LOCUS       NM_015540               4663 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RNA polymerase II associated protein 1 (RPAP1), mRNA.
ACCESSION   NM_015540
VERSION     NM_015540.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4663)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4663)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   3  (bases 1 to 4663)
  AUTHORS   Kuraoka,I., Suzuki,K., Ito,S., Hayashida,M., Kwei,J.S., Ikegami,T.,
            Handa,H., Nakabeppu,Y. and Tanaka,K.
  TITLE     RNA polymerase II bypasses 8-oxoguanine in the presence of
            transcription elongation factor TFIIS
  JOURNAL   DNA Repair (Amst) 6 (6), 841-851 (2007)
   PUBMED   17374514
  REMARK    GeneRIF: SII is important for preventing cellular death due to
            oxidative DNA damage, assisting RNAPII to bypass 8-oxoG
REFERENCE   4  (bases 1 to 4663)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   5  (bases 1 to 4663)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   6  (bases 1 to 4663)
  AUTHORS   Jeronimo,C., Langelier,M.F., Zeghouf,M., Cojocaru,M., Bergeron,D.,
            Baali,D., Forget,D., Mnaimneh,S., Davierwala,A.P., Pootoolal,J.,
            Chandy,M., Canadien,V., Beattie,B.K., Richards,D.P., Workman,J.L.,
            Hughes,T.R., Greenblatt,J. and Coulombe,B.
  TITLE     RPAP1, a novel human RNA polymerase II-associated protein affinity
            purified with recombinant wild-type and mutated polymerase subunits
  JOURNAL   Mol Cell Biol 24 (16), 7043-7058 (2004)
   PUBMED   15282305
  REMARK    GeneRIF: Data report the purification of RNA polymerase
            II-associated protein 1 (RPAP1), a 153-kDa polypeptide of unknown
            function.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016134.7.
            
            On Nov 23, 2018 this sequence version replaced NM_015540.3.
            
            Summary: This protein forms part of the RNA polymerase II (RNAPII)
            enzyme complex and may recruit RNAPII to chromatin through its
            interaction with acetylated histones. [provided by RefSeq, Jul
            2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000246.1, SRR1803615.29460.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304330.9/ ENSP00000306123.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC016134.7         39997-40035         c
            40-296              AC016134.7         32723-32979         c
            297-445             AC016134.7         32279-32427         c
            446-535             AC016134.7         31907-31996         c
            536-656             AC016134.7         31290-31410         c
            657-878             AC016134.7         30492-30713         c
            879-1058            AC016134.7         26801-26980         c
            1059-1174           AC016134.7         25642-25757         c
            1175-1273           AC016134.7         25248-25346         c
            1274-1375           AC016134.7         24013-24114         c
            1376-1543           AC016134.7         23638-23805         c
            1544-1726           AC016134.7         23201-23383         c
            1727-1861           AC016134.7         22945-23079         c
            1862-2032           AC016134.7         22676-22846         c
            2033-2190           AC016134.7         20769-20926         c
            2191-2349           AC016134.7         19874-20032         c
            2350-2551           AC016134.7         19549-19750         c
            2552-2661           AC016134.7         19023-19132         c
