LOCUS       NM_025065               1948 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ribosome production factor 1 homolog (RPF1), mRNA.
ACCESSION   NM_025065
VERSION     NM_025065.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1948)
  AUTHORS   Deryabin,A., Moraleva,A., Dobrochaeva,K., Kovaleva,D., Rubtsova,M.,
            Dontsova,O. and Rubtsov,Y.
  TITLE     Human RPF1 and ESF1 in Pre-rRNA Processing and the Assembly of
            Pre-Ribosomal Particles: A Functional Study
  JOURNAL   Cells 13 (4), 326 (2024)
   PUBMED   38391939
  REMARK    GeneRIF: Human RPF1 and ESF1 in Pre-rRNA Processing and the
            Assembly of Pre-Ribosomal Particles: A Functional Study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1948)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   3  (bases 1 to 1948)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 1948)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   5  (bases 1 to 1948)
  AUTHORS   Wehner,K.A. and Baserga,S.J.
  TITLE     The sigma(70)-like motif: a eukaryotic RNA binding domain unique to
            a superfamily of proteins required for ribosome biogenesis
  JOURNAL   Mol Cell 9 (2), 329-339 (2002)
   PUBMED   11864606
REFERENCE   6  (bases 1 to 1948)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844170.2, AF322053.1, AL359584.2 and AL359762.24.
            
            On Nov 23, 2018 this sequence version replaced NM_025065.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.169299.1,
                                           SRR1803614.143092.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370654.6/ ENSP00000359688.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AL844170.2         18316-18331
            17-1066             AF322053.1         1-1050
            1067-1946           AL359584.2         773-1652
            1947-1948           AL359762.24        8596-8597
FEATURES             Location/Qualifiers
     source          1..1948
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.3"
     gene            1..1948
                     /gene="RPF1"
                     /gene_synonym="BXDC5"
                     /note="ribosome production factor 1 homolog"
                     /db_xref="GeneID:80135"
                     /db_xref="HGNC:HGNC:30350"
     exon            1..244
                     /gene="RPF1"
                     /gene_synonym="BXDC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1066
                     /gene="RPF1"
                     /gene_synonym="BXDC5"
                     /note="brix domain containing 5; 2310066N05Rik; RNA
                     processing factor 1 (RPF1); brix domain-containing protein
                     5; ribosome biogenesis protein RPF1"
                     /codon_start=1
                     /product="ribosome production factor 1"
                     /protein_id="NP_079341.2"
                     /db_xref="CCDS:CCDS695.1"
                     /db_xref="GeneID:80135"
                     /db_xref="HGNC:HGNC:30350"
                     /translation="MAKAGDKSSSSGKKSLKRKAAAEELQEAAGAGDGATENGVQPPK
                     AAAFPPGFSISEIKNKQRRHLMFTRWKQQQRKEKLAAKKKLKKEREALGDKAPPKPVP
                     KTIDNQRVYDETTVDPNDEEVAYDEATDEFASYFNKQTSPKILITTSDRPHGRTVRLC
                     EQLSTVIPNSHVYYRRGLALKKIIPQCIARDFTDLIVINEDRKTPNGLILSHLPNGPT
                     AHFKMSSVRLRKEIKRRGKDPTEHIPEIILNNFTTRLGHSIGRMFASLFPHNPQFIGR
                     QVATFHNQRDYIFFRFHRYIFRSEKKVGIQELGPRFTLKLRSLQKGTFDSKYGEYEWV
                     HKPREMDTSRRKFHL"
     exon            245..301
                     /gene="RPF1"
                     /gene_synonym="BXDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            302..382
                     /gene="RPF1"
                     /gene_synonym="BXDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            383..478
