LOCUS       NM_024813              16899 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RNA polymerase II associated protein 2 (RPAP2), mRNA.
ACCESSION   NM_024813
VERSION     NM_024813.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 16899)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 16899)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 16899)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 16899)
  AUTHORS   Zhang,B., Zhong,X., Sauane,M., Zhao,Y. and Zheng,Z.L.
  TITLE     Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42
            Small GTPases in Cultured Human Cancer Cells and Its Implication
            for Developing a Synthetic-Lethal Cancer Therapy
  JOURNAL   Cells 9 (3), 621 (2020)
   PUBMED   32143485
  REMARK    GeneRIF: Modulation of the Pol II CTD Phosphorylation Code by Rac1
            and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its
            Implication for Developing a Synthetic-Lethal Cancer Therapy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 16899)
  AUTHORS   Chang,T.K., Lawrence,D.A., Lu,M., Tan,J., Harnoss,J.M.,
            Marsters,S.A., Liu,P., Sandoval,W., Martin,S.E. and Ashkenazi,A.
  TITLE     Coordination between Two Branches of the Unfolded Protein Response
            Determines Apoptotic Cell Fate
  JOURNAL   Mol Cell 71 (4), 629-636 (2018)
   PUBMED   30118681
  REMARK    GeneRIF: Coordination between two branches of the unfolded protein
            response determines apoptotic cell fate so that PERK attenuates
            IRE1 via RPAP2 to abort failed endoplasmic reticulum stress
            adaptation and trigger apoptosis.
REFERENCE   6  (bases 1 to 16899)
  AUTHORS   Horejsi,Z., Stach,L., Flower,T.G., Joshi,D., Flynn,H., Skehel,J.M.,
            O'Reilly,N.J., Ogrodowicz,R.W., Smerdon,S.J. and Boulton,S.J.
  TITLE     Phosphorylation-dependent PIH1D1 interactions define substrate
            specificity of the R2TP cochaperone complex
  JOURNAL   Cell Rep 7 (1), 19-26 (2014)
   PUBMED   24656813
REFERENCE   7  (bases 1 to 16899)
  AUTHORS   Xiang,K., Manley,J.L. and Tong,L.
  TITLE     The yeast regulator of transcription protein Rtr1 lacks an active
            site and phosphatase activity
  JOURNAL   Nat Commun 3, 946 (2012)
   PUBMED   22781759
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 16899)
  AUTHORS   Egloff,S., Zaborowska,J., Laitem,C., Kiss,T. and Murphy,S.
  TITLE     Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase
            to snRNA genes
  JOURNAL   Mol Cell 45 (1), 111-122 (2012)
   PUBMED   22137580
  REMARK    GeneRIF: During transcription of snRNA genes, Ser7 phosphorylation
            facilitates recruitment of RPAP2, which in turn both recruits
            Integrator and dephosphorylates Ser5.
REFERENCE   9  (bases 1 to 16899)
  AUTHORS   Ni,Z., Olsen,J.B., Guo,X., Zhong,G., Ruan,E.D., Marcon,E.,
            Young,P., Guo,H., Li,J., Moffat,J., Emili,A. and Greenblatt,J.F.
  TITLE     Control of the RNA polymerase II phosphorylation state in promoter
            regions by CTD interaction domain-containing proteins RPRD1A and
            RPRD1B
  JOURNAL   Transcription 2 (5), 237-242 (2011)
   PUBMED   22231121
REFERENCE   10 (bases 1 to 16899)
  AUTHORS   Jeronimo,C., Forget,D., Bouchard,A., Li,Q., Chua,G., Poitras,C.,
            Therien,C., Bergeron,D., Bourassa,S., Greenblatt,J., Chabot,B.,
            Poirier,G.G., Hughes,T.R., Blanchette,M., Price,D.H. and
            Coulombe,B.
  TITLE     Systematic analysis of the protein interaction network for the
            human transcription machinery reveals the identity of the 7SK
            capping enzyme
  JOURNAL   Mol Cell 27 (2), 262-274 (2007)
   PUBMED   17643375
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC039014.1, AL451010.4, AI612918.1 and AC104456.2.