            2662-2857           AC016134.7         18543-18738         c
            2858-3010           AC016134.7         17876-18028         c
            3011-3153           AC016134.7         17516-17658         c
            3154-3910           AC016134.7         16169-16925         c
            3911-4087           AC016134.7         13784-13960         c
            4088-4147           AC016134.7         13576-13635         c
            4148-4663           AC016134.7         12954-13469         c
FEATURES             Location/Qualifiers
     source          1..4663
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..4663
                     /gene="RPAP1"
                     /note="RNA polymerase II associated protein 1"
                     /db_xref="GeneID:26015"
                     /db_xref="HGNC:HGNC:24567"
                     /db_xref="MIM:611475"
     exon            1..39
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            40..296
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..4297
                     /gene="RPAP1"
                     /codon_start=1
                     /product="RNA polymerase II-associated protein 1"
                     /protein_id="NP_056355.2"
                     /db_xref="CCDS:CCDS10079.1"
                     /db_xref="GeneID:26015"
                     /db_xref="HGNC:HGNC:24567"
                     /db_xref="MIM:611475"
                     /translation="MLSRPKPGESEVDLLHFQSQFLAAGAAPAVQLVKKGNRGGGDAN
                     SDRPPLQDHRDVVMLDNLPDLPPALVPSPPKRARPSPGHCLPEDEDPEERLRRHDQHI
                     TAVLTKIIERDTSSVAVNLPVPSGVAFPAVFLRSRDTQGKSATSGKRSIFAQEIAARR
                     IAEAKGPSVGEVVPNVGPPEGAVTCETPTPRNQGCQLPGSSHSFQGPNLVTGKGLRDQ
                     EAEQEAQTIHEENIARLQAMAPEEILQEQQRLLAQLDPSLVAFLRSHSHTQEQTGETA
                     SEEQRPGGPSANVTKEEPLMSAFASEPRKRDKLEPEAPALALPVTPQKEWLHMDTVEL
                     EKLHWTQDLPPVRRQQTQERMQARFSLQGELLAPDVDLPTHLGLHHHGEEAERAGYSL
                     QELFHLTRSQVSQQRALALHVLAQVISRAQAGEFGDRLAGSVLSLLLDAGFLFLLRFS
                     LDDRVDGVIATAIRALRALLVAPGDEELLDSTFSWYHGALTFPLMPSQEDKEDEDEDE
                     ECPAGKAKRKSPEEESRPPPDLARHDVIKGLLATSLLPRLRYVLEVTYPGPAVVLDIL
                     AVLIRLARHSLESATRVLECPRLIETIVREFLPTSWSPVGAGPTPSLYKVPCATAMKL
                     LRVLASAGRNIAARLLSSFDLRSRLCRIIAEAPQELALPPEEAEMLSTEALRLWAVAA
                     SYGQGGYLYRELYPVLMRALQVVPRELSTHPPQPLSMQRIASLLTLLTQLTLAAGSTP
                     AETISDSAEASLSATPSLVTWTQVSGLQPLVEPCLRQTLKLLSRPEMWRAVGPVPVAC
                     LLFLGAYYQAWSQQPSSCPEDWLQDMQRLSEELLLPLLSQPTLGSLWDSLRHCSLLCN
                     PLSCVPALEAPPSLVSLGCSGGCPRLSLAGSASPFPFLTALLSLLNTLAQIHKGLCGQ
                     LAAILAAPGLQNYFLQCVAPGAAPHLTPFSAWALRHEYHLQYLALALAQKAAALQPLP
                     ATHAALYHGMALALLSRLLPGSEYLTHELLLSCVFRLEFLPERTSGGPEAADFSDQLS
                     LGSSRVPRCGQGTLLAQACQDLPSIRNCYLTHCSPARASLLASQALHRGELQRVPTLL
                     LPMPTEPLLPTDWPFLPLIRLYHRASDTPSGLSPTDTMGTAMRVLQWVLVLESWRPQA
                     LWAVPPAARLARLMCVFLVDSELFRESPVQHLVAALLAQLCQPQVLPNLNLDCRLPGL
                     TSFPDLYANFLDHFEAVSFGDHLFGALVLLPLQRRFSVTLRLALFGEHVGALRALSLP
                     LTQLPVSLECYTVPPEDNLALLQLYFRTLVTGALRPRWCPVLYAVAVAHVNSFIFSQD
                     PQSSDEVKAARRSMLQKTWLLADEGLRQHLLHYKLPNSTLPEGFELYSQLPPLRQHYL
                     QRLTSTVLQNGVSET"
     exon            297..445
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..535
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..656
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..878
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1058
