LOCUS       NM_178857               8014 bp    mRNA    linear   PRI 24-APR-2024
DEFINITION  Homo sapiens RP1 like 1 (RP1L1), mRNA.
ACCESSION   NM_178857
VERSION     NM_178857.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8014)
  AUTHORS   Liu,J., Hayden,M.R. and Yang,Y.
  TITLE     Research progress of RP1L1 gene in disease
  JOURNAL   Gene 912, 148367 (2024)
   PUBMED   38485037
  REMARK    GeneRIF: Research progress of RP1L1 gene in disease.
            Review article
REFERENCE   2  (bases 1 to 8014)
  AUTHORS   Fujinami-Yokokawa,Y., Joo,K., Liu,X., Tsunoda,K., Kondo,M.,
            Ahn,S.J., Robson,A.G., Naka,I., Ohashi,J., Li,H., Yang,L., Arno,G.,
            Pontikos,N., Park,K.H., Michaelides,M., Tachimori,H., Miyata,H.,
            Sui,R., Woo,S.J. and Fujinami,K.
  CONSRTM   East Asia Inherited Retinal Disease Society Study Group*
  TITLE     Distinct Clinical Effects of Two RP1L1 Hotspots in East Asian
            Patients With Occult Macular Dystrophy (Miyake Disease): EAOMD
            Report 4
  JOURNAL   Invest Ophthalmol Vis Sci 65 (1), 41 (2024)
   PUBMED   38265784
  REMARK    GeneRIF: Distinct Clinical Effects of Two RP1L1 Hotspots in East
            Asian Patients With Occult Macular Dystrophy (Miyake Disease):
            EAOMD Report 4.
REFERENCE   3  (bases 1 to 8014)
  AUTHORS   Daniute,G., Vilkeviciute,A., Gedvilaite,G., Kriauciuniene,L. and
            Liutkeviciene,R.
  TITLE     RP1L1 rs3924612 gene polymorphism and RP1L1 protein associations
            among patients with early age-related macular degeneration
  JOURNAL   Ophthalmic Genet 43 (2), 164-171 (2022)
   PUBMED   34865606
  REMARK    GeneRIF: RP1L1 rs3924612 gene polymorphism and RP1L1 protein
            associations among patients with early age-related macular
            degeneration.
REFERENCE   4  (bases 1 to 8014)
  AUTHORS   Hiraoka,M., Ishikawa,A., Matsuzawa,F., Aikawa,S.I. and Sakurai,A.
  TITLE     A variant in the RP1L1 gene in a family with occult macular
            dystrophy in a predicted intrinsically disordered region
  JOURNAL   Ophthalmic Genet 41 (6), 599-605 (2020)
   PUBMED   32940107
  REMARK    GeneRIF: A variant in the RP1L1 gene in a family with occult
            macular dystrophy in a predicted intrinsically disordered region.
REFERENCE   5  (bases 1 to 8014)
  AUTHORS   Wang,D.D., Gao,F.J., Li,J.K., Chen,F., Hu,F.Y., Xu,G.Z.,
            Zhang,J.G., Sun,H.X., Zhang,S.H., Xu,P., Tian,G.H. and Wu,J.H.
  TITLE     Clinical and Genetic Characteristics of Chinese Patients with
            Occult Macular Dystrophy
  JOURNAL   Invest Ophthalmol Vis Sci 61 (3), 10 (2020)
   PUBMED   32176261
  REMARK    GeneRIF: Two recurrent RP1L1 variants are related to occult macular
            dystrophy in the Chinese population.
REFERENCE   6  (bases 1 to 8014)
  AUTHORS   Glancy,M., Barnicoat,A., Vijeratnam,R., de Souza,S., Gilmore,J.,
            Huang,S., Maloney,V.K., Thomas,N.S., Bunyan,D.J., Jackson,A. and
            Barber,J.C.