            
            On Nov 23, 2018 this sequence version replaced NM_024813.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.142049.1,
                                           SRR1803611.101677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000610020.2/ ENSP00000476948.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2153              BC039014.1         95-2247
            2154-2882           AL451010.4         180258-180986
            2883-3018           AI612918.1         1-136               c
            3019-6040           AL451010.4         181123-184144
            6041-16899          AC104456.2         2001-12859
FEATURES             Location/Qualifiers
     source          1..16899
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.1"
     gene            1..16899
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /note="RNA polymerase II associated protein 2"
                     /db_xref="GeneID:79871"
                     /db_xref="HGNC:HGNC:25791"
                     /db_xref="MIM:611476"
     exon            1..88
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1854
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /EC_number="3.1.3.16"
                     /codon_start=1
                     /product="putative RNA polymerase II subunit B1 CTD
                     phosphatase RPAP2"
                     /protein_id="NP_079089.2"
                     /db_xref="CCDS:CCDS740.1"
                     /db_xref="GeneID:79871"
                     /db_xref="HGNC:HGNC:25791"
                     /db_xref="MIM:611476"
                     /translation="MADFAGPSSAGRKAGAPRCSRKAAGTKQTSTLKQEDASKRKAEL
                     EAAVRKKIEFERKALHIVEQLLEENITEEFLMECGRFITPAHYSDVVDERSIVKLCGY
                     PLCQKKLGIVPKQKYKISTKTNKVYDITERKSFCSNFCYQASKFFEAQIPKTPVWVRE
                     EERHPDFQLLKEEQSGHSGEEVQLCSKAIKTSDIDNPSHFEKQYESSSSSTHSDSSSD
                     NEQDFVSSILPGNRPNSTNIRPQLHQKSIMKKKAGHKANSKHKDKEQTVVDVTEQLGD
                     CKLDSQEKDATCELPLQKVNTQSSSNSTLPERLKASENSESEYSRSEITLVGISKKSA
                     EHFKRKFAKSNQVSRSVSSSVQVCPEVGKRNLLKVLKETLIEWKTEETLRFLYGQNYA
                     SVCLKPEASLVKEELDEDDIISDPDSHFPAWRESQNSLDESLPFRGSGTAIKPLPSYE
                     NLKKETEKLNLRIREFYRGRYVLGEETTKSQDSEEHDSTFPLIDSSSQNQIRKRIVLE
                     KLSKVLPGLLVPLQITLGDIYTQLKNLVRTFRLTNRNIIHKPAEWTLIAMVLLSLLTP
                     ILGIQKHSQEGMVFTRFLDTLLEELHLKNEDLESLTIIFRTSCLPE"
     exon            89..134
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            135..249
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            250..348
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            349..414
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..503
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..539
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..1470
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1553
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1634
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1703
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1853
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..16899
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2132..2137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /note="hexamer: ATTAAA"
     polyA_site      2153
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /note="major polyA site"
     regulatory      13169..13174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /note="hexamer: ATTAAA"
     polyA_site      13198
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
