LOCUS       NM_020366               4061 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens RPGR interacting protein 1 (RPGRIP1), transcript
            variant 1, mRNA.
ACCESSION   NM_020366
VERSION     NM_020366.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4061)
  AUTHORS   Khan,A.O.
  TITLE     RPGRIP1-related retinal disease presenting as isolated cone
            dysfunction
  JOURNAL   Ophthalmic Genet 44 (6), 595-597 (2023)
   PUBMED   36762997
  REMARK    GeneRIF: RPGRIP1-related retinal disease presenting as isolated
            cone dysfunction.
REFERENCE   2  (bases 1 to 4061)
  AUTHORS   Zhu,L., Ouyang,W., Zhang,M., Wang,H., Li,S., Meng,X. and Yin,Z.Q.
  TITLE     Molecular genetics with clinical characteristics of Leber
            congenital amaurosis in the Han population of western China
  JOURNAL   Ophthalmic Genet 42 (4), 392-401 (2021)
   PUBMED   33970760
  REMARK    GeneRIF: Molecular genetics with clinical characteristics of Leber
            congenital amaurosis in the Han population of western China.
REFERENCE   3  (bases 1 to 4061)
  AUTHORS   Zou,G., Zhang,T., Cheng,X., Igelman,A.D., Wang,J., Qian,X., Fu,S.,
            Wang,K., Koenekoop,R.K., Fishman,G.A., Yang,P., Li,Y., Pennesi,M.E.
            and Chen,R.
  TITLE     Noncoding mutation in RPGRIP1 contributes to inherited retinal
            degenerations
  JOURNAL   Mol Vis 27, 95-106 (2021)
   PUBMED   33907365
  REMARK    GeneRIF: Noncoding mutation in RPGRIP1 contributes to inherited
            retinal degenerations.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4061)
  AUTHORS   Perrault,I., Hanein,S., Gerard,X., Mounguengue,N., Bouyakoub,R.,
            Zarhrate,M., Fourrage,C., Jabot-Hanin,F., Bocquet,B., Meunier,I.,
            Zanlonghi,X., Kaplan,J. and Rozet,J.M.
  TITLE     Whole Locus Sequencing Identifies a Prevalent Founder Deep Intronic
            RPGRIP1 Pathologic Variant in the French Leber Congenital Amaurosis
            Cohort
  JOURNAL   Genes (Basel) 12 (2), 287 (2021)
   PUBMED   33670832
  REMARK    GeneRIF: Whole Locus Sequencing Identifies a Prevalent Founder Deep
            Intronic RPGRIP1 Pathologic Variant in the French Leber Congenital
            Amaurosis Cohort.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4061)
  AUTHORS   Dryja,T.P., Adams,S.M., Grimsby,J.L., McGee,T.L., Hong,D.H., Li,T.,
            Andreasson,S. and Berson,E.L.
  TITLE     Null RPGRIP1 alleles in patients with Leber congenital amaurosis
  JOURNAL   Am J Hum Genet 68 (5), 1295-1298 (2001)
   PUBMED   11283794
REFERENCE   6  (bases 1 to 4061)
  AUTHORS   Hong,D.H., Yue,G., Adamian,M. and Li,T.
  TITLE     Retinitis pigmentosa GTPase regulator (RPGRr)-interacting protein
            is stably associated with the photoreceptor ciliary axoneme and
            anchors RPGR to the connecting cilium
  JOURNAL   J Biol Chem 276 (15), 12091-12099 (2001)
   PUBMED   11104772
REFERENCE   7  (bases 1 to 4061)
  AUTHORS   Roepman,R., Bernoud-Hubac,N., Schick,D.E., Maugeri,A., Berger,W.,
            Ropers,H.H., Cremers,F.P. and Ferreira,P.A.
  TITLE     The retinitis pigmentosa GTPase regulator (RPGR) interacts with
            novel transport-like proteins in the outer segments of rod
            photoreceptors
  JOURNAL   Hum Mol Genet 9 (14), 2095-2105 (2000)
   PUBMED   10958648
REFERENCE   8  (bases 1 to 4061)
  AUTHORS   Boylan,J.P. and Wright,A.F.
  TITLE     Identification of a novel protein interacting with RPGR
  JOURNAL   Hum Mol Genet 9 (14), 2085-2093 (2000)
   PUBMED   10958647
REFERENCE   9  (bases 1 to 4061)
  AUTHORS   Kumaran,N., Pennesi,M.E., Yang,P., Trzupek,K.M., Schlechter,C.,
            Moore,A.T., Weleber,R.G. and Michaelides,M.