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1174
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1273
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1375
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1543
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1726
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1861
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2032
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2190
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2349
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2551
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2661
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2857
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..3010
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3011..3153
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3154..3910
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3911..4087
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4088..4147
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4148..4663
                     /gene="RPAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4638..4643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPAP1"
                     /note="hexamer: AATAAA"
     polyA_site      4663
                     /gene="RPAP1"
                     /note="major polyA site"
ORIGIN      
        1 gcggggcaag atggcggcgc ccagacaggc ctggagcacg gatgaataag agggaacccc
       61 cacacggaga cactgctgga gagagtcgta ctggggaggc agctggagca gcaagatgct
      121 gtcgagaccg aagccagggg agtccgaggt ggacctgctg cacttccaga gtcagtttct
      181 cgcagctggt gcagccccag cagtgcagtt ggtgaagaaa ggaaataggg gcggtggtga
      241 tgccaactca gaccggcctc cgctccagga ccatcgggat gtggtgatgt tggacaatct
      301 cccagatttg cccccagctt tggtcccttc tcctccaaag agagccaggc ccagccctgg
      361 ccactgcctg cctgaggatg aggacccaga agagaggctg aggaggcatg atcagcacat
      421 cactgctgtc ttgactaaga ttattgaacg agatacaagt tcagtggccg tgaatctgcc
      481 tgtgcccagt ggtgttgctt tccctgctgt gttccttcgc tcgcgggaca cacaggggaa
      541 atcagcaaca tctggtaaga gaagcatctt tgcccaggaa attgcggcaa ggaggatagc
      601 tgaagccaag ggcccatcag ttggggaagt tgtgcccaac gtgggcccac cagagggtgc
      661 cgtgacctgt gagacaccca ctcctaggaa ccagggctgc cagcttcctg ggagcagcca
      721 cagctttcag ggacccaatc tggtcacagg gaaggggctc agggatcaag aagctgagca
      781 ggaagcccag actatccatg aagagaacat agcaagactg caggccatgg ctcctgagga
      841 gatcctgcag gaacagcagc ggttgctggc ccagcttgac cccagcttgg ttgctttctt
      901 gagatctcac agccacacgc aagagcaaac aggagagaca gcctctgagg agcagaggcc
      961 aggaggaccc tctgctaatg tcaccaagga ggaacccctc atgtcagctt ttgccagtga
     1021 gcccaggaag agagacaagc tggagccaga agccccagct ctggcattgc ccgtgacccc
     1081 tcagaaagaa tggctgcaca tggacactgt cgagctggag aagctccact ggacccagga
     1141 cttgccccct gtccggcggc agcagacaca ggagaggatg caggctcgat tcagtcttca
     1201 gggagaacta ctggcccctg acgtggacct gcccacccac ctgggtctgc accaccatgg
     1261 agaggaggca gagagagcgg ggtattccct acaggagctg ttccacctga cccgcagcca
     1321 ggtttcccag cagagagcac tggcactgca tgtgttagcc caggtcatca gcagggccca
     1381 ggctggtgag tttggggacc ggctagcagg cagtgtctta agcctccttt tggatgctgg
     1441 tttcctcttc ctactgcgct tctccttgga tgacagagtg gatggggtca ttgcaaccgc
     1501 catccgtgct cttcgggctc tgctggtggc tcctggagat gaggagctcc tcgacagcac
     1561 cttctcttgg taccatggag ctttgacgtt ccctctgatg cccagccagg aggacaagga
     1621 ggatgaggac gaggatgaag aatgcccagc aggaaaagca aaaaggaaaa gccctgaaga
     1681 agaaagccgg cctccacctg acctggcccg acatgatgtc atcaaggggc tcctggctac
     1741 cagcctgctg cctcggctgc gctacgtgct ggaggtgaca tacccaggac ctgcggtggt
