LOCUS       NM_199229               3180 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ribulose-5-phosphate-3-epimerase (RPE), transcript
            variant 1, mRNA.
ACCESSION   NM_199229
VERSION     NM_199229.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3180)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3180)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3180)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   4  (bases 1 to 3180)
  AUTHORS   Liang,W., Ouyang,S., Shaw,N., Joachimiak,A., Zhang,R. and Liu,Z.J.
  TITLE     Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new
            insights from structural and biochemical studies on human RPE
  JOURNAL   FASEB J 25 (2), 497-504 (2011)
   PUBMED   20923965
  REMARK    GeneRIF: The binary complexes of RPE reported here will aid in the
            design of small molecules for modulating the activity of the enzyme
            and altering flux through the pentose phosphate pathway.
REFERENCE   5  (bases 1 to 3180)
  AUTHORS   Stanchi,F., Bertocco,E., Toppo,S., Dioguardi,R., Simionati,B.,
            Cannata,N., Zimbello,R., Lanfranchi,G. and Valle,G.
  TITLE     Characterization of 16 novel human genes showing high similarity to
            yeast sequences
  JOURNAL   Yeast 18 (1), 69-80 (2001)
   PUBMED   11124703
REFERENCE   6  (bases 1 to 3180)
  AUTHORS   Miyazaki,K., Yamanaka,T. and Ogasawara,N.
  TITLE     Interstitial deletion 2q32.1----q34 in a child with half normal
            activity of ribulose 5-phosphate 3-epimerase (RPE)
  JOURNAL   J Med Genet 25 (12), 850-851 (1988)
   PUBMED   3236368
REFERENCE   7  (bases 1 to 3180)
  AUTHORS   Dallapiccola,B., Novelli,G. and Giannotti,A.
  TITLE     Deletion 2q31.3----2q33.3: gene dosage effect of ribulose
            5-phosphate 3-epimerase
  JOURNAL   Hum Genet 79 (1), 92 (1988)
   PUBMED   3366467
REFERENCE   8  (bases 1 to 3180)
  AUTHORS   Boss,G.R. and Pilz,R.B.
  TITLE     Phosphoribosylpyrophosphate synthesis from glucose decreases during
            amino acid starvation of human lymphoblasts
  JOURNAL   J Biol Chem 260 (10), 6054-6059 (1985)
   PUBMED   2581946
REFERENCE   9  (bases 1 to 3180)
  AUTHORS   Spencer,N. and Hopkinson,D.A.
  TITLE     Biochemical genetics of the pentose phosphate cycle: human ribose
            5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase
            (RPE)
  JOURNAL   Ann Hum Genet 43 (4), 335-342 (1980)
   PUBMED   7396409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC403549.1, BC005148.2, AB075523.1 and AI222711.1.
            
            On Nov 23, 2018 this sequence version replaced NM_199229.2.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291035.1, SRR1660803.86589.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359429.11/ ENSP00000352401.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DC403549.1         74-92
            20-2487             BC005148.2         1-2468
            2488-2935           AB075523.1         1186-1633
            2936-3180           AI222711.1         13-257              c
FEATURES             Location/Qualifiers
     source          1..3180
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3180
                     /gene="RPE"
                     /gene_synonym="RPE2-1"
                     /note="ribulose-5-phosphate-3-epimerase"
                     /db_xref="GeneID:6120"
                     /db_xref="HGNC:HGNC:10293"