  TITLE     Transmitted duplication of 8p23.1-8p23.2 associated with speech
            delay, autism and learning difficulties
  JOURNAL   Eur J Hum Genet 17 (1), 37-43 (2009)
   PUBMED   18716609
REFERENCE   7  (bases 1 to 8014)
  AUTHORS   Liu,Y., Fu,L., Chen,D.G. and Deeb,S.S.
  TITLE     Identification of novel retinal target genes of thyroid hormone in
            the human WERI cells by expression microarray analysis
  JOURNAL   Vision Res 47 (17), 2314-2326 (2007)
   PUBMED   17655910
REFERENCE   8  (bases 1 to 8014)
  AUTHORS   Reiner,O., Coquelle,F.M., Peter,B., Levy,T., Kaplan,A., Sapir,T.,
            Orr,I., Barkai,N., Eichele,G. and Bergmann,S.
  TITLE     The evolving doublecortin (DCX) superfamily
  JOURNAL   BMC Genomics 7, 188 (2006)
   PUBMED   16869982
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 8014)
  AUTHORS   Bowne,S.J., Daiger,S.P., Malone,K.A., Heckenlively,J.R., Kennan,A.,
            Humphries,P., Hughbanks-Wheaton,D., Birch,D.G., Liu,Q.,
            Pierce,E.A., Zuo,J., Huang,Q., Donovan,D.D. and Sullivan,L.S.
  TITLE     Characterization of RP1L1, a highly polymorphic paralog of the
            retinitis pigmentosa 1 (RP1) gene
  JOURNAL   Mol Vis 9, 129-137 (2003)
   PUBMED   12724644
  REMARK    GeneRIF: The RP1L1 gene encodes a large, highly polymorphic,
            retinal-specific protein. No RP1L1 disease-causing mutations were
            identified in any of the samples tested.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 8014)
  AUTHORS   Conte,I., Lestingi,M., den Hollander,A., Alfano,G., Ziviello,C.,
            Pugliese,M., Circolo,D., Caccioppoli,C., Ciccodicola,A. and
            Banfi,S.
  TITLE     Identification and characterisation of the retinitis pigmentosa
            1-like1 gene (RP1L1): a novel candidate for retinal degenerations
  JOURNAL   Eur J Hum Genet 11 (2), 155-162 (2003)
   PUBMED   12634863
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105001.3 and AC104964.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_178857.5.
            
            Summary: This gene encodes a member of the doublecortin family. The
            protein encoded by this gene contains two N-terminal doublecortin
            domains, which bind microtubules and regulate microtubule
            polymerization, and two C-terminal large repetitive regions, both
            of which contain a high percentage of glutamine and glutamic acid
            residues. This protein is a retinal-specific protein. Its exact
            length varies among individuals due to the presence of a 16aa
            repeat in the first C-terminal repetitive region. The 16aa repeat
            is encoded by the highly polymorphic 48-bp repeat, and 1-6 copies
            of the 16aa repeat have been identified in normal individuals. The
            current reference sequence shown here has a single copy of the 16aa
            repeat. This protein and the RP1 protein, another retinal-specific
            protein, play essential and synergistic roles in affecting
            photosensitivity and outer segment morphogenesis of rod
            photoreceptors. Mutations in this gene cause occult macular
