacaaagc ttggcatctt ctgaagatga aacagaaata acagaggact tggaaccaga
     3181 agttgaagag gacatgtcag cttctgacag tgatgactgt attattccag gtcctatctc
     3241 caagaatatc aaacagagtc tcgcattgtc tcccgggctg gggtgcagta gcgcgatctc
     3301 agctcactgc aacttccgcc tcccgggttc cagcgatttt cctgcctcag cctcccaagt
     3361 agatgggatt acaggtgcct gccaccacac ccagccatca gaaaaaattc ggattgagat
     3421 catagctcta agccttaatg attctcaagt aaccatggat gacactatcc aacggctgtt
     3481 tgttgagtgt cgattctaca gtcttcctgc tgaagagaca cccgtgtcac ttccaaaacc
     3541 caagagtggg cagtgggtct actataacta tagcaatgtg atctacgtgg ataaagaaaa
     3601 caacaaagca aagagagaca tcttaaaagc tatactacaa aaacaagaga tgcctaatag
     3661 aagccttcgc ttcaccgtgg tcagtgaccc tccagaggac gagcaggacc tggagtgtga
     3721 ggacattggc gtggctcacg tcgaccttgc cgacatgttt caggaaggga gggacctcat
     3781 tgagcaaaat atcgatgttt ttgatgcacg agcagatggt gaaggtattg gcaagctcag
     3841 ggtaacagtc gaagctctcc atgccctcca gtctgtctac aagcaataca gagatgactt
     3901 ggaggcttga aagcaaatgc tccagaggca tctcctactc ctcagtaaat gctcacatga
     3961 aagttcctac atgagatttt tgtaattact ctggtgtata taatctataa ttcatgggaa
     4021 gctgggagcg gggagacctg ggtttgaagt gttgaagttt tgtatacttt ttcatttgtt
     4081 tatttctcta ttccctcctt ctcataactg ccacccctca ggacttaagt tctccataat
     4141 gggcagtacc ttctcaataa tttataccta cgtgatagcg tgagaaagtc tatttgcatt
     4201 ttcaacattt tcttaggaag aaccgaaatg caattcccat ttttattttt aataagcaaa
     4261 agcataaatc ttagaaaacc tatgaaaaag aaatactttt atgttatccc taatcgtccc
     4321 actaaatgga atgcctatga ttagcttcat taagagtttt atactgtgaa gattttatta
     4381 gaagcaatat atgaaaatta cttggattaa tgtgttaatc ttcctcttta aaatgctaat
     4441 atccatttta tgcacattaa agctcagtat gcattttctt tgatgcatgc agtttctatc
     4501 aattaaatat aaagaatgaa acttagcacc aacttattca atgactgcaa gttttttgtc
     4561 tttctttctt aaaagttcat tctatttgta ttattttcat acatttgtaa tggtgaccca
     4621 gggatgtata tataaaaagg agatagttat atagatagat gtgaaattta cacgttgaaa
     4681 acttagtata tgacacagaa agaaattatg aaaagtataa ctcaaattct gatatgctta
     4741 gttagacgtg aaaggagtat ctttttatca ttttttaaat ttacatcaag ccagtacagt
     4801 gccagggtgt atctgggtaa ccagatcctc gaaaagcagc tctgaaagtt aattttctag
     4861 cttttaccca atctcactga aggatttaat tgatattttt aatggagctg tgaatcaatg
     4921 ctgcaaagga attgtctcta gaggtctagg atataatgca tttcattttt taatttactt
     4981 ttttatttgt cattttcttc aaaggatttt tataggctgt gggttttcac tgtttgcaaa
     5041 caggctatgt tccttcttaa gcatatgtaa agtattcagg gagataagta atttattaaa
     5101 atctacctaa tttgccgtga tatattaaat ctctgcttca gtgatcacag accatttcat
     5161 ttagagaatt aggcattccc tctttgtgtg attaaagctc tggaaaatga gttctttgct
     5221 cctatttgtg aacattcaaa gcctgctaat ggcaagaaga tggaatagat tatgagacaa
     5281 ttcattacag ttcaatagaa aaaaaaagca gctataatgc aaaaatgcaa gtatgaatat
     5341 ctgcatatag tttgaaccat ctgtgctcta atggcttcaa taatgactct cgtctttaga
     5401 aggctttgaa atgacatccg tacaatatta atttgttgat gtacattgtg ggaccagtag