                     /db_xref="MIM:180480"
     exon            1..146
                     /gene="RPE"
                     /gene_synonym="RPE2-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..711
                     /gene="RPE"
                     /gene_synonym="RPE2-1"
                     /EC_number="5.1.3.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ribulose-phosphate 3-epimerase"
                     /codon_start=1
                     /product="ribulose-phosphate 3-epimerase isoform 1"
                     /protein_id="NP_954699.1"
                     /db_xref="CCDS:CCDS2388.1"
                     /db_xref="GeneID:6120"
                     /db_xref="HGNC:HGNC:10293"
                     /db_xref="MIM:180480"
                     /translation="MASGCKIGPSILNSDLANLGAECLRMLDSGADYLHLDVMDGHFV
                     PNITFGHPVVESLRKQLGQDPFFDMHMMVSKPEQWVKPMAVAGANQYTFHLEATENPG
                     ALIKDIRENGMKVGLAIKPGTSVEYLAPWANQIDMALVMTVEPGFGGQKFMEDMMPKV
                     HWLRTQFPSLDIEVDGGVGPDTVHKCAEAGANMIVSGSAIMRSEDPRSVINLLRNVCS
                     EAAQKRSLDR"
     exon            147..226
                     /gene="RPE"
                     /gene_synonym="RPE2-1"
                     /inference="alignment:Splign:2.1.0"
     exon            227..366
                     /gene="RPE"
                     /gene_synonym="RPE2-1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..501
                     /gene="RPE"
                     /gene_synonym="RPE2-1"
                     /inference="alignment:Splign:2.1.0"
     exon            502..588
                     /gene="RPE"
                     /gene_synonym="RPE2-1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..3180
                     /gene="RPE"
                     /gene_synonym="RPE2-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2467..2472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPE"
                     /gene_synonym="RPE2-1"
                     /note="hexamer: AATAAA"
     regulatory      2478..2483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPE"
                     /gene_synonym="RPE2-1"
                     /note="hexamer: AGTAAA"
     polyA_site      2490
                     /gene="RPE"
                     /gene_synonym="RPE2-1"
                     /note="major polyA site"
     polyA_site      2496
                     /gene="RPE"
                     /gene_synonym="RPE2-1"
                     /note="major polyA site"
     regulatory      3155..3160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPE"
                     /gene_synonym="RPE2-1"
                     /note="hexamer: AATAAA"
     polyA_site      3180
                     /gene="RPE"
                     /gene_synonym="RPE2-1"
ORIGIN      
        1 aacttgcttt tgggagccag cggtatggcg tcgggctgca agattggccc gtccatcctc
       61 aacagcgacc tggccaattt aggggccgag tgcctccgga tgctagactc tggggccgat
      121 tatctgcacc tggacgtaat ggacgggcat tttgttccca acatcacctt tggtcaccct
      181 gtggtagaaa gccttcgaaa gcagctaggc caggaccctt tctttgacat gcacatgatg
      241 gtgtccaagc cagaacagtg ggtaaagcca atggctgtag caggagccaa tcagtacacc
      301 tttcatctcg aggctactga gaacccaggg gctttgatta aagacattcg ggagaatggg
      361 atgaaggttg gccttgccat caaaccagga acctcagttg agtatttggc accatgggct
      421 aatcagatag atatggcctt ggttatgaca gtggaaccgg ggtttggagg gcagaaattc
