LOCUS       NM_001033002             995 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens RPA interacting protein (RPAIN), transcript variant 2,
            mRNA.
ACCESSION   NM_001033002
VERSION     NM_001033002.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 995)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 995)
  AUTHORS   Song,X., Rui,C., Meng,L., Zhang,R., Shen,R., Ding,H., Li,J., Li,J.
            and Long,W.
  TITLE     Long non-coding RNA RPAIN regulates the invasion and apoptosis of
            trophoblast cell lines via complement protein C1q
  JOURNAL   Oncotarget 8 (5), 7637-7646 (2017)
   PUBMED   28032589
  REMARK    GeneRIF: Suggest that increased RPAIN levels may contribute to the
            development of preeclampsia through regulating trophoblast invasion
            and apoptosis via C1q.
REFERENCE   3  (bases 1 to 995)
  AUTHORS   Namkoong,S., Lee,E.J., Jang,I.S. and Park,J.
  TITLE     Elevated level of human RPA interacting protein alpha (hRIPalpha)
            in cervical tumor cells is involved in cell proliferation through
            regulating RPA transport
  JOURNAL   FEBS Lett 586 (20), 3753-3760 (2012)
   PUBMED   23010595
  REMARK    GeneRIF: hRIPalpha is involved in cell proliferation through
            regulation of RPA transport
REFERENCE   4  (bases 1 to 995)
  AUTHORS   Liu,J., Henao-Mejia,J., Liu,H., Zhao,Y. and He,J.J.
  TITLE     Translational regulation of HIV-1 replication by HIV-1 Rev cellular
            cofactors Sam68, eIF5A, hRIP, and DDX3
  JOURNAL   J Neuroimmune Pharmacol 6 (2), 308-321 (2011)
   PUBMED   21360055
  REMARK    GeneRIF: The results show that DDX3, eIF5A, and hRIP enhance HIV-1
            internal ribosomal entry site-mediated translation.
REFERENCE   5  (bases 1 to 995)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 995)
  AUTHORS   Dagle,J.M., Lepp,N.T., Cooper,M.E., Schaa,K.L., Kelsey,K.J.,
            Orr,K.L., Caprau,D., Zimmerman,C.R., Steffen,K.M., Johnson,K.J.,
            Marazita,M.L. and Murray,J.C.
  TITLE     Determination of genetic predisposition to patent ductus arteriosus
            in preterm infants
  JOURNAL   Pediatrics 123 (4), 1116-1123 (2009)
   PUBMED   19336370
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 995)
  AUTHORS   Park,J., Seo,T., Kim,H. and Choe,J.
  TITLE     Sumoylation of the novel protein hRIP{beta} is involved in
            replication protein A deposition in PML nuclear bodies
  JOURNAL   Mol Cell Biol 25 (18), 8202-8214 (2005)
   PUBMED   16135809
  REMARK    GeneRIF: hRIPbeta localises to the PML nuclear body and transports
            replication protein A (PML) into the PML nuclear body and releases
            RPA upon UV irradiation.
REFERENCE   8  (bases 1 to 995)
  AUTHORS   Chen,J.Z., Huang,S.D., Ji,C.N., Pang,R.Y., Xie,Y. and Xue,J.L.
  TITLE     Identification, expression pattern, and subcellular location of
            human RIP isoforms
  JOURNAL   DNA Cell Biol 24 (7), 464-469 (2005)
   PUBMED   16008515
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY775314.1, BC013831.1 and BI091755.1.
            
            On Aug 11, 2020 this sequence version replaced NM_001033002.3.