     regulatory      13708..13713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /note="hexamer: AATAAA"
     polyA_site      13731
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
     regulatory      16879..16884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
                     /note="hexamer: AATAAA"
     polyA_site      16899
                     /gene="RPAP2"
                     /gene_synonym="C1orf82; Rtr1"
ORIGIN      
        1 agactactct cccccatggc ggacttcgct gggccgtctt ctgccggccg caaggccggg
       61 gctccccgct gctctcgaaa agccgcaggt actaaacaga caagtacttt gaaacaagaa
      121 gatgcttcta aaaggaaagc tgaactagaa gcagctgtga gaaagaagat tgaatttgag
      181 agaaaagctc tacatattgt tgaacagctt ttagaggaga atattacaga agagttccta
      241 atggagtgtg ggaggttcat tacacctgct cactacagtg atgtcgtgga tgaacgttct
      301 attgtcaaac tctgtggtta tcctttatgt cagaagaagc tgggaattgt accaaaacag
      361 aaatataaaa tttctaccaa aaccaataaa gtctatgata ttactgaaag aaagtctttt
      421 tgcagcaatt tttgttatca agcatctaag ttttttgaag cacaaattcc caaaactcca
      481 gtatgggttc gagaagaaga gaggcatcct gattttcaac tgctaaagga agaacaaagt
      541 ggccattctg gagaagaagt acagttatgc agtaaagcca ttaaaacatc agatatcgac
      601 aatcctagcc actttgaaaa gcaatatgaa tctagttctt ctagcactca cagtgatagt
      661 agcagtgaca atgagcaaga ctttgtttcc tccattctac caggaaacag accaaattca
      721 acaaatatta gaccacagct gcaccaaaaa agcataatga aaaagaaagc tggtcacaaa
      781 gctaactcca aacacaaaga caaagaacag acagtagtag atgtcactga gcagttaggc
      841 gattgcaaat tagatagtca ggagaaagat gctacatgtg aacttccttt acagaaagta
      901 aatactcaga gttcttcaaa tagcactttg cctgaaagat taaaagcgtc agaaaattct
      961 gaaagtgaat acagtaggtc agaaataact ctagtaggca taagtaagaa aagtgcagag
     1021 cattttaaga gaaaatttgc caaatcaaac caagtgtcta ggtcagtgtc tagttcagtg
     1081 caggtgtgtc ctgaagttgg aaagagaaac ttacttaaag ttttgaagga gactttgatt
     1141 gagtggaaga cagaagaaac attgaggttt ttgtatggcc agaattatgc ttctgtgtgt
     1201 ctgaaacccg aagcctctct ggttaaagaa gaacttgatg aagatgacat aatctcagat
     1261 ccagatagtc atttccctgc ctggagggaa tctcagaaca gcttggatga gtctttacct
     1321 tttaggggct caggtacagc cattaaacca ctgccaagtt acgagaattt gaaaaaagaa
     1381 actgaaaagt taaatctgag gatcagggag ttttacagag gacggtatgt tttgggtgaa
     1441 gaaaccacca aatcacaaga ctcagaagag catgattcca cctttccact gatagactca
     1501 agttcccaga accagattag aaaacgcatc gtacttgaaa agttgagtaa agtgttgcct
     1561 gggcttctgg ttcctcttca gattacattg ggagatattt acacacaact taaaaatctt
     1621 gttcgaactt tcaggttaac aaatagaaat attatacaca aacctgcgga atggacttta
     1681 attgctatgg tgttgctgtc attactgacc ccaattcttg gcattcagaa acattctcag
     1741 gaaggtatgg tgtttacacg gtttctagac accctccttg aagaattaca tctaaaaaat
     1801 gaagaccttg aaagtctaac catcatattt agaaccagct gtttaccaga gtgatatatt
     1861 ccatgaagac aaaatagaag atgaacttct attcaccgtt tctggaattc tagccgccat
     1921 gatggtctgg tggtgactga taactagttt tattccaaga cataccttta cctctttaag
     1981 tttcaatctc ccatctccca gtccttcagt ccccaactgc agaggatgac ctccccagat
     2041 agaggagaat cattactcca acaagaataa ccaagtcttt gtatccctag tacaagacat
     2101 agtattttta ttcgaaaatg aatgtttaag tattaaattg aaacttgaat gaatattcaa
     2161 gaaaatataa tgatctctac tttttctgga tgatttccag ccatcatatc agtttgccaa
     2221 aaaaattgag aaagttatga ttttgacctc ccaacctaaa ctctaaattc taaagatcag
     2281 taaacaatta ggtcaataaa tacatacaat ttaagatgaa gccctttgga agtctagtcc
     2341 aaaacaggaa aatctcagaa ctttctggac tcaaggaaat gctttaaatg gaatctgtag
     2401 tttgtttgca ggagagacaa tttctagaat ttagattgct tttcaaaatg tttatcaggt
     2461 aggcaagtta gcagttgagg cggaacacag acaacttggg gagctttact ggaaggccaa