  TITLE     Leber Congenital Amaurosis / Early-Onset Severe Retinal Dystrophy
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   30285347
REFERENCE   10 (bases 1 to 4061)
  AUTHORS   Weleber,R.G., Francis,P.J., Trzupek,K.M. and Beattie,C.
  TITLE     Leber Congenital Amaurosis - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301475
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL135744.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 25, 2020 this sequence version replaced NM_020366.3.
            
            Summary: This gene encodes a photoreceptor protein that interacts
            with retinitis pigmentosa GTPase regulator protein and is a key
            component of cone and rod photoreceptor cells. Mutations in this
            gene lead to autosomal recessive congenital blindness. [provided by
            RefSeq, Oct 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AJ417067.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMEA1968968,
                                    SAMEA2142586 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400017.7/ ENSP00000382895.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AL135744.4         81023-81099
            78-200              AL135744.4         88879-89001
            201-333             AL135744.4         95617-95749
            334-605             AL135744.4         101906-102177
            606-702             AL135744.4         103428-103524
            703-915             AL135744.4         104271-104483
            916-1021            AL135744.4         108671-108776
            1022-1045           AL135744.4         111524-111547
            1046-1192           AL135744.4         112764-112910
            1193-1266           AL135744.4         113373-113446
            1267-1421           AL135744.4         118636-118790
            1422-1582           AL135744.4         120957-121117
            1583-1726           AL135744.4         122199-122342
            1727-1877           AL135744.4         122794-122944
            1878-2330           AL135744.4         125558-126010
            2331-2482           AL135744.4         126172-126323
            2483-2825           AL135744.4         126771-127113
            2826-3010           AL135744.4         128563-128747
            3011-3214           AL135744.4         129364-129567
            3215-3353           AL135744.4         131189-131327
            3354-3454           AL135744.4         135545-135645
            3455-3647           AL135744.4         143976-144168
            3648-3732           AL135744.4         146053-146137
            3733-3863           AL135744.4         149112-149242
            3864-4061           AL135744.4         152044-152241
FEATURES             Location/Qualifiers
     source          1..4061
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..4061
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /note="RPGR interacting protein 1"
                     /db_xref="GeneID:57096"
                     /db_xref="HGNC:HGNC:13436"
                     /db_xref="MIM:605446"
     exon            1..77
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            78..200
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..3976
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /note="isoform 1 is encoded by transcript variant 1;
                     X-linked retinitis pigmentosa GTPase regulator-interacting
                     protein 1; retinitis pigmentosa GTPase regulator
                     interacting protein 1"
                     /codon_start=1
                     /product="X-linked retinitis pigmentosa GTPase
                     regulator-interacting protein 1 isoform 1"
                     /protein_id="NP_065099.3"
                     /db_xref="CCDS:CCDS45080.1"
                     /db_xref="GeneID:57096"
                     /db_xref="HGNC:HGNC:13436"
                     /db_xref="MIM:605446"
                     /translation="MSHLVDPTSGDLPVRDIDAIPLVLPASKGKNMKTQPPLSRMNRE
                     ELEDSFFRLREDHMLVKELSWKQQDEIKRLRTTLLRLTAAGRDLRVAEEAAPLSETAR
                     RGQKAGWRQRLSMHQRPQMHRLQGHFHCVGPASPRRAQPRVQVGHRQLHTAGAPVPEK
