LOCUS       NM_013347               1560 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens replication protein A4 (RPA4), mRNA.
ACCESSION   NM_013347
VERSION     NM_013347.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1560)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1560)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1560)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1560)
  AUTHORS   Mason,A.C., Roy,R., Simmons,D.T. and Wold,M.S.
  TITLE     Functions of alternative replication protein A in initiation and
            elongation
  JOURNAL   Biochemistry 49 (28), 5919-5928 (2010)
   PUBMED   20545304
REFERENCE   5  (bases 1 to 1560)
  AUTHORS   Kemp,M.G., Mason,A.C., Carreira,A., Reardon,J.T., Haring,S.J.,
            Borgstahl,G.E., Kowalczykowski,S.C., Sancar,A. and Wold,M.S.
  TITLE     An alternative form of replication protein a expressed in normal
            human tissues supports DNA repair
  JOURNAL   J Biol Chem 285 (7), 4788-4797 (2010)
   PUBMED   19996105
  REMARK    GeneRIF: Findings provide the first direct evidence for the
            function of alternative form of RPA in human DNA metabolism and
            support a model for aRPA functioning in chromosome maintenance
            functions in nonproliferating cells.
REFERENCE   6  (bases 1 to 1560)
  AUTHORS   Mason,A.C., Haring,S.J., Pryor,J.M., Staloch,C.A., Gan,T.F. and
            Wold,M.S.
  TITLE     An alternative form of replication protein a prevents viral
            replication in vitro
  JOURNAL   J Biol Chem 284 (8), 5324-5331 (2009)
   PUBMED   19116208
REFERENCE   7  (bases 1 to 1560)
  AUTHORS   Hosgood,H.D. 3rd, Menashe,I., Shen,M., Yeager,M., Yuenger,J.,
            Rajaraman,P., He,X., Chatterjee,N., Caporaso,N.E., Zhu,Y.,
            Chanock,S.J., Zheng,T. and Lan,Q.
  TITLE     Pathway-based evaluation of 380 candidate genes and lung cancer
            susceptibility suggests the importance of the cell cycle pathway
  JOURNAL   Carcinogenesis 29 (10), 1938-1943 (2008)
   PUBMED   18676680
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1560)
  AUTHORS   Wu,X., Yang,Z., Liu,Y. and Zou,Y.
  TITLE     Preferential localization of hyperphosphorylated replication
            protein A to double-strand break repair and checkpoint complexes
            upon DNA damage
  JOURNAL   Biochem J 391 (Pt 3), 473-480 (2005)
   PUBMED   15929725
  REMARK    GeneRIF: Hyperphosphorylated replication protein A is
            preferentially localized to double-stranded break repair and the
            DNA damage checkpoint complexes in response to DNA damage.
REFERENCE   9  (bases 1 to 1560)
  AUTHORS   Li,L., Lu,X., Peterson,C.A. and Legerski,R.J.
  TITLE     An interaction between the DNA repair factor XPA and replication
            protein A appears essential for nucleotide excision repair
  JOURNAL   Mol Cell Biol 15 (10), 5396-5402 (1995)
   PUBMED   7565690
REFERENCE   10 (bases 1 to 1560)
  AUTHORS   Keshav,K.F., Chen,C. and Dutta,A.
  TITLE     Rpa4, a homolog of the 34-kilodalton subunit of the replication
            protein A complex
  JOURNAL   Mol Cell Biol 15 (6), 3119-3128 (1995)
   PUBMED   7760808
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z86061.1, BC069791.1 and
            U24186.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 25, 2010 this sequence version replaced NM_013347.3.
            
            Summary: This gene encodes a single-stranded DNA-binding protein
            that is the 30-kDa subunit of the replication protein A complex.