            dystrophy (OMD). [provided by RefSeq, Sep 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY168341.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2148874,
                                           SAMEA2149398 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382483.4/ ENSP00000371923.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC105001.3         11001-11036         c
            37-246              AC105001.3         10791-11000         c
            247-874             AC104964.12        23316-23943
            875-1016            AC104964.12        29949-30090
            1017-8014           AC104964.12        33190-40187
FEATURES             Location/Qualifiers
     source          1..8014
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..8014
                     /gene="RP1L1"
                     /gene_synonym="DCDC4B; OCMD; RP88"
                     /note="RP1 like 1"
                     /db_xref="GeneID:94137"
                     /db_xref="HGNC:HGNC:15946"
                     /db_xref="MIM:608581"
     exon            1..246
                     /gene="RP1L1"
                     /gene_synonym="DCDC4B; OCMD; RP88"
                     /inference="alignment:Splign:2.1.0"
     exon            247..874
                     /gene="RP1L1"
                     /gene_synonym="DCDC4B; OCMD; RP88"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..7468
                     /gene="RP1L1"
                     /gene_synonym="DCDC4B; OCMD; RP88"
                     /note="retinitis pigmentosa 1 like 1; doublecortin domain
                     containing 4B"
                     /codon_start=1
                     /product="retinitis pigmentosa 1-like 1 protein"
                     /protein_id="NP_849188.4"
                     /db_xref="CCDS:CCDS43708.1"
                     /db_xref="GeneID:94137"
                     /db_xref="HGNC:HGNC:15946"
                     /db_xref="MIM:608581"
                     /translation="MNSTPRNAQAPSHRECFLPSVARTPSVTKVTPAKKITFLKRGDP
                     RFAGVRLAVHQRAFKTFSALMDELSQRVPLSFGVRSVTTPRGLHSLSALEQLEDGGCY
                     LCSDKKPPKTPSGPGRPQERNPTAQQLRDVEGQREAPGTSSSRKSLKTPRRILLIKNM
                     DPRLQQTVVLSHRNTRNLAAFLGKASDLLRFPVKQLYTTSGKKVDSLQALLHSPSVLV
                     CAGHEAFRTPAMKNARRSEAETLSGLTSRNKNGSWGPKTKPSVIHSRSPPGSTPRLPE
                     RPGPSNPPVGPAPGRHPQDTPAQSGPLVAGDDMKKKVRMNEDGSLSVEMKVRFHLVGE
                     DTLLWSRRMGRASALTAASGEDPVLGEVDPLCCVWEGYPWGFSEPGVWGPRPCRVGCR
                     EVFGRGGQPGPKYEIWTNPLHASQGERVAARKRWGLAQHVRCSGLWGHGTAGRERCSQ
                     DSASPASSTGLPEGSEPESSCCPRTPEDGVDSASPSAQIGAERKAGGSLGEDPGLCID
                     GAGLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGRPQGCPGKARAETSQQ
                     EASEGGDPASPALSLSSLRSDDLQAETQGQGTEQATGAAVTREPLVLGLSCSWDSEGA
                     SSTPSTCTSSQQGQRRHRSRASAMSSPSSPGLGRVAPRGHPRHSHYRKDTHSPLDSSV
                     TKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLRPPSSGSLPSQDLLGTSSATV
                     TPAVHSDFVSGVSPHNAPSAGWAGDAGSRTCSPAPIPPHTSDSCSKSGAASLGEEARD
                     TPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEAQRGPSPEASWLCGRYCPTP
                     PRGRPCPQRRSSSCGSTGSSHQSTARGPGGSPQEGTRQPGPTPSPGPNSGASRRSSAS