     2521 gaaaatactc ttggacactg gaggaaatga cagctactaa agcccaatca tggaaaagga
     2581 ccagaaagca gcccactgga atggggagct tagtgggcaa ggaggtaggg atataatttc
     2641 tcttcttggc tccaccagta attagctctg tggcccagtc acctaaactt tctggacttc
     2701 agttcaggtt gtatggcagt aggccataga attggctact gccatacaat ctctatggga
     2761 aaggactgca aaaactaaat tttatctctg tatgggcaaa ggctactgtc atcctgttgt
     2821 tggtctgggg ccactctgac aatttttttt aacctcattt gattgtgtaa gggtctaacc
     2881 acaacaaaaa atcatagtgt aatagaatta atcaagttca gcaaggtcac aggctagatc
     2941 aatatacaga aaatcaattg tatttttctg ttcagaaaac tccaaaaatg aaataaagaa
     3001 aattgtgttc acaatatcac caaagagaat taaatactta ggaataaatt taacaaaata
     3061 agtataagac ttgtataacg aaaactataa aacattcaag agggctgggc atggtggctc
     3121 atgcctttag ttctagcact ttggaggcag aggcaggagg actgcttgag cccaggagtt
     3181 caagaccagc ctgggcaaca aagtgagacc ctgtctccac aaaaaataaa aataaaaata
     3241 aattgaagat ggccgaatag gaacagctcc agtctacagc tcccagcagg atggacacag
     3301 aagatgggtg atttctgcat tttcaactaa agtacctggt tcgtctcact gggactggct
     3361 ggacagtggg tgtagcccac agagggttag ccgaagcaag gtggggcatc gcctcacctg
     3421 ggaagcgcca aggggtcggg ggatttccct ttcctagcca agggaagccg tgagtgacta
     3481 tacctggagg aggggtacac tcctgcccaa atactgctct tttcccacag tcttcgcaac
     3541 tggcagacca cgaaatcccc tcccatgcct ggttcagtgg gtcccacgcc cacagagcct
     3601 tgctcactgc tagcgccagc agtctgaaat cgacctggga cgtgggagct tggcggggta
     3661 gaggtgtccg ccattgctga ggcttgagta ggcggttcta tgctcacagt gtaaacaaag
     3721 cagcagggaa gctcaaactg ggcagagccc accacagctc agcaaggcct actgtctctg
     3781 tagattccac ctccaggggc agggcatatc tgaacaaaag gcagcagaca gcttctccag
     3841 acttaaacgt ccctgcctga cagctctgaa gagagcagtg gttctcccag caccgcgttc
     3901 aagctccgat aatagacaga ctgcctcctc aagtgggtcc ctgacccccg tgtagcctga
     3961 ctgggagaca tctcccagta ggcgccgaaa gacacctcag agaggtagat gccccactgg
     4021 aacgaagctt ccacagtaag gatcaggcag caatatttgc tgttctgcag cctccactgg
     4081 tgacacccag gcaaacaggg tctggagtgg acctccagca aactccaaca gacctgcagc
     4141 taaggggcct gtctattaga aggaaaacta acagaaagga atagcatcaa catcaaaaaa
     4201 aggacatcta caccaaaacc ccatccatag gacaccaaca tcagagacca aaggtaggta
     4261 aaaccacaaa gatggggaga aaccagacca gaaaggctga aaattccaaa aaccagaatg
     4321 cctcttctcc tccaaaggaa cacaactcct tgccagcaag ggaacaaaac tggacagaga
     4381 atgagtttga caagttgaca gaagtaggct tcagaaggtc ggtaataaca aacttctcca
     4441 agctaaagga gcatgttcta atgcgtcgca aggaagctaa aaatcttgaa aaaaggttag
     4501 acaaatggct aactagaata accagtgtag agaagagctt aaatgacctg atggagctga
     4561 aaaccacagt acgggaactt cgtgaagcat acacaagctt caatagccaa ttcgatcaag
     4621 tggaagaaag gatatcagta actgaagatc aaattaatga aataaagcga gaggacaaga
     4681 ttagagaaaa aagagtgaaa agaaatgaac aaagcctcca agaaatatga gactatgtga
     4741 aaagaccaaa tctatgtttg attggtgtac ctgaaagtga tggggagaac agaaccaagt
     4801 ttgaaaacac tcttcaggat attatccagg agagcttccc caacctagca aggaaggcca
     4861 acattcaaat tcaggaaata cagagaacac cacaaagata ctcctcaaga agagcaaccc
     4921 caagacacat aattgtcaga ttcaccaagg ttgaaatgaa ggaaaaactg ttaagggcag
     4981 ccagagagaa aggtcaggtt acccacaaag ggaagcccat cagattaaca gcggacctct
     5041 gggcagaaac cctacaagcc agaagagaat gggggccaat attcaacatt cttaaagaaa
     5101 agaattttca acccagaatc tcatatccag ccaaactaag cttcttaagt gaaggagaaa
     5161 taaaatcctt tacagacaag caaatgctga gagattttgt caccaccagg cctgccttac
     5221 aagagctcct gaagtaagca ctaaaatgga caggaacaac cagtaccagc cactgcaaaa
     5281 acatgccaaa tggtaaagac catcaacact atgaagaaac tgcatcaatt aatggatgaa
     5341 ataaccagct agcatcataa tgacaggatc aaattcccac ataacaatat taaccttaaa
