LOCUS       NM_001034853            4733 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens retinitis pigmentosa GTPase regulator (RPGR),
            transcript variant C, mRNA.
ACCESSION   NM_001034853
VERSION     NM_001034853.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4733)
  AUTHORS   Baz-Redon,N., Sanchez-Bellver,L., Fernandez-Cancio,M.,
            Rovira-Amigo,S., Burgoyne,T., Ranjit,R., Aquino,V.,
            Toro-Barrios,N., Carmona,R., Polverino,E., Cols,M.,
            Moreno-Galdo,A., Camats-Tarruella,N. and Marfany,G.
  TITLE     Primary Ciliary Dyskinesia and Retinitis Pigmentosa: Novel RPGR
            Variant and Possible Modifier Gene
  JOURNAL   Cells 13 (6), 524 (2024)
   PUBMED   38534367
  REMARK    GeneRIF: Primary Ciliary Dyskinesia and Retinitis Pigmentosa: Novel
            RPGR Variant and Possible Modifier Gene.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4733)
  AUTHORS   Pantrangi,M., Rath,J., Kaetterhenry,N., Branham,K., Talsness,D. and
            Weber,J.L.
  TITLE     Clinical sequencing of the retinitis pigmentosa gene RPGR in over
            1,000 cases of vision loss
  JOURNAL   Mol Vis 30, 49-57 (2024)
   PUBMED   38586605
  REMARK    GeneRIF: Clinical sequencing of the retinitis pigmentosa gene RPGR
            in over 1,000 cases of vision loss.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4733)
  AUTHORS   Bonetti,G., Cozza,W., Bernini,A., Kaftalli,J., Mareso,C.,
            Cristofoli,F., Medori,M.C., Colombo,L., Martella,S., Staurenghi,G.,
            Salvetti,A.P., Falsini,B., Placidi,G., Attanasio,M., Pertile,G.,
            Bengala,M., Bosello,F., Petracca,A., D'Esposito,F., Toschi,B.,
            Lanzetta,P., Ricci,F., Viola,F., Marceddu,G. and Bertelli,M.
  TITLE     Towards a Long-Read Sequencing Approach for the Molecular Diagnosis
            of RPGRORF15 Genetic Variants
  JOURNAL   Int J Mol Sci 24 (23), 16881 (2023)
   PUBMED   38069202
  REMARK    GeneRIF: Towards a Long-Read Sequencing Approach for the Molecular
            Diagnosis of RPGR[ORF15] Genetic Variants.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4733)
  AUTHORS   Nowomiejska,K., Baltaziak,K., Calka,P., Ciesielka,M., Teresinski,G.
            and Rejdak,R.
  TITLE     Identification of the RPGR Gene Pathogenic Variants in a Cohort of
            Polish Male Patients with Retinitis Pigmentosa Phenotype
  JOURNAL   Genes (Basel) 14 (10), 1950 (2023)
   PUBMED   37895299
  REMARK    GeneRIF: Identification of the RPGR Gene Pathogenic Variants in a
            Cohort of Polish Male Patients with Retinitis Pigmentosa Phenotype.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4733)
  AUTHORS   Benson,M.D., Mukherjee,S., Agather,A.R., Blain,D., Cunningham,D.,
            Mays,R., Sun,X., Li,T., Hufnagel,R.B., Brooks,B.P., Huryn,L.A.,
            Zein,W.M. and Cukras,C.A.
  TITLE     RPGR: Deep Phenotyping and Genetic Characterization With Findings
            Specific to the 3'-end of ORF15
  JOURNAL   Invest Ophthalmol Vis Sci 64 (12), 19 (2023)
   PUBMED   37695603
  REMARK    GeneRIF: RPGR: Deep Phenotyping and Genetic Characterization With
            Findings Specific to the 3'-end of ORF15.
REFERENCE   6  (bases 1 to 4733)
  AUTHORS   Roepman,R., van Duijnhoven,G., Rosenberg,T., Pinckers,A.J.,
            Bleeker-Wagemakers,L.M., Bergen,A.A., Post,J., Beck,A.,
            Reinhardt,R., Ropers,H.H., Cremers,F.P. and Berger,W.
  TITLE     Positional cloning of the gene for X-linked retinitis pigmentosa 3:
            homology with the guanine-nucleotide-exchange factor RCC1
  JOURNAL   Hum Mol Genet 5 (7), 1035-1041 (1996)
   PUBMED   8817343
REFERENCE   7  (bases 1 to 4733)
  AUTHORS   Meindl,A., Dry,K., Herrmann,K., Manson,F., Ciccodicola,A.,
            Edgar,A., Carvalho,M.R., Achatz,H., Hellebrand,H., Lennon,A.,
            Migliaccio,C., Porter,K., Zrenner,E., Bird,A., Jay,M., Lorenz,B.,
            Wittwer,B., D'Urso,M., Meitinger,T. and Wright,A.