                     PKRGPRDRLSYTAPPSFKEHATNENRGEVASKPSELVSGSNSIISFSSVISMAKPIGL
                     CMPNSAHIMASNTMQVEEPPKSPEKMWPKDENFEQRSSLECAQKAAELRASIKEKVEL
                     IRLKKLLHERNASLVMTKAQLTEVQEAYETLLQKNQGILSAAHEALLKQVNELRAELK
                     EESKKAVSLKSQLEDVSILQMTLKEFQERVEDLEKERKLLNDNYDKLLESMLDSSDSS
                     SQPHWSNELIAEQLQQQVSQLQDQLDAELEDKRKVLLELSREKAQNEDLKLEVTNILQ
                     KHKQEVELLQNAATISQPPDRQSEPATHPAVLQENTQIEPSEPKNQEEKKLSQVLNEL
                     QVSHAETTLELEKTRDMLILQRKINVCYQEELEAMMTKADNDNRDHKEKLERLTRLLD
                     LKNNRIKQLEGILRSHDLPTSEQLKDVAYGTRPLSLCLETLPAHGDEDKVDISLLHQG
                     ENLFELHIHQAFLTSAALAQAGDTQPTTFCTYSFYDFETHCTPLSVGPQPLYDFTSQY
                     VMETDSLFLHYLQEASARLDIHQAMASEHSTLAAGWICFDRVLETVEKVHGLATLIGA
                     GGEEFGVLEYWMRLRFPIKPSLQACNKRKKAQVYLSTDVLGGRKAQEEEFRSESWEPQ
                     NELWIEITKCCGLRSRWLGTQPSPYAVYRFFTFSDHDTAIIPASNNPYFRDQARFPVL
                     VTSDLDHYLRREALSIHVFDDEDLEPGSYLGRARVPLLPLAKNESIKGDFNLTDPAEK
                     PNGSIQVQLDWKFPYIPPESFLKPEAQTKGKDTKDSSKISSEEEKASFPSQDQMASPE
                     VPIEAGQYRSKRKPPHGGERKEKEHQVVSYSRRKHGKRIGVQGKNRMEYLSLNILNGN
                     TPEQVNYTEWKFSETNSFIGDGFKNQHEEEEMTLSHSALKQKEPLHPVNDKESSEQGS
                     EVSEAQTTDSDDVIVPPMSQKYPKADSEKMCIEIVSLAFYPEAEVMSDENIKQVYVEY
                     KFYDLPLSETETPVSLRKPRAGEEIHFHFSKVIDLDPQEQQGRRRFLFDMLNGQDPDQ
                     GHLKFTVVSDPLDEEKKECEEVGYAYLQLWQILESGRDILEQELDIVSPEDLATPIGR
                     LKVSLQAAAVLHAIYKEMTEDLFS"
     exon            201..333
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            334..605
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            606..702
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            703..915
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1021
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1045
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1192
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1266
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1421
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1582
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1726
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1877
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2330
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2482
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2825
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..3010
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            3011..3214
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3353
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3454
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3647
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..3732
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            3733..3863
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     exon            3864..4061
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4035..4040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /note="hexamer: TATAAA"
     polyA_site      4061
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /note="major polyA site"
ORIGIN      
        1 ggaacctaga gtactaaagg acaccagaac attgagagaa aagaattagc gacagctatc
       61 tggagcaagc aagaacttgt cctctgggat ctcttacagc ttgggaacag agatcatgtc
      121 acatctggtg gaccctacat caggagactt gccagttaga gacatagatg ctatacctct
      181 ggtgctacca gcctcaaaag gtaagaatat gaaaactcaa ccacccttga gcaggatgaa
      241 ccgggaggaa ttggaggaca gtttctttcg acttcgcgaa gatcacatgt tggtgaagga
      301 gctttcttgg aagcaacagg atgagatcaa aaggctgagg accaccttgc tgcggttgac
      361 cgctgctggc cgggacctgc gggtcgcgga ggaggcggcg ccgctctcgg agaccgcaag
      421 gcgcgggcag aaggcgggat ggcggcagcg cctctccatg caccagcgcc cccagatgca
      481 ccgactgcaa gggcatttcc actgcgtcgg ccctgccagc ccccgccgcg cccagcctcg
      541 cgtccaagtg ggacacagac agctccacac agccggtgca ccggtgccgg agaaacccaa
      601 gagggggcca agggacaggc tgagctacac agcccctcca tcgtttaagg agcatgcgac
      661 aaatgaaaac agaggtgaag tagccagtaa acccagtgaa cttgtttctg gttctaacag