     1801 ccttgacatc ctggctgtgc tcatccgcct ggcccggcat tccctggaat cagccacaag
     1861 ggtcctggag tgccctcggc tgatagagac tatagttcga gagttcttgc ccaccagttg
     1921 gtctcctgtg ggggcagggc ctacccctag tctatacaaa gtaccctgtg ctactgccat
     1981 gaaactactt cgtgtcctgg cctcagctgg gaggaatatt gctgcccggc tgttgagcag
     2041 ctttgatctc cggagccgcc tgtgccgcat catagctgag gctccccaag aactggcctt
     2101 gcccccagag gaagctgaga tgctgagcac cgaggccctc cgtctgtggg ctgtggctgc
     2161 ctcctatggc cagggcggtt acctttacag ggagctctac ccagtgctga tgcgggcctt
     2221 gcaggtggtg ccgcgggagc tcagcaccca cccacctcaa cccctgtcca tgcagcggat
     2281 agcctcactg ctcactctcc tcacccagct aaccctggca gccggcagta cccctgctga
     2341 aaccatcagt gattctgctg aggccagcct ctcggccacc ccttccttag tcacttggac
     2401 acaggtgtct gggctccagc ctcttgttga gccgtgtcta aggcagacct tgaagttgct
     2461 gtccagacct gagatgtgga gagccgtggg cccagtgccc gttgcctgcc tgttgttcct
     2521 gggagcctac taccaggcct ggagccagca accaagctca tgcccggagg attggctcca
     2581 ggacatgcag cgcctgtcag aggagctgct gctgccactg ctgagtcagc ccacactggg
     2641 cagcctgtgg gattccctta ggcactgctc ccttctctgc aacccgctgt cctgtgtgcc
     2701 agcccttgaa gctcccccca gcctcgtgtc actgggctgc tcgggaggct gcccccgtct
     2761 cagtctggct ggctcagcct cacccttccc attcctcact gccctcctct ctcttcttaa
     2821 taccctggcc cagatccaca aggggctgtg tggccagctg gctgccatat tggctgcccc
     2881 gggactccag aattacttcc tccagtgtgt ggctcctggg gctgccccac acctcacacc
     2941 tttctctgca tgggccctgc gccatgagta ccacctgcag tacctggcac tcgctctggc
     3001 ccagaaagcg gcagcgctgc agccactgcc agccacccat gctgccctct atcatggtat
     3061 ggccttggcc ctgctgagcc ggctgctgcc cggaagtgag tacctcaccc atgagctgct
     3121 gctgagctgt gtattccggc tggagttcct cccggaaaga acatcagggg gtccagaggc
     3181 agccgacttc tctgaccagc tgtcgttagg aagcagcagg gtccctcggt gtgggcaagg
     3241 gactctgctg gctcaggcct gccaggacct ccccagcatc cgcaactgct acctgactca
     3301 ttgctcgcca gcccgagcca gtctgctggc ctcccaggct ctgcaccgag gggagctaca
     3361 gcgagtccca accctgctac tgcccatgcc tacggagccg ctgctgccca ccgactggcc
     3421 cttcctgcca ctgattcgcc tctaccaccg ggcttcagac accccctcgg gactctctcc
     3481 cacagacacc atgggcacag ccatgcgggt cctgcagtgg gtgctagttt tggagagctg
     3541 gcgcccccag gctctctggg ctgtgccccc tgctgcccgc ctggcacggc tcatgtgtgt
     3601 gttcctggtg gacagtgagc tgttccggga gtccccagta cagcatctgg tggcagccct
     3661 cctcgcccag ctctgtcagc ctcaagtctt gccaaacctc aacctggact gccgactccc
     3721 tggcctgacg tctttccctg acctctatgc caacttcctg gatcattttg aggctgtctc
     3781 ttttggggac cacctctttg gggccctggt cctcctgccc ctgcagcgtc ggttcagtgt
     3841 caccttgcgc cttgccctct ttggggaaca cgtgggagcc ttgcgagctc tgagcctgcc
     3901 tctgacccag ttgcctgtgt ccctggagtg ttacacagtg cctcctgaag acaacctggc
     3961 cctccttcag ctctacttcc ggaccctggt tactggtgcg ctccgcccac gttggtgccc
     4021 cgtgctctat gctgtggctg tggctcatgt caatagcttc atcttctctc aggacccaca
     4081 gagctcagat gaggtcaaag ctgcccgcag gagtatgctg cagaaaacat ggctgctggc
     4141 agatgagggt ctccggcagc acctcctgca ctataagctt cccaattcca cgctcccaga
     4201 gggctttgag ctctattctc agttgccccc tctgcgtcag cactacctcc agagactgac
     4261 ttcaacagtg ctccaaaatg gggtatcaga gacctaggat agttgatata gatggaaaga
     4321 tgggtacgtt gtcctgtatc cagcctttca acagatgtct ggccagacga agaacattgt
     4381 gtcctaatgg taggcaggag accaaggagc agaaggcttg ccttcctggg agcaggttgt
     4441 ttgagctgtt ttagagcagt gagccctacc attacatcct gatatctggg gcttctgaag
     4501 gtctgtactg ggagtgaaga gtggcttagc tatttacccg ctctttgggg acagggcaaa
     4561 ctaaatgcat cccttcttac ctaactccca acccctgccc tgggctgagg catatgaatg
     4621 ctatagttgt gcattaaaat aaatgttttt tatctcctgg aaa
//