                     /gene="RPF1"
                     /gene_synonym="BXDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            479..632
                     /gene="RPF1"
                     /gene_synonym="BXDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            633..715
                     /gene="RPF1"
                     /gene_synonym="BXDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            716..897
                     /gene="RPF1"
                     /gene_synonym="BXDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1024
                     /gene="RPF1"
                     /gene_synonym="BXDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1948
                     /gene="RPF1"
                     /gene_synonym="BXDC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1242..1247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPF1"
                     /gene_synonym="BXDC5"
                     /note="hexamer: AATAAA"
     polyA_site      1277
                     /gene="RPF1"
                     /gene_synonym="BXDC5"
                     /note="major polyA site"
     regulatory      1917..1922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPF1"
                     /gene_synonym="BXDC5"
                     /note="hexamer: AATAAA"
     polyA_site      1948
                     /gene="RPF1"
                     /gene_synonym="BXDC5"
ORIGIN      
        1 caaaggagcc aagaccatgg cgaaagccgg ggataagagc agcagcagcg ggaagaaaag
       61 tctaaaacgg aaagccgctg ccgaagaact tcaggaggct gcaggcgctg gggatggggc
      121 gacggaaaac ggggtccaac ccccgaaagc ggctgccttt ccgccaggct ttagcatttc
      181 ggagattaaa aacaaacagc ggcgacactt aatgttcacg cggtggaaac agcagcagcg
      241 gaaggaaaag ttggcagcta agaaaaaact taaaaaagaa agagaggctc ttggcgataa
      301 ggctccacca aagcctgtac ccaagaccat tgacaaccag cgagtgtatg atgaaaccac
      361 agtagaccct aatgatgaag aggtcgctta tgatgaagct acagatgaat ttgcttctta
      421 cttcaacaaa cagacttctc ccaagattct catcacaaca tcagatagac ctcatgggag
      481 aacagtacga ctctgtgaac agctctccac agttatacca aactcacatg tttattacag
      541 aagaggactg gctctgaaaa aaattattcc acagtgcatc gcaagagatt tcacagacct
      601 gattgttatt aatgaagatc gtaaaacccc aaatggactt attttgagtc acttgccaaa
      661 tggcccaact gctcatttta aaatgagcag tgttcgtctt cgtaaagaaa ttaagagaag
      721 aggcaaggac cccacagaac acatacctga aataattctg aataatttta caacacggct
      781 gggtcattca attggacgta tgtttgcatc tctctttcct cataatcctc aatttatcgg
      841 aaggcaggtt gccacattcc acaatcaacg ggattacata ttcttcagat ttcacagata
      901 catattcagg agtgaaaaga aagtgggaat tcaggaactt ggaccacgtt ttaccttaaa
      961 attaaggtct cttcagaaag gaacctttga ttctaaatat ggagagtatg aatgggtcca
     1021 taagccccgg gaaatggata caagtagaag aaaattccat ttataaagta ctgagagaat
     1081 gatattggat tttgctgaac aggcctatct tgaactttgg taaattattt ttgacagaat
     1141 actcttttca aaatggcatt tgctgatttc ataaaccttt cacgtctgga cgaattacca
     1201 aatgccatga attgccactg tgtgtttatg tagaaaatac aaataaaagt tattttgatg
     1261 gcttaggttt ccttaaactt agttctcttg tttttgggta actgtgaata attaagttgg
     1321 aatcaagatt cagattaact ttcctatttg catagaacac atgagaggaa taaaatggtt
     1381 ggtaaatatt ggctaaccct tgatttttat accagattaa ccttggattc ccagtgtctg
     1441 gcacagtttt aatagcttaa atggaggcca ggtttctgga tgttttaaca ttctcttaag
     1501 ccttcagaag ggtaaaaaat ttaaagcaaa atgatctacc agggtttaaa gcaaagttgc
     1561 aaattactga agctaatctt tgcttcctga ttttgaggtt tttggttttt tgtgcccacg
     1621 ttgtggggag ctctttttta cctcattaca tggtgctgta gtactccatt caggcactga
     1681 aacaaagtta accctataag taactcatgg atggaaaccc gtagaactta acagcctcct
     1741 cctgacctta aaagaataaa ggttcacagt ttacctttaa ttccctagca gtcttgccag
     1801 atgtatggca taaagtcatg tgagaagagt aggtggaaaa aactgtacaa acttaacccc
     1861 ttcaggtgtt cagaacagat taatatacca tgtatttaat accaataata atgcaaaata
     1921 aaagtttcat actaagtttt attgtatg
//