                     QGAGSRGLSEEKTLRSGGGPQGQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMT
                     YELADETTGAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQQSLEGDPGQDPEPEGALLG
                     SSDTGPQSGEGVPQGAAPEGVSEAPAEAGADREAPAGCRVSLRALPGRVSASTQIMRA
                     LMGSKQGRPSSVPEVSRPMARRLSCSAGALITCLASLQLFEEDLGSPASKVRFKDSPR
                     YQELLSISKDLWPGCDVGEDQLDSGLWELTWSQALPDLGSHAMTENFTPTSSSGVDIS
                     SGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFL
                     NARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAV
                     QLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVK
                     EGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRAS
                     ASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQ
                     PTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDL
                     LDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRL
                     RGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVS
                     PMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGA
                     EGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAG
                     SELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEG
                     EAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQ
                     PESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPES
                     EVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEA
                     QPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEA
                     EGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGI
                     EAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQ
                     PESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGE
                     KKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSW
                     GNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQ
                     GASEGYDLQEDQALGSLAPTEAVGRADGFGQDDLDF"
     exon            875..1016
                     /gene="RP1L1"
                     /gene_synonym="DCDC4B; OCMD; RP88"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..8014
                     /gene="RP1L1"
                     /gene_synonym="DCDC4B; OCMD; RP88"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7990..7995
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RP1L1"
                     /gene_synonym="DCDC4B; OCMD; RP88"
                     /note="hexamer: GATAAA"
     polyA_site      8014
                     /gene="RP1L1"
                     /gene_synonym="DCDC4B; OCMD; RP88"
                     /note="major polyA site"
ORIGIN      
        1 gcaaatggac catctgttgg agctcaggag gctgggctcc tgcccaaggg actggggcct
       61 caggctctca ggccaaggag agtggccccg aggactgtcc ggaggagggt ggccagccct
      121 gctgcccaga gggactgagc cactggcagg gaaggaggcg gtgttccccc tggcctgact
      181 ttcctccaaa ggacgtcccc ctgaggctta ggggctgagc catgcccttg tgctccctgg
      241 aggacgcggc cagagccccc acaccatgaa cagcaccccc aggaatgccc aggccccgag
      301 ccaccgtgag tgcttcctgc cctctgtggc tcgcaccccc tcggtcacca aggtcacgcc