  TITLE     A gene (RPGR) with homology to the RCC1 guanine nucleotide exchange
            factor is mutated in X-linked retinitis pigmentosa (RP3)
  JOURNAL   Nat Genet 13 (1), 35-42 (1996)
   PUBMED   8673101
REFERENCE   8  (bases 1 to 4733)
  AUTHORS   McGuire,R.E., Sullivan,L.S., Blanton,S.H., Church,M.W.,
            Heckenlively,J.R. and Daiger,S.P.
  TITLE     X-linked dominant cone-rod degeneration: linkage mapping of a new
            locus for retinitis pigmentosa (RP 15) to Xp22.13-p22.11
  JOURNAL   Am J Hum Genet 57 (1), 87-94 (1995)
   PUBMED   7611300
REFERENCE   9  (bases 1 to 4733)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
REFERENCE   10 (bases 1 to 4733)
  AUTHORS   Ott,J., Bhattacharya,S., Chen,J.D., Denton,M.J., Donald,J.,
            Dubay,C., Farrar,G.J., Fishman,G.A., Frey,D., Gal,A. et al.
  TITLE     Localizing multiple X chromosome-linked retinitis pigmentosa loci
            using multilocus homogeneity tests
  JOURNAL   Proc Natl Acad Sci U S A 87 (2), 701-704 (1990)
   PUBMED   2300556
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP233620.1, BK005711.1 and
            AL606748.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001034853.1.
            
            Summary: This gene encodes a protein with a series of six RCC1-like
            domains (RLDs), characteristic of the highly conserved guanine
            nucleotide exchange factors. The encoded protein is found in the
            Golgi body and interacts with RPGRIP1. This protein localizes to
            the outer segment of rod photoreceptors and is essential for their
            viability. Mutations in this gene have been associated with
            X-linked retinitis pigmentosa (XLRP). Multiple alternatively
            spliced transcript variants that encode different isoforms of this
            gene have been reported, but the full-length natures of only some
            have been determined. [provided by RefSeq, Dec 2008].
            
            Transcript Variant: This variant (C) encodes the longest isoform
            (C).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK005711.1, SRR14038193.4037070.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000645032.1/ ENSP00000495537.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                BP233620.1         36-118
            84-3537             BK005711.1         1-3454
            3538-4345           AL606748.9         72136-72943         c
            4346-4692           BK005711.1         4260-4606
            4693-4733           AL606748.9         71748-71788         c
FEATURES             Location/Qualifiers
     source          1..4733
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.4"
     gene            1..4733
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /note="retinitis pigmentosa GTPase regulator"
                     /db_xref="GeneID:6103"
                     /db_xref="HGNC:HGNC:10295"
                     /db_xref="MIM:312610"
     exon            1..170
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..3601
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /note="isoform C is encoded by transcript variant C;
                     retinitis pigmentosa 3 GTPase regulator; X-linked
                     retinitis pigmentosa GTPase regulator; retinitis
                     pigmentosa 15"
                     /codon_start=1
                     /product="X-linked retinitis pigmentosa GTPase regulator
                     isoform C"
                     /protein_id="NP_001030025.1"
                     /db_xref="CCDS:CCDS35229.1"
                     /db_xref="GeneID:6103"
                     /db_xref="HGNC:HGNC:10295"
                     /db_xref="MIM:312610"
                     /translation="MREPEELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGD
                     EHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVS
                     TEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGR
                     LFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPE
                     NGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGL
                     GTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENF
                     TNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAPHRGVAKEIEFDEINDTCLSVATFLP
                     YSSLTSGNVLQRTLSARMRRRERERSPDSFSMRRTLPPIEGTLGLSACFLPNSVFPRC
                     SERNLQESVLSEQDLMQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSL
                     NSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQG
                     IFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTE
                     ILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKG
                     RGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEE
                     EEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEE
                     EETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEG
                     KGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEE
                     EEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEG
                     EGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEG
                     EGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKV
                     SKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKKFWNNVLP
                     HYLELK"
     exon            171..296
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            297..389
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            390..452
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            453..611
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            612..761
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            762..920
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1076
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1201
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1387
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1556
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1648
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1714
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1895
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..4733
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4716..4721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /note="hexamer: AATAAA"
     polyA_site      4733
                     /gene="RPGR"
                     /gene_synonym="COD1; CORDX1; CRD; orf15; PCDX; RP15; RP3;
                     XLRP3"
                     /note="major polyA site"
ORIGIN      
        1 gtagttgatc tccggagttt cgccatgcgg aacttggggg ctttcgcggc ccgcgtcggt
       61 gcggagtagc tgctttagcc ccgaccaaac cgtcctctac agcctcctgg ccccggcgca
      121 ggctgcccgt actgcccgtg gcatgaggga gccggaagag ctgatgcccg attcgggtgc
      181 tgtgtttaca tttgggaaaa gtaaatttgc tgaaaataat cccggtaaat tctggtttaa
      241 aaatgatgtc cctgtacatc tttcatgtgg agatgaacat tctgctgttg ttaccggaaa
      301 taataaactt tacatgtttg gcagtaacaa ctggggtcag ttaggattag gatcaaagtc
      361 agccatcagc aagccaacat gtgtcaaagc tctaaaacct gaaaaagtga aattagctgc
      421 ctgtggaagg aaccacaccc tggtgtcaac agaaggaggc aatgtatatg caactggtgg
      481 aaataatgaa ggacagttgg ggcttggtga caccgaagaa agaaacactt ttcatgtaat
      541 tagctttttt acatccgagc ataagattaa gcagctgtct gctggatcta atacttcagc
      601 tgccctaact gaggatggaa gactttttat gtggggtgac aattccgaag ggcaaattgg
      661 tttaaaaaat gtaagtaatg tctgtgtccc tcagcaagtg accattggga aacctgtctc
      721 ctggatctct tgtggatatt accattcagc ttttgtaaca acagatggtg agctatatgt
      781 gtttggagaa cctgagaatg ggaagttagg tcttcccaat cagctcctgg gcaatcacag
      841 aacaccccag ctggtgtctg aaattccgga gaaggtgatc caagtagcct gtggtggaga
      901 gcatactgtg gttctcacgg agaatgctgt gtataccttt gggctgggac aatttggtca
      961 gctgggtctt ggcacttttc tttttgaaac ttcagaaccc aaagtcattg agaatattag
     1021 ggatcaaaca ataagttata tttcttgtgg agaaaatcac acagctttga taacagatat
     1081 cggccttatg tatacttttg gagatggtcg ccacggaaaa ttaggacttg gactggagaa
     1141 ttttaccaat cacttcattc ctactttgtg ctctaatttt ttgaggttta tagttaaatt
     1201 ggttgcttgt ggtggatgtc acatggtagt ttttgctgct cctcatcgtg gtgtggcaaa
     1261 agaaattgaa ttcgatgaaa taaatgatac ttgcttatct gtggcgactt ttctgccgta
     1321 tagcagttta acctcaggaa atgtactgca gaggactcta tcagcacgta tgcggcgaag