      721 cataatttct ttcagcagtg tcataagtat ggctaaaccc attggtctat gcatgcctaa
      781 cagtgcccac atcatggcca gcaataccat gcaagtggaa gagccaccca agtctcctga
      841 gaaaatgtgg cctaaagatg aaaattttga acagagaagc tcattggagt gtgctcagaa
      901 ggctgcagag cttcgagctt ccattaaaga gaaggtagag ctgattcgac ttaagaagct
      961 cttacatgaa agaaatgctt cattggttat gacaaaagca caattaacag aagttcaaga
     1021 ggcatacgaa accttgctcc agaagaatca gggaatcctg agtgcagccc atgaggccct
     1081 cctcaagcaa gtgaatgagc tcagggcaga gctgaaggaa gaaagcaaga aggctgtgag
     1141 cttgaagagc caactggaag atgtgtctat cttgcagatg actctgaagg agtttcagga
     1201 gagagttgaa gatttggaaa aagaacgaaa attgctgaat gacaattatg acaaactctt
     1261 agaaagcatg ctggacagca gtgacagctc cagtcagccc cactggagca acgagctcat
     1321 agcggaacag ctacagcagc aagtctctca gctgcaggat cagctggatg ctgagctgga
     1381 ggacaagaga aaagttttac ttgagctgtc cagggagaaa gcccaaaatg aggatctgaa
     1441 gcttgaagtc accaacatac ttcagaagca taaacaggaa gtagagctcc tccaaaatgc
     1501 agccacaatt tcccaacctc ctgacaggca atctgaacca gccactcacc cagctgtatt
     1561 gcaagagaac actcagatcg agccaagtga acccaaaaac caagaagaaa agaaactgtc
     1621 ccaggtgcta aatgagttgc aagtatcaca cgcagagacc acattggaac tagaaaagac
     1681 cagggacatg cttattctgc agcgcaaaat caacgtgtgt tatcaggagg aactggaggc
     1741 aatgatgaca aaagctgaca atgataatag agatcacaaa gaaaagctgg agaggttgac
     1801 tcgactacta gacctcaaga ataaccgtat caagcagctg gaaggtattt taagaagcca
     1861 tgaccttcca acatctgaac agctcaaaga tgttgcttat ggcacccgac cgttgtcgtt
     1921 atgtttggaa acactgccag cccatggaga tgaggataaa gtggatattt ctctgctgca
     1981 tcagggtgag aatctttttg aactgcacat ccaccaggcc ttcctgacat ctgccgccct
     2041 agctcaggct ggagataccc aacctaccac tttctgcacc tattccttct atgactttga
     2101 aacccactgt accccattat ctgtggggcc acagcccctc tatgacttca cctcccagta
     2161 tgtgatggag acagattcgc ttttcttaca ctaccttcaa gaggcttcag cccggcttga
     2221 catacaccag gccatggcca gtgaacacag cactcttgct gcaggatgga tttgctttga
     2281 cagggtgcta gagactgtgg agaaagtcca tggcttggcc acactgattg gagctggtgg
     2341 agaagagttc ggggttctag agtactggat gaggctgcgt ttccccataa aacccagcct
     2401 acaggcgtgc aataaacgaa agaaagccca ggtctacctg tcaaccgatg tgcttggagg
     2461 ccggaaggcc caggaagagg agttcagatc ggagtcttgg gaacctcaga acgagctgtg
     2521 gattgaaatc accaagtgct gtggcctccg gagtcgatgg ctgggaactc aacccagtcc
     2581 atatgctgtg taccgcttct tcaccttttc tgaccatgac actgccatca ttccagccag
     2641 taacaacccc tactttagag accaggctcg attcccagtg cttgtgacct ctgacctgga
     2701 ccattatctg agacgggagg ccttgtctat acatgttttt gatgatgaag acttagagcc
     2761 tggctcgtat cttggccgag cccgagtgcc tttactgcct cttgcaaaaa atgaatctat
     2821 caaaggtgat tttaacctca ctgaccctgc agagaaaccc aacggatcta ttcaagtgca
     2881 actggattgg aagtttccct acataccccc tgagagcttc ctgaaaccag aagctcagac
     2941 taaggggaag gataccaagg acagttcaaa gatctcatct gaagaggaaa aggcttcatt
     3001 tccttcccag gatcagatgg catctcctga ggttcccatt gaagctggcc agtatcgatc
     3061 taagagaaaa cctcctcatg ggggagaaag aaaggagaag gagcaccagg ttgtgagcta
     3121 ctcaagaaga aaacatggca aaagaatagg tgttcaagga aagaatagaa tggagtatct
     3181 tagccttaac atcttaaatg gaaatacacc agagcaggtg aattacactg agtggaagtt
     3241 ctcagagact aacagcttca taggtgatgg ctttaaaaat cagcacgagg aagaggaaat
     3301 gacattatcc cattcagcac tgaaacagaa ggaacctcta catcctgtaa atgacaaaga
     3361 atcctctgaa caaggttctg aagtcagtga agcacaaact accgacagtg atgatgtcat
     3421 agtgccaccc atgtctcaga aatatcctaa ggcagattca gagaagatgt gcattgaaat
     3481 tgtctccctg gccttctacc cagaggcaga agtgatgtct gatgagaaca taaaacaggt
     3541 gtatgtggag tacaaattct acgacctacc cttgtcggag acagagactc cagtgtccct
     3601 aaggaagcct agggcaggag aagaaatcca ctttcacttt agcaaggtaa tagacctgga
     3661 cccacaggag cagcaaggcc gaaggcggtt tctgttcgac atgctgaatg gacaagatcc
     3721 tgatcaagga catttaaagt ttacagtggt aagtgatcct ctggatgaag aaaagaaaga
     3781 atgtgaagaa gtgggatatg catatcttca actgtggcag atcctggagt caggaagaga
     3841 tattctagag caagagctag acattgttag ccctgaagat ctggctaccc caataggaag
     3901 gctgaaggtt tcccttcaag cagctgctgt cctccatgct atttacaagg agatgactga
     3961 agatttgttt tcatgaagga acaagtgcta ttccaatcta aaagtctctg agggaaccat
     4021 agtaaaaagt ctcttataaa gttagcttgc tataacatga a
//