      361 agccaagaag atcaccttcc tcaagcgagg ggatccacgg tttgctgggg tccgcctggc
      421 cgttcaccag cgcgccttta agaccttcag cgccctcatg gacgagctct cccagcgcgt
      481 gcctctctcc tttggggtgc gctctgtcac cacaccccgg ggcctgcata gcctcagcgc
      541 cctggagcag ctggaagatg gaggctgcta cctctgctct gataagaagc cccccaagac
      601 ccccagtgga ccaggccggc cacaggagag aaaccccact gctcagcagt tgcgggatgt
      661 cgaaggccag cgtgaagccc caggcacctc ctcctcccgg aagagtctta aaaccccccg
      721 gaggatactg ctgattaaga acatggaccc tcgcctccag cagacagtgg ttctcagtca
      781 caggaatact aggaacctgg ccgcctttct cggcaaagcc tcagatctcc tgcgctttcc
      841 tgtgaagcag ttgtacacga ccagcgggaa aaaggtggac tcgctgcagg ccctgctgca
      901 cagcccctct gtgctggtgt gtgccgggca tgaggccttc agaaccccag ccatgaaaaa
      961 tgccaggaga agcgaggctg aaactttatc tgggctgact tcaagaaaca aaaacgggag
     1021 ctgggggcca aagaccaagc cgagtgtgat ccattcgcgg tctccgccag gcagcacgcc
     1081 acggctgcca gaaaggcctg gtcctagcaa ccccccggtg ggccctgctc ctggcaggca
     1141 ccctcaggac acgccagctc agtcgggccc gctggtggct ggcgatgaca tgaagaagaa
     1201 ggtccgcatg aatgaggacg gcagcctgtc cgtggagatg aaagtccgct tccacctggt
     1261 cggcgaggac acgctcctat ggtcccggag gatgggcagg gccagcgccc tcacggcagc
     1321 cagtggggaa gaccccgttc tgggggaggt agaccccctc tgctgtgtgt gggagggcta
     1381 cccttggggc ttctcagagc ctggggtgtg gggaccccgg ccctgcaggg tgggatgcag
     1441 ggaagtcttt ggccgaggcg ggcagccagg gcccaagtat gaaatctgga cgaatcccct
     1501 gcatgcctcc cagggagaga gagtggcagc tcggaagagg tggggactgg cccagcacgt
     1561 ccgctgcagt ggcctgtggg gccacgggac tgccgggagg gagagatgca gccaggacag
     1621 tgccagccca gcctccagca ccggcctccc cgagggctcg gagccagagt cctcctgctg
     1681 ccccaggacc ccggaggacg gggtggacag tgccagcccc tctgcccaga taggggctga
     1741 gcggaaagct ggagggagcc tgggtgagga ccccggccta tgcatagatg gagcagggct
     1801 gggcggccca gagcaaggcg gccgcctgac accgagggcc cggagtgagg agggggcttc
     1861 ttcggactcg tcagccagca ccggctctca tgagggatcc agcgaatggg gtgggcggcc
     1921 ccagggctgt ccaggcaagg caagggccga gacctctcag caggaggcca gcgagggagg
     1981 cgaccccgct tctccagccc tgagtctttc atctttaagg agtgacgacc tgcaggcaga
     2041 gacgcaagga cagggcaccg agcaggccac gggagcggct gtgacaaggg agcctctggt
     2101 tctgggcctt tcctgctcct gggactcgga aggagcctct tccacccctt ccacctgcac
     2161 ttcatcccag caggggcaga gaaggcacag aagccgggcc agtgcaatgt cctcacccag
     2221 cagccctggc cttggccgag tggccccgag aggccatccc aggcattctc actaccgcaa
     2281 ggacacccac agcccactgg actcctctgt aaccaagcaa gtgccgaggc ctcctgagcg
     2341 gcgaagggcc tgccaggatg gctcagtgcc acgatattct ggaagctcat cgagcaccag
     2401 gacacaggcc tctgggaacc tgagacctcc ctcctcgggc tctcttcctt cccaggacct
     2461 tctgggaacc agcagtgcca ctgtcacccc tgcagtccac tcggattttg tttctggagt
     2521 ctccccgcac aacgctccct ctgccgggtg ggcaggggac gcggggtcca ggacatgctc
     2581 gccggccccc atacctcccc acacatccga ctcctgctca aaatctgggg ctgccagcct
     2641 gggggaagag gccagggaca cgcctcagcc ctcctcaccc ttggttctgc aggttggacg
     2701 gcctgagcaa ggggcggtgg gcccccaccg aagccactgc tgctcacagc ctgggacgca
     2761 gccggcccaa gaggcccagc ggggaccctc ccctgaggct agctggctgt gtggcaggta
     2821 ctgtcccacc ccgcccaggg ggcggccctg cccccagagg cgctcttcca gctgtgggag
     2881 caccggcagc agccaccaaa gcactgcccg ggggccaggt gggagcccgc aggaggggac
