LOCUS       NM_006269               7071 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens RP1 axonemal microtubule associated (RP1), transcript
            variant 1, mRNA.
ACCESSION   NM_006269 XM_001714792 XM_001714875 XM_001714923
VERSION     NM_006269.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7071)
  AUTHORS   Natsume,K., Kominami,T., Goto,K., Koyanagi,Y., Inooka,T., Ota,J.,
            Kawano,K., Yamada,K., Okuda,D., Yuki,K., Nishiguchi,K.M. and
            Ushida,H.
  TITLE     Phenotypic variability of RP1-related inherited retinal dystrophy
            associated with the c.5797 C > T (p.Arg1933*) variant in the
            Japanese population
  JOURNAL   Sci Rep 14 (1), 25669 (2024)
   PUBMED   39463394
  REMARK    GeneRIF: Phenotypic variability of RP1-related inherited retinal
            dystrophy associated with the c.5797 C > T (p.Arg1933*) variant in
            the Japanese population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7071)
  AUTHORS   D'Esposito,F., Randazzo,V., Vega,M.I., Esposito,G., Maltese,P.E.,
            Torregrossa,S., Scibetta,P., Listi,F., Gagliano,C., Scalia,L.,
            Pioppo,A., Marino,A., Piergentili,M., Malvone,E., Fioretti,T.,
            Vitrano,A., Piccione,M., Avitabile,T., Salvatore,F., Bertelli,M.,
            Costagliola,C., Cordeiro,M.F., Maggio,A. and D'Alcamo,E.
  TITLE     RP1 Dominant p.Ser740* Pathogenic Variant in 20 Knowingly Unrelated
            Families Affected by Rod-Cone Dystrophy: Potential Founder Effect
            in Western Sicily
  JOURNAL   Medicina (Kaunas) 60 (2), 254 (2024)
   PUBMED   38399542
  REMARK    GeneRIF: RP1 Dominant p.Ser740* Pathogenic Variant in 20 Knowingly
            Unrelated Families Affected by Rod-Cone Dystrophy: Potential
            Founder Effect in Western Sicily.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7071)
  AUTHORS   Chen,L., Zhao,M., Zhou,M., Luo,J., Li,S., Liu,X., Cheng,Z.,
            Zhuo,Y., Zeng,W., Zhang,Z. and Zhou,L.
  TITLE     LncRNA RP1-276N6.2 Expression and RP1-276N6.2 Gene Polymorphisms
            Contribute to the Risk of Coronary Artery Disease in Chinese Han
            Population
  JOURNAL   DNA Cell Biol 42 (12), 746-752 (2023)
   PUBMED   37843894
  REMARK    GeneRIF: LncRNA RP1-276N6.2 Expression and RP1-276N6.2 Gene
            Polymorphisms Contribute to the Risk of Coronary Artery Disease in
            Chinese Han Population.
REFERENCE   4  (bases 1 to 7071)
  AUTHORS   Lazaro-Guevara,J.M., Flores-Robles,B.J., Garrido-Lopez,K.M.,
            McKeown,R.J., Flores-Moran,A.E., Labrador-Sanchez,E.,
            Pinillos-Aransay,V., Trasahedo,E.A., Lopez-Martin,J.A.,
            Soberanis,L.S.R., Melgar,M.Y., Tellez-Arreola,J.L. and
            Thebault,S.C.
  TITLE     Identification of RP1 as the genetic cause of retinitis pigmentosa
            in a multi-generational pedigree using Extremely Low-Coverage Whole
            Genome Sequencing (XLC-WGS)
  JOURNAL   Gene 851, 146956 (2023)
   PUBMED   36341727
  REMARK    GeneRIF: Identification of RP1 as the genetic cause of retinitis
            pigmentosa in a multi-generational pedigree using Extremely
            Low-Coverage Whole Genome Sequencing (XLC-WGS).
REFERENCE   5  (bases 1 to 7071)
  AUTHORS   Won,D., Hwang,J.Y., Shim,Y., Byeon,S.H., Lee,J., Lee,C.S., Kim,M.,
            Lim,H.T., Choi,J.R., Lee,S.T. and Han,J.
  TITLE     In Silico identification of a common mobile element insertion in
            exon 4 of RP1
  JOURNAL   Sci Rep 11 (1), 13381 (2021)
   PUBMED   34183725
  REMARK    GeneRIF: In Silico identification of a common mobile element
            insertion in exon 4 of RP1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7071)
  AUTHORS   Sullivan,L.S., Heckenlively,J.R., Bowne,S.J., Zuo,J., Hide,W.A.,
            Gal,A., Denton,M., Inglehearn,C.F., Blanton,S.H. and Daiger,S.P.