     5401 tgtaaatggg ataaatgccc caattaaaag acacagactg gcaaattgaa taaacagtca
     5461 agacccatca gtgagctata ttcaggagac ccatctcatg tgcaaagaca cacataggct
     5521 cagaataaaa ggatgtagga agatttacca agcaaatgga aagcagaaaa aagcaggggt
     5581 tgcaatccta gtctctgata aaacagactt taaaccaaca aagatcaaaa gagacaaaga
     5641 aggtcattac ataatggtaa agggatcaat tcaacaagaa cagctaacta tcctaaatat
     5701 atatgcaccc aatacaggag cacccagatt cataaagcaa gttctacaaa gagatttaga
     5761 ctcccacaca atattaatgg gtgactttaa caccccactg tcaatattag acagatcaac
     5821 aagacagaaa attaacaaag atatccagga cttgaactca gctctggacc aagcagacct
     5881 aatagacatc gacagaactc tccaccccaa atcaacagaa tatacattct tgtcagcacc
     5941 acatcacact tattccaaaa ttgaccacat aattggaagt aaagcactct tcagcaaatg
     6001 caaaagaaca gaaatcacaa caaaccgtct cagaccacaa tgcaatcaaa ttagaactca
     6061 ggatcaagaa tctcactcaa ctgcacaact gcatggaaac tgaacaacct gttcctgaat
     6121 gactactggg taaataacga aatgaaggca gaaataaaga tgttctttgg aaccaacgag
     6181 aacaaagaca caatgtacca gaatctctag gacatgttta aagcagtatg tagagggaaa
     6241 tttatagcac taaatgccca caagtgaaag caggagtgat ctaaaatcaa caccctaaca
     6301 tcacaattaa aagaactaga gaagcaagac caaacaaatt caaaagctag cagaaggcaa
     6361 gaaataacta agatcagagc agaactgaag gagatagaga ctcaacaaac ccttcaaaaa
     6421 atcagtgaat ccaggagcta gttttttgaa aagatcaaca aaattgatag accgttagca
     6481 aggctaaaaa agaagaaaag agagaagagt caaatagatg caataaaaaa tgataaaggg
     6541 gatatcacca ctgatcccac agaaatacaa actaccatca gcgaatacta taaacacctc
     6601 tacacaaata aactagaaaa tctagaagaa atggataaat tcctcgacac atacaccctc
     6661 ccaagactaa accaggaaga agttgaatct ctgaataaac cagtaacagg ttctgaaatt
     6721 gaggcaataa ttaatagcct accaaccaaa aaaagtccag gaccagacgg attcacagcc
     6781 aaattctacg aaaggtacaa agaggtgctg gtaccattcc ttctgaaact attccaatca
     6841 atagaagaaa agggaatcct ccctaactca ttttatgagg ctaacatcat cctgatacca
     6901 aagcctggca gagacacaac aaaaaaagag aattttaggc caatatccct gatgaacatc
     6961 gatgcgaaaa tcctcaataa aatactggca aaccgaatcc agcagcatat caaaaagctt
     7021 atccaccacg atcaagtcag cttcttccct gggatgcaag gctggttcaa catatgcaaa
     7081 tcaataaaca taatccatca cataaacaga accaacggca aaaaccacat gattatctca
     7141 atagatacaa aaaaggcctt caacaaaatt caacagcctt tcatgctaaa aaccctcaat
     7201 aaactaggta ttgatggaat gtatctcaat ataataagag gttatttatg acaaacccac
     7261 agccaatagc atactgaatg ggcaaaagct ggaagcattt cctttgaaga ccagcacaag
     7321 gcaaggatgc cctctctcac cactcctatt caacatagta ttggaagttc tggccagggc
     7381 aatcaggcaa gagaaagcaa taaagcatat tcaaatagga agagaggaag tcaaattgtc
     7441 tctgtttgca gatgacatga ttgtatattt agaaaacccc atcgtctcat cccaaaatct
     7501 ccttaagctg ataagcaact tcagcaaagt ctcaggatac aaaatcggtg tgcaaaaatc
     7561 acaagcattc ctatatacca ataatagaca aagagccaaa tcatgagtga actcccattc
     7621 acaattgcta ctaagaaaat aaaatacaaa gcactgctca aggaaataag agaggacaca
     7681 aacaaatgga aaaacattcc atgctcatgg ataggaagaa tcaatatcat gacaatggcc
     7741 ttgttgccca aactgattta tagattcaat gctatcccca tcaagctacc actaactttc
     7801 ttcacagaat tggaaaaaac tactttaaga ttcatatgga accaaaaaag agcccaccta
     7861 gccaagacaa tcctgggcaa gaagaacaaa gctggaggca tcacactacc tgacttcaaa
     7921 ctttactaca agcctacagt aaccaaaaca gcatggcact ggtacaaaaa cagatatgca
     7981 gacgaatgga acagaatgga ggcctcagaa ataacaccac acgtctacca ccatctgatc
     8041 tttgacaaac ctgacacaca caagcaatgg ggaaaagatt ccctatttaa taaatggtgt
     8101 tgggaaaacg ggctagccat atgcagaaaa ctgtaactgg accctttcct tacaccttat
     8161 acaaaaatca actcaagatg gaacaaagac ttaaacgtaa gacctaggac cataaaaatc
     8221 ctagaagaaa acctgggcaa taccattcag gacataggca tgggcaaaga cttcatgtct