     5461 agtatgatct gaccacagaa atctataaat tctgtctata ccactgggcc tccctgtcct
     5521 ggggcctgcc atctccgaga agaatcttgc tctcatccaa ctctgcaaat cttcataaca
     5581 actcgttcct ctggaacctt ctggagacca caaacatctg cagactaaac ctctccagtc
     5641 ctagtaaaca accacatgtt tgttgtcact tcggctggct ctgagctcat ttttttggcc
     5701 cctttttcta gctttctttg gctttatgca gttacagtgt cattaaggcc cataatattc
     5761 cctgcagtaa tttaaaacag ccagattata ccctgggatt aactgagtgg tttttgagac
     5821 atttattgtg gtattctccc aggaggtttg tattattgtt gtaaaatgtt acatcccaaa
     5881 ctaaataacc cttctgcagg gagaagaacc agattgcact gacttcttag gatcattaag
     5941 tggaaaggaa aagtttttct tagaaaactt atgggaccca gtcacctgta tggaatgtat
     6001 atctcagaca agatgagaga aacagccatg tttctgtcac attgtttact gtcatattaa
     6061 agatatctag ttttaaaata ttcagtttca aactattgcg aattttcaca acactcattt
     6121 tcatagctaa ttgctgctga cacattttga agtggcgagg tagtattgaa cgctgtcatg
     6181 tggatacttc agttgggttt cataatctgt ttgagaattt tgtttgtttt atcttgtggt
     6241 aactggaggc cattgaaaag cttaccacct tttgggttaa agagcagtgg atttctcttg
     6301 gtgagccaaa ctggatccat tgaagagggc ttggcgtcag gggccaccag cagtggcctt
     6361 gccacacaga taccagctta aggtgttgct ggtgtgaaca tacacttctt ggtgtaacta
     6421 gaccagtgca cgcagcactt ttttgggctg taatgctttt agtttggaaa tacaaataga
     6481 gatgtgatgt ggtatgtggg agagtgtatt ttacatgtat ttttgcctac tgtagtagaa
     6541 atgtcaaatt cccagccact gtcatgaaaa gcagttgaca aaaataagtt ttatggttta
     6601 cagtgtggtt tacgtaaaga acatttctct tcactctcag tttcaccatg ttttctaaat
     6661 tatcatggtt tactgccatt taacttaaat tagttttttt aaaaatacat aaagaatatg
     6721 tttaatcaaa taaagaaagg ccacactgaa attctgctgt tcctgccatt cattcgttac
     6781 cacaaaacac aaataatttc tatgtgttat gaagacatgt gggctgagaa gtggtcatgt
     6841 gattggagag gttttgcgtg cactcatgtt cccacaacaa aacataaatt attttagtaa
     6901 tctgacatca agagctgtga aaatgaaaac cagttcttac acatgttcta acaagaatct
     6961 gattaacatt tttgtggata tggaaaattt tttttttagt caaactggca ctattgctga
     7021 atgtagaatg atttccttat gcactagata gaaaaatgtg aatcatgtct gtgaacaaat
     7081 atgagaataa aatgtcatct ttgtgtagga caaaacaacc aggagagaga ttttgggata
     7141 aaaattatca agtgattgac aatatcagga tgataattca tccccaacta tcagagtaca
     7201 ttttaataag tcactcatgc ctgaaggcct ctgactacct taacaaagaa aaactaaacc
     7261 cgtgatttat tagagattgg gcaacatgcc taattaaatc catgaatggg aacaaacaga
     7321 tttacatccc ctttgttcag aacaaaaaca acctctaggt caaccagaaa gctagaaaat
     7381 atcaaagcaa gagaaacaag tgtttttaaa actaaaaata tagaattaga aaacatctcc
     7441 tcatcctaat ctcttttatc ttacaaggta gaattttcac ttccatttca aagtgccacc
     7501 agtggactgc accctccagc ctgaccgcct ggaaaattgg acccatatta ctggtattct
     7561 tatacctttt gttcttgccc tttcattttc catatgacat tcactaatat atcaagctat
     7621 gtttttcctt caggcttttg gaagtgcaat ctggtactct tagacttcga tcatgacctg
     7681 ttttctgagg tagatgctgt ttgacttttc tgctttttgc ctcttctcac tctattgaga
     7741 gtcacctttt tcatccctag aacagcatta cctctgtctt cactgtgcac catttgtttt
     7801 ctttttaaat aaaatttaac atcttgattt tta
//