  TITLE     Mutations in a novel retina-specific gene cause autosomal dominant
            retinitis pigmentosa
  JOURNAL   Nat Genet 22 (3), 255-259 (1999)
   PUBMED   10391212
REFERENCE   7  (bases 1 to 7071)
  AUTHORS   Pierce,E.A., Quinn,T., Meehan,T., McGee,T.L., Berson,E.L. and
            Dryja,T.P.
  TITLE     Mutations in a gene encoding a new oxygen-regulated photoreceptor
            protein cause dominant retinitis pigmentosa
  JOURNAL   Nat Genet 22 (3), 248-254 (1999)
   PUBMED   10391211
REFERENCE   8  (bases 1 to 7071)
  AUTHORS   Juwana,J.P., Henderikx,P., Mischo,A., Wadle,A., Fadle,N.,
            Gerlach,K., Arends,J.W., Hoogenboom,H., Pfreundschuh,M. and
            Renner,C.
  TITLE     EB/RP gene family encodes tubulin binding proteins
  JOURNAL   Int J Cancer 81 (2), 275-284 (1999)
   PUBMED   10188731
REFERENCE   9  (bases 1 to 7071)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
REFERENCE   10 (bases 1 to 7071)
  AUTHORS   Blanton,S.H., Heckenlively,J.R., Cottingham,A.W., Friedman,J.,
            Sadler,L.A., Wagner,M., Friedman,L.H. and Daiger,S.P.
  TITLE     Linkage mapping of autosomal dominant retinitis pigmentosa (RP1) to
            the pericentric region of human chromosome 8
  JOURNAL   Genomics 11 (4), 857-869 (1991)
   PUBMED   1783394
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF141021.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_006269.1.
            
            Summary: This gene encodes a member of the doublecortin family. The
            protein encoded by this gene contains two doublecortin domains,
            which bind microtubules and regulate microtubule polymerization.
            The encoded protein is a photoreceptor microtubule-associated
            protein and is required for correct stacking of outer segment disc.
            This protein and the RP1L1 protein, another retinal-specific
            protein, play essential and synergistic roles in affecting
            photosensitivity and outer segment morphogenesis of rod
            photoreceptors. Because of its response to in vivo retinal oxygen
            levels, this protein was initially named ORP1 (oxygen-regulated
            protein-1). This protein was subsequently designated RP1 (retinitis
            pigmentosa 1) when it was found that mutations in this gene cause
            autosomal dominant retinitis pigmentosa. Mutations in this gene
            also cause autosomal recessive retinitis pigmentosa. Transcript
            variants resulted from an alternative promoter and alternative
            splicings have been found, which overlap the current reference
            sequence and has several exons upstream and downstream of the
            current reference sequence. However, the biological validity and
            full-length nature of some variants cannot be determined at this
            time.[provided by RefSeq, Sep 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF141021.1, AF146592.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2144333 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000220676.2/ ENSP00000220676.1
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7071              AF141021.1         30-7100
FEATURES             Location/Qualifiers
     source          1..7071
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.23-q12.1"
     gene            1..7071
                     /gene="RP1"
                     /gene_synonym="DCDC4A; ORP1"