     8281 aaaacaccaa aagcaatggc aacaaaagcc aaaattgaca aatgggttct aattaaagag
     8341 cttctgcaca gcaaaataaa ctatcatcag agtgaacagg caacctacag aatgggagaa
     8401 catttttgca atatatccat ctgacaaagg gctaatatcc agaatctaca aagaacttaa
     8461 acaaatttac aagaaaaaag caaacaaccc catcaaaaaa tgggcaaagg atatgaacag
     8521 atacttctca aaagaagaca tttatgcagc caacagacat atgaaaaaat gctcatcatc
     8581 actagtcatt agagaaatga aaatcaaaac cacagtgaga taccatctca tgccagttag
     8641 aatggcgatc attaaaaatc aggaaacaat agatgctgga gaggttgtgg aaaaattgga
     8701 acgcttttac actgttggtg ggagtgcaaa ttagtccgac cattgtggaa gtcagtgtga
     8761 cgactcctca aggatctaga actggaaata ccatttgacc cagcaatccc actattgggc
     8821 atatacccaa aagattataa atcattctac aataaagaca catgcacacg tatgtttatt
     8881 gctgcactat tcacaatagc aaagatttga aaccaaccca aatgcccgtc aatgatagac
     8941 tggattaaga aaatgtggca catgtatacc atggaatact atgcagccat aaaaaaggat
     9001 gagttcatgt cctttgcagg gacatggata aagccggaaa ccatcattct cagcaaacta
     9061 tcacaagatc agaaaaccaa acaacgcatg ttctcactca taagtgggag ttaaacaatg
     9121 agaacacatg gacacaggga gggtaacatc acacaccagg gcctgtgggg ggtggggggc
     9181 taagggaggg ataacattag gagaaatacc taatgtaggt gacaggttgg tgggtgcagc
     9241 aaaccaccat ggcatgtgta tacctatgta acaaaactac atgttctgca catgtaaccc
     9301 agaacttaaa gtataataaa aaaaataatt attaaatttt aaaaaactag ccaggcatgg
     9361 tgctgcacac ctgtagtccc agctacttga gaggctacat tgggaggatt gcctgagctt
     9421 gggaggttga ggctgcagtt agctgtgact gtgccagtgc actccagcct gggcaacaga
     9481 gcaagaccct gtctcaaaaa aagaaaaaga aaaattcaga gagattaaag aaggtatcaa
     9541 gaaatgtaga cacaatccat gttcatgaat tggaagatca aatgttgtta agatagcagt
     9601 tctccccaaa ttaatctaca atgcaatccc tatcaaaatc acagcaggct tttttgaaaa
     9661 attgacaagc caatcttaaa atctgtatga aaacataaag gattcagaat agccaaaata
     9721 attctgaaaa tgaagaaata attctgatcc agaacttact acaaagctac attaatcaag
     9781 acagtgtggt actgatataa agataggcat acagatcagt ggaacagagt ccaggaataa
     9841 accttcacat ttatgatcaa ttaagttttg acaaaaatcc caatgaaatt atggagaaaa
     9901 gatggtcttt tcaacaaata gtgctaggat atttggatat caaatgcaga agaaattaat
     9961 ttagattctt acctcctacc atatgcaaaa ataaactcaa aattgatcac acacctacat
    10021 gtaagagcta aaactataaa acatgtagaa gaaaacatgg gagaaaacct agatgacctt
    10081 ggtttaggaa gaattcttaa gacactaata gcacaattca taaaagaaaa tattaataaa
    10141 ttggacttca ttaaaatata aaattttgtt tcaaaaaact attaagaaaa ttaattggcc
    10201 cggggaggtg gttcacatct gaaatccctg cactttcgga agccaaggag ggtggaccac
    10261 ttgagctcag gaatttgaga ccagactgga caacagagca aaatgccatc tccacaaaaa
    10321 atacaaaaat taaccaggca tggtggcgtg ctcctgtagt cctggctact cagaaggctg
    10381 aggtgggagg atctcttgac cctgggaggc agaggttgca gtgagccaag atcacaccac
    10441 cgcactagag cctgggtgac agagtgagac cctgtctcaa aaaaaaaaaa aaaaaaaaaa
    10501 attaattgaa aaatcacaga ctgggagaaa atattttcaa accataataa gtatctgata
    10561 gaggacttgt atctagacta tgtaaagaat tcttaaaact caaaaataag gcagacaact
    10621 taaaaatgga caaaatgttt gaatagatat ttcagcaaag atatacaaat tgcttagcat
    10681 atgaagagat gtgtactatc actagtcatt aggaaaatac aagttaaaag caaaattaga
    10741 taccattttg gacccactaa aatgactata ataaaaaaga cagacaaaga tatgtgttgg
    10801 tgatgatgtg gagaaactgg agccctaatg cattgctggt gggaatgtaa aatggtgcag
    10861 ccactttgga aaacagtttg gcagtttctt aaaaagataa acataagttt accatatgat
    10921 cctgctattc catgagaaga gaagtggaaa tgtgttcaca tcaagactcg taggcaaatg
    10981 ttcatagcat tatcattcat attagtcaaa aagtggaaac caaatgacca tcaactactg
    11041 gatttttttt ttttttttaa gagatgaggc ctcactatgt tgcatactct gaagtcaaac
    11101 tcctgggctc aaacaatcct cctgcctcag cctcctcagt aactgggact gcaggcaggc