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR, compared to variant 1. It encodes isoform b,
            which has a shorter and distinct C-terminus compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY775314.1, BC013831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381209.8/ ENSP00000370606.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               AY775314.1         542-878
            338-644             BC013831.1         350-656
            645-994             AY775314.1         1186-1535
            995-995             BI091755.1         658-658
FEATURES             Location/Qualifiers
     source          1..995
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..995
                     /gene="RPAIN"
                     /gene_synonym="HRIP; RIP"
                     /note="RPA interacting protein"
                     /db_xref="GeneID:84268"
                     /db_xref="HGNC:HGNC:28641"
                     /db_xref="MIM:617299"
     exon            1..110
                     /gene="RPAIN"
                     /gene_synonym="HRIP; RIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..689
                     /gene="RPAIN"
                     /gene_synonym="HRIP; RIP"
                     /note="isoform b is encoded by transcript variant 2; RAP
                     interaction protein; nuclear transporter"
                     /codon_start=1
                     /product="RPA-interacting protein isoform b"
                     /protein_id="NP_001028174.2"
                     /db_xref="CCDS:CCDS32536.1"
                     /db_xref="GeneID:84268"
                     /db_xref="HGNC:HGNC:28641"
                     /db_xref="MIM:617299"
                     /translation="MAESLRSPRRSLYKLVGSPPWKEAFRQRCLERMRNSRDRLLNRY
                     RQAGSSGPGNSQNSFLVQEVMEEEWNALQSVENCPEDLAQLEELIDMAVLEEIQQELI
                     NQEQSIISEYEKSLQFDEKCLSIMLAEWEANPLICPVCTKYNLRITSGVVVCQCGLSI
                     PSHSSELTEQKLRACLEGSINEHSAHCPHTPEFSVTGGTEEKSSLLMSCLACDTWAVI
                     L"
     exon            111..281
                     /gene="RPAIN"
                     /gene_synonym="HRIP; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            282..342
                     /gene="RPAIN"
                     /gene_synonym="HRIP; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            343..454
                     /gene="RPAIN"
                     /gene_synonym="HRIP; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            455..518
                     /gene="RPAIN"
                     /gene_synonym="HRIP; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            519..659
                     /gene="RPAIN"
                     /gene_synonym="HRIP; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            660..995
                     /gene="RPAIN"
                     /gene_synonym="HRIP; RIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      811..816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPAIN"
                     /gene_synonym="HRIP; RIP"
                     /note="hexamer: AAGAAA"
     polyA_site      833
                     /gene="RPAIN"
                     /gene_synonym="HRIP; RIP"
     regulatory      975..980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPAIN"
                     /gene_synonym="HRIP; RIP"
                     /note="hexamer: AATAAA"
     polyA_site      995
                     /gene="RPAIN"
                     /gene_synonym="HRIP; RIP"
                     /note="major polyA site"
ORIGIN      
        1 cttgtggctt tgtctcccgc gaagaggaga tggcggagtc gttgaggtct ccgcgccgct
       61 ccctgtacaa actggtgggc tcgccgcctt ggaaagaggc tttccggcag agatgcctgg
      121 agagaatgag aaacagccgg gacaggctcc taaacaggta ccgccaggct ggaagcagtg
      181 ggccagggaa ttctcagaac agctttctag ttcaagaggt gatggaagaa gagtggaatg
      241 ctttgcagtc agtggagaat tgtccagaag acttggctca gctggaggag ctgatagaca
      301 tggctgtgct ggaggaaatt caacaggagc tgatcaacca agagcagtcc atcatcagcg
      361 agtatgagaa gagcttgcag tttgatgaaa agtgtctcag catcatgctg gctgagtggg
      421 aggcaaaccc actcatctgt cctgtatgta caaagtacaa cctgagaatc acaagcggtg
      481 tggtggtgtg tcagtgtggc ctgtccatcc catctcattc ttctgagttg acagagcaga
      541 agcttcgtgc ctgtttagag ggtagtataa atgagcacag tgcacattgt ccccacacac
      601 ctgaattttc agtcactgga ggaacagaag aaaagtccag tcttctcatg agctgtctgg
      661 cctgtgatac ttgggctgtg atcctctaga gccagcttgg actcacatca ttctatgggg
      721 ttgaagacaa ctcattccct ctgaggagcc ttgtacatac aagcctttta tttataactt
      781 attttgtatt gaaactttta aacaatactg aagaaaaaaa aacttttccg acatctgttc
      841 ttggtctttt gtgacgcagg ttgaaggggg aggaatagaa aaagacaaac tgccttggag
      901 gagataaacc aattttatgt ctatcatgtt atacaaaaat ctagaaataa tagatttgta
      961 cagaaaaaaa tgataataaa tgagaacaca aaaca
//