     2941 acgccagcca ggccccacgc cgtccccagg ccccaattca ggggcatcaa ggagaagcag
     3001 tgccagccag ggtgcggggt ctcgggggct gtccgaggag aagaccttga ggagtggggg
     3061 aggcccccag gggcaggagg aggccagtgg tgtgtcaccc agctctctgc cccgctcgtc
     3121 tccagaggct gtggtccgcg aatggctgga caacattcca gaagagccca tactcatgac
     3181 atatgagttg gcggacgaga ccacaggtgc agctgggggt ggcctgagag gccccgaggt
     3241 ggaccctggg gatgaccatt ctctggaagg cctgggggag ccagctcagg cgggacagca
     3301 gtccctggaa ggggaccccg gccaggaccc agagccagag ggagccctcc tggggagtag
     3361 tgacactggt ccccaatcag gagagggtgt cccccaaggg gcagctccag agggagtttc
     3421 cgaggcccct gcagaggccg gagcagacag agaggcccca gcaggctgca gggtgagcct
     3481 gcgggcactt cctggccggg tgtctgcctc cacgcagatc atgagggcgc tgatgggctc
     3541 caagcagggc cggcccagca gcgtgcccga agtgtctagg cccatggcca ggaggctcag
     3601 ctgctcagcc ggggccctca ttacttgtct ggccagtctg cagttatttg aggaagacct
     3661 tgggtctcct gccagcaaag tgaggttcaa agactcccct cggtaccagg agctgctcag
     3721 catctcgaag gacctgtggc caggatgtga cgttggggaa gaccagctgg actcaggcct
     3781 ctgggagctc acatggagcc aggctctgcc agaccttggg tcccatgcca tgacggagaa
     3841 cttcacgccc acatcctcct ctggtgtgga catcagcagc ggctctggag gctcagggga
     3901 gagtagcgta ccctgtgcca tggacggcac cctggtgaca caggggacag agctgcccct
     3961 gaaaacctcc aaccagaggc ctgattcaag aacttatgag agcccagggg atctggaaaa
     4021 ccaacagcag tgttgtttcc caaccttctt gaacgcccga gcctgcgctt gtgccaccaa
     4081 tgaggatgaa gcagaaagag acagtgagga gcagagggcg agctcgaacc tggagcagtt
     4141 agctgaaaac acagtgcaag aagaggtgca attagaggaa actaaagaag gaacagaagg
     4201 agaagggctg caagaagagg cggtgcagtt agaggaaact aaaacagaag aagggctgca
     4261 agaagagggg gtgcagttag aggaaactaa agaaacagaa ggagaaggac agcaagaaga
     4321 agaggcgcag ttagaggaaa ttgaagaaac aggaggagaa gggctgcaag aagagggggt
     4381 gcagttagag gaagttaaag aagggccaga aggaggactg caaggagagg ctcttgaaga
     4441 gggtctcaaa gaggaaggac ttccagaaga aggaagcgtc cacgggcagg aattgtcaga
     4501 ggccagctct ccggatggga aaggctccca ggaagatgac ccagtccagg aggaggaagc
     4561 aggaagagcc tctgcctctg cagagccgtg ccccgcagag ggcacagagg aacccacaga
     4621 gccccctagt catctcagcg agacggaccc aagtgccagc gagaggcaga gtggctccca
     4681 gcttgagcct ggtttggaaa agccgcccgg agccaccatg atgggccaag agcacacgca
     4741 ggcccaaccc acccaggggg ctgcagagag gagctcttcg gtggcctgca gcgcggctct
     4801 ggactgcgac cccatctggg tgtccgtgtt actgaagaag acggagaagg ccttcctggc
     4861 ccaccttgcc agtgcggtgg ctgagctccg agcacgctgg ggcctgcagg acaatgatct
     4921 gctggaccag atggcggccg agctgcagca ggacgtggcc caacgcctcc aggacagcac
     4981 caagagagag ctccagaagc tccagggccg ggcgggtagg atggtgctgg agcctccaag
     5041 ggaggccctc accggggagc tgctcctgca gacccagcag cgcagacacc gtctccgggg
     5101 cctgcgaaac ctctcggcct tctctgagcg gaccctgggc ctggggcccc tctccttcac
     5161 cctggaggac gagccagccc tcagcacagc cctggggagc cagctgggcg aggaggcgga
     5221 gggggaggag ttctgtccct gcgaggcctg cgtgaggaag aaagtgagcc ctatgtcccc
     5281 caaggccaca atgggggcaa ccagaggtcc catcaaagag gcctttgacc tgcagcagat
     5341 tctgcagagg aagaggggag aacacactga tggggaggca gcagaggtgg cccctggcaa
     5401 gacccacacg gaccccacga gcactaggac tgtccaggga gctgagggag ggctggggcc