    11161 accaacatac ccagattatt tctttttctt ttttttttta actggtggat ttctttaaat
    11221 gatatatgta tacaatggag tagtgatata ggctacaata tggatgcatc tcaaaacatt
    11281 atgcttagtg aaagaagtct gatgcaatat cccacatatg gtatgtttcc atttacagtc
    11341 cagaaaaggc atatactaaa ttagcagttg catgggtctg atgtgaaaac atggattgcc
    11401 tgcagatggg cacaagggat cttttggggg tgacaaaaat gttccaaaac taagttgtaa
    11461 tttttgcaca acttttatgt gtgtgtgtgt gtgtgtgtgt gagatggagt ttcactcttg
    11521 ttgcccaggc tggagtgcaa tggcgcgatc tcagctcacc acaacctccg cctcctgggt
    11581 tgaagcattt ctcctgcctc agcttcctga gtagctggga ttacaggcat gtgccaccat
    11641 gcccggctaa ttttgtattt ttagtagaga caggttttct ccaggttggt caggctggtc
    11701 tcgaactcct gacctcaggt gatcctcctg cctcggcctc ccaaagcgct gggattacag
    11761 gcgtgagcca ccacacccag ccatttttgc acaactttat aaactttaaa aataattgat
    11821 ttatgcactt aaaacaggta aagtttatgt gtataaatta taccttaata aagctattaa
    11881 aagtcaaaga ttataacagg gcctctctct ctctgaccta gtgacctagg gtaaagagaa
    11941 aaagaagcta gccaggcaca ggggctcaca cctgtaatcc cagcactttg ggaagccaag
    12001 atgggctgat tgcttgagtc caggagtttg agaccaactt gggcaacata gcaaaaccct
    12061 gtctccacca aaaataaaaa aaattagcca ggcatggcgg tgtatgcctg gagtcccagc
    12121 tactcaggag tcagaggtgg gaggatcact tgagcccagg aggcagaggt tgtagggagc
    12181 caagattgca ccactgcact ccagcctggg tgacagagca agacactgtc tcaaaaatta
    12241 aaaattaaaa aatgagggaa gctgctgtat ctccacttct tccctctctg tgcccagaga
    12301 tatctcttca gttatctcac atgccctaca agtctagaga cctcaggtga ggagccagta
    12361 gctcagtata gaaactaagg atccaagtgg acaactgcca ccaagtcacc acagggccag
    12421 ctgctttggg agggtgctgc atctgcctcc catacacttc tgccaagttt atgttagttt
    12481 gggaggactg aagcagaatt cagttcaaag tactgtgctg gattttggtt tctaaatatt
    12541 ttccaataga aaagaaccca ggcttcttga gaaaatagct aggttctaag gctagagcca
    12601 aaaaaatgca agataagcct ggagcatctt gtagtaccag aaactaagca agtgctcaaa
    12661 aacaaaagga tagaagcatg tcagacagac acaggagcca atctgaaaga gctccctggc
    12721 cgggcacggt ggctcacgcc tgtaatccca gcactttggg agactgaggt gggaggatga
    12781 cttgagccca ggagtttgag accagcctgg gcaacatagg gagaccccat ctctacaaaa
    12841 aagtaaacaa ttagccgggc atggtggcac acgcctatag tcccagctac tcaggagggt
    12901 gaagatcacc tgagaccagg cggtcaaggc ttcagtgagc catgattgtg gcactgcact
    12961 ccagcctagg caatagagtg agactgtctc aaaaaataaa attttaaaat aactgaagag
    13021 tataactgga ttgtttgtaa cacaaaggat aagtgcttaa gatgatggaa accctattta
    13081 tcctgatgtg attattacac attgcatgcc tgtaccaaaa tatttcatgt aacccataaa
    13141 tatatacatc tactatgtac ccacaaaaat taaaaaatgt ttacaggagt gaaccaccgc
    13201 acctggccag tggagtcttt ttaaggtatt atttagcatc ttctgcttat agtcatgtcc
    13261 aaaaaccagt tgatcttcct actcattagg ggacaagatc aattctctaa aaaattaacc
    13321 tagcccaagg taagtggtac tattctgaaa tctgaaaatc tttagtagcc tcacattata
    13381 agcccttcgt agaaaaagaa aagtaagcat ttctagaagc acatttttgt tggactgagg
    13441 gtggggcaag gagcaggggt gactttcatc tgaaatgtac ctaggcaggc cagagtctga
    13501 gttaggactg gctcctggga ctttgccatc caggccaaga agcatgctcc agtgtgcatg
    13561 cactctcatc aaagccctag tcaggaatcc cagccactcc tctcctgtgc agcacaagct
    13621 gaaggataag gtgtggggca gtgactgcgt ggggctgcct gtgtgattcc tgataaagaa
    13681 atgccttcat gaaatgtatt gttccccaat aaagctcatt ttctgtgaga attcatgtgt
    13741 ccttttccaa attaaactag caaaatatga acttttgtaa aaggtccaca cccagccagt
    13801 tttctactct ctaaatgttc aggcctttgc ctgtccttcc ctcagcaaaa atactgtgtt
    13861 ttggaaaaca ttaccaataa aggagctggg aggtggaatt ggatcaaaat acctttagat
    13921 gaaagcagca gcacaagcca ttccctttaa atgagctggc ctcacctctg gggcctatga
    13981 agaaaagcct gcttcaaggt gatagttttc attttgcttc ccagcacctc tgcagtcata