                     /note="RP1 axonemal microtubule associated"
                     /db_xref="GeneID:6101"
                     /db_xref="HGNC:HGNC:10263"
                     /db_xref="MIM:603937"
     exon            1..107
                     /gene="RP1"
                     /gene_synonym="DCDC4A; ORP1"
                     /inference="alignment:Splign:2.1.0"
     exon            108..734
                     /gene="RP1"
                     /gene_synonym="DCDC4A; ORP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..6590
                     /gene="RP1"
                     /gene_synonym="DCDC4A; ORP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     oxygen-regulated protein 1; retinitis pigmentosa 1
                     protein; retinitis pigmentosa 1 (autosomal dominant);
                     doublecortin domain containing 4A; retinitis pigmentosa
                     RP1 protein"
                     /codon_start=1
                     /product="oxygen-regulated protein 1 isoform 1"
                     /protein_id="NP_006260.1"
                     /db_xref="CCDS:CCDS6160.1"
                     /db_xref="GeneID:6101"
                     /db_xref="HGNC:HGNC:10263"
                     /db_xref="MIM:603937"
                     /translation="MSDTPSTGFSIIHPTSSEGQVPPPRHLSLTHPVVAKRISFYKSG
                     DPQFGGVRVVVNPRSFKSFDALLDNLSRKVPLPFGVRNISTPRGRHSITRLEELEDGE
                     SYLCSHGRKVQPVDLDKARRRPRPWLSSRAISAHSPPHPVAVAAPGMPRPPRSLVVFR
                     NGDPKTRRAVLLSRRVTQSFEAFLQHLTEVMQRPVVKLYATDGRRVPSLQAVILSSGA
                     VVAAGREPFKPGNYDIQKYLLPARLPGISQRVYPKGNAKSESRKISTHMSSSSRSQIY
                     SVSSEKTHNNDCYLDYSFVPEKYLALEKNDSQNLPIYPSEDDIEKSIIFNQDGTMTVE
                     MKVRFRIKEEETIKWTTTVSKTGPSNNDEKSEMSFPGRTESRSSGLKLAACSFSADVS
                     PMERSSNQEGSLAEEINIQMTDQVAETCSSASWENATVDTDIIQGTQDQAKHRFYRPP
                     TPGLRRVRQKKSVIGSVTLVSETEVQEKMIGQFSYSEERESGENKSEYHMFTHSCSKM
                     SSVSNKPVLVQINNNDQMEESSLERKKENSLLKSSAISAGVIEITSQKMLEMSHNNGL
                     PSTISNNSIVEEDVVDCVVLDNKTGIKNFKTYGNTNDRFSPISADATHFSSNNSGTDK
                     NISEAPASEASSTVTARIDRLINEFAQCGLTKLPKNEKKILSSVASKKKKKSRQQAIN
                     SRYQDGQLATKGILNKNERINTKGRITKEMIVQDSDSPLKGGILCEEDLQKSDTVIES
                     NTFCSKSNLNSTISKNFHRNKLNTTQNSKVQGLLTKRKSRSLNKISLGAPKKREIGQR
                     DKVFPHNESKYCKSTFENKSLFHVFNILEQKPKDFYAPQSQAEVASGYLRGMAKKSLV
                     SKVTDSHITLKSQKKRKGDKVKASAILSKQHATTRANSLASLKKPDFPEAIAHHSIQN
                     YIQSWLQNINPYPTLKPIKSAPVCRNETSVVNCSNNSFSGNDPHTNSGKISNFVMESN
                     KHITKIAGLTGDNLCKEGDKSFIANDTGEEDLHETQVGSLNDAYLVPLHEHCTLSQSA
                     INDHNTKSHIAAEKSGPEKKLVYQEINLARKRQSVEAAIQVDPIEEETPKDLLPVLML
                     HQLQASVPGIHKTQNGVVQMPGSLAGVPFHSAICNSSTNLLLAWLLVLNLKGSMNSFC
                     QVDAHKATNKSSETLALLEILKHIAITEEADDLKAAVANLVESTTSHFGLSEKEQDMV
                     PIDLSANCSTVNIQSVPKCSENERTQGISSLDGGCSASEACAPEVCVLEVTCSPCEMC
                     TVNKAYSPKETCNPSDTFFPSDGYGVDQTSMNKACFLGEVCSLTDTVFSDKACAQKEN
                     HTYEGACPIDETYVPVNVCNTIDFLNSKENTYTDNLDSTEELERGDDIQKDLNILTDP
                     EYKNGFNTLVSHQNVSNLSSCGLCLSEKEAELDKKHSSLDDFENCSLRKFQDENAYTS
                     FDMEEPRTSEEPGSITNSMTSSERNISELESFEELENHDTDIFNTVVNGGEQATEELI
                     QEEVEASKTLELIDISSKNIMEEKRMNGIIYEIISKRLATPPSLDFCYDSKQNSEKET
                     NEGETKMVKMMVKTMETGSYSESSPDLKKCIKSPVTSDWSDYRPDSDSEQPYKTSSDD