     5461 ggggctgagc caggggcctg gagtggacga gggtgaggat ggcgagggga gccagagact
     5521 caacagagac aaagatccca aactcgggga ggcagaggga gatgcaatgg ctcaggagag
     5581 agaagggaaa acccacaaca gtgaaaccag tgcgggcagt gagttggggg aagctgagca
     5641 ggagggagag ggcataagtg aaaggggaga aactgggggt caaggctctg ggcatgagga
     5701 caacttgcag ggtgaagctg cggcaggagg tgaccaagat ccaggacaga gtgatggggc
     5761 cgaaggcata gaggccccgg aggctgaagg ggaggcccag ccagagtcag aaggtgtaga
     5821 ggccccagag gcagaagggg atgcccagga ggctgaaggg gaggcccagc cagagtcaga
     5881 agatgtagag gccccagagg cagaaggaga ggcccagcca gagtcagaag atgtagagac
     5941 cccagaggca gaatgggagg tccagccaga gtcagaaggt gcagaagccc cggaggcaga
     6001 aaaggaggcc cagccagaga cagaaagtgt agaggccctg gagactgaag gggaggacga
     6061 gccagagtca gaaggtgcag aggcccaaga ggcagaagag gcggcccagg aggcagaagg
     6121 gcagacccag ccagagtcag aagttataga gtcccaggag gcagaagagg aagcccagcc
     6181 agagtcagaa gatgtagagg ccctggaggt tgaagtggag acccaggagg cagaagggga
     6241 ggcccagcca gagtcagaag atgtagaggc cccagaggct gaaggggaga tgcaagaggc
     6301 agaagaggag gcccagccag agtcagacgg tgtagaggcc cagccaaagt cagaaggtga
     6361 agaggcccag gaggttgaag gggagaccca gaagacagaa ggggatgccc agccagagtc
     6421 agacggtgta gaggccccgg aggcagaaga ggaggcacag gaggctgaag gggaggtcca
     6481 ggaggcagaa ggggaggccc acccagagtc agaagatgta gatgcccagg aggcagaagg
     6541 ggaggcccag ccagaatcag aaggtgtaga ggccccagag gcagaagggg aggcccagaa
     6601 ggcagaaggt atagaggccc cagagactga aggggaggcc cagccagagt cagaaggtat
     6661 agaggcccca gaggctgaag gggaggccca gcctgagtca gaaggtgtag aggcccagga
     6721 tgcagaaggg gaggcccagc cagagtcaga aggtatagag gcccaggagg ctgaagagga
     6781 ggcccaacca gagttagaag gtgtagaggc cccagaggca gaaggggagg cccagccaga
     6841 gtcagaaggt atagaggccc cagaggcaga aggggaggcc caaccagagt tagaaggtgt
     6901 agaggccccg gaggctgaag aggaggccca gccagagcca gaaggcgtag agaccccgga
     6961 ggctgaaggg gaggcccagc cagagtcaga aggagaaact caaggtgaga aaaaggggag
     7021 ccctcaggtc agtctaggag atggccaatc tgaggaggct tctgaaagca gcagcccagt
     7081 ccctgaggac aggcccactc cacccccttc cccaggtgga gacactcccc accaaaggcc
     7141 aggctcccaa acaggccctt cctcctccag agcatcctct tggggcaact gctggcagaa
     7201 agactcagaa aatgaccatg tacttggaga cacaaggagc cctgatgcca agtccacggg
     7261 gacccctcat gcagagagga aggccaccag gatgtaccca gaaagttcta cttctgagca
     7321 agaagaggcc cctttgggct caaggactcc agagcagggg gccagtgaag gttatgacct
     7381 acaagaggac caggcactcg gaagtctcgc ccccactgag gcagtgggca gggcagacgg
     7441 ctttggccaa gatgacttag atttctagac aagatcaagc tagaaaacaa tcacgagctt
     7501 gggagctctg tttttattca tattttttct acaaaactga gcaacgttca gtccactgga
     7561 gatgtccata gtacatggac aaagaccaag gacttgccaa ggacacagcc catgccatgc
     7621 tgtcctggga ctcttaagtc cagaagtgtc agagagctct gcggcccgtc ccacacgcag
     7681 tgtgaagaaa gggggtgtct gcggatctgc ccggttatcg gaggtcagcc cggctcctat
     7741 ttatttgtct gcagagcccg aaagatggaa ctgattggaa aggctccagt ttagcttttg
     7801 tttgtgggtt tgttttctgc tagcaagtgt tgctctctgt cttttccctg ttgatctcct
     7861 gttacttttc tccttggctt ctgttggcac tcacctcatt tgactttgag gtgctttttt
     7921 tctagtcttg aatatatttg atgactctgc agaaatactt gggcaaagca ggtaacttca
     7981 gagtcattgg ataaagtttg ttctcaactc caaa
//