    14041 accaaagtga aggacaatat tgcatgactt cagaagaaag ccatccagcc accttgcaac
    14101 atgttcagga aattctggac tcccttgggg cttgcaaaac tccctatgtc ttgcagacca
    14161 aaagcaagtt ctcagtcacc tagctctagt ttgcataatt aaagaaagtg gaagctggtt
    14221 cttttctggg tgacccttca cccaaccaag ctcataagga cttgtgacaa aaataagagc
    14281 aataaaatga agttttaaca gtgaaaactt ctatcactta gataagcagg aaaagccagt
    14341 cccctagatg cccatctgac cctaccttac tggggtcata cagccaaagc agtgtccact
    14401 tcaggtactg taatgttttg aagttgacac atataattta atgtagtttc atgtcataag
    14461 ttataagact tttcagagaa acaatttagt aatatcttct gtaataccca tcttcatttt
    14521 ttatatgaaa aagcatagcc tatgatctgt caccttgctc actcccacat ccttacctct
    14581 tatccttctc acatcgtccc attaacacat tatccatctt tggggggaaa aaatacacta
    14641 aattttagac agagtcactt tcactatggc cacaatggga gaaaagacag tccaccttca
    14701 aagtcaacca gaatgactct taacctctct tgtctgggtt gggcatccag ataagatttt
    14761 cttcgtacaa agagtcttgc tactaggaaa aagagtttga aaatcactag tctaactaaa
    14821 tatctcactt taaaaaaagc acaaactaag actcaatgag gtttatcttc cacaagatca
    14881 gccagtttta gcagagcagt tgctaaaacc caggtctcaa actccttgtc tatggctcat
    14941 ctaactaagc aacaaaaagc ccaatgagct ctggagagag agagggagct aaaacaggac
    15001 tcaatcaaaa cccacttggg attagggaag ccaccctctg tgagtgagtt aaactgagat
    15061 tccctcccct tcaccctggc ttcctttgca gaacaagggt caccgccaga gggaaagctg
    15121 agtttacgga ggggatcctg gttggagtca gagtatacct tggtttggtt ttgtggggtt
    15181 ttttgagaca gggtctcact gtcacccagg ctggagcaca gtgacagtca tagctcacta
    15241 tagcctcaga ctcctggcct caagcgatcc tcccacctca acctccagag tatctgggac
    15301 tataggcacg taccaccata cccagctaat atttttttta attttatatt ttttagagac
    15361 agggtgtcac tatgttaccc aggtctcaat cactatgtta ctccttgcct caagcaatcc
    15421 tctcaccttg gcctcccaaa gtgctgagct tacaggtgtc aaccactgtg gccagccacg
    15481 cattggtttt aaggtccaga atttttctgt ttggagcctt cacaattagt tttaggttgg
    15541 gagaccgtga acccaccaag cagcccttta gaggctggaa aaagagtttg gaaaaagaac
    15601 tctgtggctt taggaatttc tctcggaaat cctctagggc agagaaggaa aatttaccaa
    15661 atgggagagt gtattagtct attcttacat tgctataagg aaatacccca gactgggtaa
    15721 tttataaagg aaagagtttt aattgactca cagttccaca tggctgggaa agcctcagga
    15781 aacttacaat catagcagaa ggcaaagggg aagaaaggca ccttcttcac agggcggcag
    15841 gaaggagaag tgcagagcaa agtggggcaa agcctctata aagccatcag atctcatgag
    15901 aactcactat catgagaaca gcaggggaga accaccccca tgatccaatc accttccacg
    15961 aggtccctcc cccaacacgt ggggatcaca atttggatta caattcaaga tgagatttgg
    16021 gtgaggacac agagccggac catatcagag agaaagctat tactgaagac ctttctaact
    16081 cacttctgta aagatcaatt caataaaagc agcaaacaca catactttgc tttccttgtg
    16141 attaatgcct tgactttttt gtggaaagta acaccccaag aaagccagct actcatgttg
    16201 gcaataaagg taaaagtatc tatggaataa ggaccatttt taggacaata ctttccctac
    16261 tacttagttc tagtcccttt tttgtagaat tctgaggact ttctacatac acaatcatgt
    16321 catcagcaaa taaagattat tgtacttgtt ctttgccaac ccatatgtct tgccttactg
    16381 ccctggttag gaccttcaga acaatactgg atataagtgg tgaaagcaca tatcctcccc
    16441 ttgttcctaa ttttagaggg aaagtactca gtctttcgcc attaagtaca atgtcagctg
    16501 taagttttcc tagagaccct ttctcagctt gaagatgttc cctggtattc atagtttgct
    16561 aaaaggtttt tgtcatttta aatcataaat gggtgttgaa ttttgtcaaa ggcttttaat
    16621 gcatctatgg agatgatcca agtttttttc ctccttattt ctgctaaggt tgtataatta
    16681 tgctcattgg tattttaaat gttaaattaa ccttgcgttc ctgggataag acccactgat
    16741 catgatgcat tttcctcttt gtaaattgct gtattcattt tagtttcttc aggattttgc
    16801 ctatgtttga aggatattgg tttgtaattt ttcttgtaac atctttgtct ggttttgaaa
    16861 tcaaagtaat actggcctaa taaaatgagt tggaatgtg
//