      481 atggaagata tgatgccaaa ggttcactgg ttgaggaccc agttcccatc tttggatata
      541 gaggtcgatg gtggagtagg tcctgacact gtccataaat gtgcagaggc aggagctaac
      601 atgattgtgt ctggcagtgc tattatgagg agtgaagacc ccagatctgt gatcaatcta
      661 ttaagaaatg tttgctcaga agctgctcag aaacgttctc ttgatcggtg aaaccataag
      721 gagcccagtg ttcctgttca tgaaatctcc cttttactgg aaaacaggaa tattgactac
      781 caaatcacaa tgcaattgaa gccgtactgc ttttttgagc agttattcat tccagtgatt
      841 aaaactgatt gtgcagaata ttctaagagg tcagaaattg gtgtgtataa ctacattttt
      901 agtgatgcaa tttattgatt agtgagtaag atactgtttt tattgagaga tttgattttt
      961 ataaagtaaa aatacggctg cattagggtt acaaacagaa aagtgtctta atgtctaagg
     1021 agggcatatt agctacacta caaaaacaaa ttttgtctgt acttctgaaa agaattttgt
     1081 tgtttctcag ctgttttcca aaagcaaagg aagtctttat ggtttttttc tatttcatgt
     1141 tattgtgatt tgtttataag tttgggtggg gtgcatacca tattcttggt tcttaaaatc
     1201 tatcactttt caccttacac ttgatgtgtg aaaactataa aaacaatgtg tgaaacccag
     1261 gggttctaaa atacaagcat agattttatc agggtgtttt gtcaaagcag gttattcagt
     1321 gattcctccc caccattctt aagaacgtta aataatgctg ttgtgttagc tctgagtaga
     1381 aaggaaaaag taaaacctct gtttggaggt aatattgggt tgaattctga ctgccccttt
     1441 ctagctggac ctttaacaaa tcacccaatc ttttttgtgt ttctctaaag tcatttatac
     1501 attaaatgta attatagcaa ctgtggggtt ctgttgagaa ttaagagcta acactatata
     1561 tgtaaagttt ccagtactag tcccagaatt tagaatatgc tcaacacaaa gtaaacagca
     1621 ttatataagt ttatattttt gtgagttata aagtactttg atatattctc attaaatctg
     1681 taaatcacct ctataagtaa gtggtaataa taaagcagat atttttgtcc ccatttaaaa
     1741 aatgaagaaa ttaatgctta atagggtggt accctggaaa ggatctggga agtggtagaa
     1801 tttctggtct gtacttttac aaatggagcc cttgggaggt gggttaggta aaagaagctt
     1861 tttacttaac gttgtcttat ttccagtcta attttacgct gtagcagaac cagatggctg
     1921 agaaaattct ggaactatgg atcttgaccc caaggatata ttattttatt ccaagaaaga
     1981 tcaggtaggc gaaaagatga caggatacag agtcaatcca taaactaaat atttataact
     2041 gttctgaatt atacagagtc taaaaatatg tgtcagctac ttcattcctg taaatactct
     2101 tgctgtgtta taaatatggc aagaaataaa catgaccaat atcaatagac ttcttgaggc
     2161 tactataagt tttgagaaat aaggttcaaa aaataagaat gctaacactt aagcacagac
     2221 tagagcttgc ttgggtttct tcctgcatta caaggtaaaa atttgttaat gtttgttttt
     2281 attcagcttg ggaaagcttt gtgccatgaa tacgtcgcat ttaataacaa gcaacacacg
     2341 gcatatagaa ataactttaa ttaaaaaact tacatagaag attataatat cagacgtgac
     2401 aaagatttga gtttatttgc ctggacaact tgggtttgtc tggcttttgt tttctttttc
     2461 tttaaaaata aatgtacagt aaaactacaa gcaaaagttt gtcagtattg aattgaattt
     2521 tttacccctt aaaaggacta gtataatttc caatctctaa caaaaactta gtgtcaaatc
     2581 tcacagataa ggccaaatgg ccaatatttt cagttatgtg ggtagtacaa cttgagtaac
     2641 cttttttaca tgacaaaaag tgagttatat aaattgtcct caactttcac ataggaaaaa
     2701 aatggtttaa tagcttcaaa aggaattttc tttcatgtat actcttcagt atccaatatt
     2761 gaagctttgt tctttgaaaa attttaattt ccaatctagg atgcaagcaa gaatatatgt
     2821 ttatttgaat agagtaagct atggcaaaga atgaccaaat tagctagaaa tagaaatcag
     2881 ccagaattaa ctaatttctt gctaatctag aaatacaatc atcttttttt tttttttcaa
     2941 attttatact gatagggctt tactgtttgt ggctcatttt aaaactggtg tcttctcttc
     3001 atgagacaca ttaattggta aaactcaaat tgagttttca aagatgtgat agtattaaag
     3061 tgcaccaata tttgactcaa atttgcttgc tttattttgt taggagtaaa cagaaagtag
     3121 cctgtgttta gtcccaaaga tagcagtgat tttgaataaa ggagttttgt gttgcctgga
//