     1381 agagagggag aggtctccag attctttttc aatgaggaga acactacctc caatagaagg
     1441 gactcttggc ctttctgctt gttttctccc caattcagtc tttccacgat gttctgagag
     1501 aaacctccaa gagagtgtct tatctgaaca ggacctcatg cagccagagg aaccagatta
     1561 tttgctagat gaaatgacca aagaagcaga gatagataat tcttcaactg tagaaagcct
     1621 tggagaaact actgatatct taaacatgac acacatcatg agcctgaatt ccaatgaaaa
     1681 gtcattaaaa ttatcaccag ttcagaaaca aaagaaacaa caaacaattg gggaactgac
     1741 gcaggataca gctcttactg aaaacgatga tagtgatgaa tatgaagaaa tgtcagaaat
     1801 gaaagaaggg aaagcatgta aacaacatgt gtcacaaggg attttcatga cgcagccagc
     1861 tacgactatc gaagcatttt cagatgagga agtagagatc ccagaggaga aggaaggagc
     1921 agaggattca aaaggaaatg gaatagagga gcaagaggta gaagcaaatg aggaaaatgt
     1981 gaaggtgcat ggaggaagaa aggagaaaac agagatccta tcagatgacc ttacagacaa
     2041 agcagaggtg agtgaaggca aggcaaaatc agtgggagaa gcagaggatg ggcctgaagg
     2101 tagaggggat ggaacctgtg aggaaggtag ttcaggagca gaacactggc aagatgagga
     2161 gagggagaag ggggagaaag acaagggtag aggagaaatg gagaggccag gagagggaga
     2221 gaaggaacta gcagagaagg aagaatggaa gaagagggat ggggaagagc aggagcaaaa
     2281 ggagagggag cagggccatc agaaggaaag aaaccaagag atggaggagg gaggggagga
     2341 ggagcatgga gaaggagaag aagaggaggg agacagagaa gaggaagaag agaaggaggg
     2401 agaagggaaa gaggaaggag aaggggaaga agtggaggga gaacgtgaaa aggaggaagg
     2461 agagaggaaa aaggaggaaa gagcggggaa ggaggagaaa ggagaggaag aaggagacca
     2521 aggagagggg gaagaggagg aaacagaggg gagaggggag gaaaaagagg agggagggga
     2581 agtagaggga ggggaagtag aggaggggaa aggagagagg gaagaggaag aggaggaggg
     2641 tgagggggaa gaggaggaag gggaggggga agaggaggaa ggggaggggg aagaggagga
     2701 aggagaaggg aaaggggagg aagaagggga agaaggagaa ggggaggaag aaggggagga
     2761 aggagaaggg gagggggaag aggaggaagg agaaggggag ggagaagagg aaggagaagg
     2821 ggagggagaa gaggaggaag gagaagggga gggagaagag gaaggagaag gggagggaga
     2881 agaggaggaa ggagaaggga aaggggagga ggaaggagag gaaggagaag gggaggggga
     2941 agaggaggaa ggagaagggg aaggggagga tggagaaggg gagggggaag aggaggaagg
     3001 agaatgggag ggggaagagg aggaaggaga aggggagggg gaagaggaag gagaagggga
     3061 aggggaggaa ggagaagggg agggggaaga ggaggaagga gaaggggagg gggaagagga
     3121 ggaaggggaa gaagaagggg aggaagaagg agagggagag gaagaagggg agggagaagg
     3181 ggaggaagaa gaggaagggg aagtggaagg ggaggtggaa ggggaggaag gagaggggga
     3241 aggagaggaa gaggaaggag aggaggaagg agaagaaagg gaaaaggagg gggaaggaga
     3301 agaaaacagg aggaacagag aagaggagga ggaagaagag gggaagtatc aggagacagg
     3361 cgaagaagag aatgaaaggc aggatggaga ggagtacaaa aaagtgagca aaataaaagg
     3421 atctgtgaaa tatggcaaac ataaaacata tcaaaaaaag tcagttacta acacacaggg
     3481 aaatgggaaa gagcagaggt ccaaaatgcc agtccagtca aaacgacttt taaaaaacgg
     3541 gccatcaggt tccaaaaagt tctggaataa tgtattacca cattacttgg aattgaagta
     3601 acaaacctta aatgtgaccc gattatggcc agtcagacaa tttaaatgcc ttgcatataa
     3661 cgggcactca ttacgtgtta ttaaattgat tttatgtcaa ttattttatg tgtagtaaaa
     3721 aaaaaagcaa ctgatgcagc tgtgttaagg agccaaagac aataggaggc actggtaaat
     3781 tttggcctct ctcaaactaa aattttcgtg tatttccccc ccaaattata aaaacataac
     3841 tagaaaatat taaaaggtca tatcagatta ttaacattat atattcatta aaggcagctt
     3901 taggaaacag gaatatacta caagagtgtt ttgtttgtgt atacaaatca ttccattttt
     3961 aaatggcaca gatgcttaag ggctataaaa acttctaatt tcttataaat atgttagcac
     4021 tttttttaag ttagtgatta cagtttacct actgtataga ataattttct aataatggat
     4081 ggtattctaa aactcaattg aggcattcac attttaaaga aagtattgtc tttcaccttt
     4141 tatgtgttct ttttgcaaaa atctacaaag tgacagctgt gttcagagct tagatcccaa
     4201 aaacgtgatc tcttttagtt actatctggg cagatggtag tatatctaat gaaatggtga
     4261 ttaatttaaa tgtataatct ggaaatatgt aaaacttgaa gtattttttg tccaggcaaa
     4321 ggtactcatt gggcctcagt ttcttcatct ctaaaatgga gtggatgaga tgatgtgata
     4381 actgcagtcc cttctaactc ttaaattctt ttcattctca cagattcact ctatcattat
     4441 tgttattcat gtaagaaacg ttttagggag aaaaattaca ctttaaaatt aatttagttt
     4501 tctatacagt tgttttcttt actcttgaaa agttatgaca gctttaacgt ctcttgtctt
     4561 ctgtaatttt ttatttctaa actcctatca tttccaagct ttaactgtac tttatcagag
     4621 ccttcatttc tggtatgtgt tatatgccct caatgtattc actgactgtt ctgtaatttc
     4681 agtttgtctg ttccttgtca gaatgtttca agtaaaataa aaaattaaat gta
//