                     PNDSGELTQEKEYNIGFVKRAIEKLYGKADIIKPSFFPGSTRKSQVCPYNSVEFQCSR
                     KASLYDSEGQSFGSSEQVSSSSSMLQEFQEERQDKCDVSAVRDNYCRGDIVEPGTKQN
                     DDSRILTDIEEGVLIDKGKWLLKENHLLRMSSENPGMCGNADTTSVDTLLDNNSSEVP
                     YSHFGNLAPGPTMDELSSSELEELTQPLELKCNYFNMPHGSDSEPFHEDLLDVRNETC
                     AKERIANHHTEEKGSHQSERVCTSVTHSFISAGNKVYPVSDDAIKNQPLPGSNMIHGT
                     LQEADSLDKLYALCGQHCPILTVIIQPMNEEDRGFAYRKESDIENFLGFYLWMKIHPY
                     LLQTDKNVFREENNKASMRQNLIDNAIGDIFDQFYFSNTFDLMGKRRKQKRINFLGLE
                     EEGNLKKFQPDLKERFCMNFLHTSLLVVGNVDSNTQDLSGQTNEIFKAVDENNNLLNN
                     RFQGSRTNLNQVVRENINCHYFFEMLGQACLLDICQVETSLNISNRNILELCMFEGEN
                     LFIWEEEDILNLTDLESSREQEDL"
     exon            735..906
                     /gene="RP1"
                     /gene_synonym="DCDC4A; ORP1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..7071
                     /gene="RP1"
                     /gene_synonym="DCDC4A; ORP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6965..6970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RP1"
                     /gene_synonym="DCDC4A; ORP1"
                     /note="hexamer: AATAAA"
     polyA_site      6984
                     /gene="RP1"
                     /gene_synonym="DCDC4A; ORP1"
                     /note="major polyA site"
ORIGIN      
        1 agtttctttg cacgaaatga ggttacatat ccagtgacat ttatttgagc tatttaaaca
       61 acttaaacat ctttttcttt tcttaataag ggacgtttca agttgtggtc tcagccaaaa
      121 tgagtgatac cccttctact ggtttttcca tcattcatcc tacgtcttct gaaggtcaag
      181 ttccaccccc tcgccatttg agcctcactc atcctgttgt ggccaagcga atcagtttct
      241 acaagagcgg agacccccaa ttcggcgggg tcagggtggt ggtcaaccct cgctccttta
      301 agtcctttga tgctctgctg gataacttgt ccaggaaggt gcccctccct tttggagtga
      361 ggaacatcag cacccctcgg ggcaggcaca gcatcacgcg cctggaggag ctggaggacg
      421 gcgagtccta cctatgttcc cacggcagga aggtgcagcc tgtagacctg gacaaagccc
      481 gtcggcgccc gcggccctgg ctcagcagcc gggccattag cgcgcactca ccgccccacc
      541 ccgtagccgt cgctgctccc ggcatgcccc gccccccacg gagcctagtg gtcttcagga
      601 atggcgaccc gaagacgagg cgtgcggttc ttctgagcag gagggtcacc cagagcttcg
      661 aggcatttct acagcacctg acagaggtca tgcagcgccc tgtggtcaag ctgtacgcta
      721 cggacggaag gagggttccc agcctccagg cagtgatcct gagctctgga gctgtggtgg
      781 cggcaggaag ggagccattt aaaccaggaa attatgacat ccaaaaatac ttgcttcctg
      841 ctagattacc agggatctct cagcgtgtgt accccaaggg aaatgcaaag tcagaaagca
      901 gaaagataag cacacatatg tcttcaagct caaggtccca gatttattct gtttcttctg
      961 agaaaacaca taataatgat tgctacttag actattcttt tgttcctgaa aagtacttgg
     1021 ccttagaaaa gaatgattct cagaatttac caatatatcc ttctgaagat gatattgaga
     1081 aatcaattat ttttaatcaa gacggcacta tgacagttga gatgaaagtt cgattcagaa
     1141 taaaagagga agaaaccata aaatggacaa ctactgtcag taaaactggt ccttctaata
     1201 atgatgaaaa gagtgagatg agttttccag gaagaacaga aagtcgatca tctggtttaa
     1261 agcttgcagc atgttcattc tctgcagatg tgtcacctat ggagcgaagc agtaatcaag
     1321 agggcagttt ggcagaggag ataaacattc aaatgacaga tcaagtggct gaaacttgca
     1381 gttctgctag ttgggagaat gctactgtgg acacagatat catccaggga actcaagacc
     1441 aagcaaagca tcgtttttat aggcccccta cacctggact aagaagagtg agacaaaaga
     1501 aatctgtgat tggcagtgtg accttagtat ctgaaactga ggttcaagag aaaatgattg
     1561 gacagttttc atatagtgaa gaaagggaaa gtggggaaaa caagtctgag tatcacatgt