            Replication protein A is an essential factor for DNA double-strand
            break repair and cell cycle checkpoint activation. The encoded
            protein localizes to DNA repair foci and may be involved in the
            cellular DNA damage response. This protein may also play a role in
            inhibiting viral replication.[provided by RefSeq, Apr 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: U24186.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373040.4/ ENSP00000362131.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               Z86061.1           9837-9941           c
            106-1553            BC069791.1         1-1448
            1554-1560           U24186.2           1554-1560
FEATURES             Location/Qualifiers
     source          1..1560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.33"
     gene            1..1560
                     /gene="RPA4"
                     /gene_synonym="HSU24186"
                     /note="replication protein A4"
                     /db_xref="GeneID:29935"
                     /db_xref="HGNC:HGNC:30305"
                     /db_xref="MIM:300767"
     exon            1..1560
                     /gene="RPA4"
                     /gene_synonym="HSU24186"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..1189
                     /gene="RPA4"
                     /gene_synonym="HSU24186"
                     /note="replication protein A4, 34kDa; replication protein
                     A complex 34 kd subunit homolog Rpa4; RP-A p30; RF-A
                     protein 4; replication factor A protein 4; replication
                     protein A4, 30kDa"
                     /codon_start=1
                     /product="replication protein A 30 kDa subunit"
                     /protein_id="NP_037479.1"
                     /db_xref="CCDS:CCDS35345.1"
                     /db_xref="GeneID:29935"
                     /db_xref="HGNC:HGNC:30305"
                     /db_xref="MIM:300767"
                     /translation="MSKSGFGSYGSISAADGASGGSDQLCERDATPAIKTQRPKVRIQ
                     DVVPCNVNQLLSSTVFDPVFKVRGIIVSQVSIVGVIRGAEKASNHICYKIDDMTAKPI
                     EARQWFGREKVKQVTPLSVGVYVKVFGILKCPTGTKSLEVLKIHVLEDMNEFTVHILE
                     TVNAHMMLDKARRDTTVESVPVSPSEVNDAGDNDESHRNFIQDEVLRLIHECPHQEGK
                     SIHELRAQLCDLSVKAIKEAIDYLTVEGHIYPTVDREHFKSAD"
ORIGIN      
        1 ctagtaaaaa tgcattttta tagagatgtt gggaaaggct tgcttgaaat tacacgtggg
       61 acttttaata gataggcgct ttgaccagct aagcaacagg gctcccctcg tgtgggactt
      121 ttagaatgta gcaaccactg acacacaggg aaggattatg cgatcaggtg agaaggtggc
      181 cgaccctgac tggctggaag cagatgcatt ctggtagttg attggtccac aggtagcgtg
      241 acgcttgtca cgtcctcagc ctcccagcat tcaatcgtag cctttcggac agctcgaagc
      301 cttctgtgga gagctcgaag ccttctgtgg agaactcaaa gccgtccgtg gagccccaga
      361 cgagccaaag cccaccttct cctcagcctg agctgtcttg aagatgagta agagtgggtt
      421 tgggagctat ggcagcattt ctgctgctga tggagcgagt ggaggcagtg accaactgtg
      481 tgagagagat gcaactcctg ctattaagac ccaaagacct aaggtccgaa ttcaggacgt
      541 tgtaccgtgt aatgtgaacc agcttctcag ctctactgtg tttgaccctg tgttcaaggt
      601 taggggaatt atagtttccc aggtctccat cgtgggggta atcagagggg cagagaaggc
      661 ttcaaatcac atttgttaca aaattgatga tatgaccgcg aaaccaatcg aggcccgaca
      721 gtggtttggt agagagaaag tcaagcaggt gactccattg tcagtcggag tatatgtcaa
      781 agtgtttggt atcctcaaat gtcccacggg aacaaagagc cttgaggtat tgaaaattca
      841 tgtcctagag gacatgaacg agttcaccgt gcatattctg gaaacggtca atgcacacat
      901 gatgctggat aaagcccgtc gtgataccac tgtagaaagt gtgcctgtgt ctccatcaga
      961 agtgaatgat gctggggata acgatgagag tcaccgcaat ttcatccagg acgaagtgct
     1021 gcgtttgatt catgagtgtc ctcatcagga agggaagagc atccatgagc tccgggctca
     1081 gctctgcgac cttagcgtca aggccatcaa ggaagcgatt gattatctga ccgttgaggg
     1141 ccacatctat cccactgtgg atcgggagca ttttaagtct gctgattgag gcagggaaaa
     1201 catcctttca tttttcgaag acccttgcat ccagctgtga gtaattttga cctgttgact
     1261 ttttaggaag taggactaaa aaaaaaaatc tcaagtggca ttctttgtca actcgctgct
     1321 tttctaactg ctttgaactt ttcggatttt ctgtatttga agctcagaga gagacggtga
     1381 tggataaatt gacaactctg taggatttac tagcaagcta atggaaacat gattttcggg
     1441 gaagaaaaac tacagaaaat gtagaaattt attatttaat tgtgttggag cttctttttc
     1501 caaaagaaaa actagttgca gtcagggagc cagcgaaaag acaaaaaaaa aaaaaaaaaa
//