     1621 ttacacattc ttgcagtaaa atgtcatcag tatctaacaa accagtactt gttcagatca
     1681 ataacaatga tcaaatggag gagtcatcat tagaaagaaa aaaggaaaac agtctgctta
     1741 agtcaagtgc aataagtgct ggtgttatag aaattacaag tcagaagatg ttagagatgt
     1801 cacataataa tggtttgcca tcaactatat caaataactc aattgtggag gaagatgtag
     1861 ttgattgtgt ggtattggac aacaaaactg gtatcaagaa cttcaaaact tatggtaaca
     1921 ccaatgatag gttcagtcct atttcagcag atgcaaccca tttttcaagt aataactctg
     1981 gaactgacaa aaatatttct gaggctccag cttcagaagc atcctctact gtcactgcaa
     2041 gaattgacag actaattaat gaatttgctc agtgtggttt aacaaaactt ccaaaaaatg
     2101 aaaagaagat tttgtcatct gttgccagca aaaagaagaa aaaatctcga cagcaagcaa
     2161 taaattccag gtatcaagat ggacagcttg caaccaaagg aattcttaat aagaatgaga
     2221 gaataaacac aaaaggtaga attacaaagg aaatgatagt gcaagattca gatagtcccc
     2281 ttaaaggagg gatactttgt gaggaagacc tccagaaaag tgatactgta attgaatcaa
     2341 atactttttg ttccaaaagt aatctcaatt ccacgatttc caagaatttc catagaaata
     2401 aattaaatac tactcaaaat tccaaggttc aaggactttt aaccaaaaga aaatctagat
     2461 cactaaataa aataagctta ggagcaccta aaaaaagaga aatcggtcaa agagataaag
     2521 tgtttcctca caatgaatct aaatattgca aaagtacttt tgaaaacaaa agtttatttc
     2581 atgtatttaa catccttgag caaaaaccca aagattttta tgcaccgcaa tctcaagcag
     2641 aagtggcatc tgggtatttg agaggaatgg caaagaagag tttagtttca aaagttactg
     2701 attcacacat aactttaaaa agccagaaaa aacgtaaagg ggataaagtg aaagcaagtg
     2761 ctattttaag taaacaacat gctacaacca gggcaaattc tttagcttct ttgaaaaaac
     2821 ctgattttcc tgaggctatt gctcatcatt caattcaaaa ttatatacag agttggttgc
     2881 agaacataaa tccatatcca actttaaagc ctataaaatc agctccagta tgtagaaatg
     2941 aaacgagtgt ggtaaattgt agcaataata gtttttcagg gaatgatccc catacaaatt
     3001 ctggaaaaat aagtaatttt gttatggaaa gtaataagca cataactaaa attgccggtt
     3061 tgacaggaga taatctatgt aaagagggag ataagtcttt tattgccaat gacactggtg
     3121 aagaagatct ccatgagaca caggttggat ctctgaatga tgcttatttg gttcccctgc
     3181 atgaacactg tactttgtca cagtcagcta ttaatgatca taatactaaa agtcatatag
     3241 ctgctgaaaa atcaggacca gagaaaaaac ttgtttacca ggaaataaac ctagctagaa
     3301 aaaggcaaag tgtagaggct gccattcaag tagatcctat agaagaggaa actccaaaag
     3361 acctcttacc agtcctgatg cttcaccaat tgcaagcttc agttcctggt attcacaaga
     3421 ctcagaatgg agttgttcaa atgccaggtt cacttgcagg tgttcccttt cattctgcaa
     3481 tatgtaattc atccactaat ctccttctag cttggctctt ggtgctaaac ctaaagggaa
     3541 gtatgaatag cttctgtcaa gttgatgctc acaaggctac caacaaatct tcagaaacac
     3601 ttgcattgtt ggagattcta aagcacatag ctatcacaga ggaagctgat gacttgaaag
     3661 ctgctgttgc caatttagtg gagtcaacta caagccactt tggactcagt gagaaagaac
     3721 aagacatggt tccaatagat ctttctgcaa attgttccac ggtcaacatt cagagtgttc
     3781 ctaagtgcag tgaaaatgaa agaacacaag gaatctcctc tttggatgga ggttgctctg
     3841 ccagtgaggc atgtgcccct gaagtctgtg ttttggaagt gacttgctct ccatgtgaga
     3901 tgtgcactgt aaataaggct tattctccaa aagagacatg taaccccagt gacacttttt
     3961 ttcctagtga tggttatggt gtggatcaga cttctatgaa taaggcttgt ttcctaggag
     4021 aggtctgttc acttactgat actgtgtttt ctgataaggc ttgtgctcaa aaggagaacc
     4081 atacctatga gggagcttgc ccaattgatg agacctacgt tcctgtcaat gtctgcaata
     4141 ccattgactt tttaaactcc aaagaaaaca catatactga taacttggat tcaactgaag
     4201 agttagaaag aggtgatgac attcagaaag atctaaatat tttgacagac cctgaatata
     4261 aaaatggatt taatacattg gtgtcacatc aaaatgtcag taatttaagc tcctgtggcc
     4321 tttgcctaag tgaaaaagaa gcagaacttg ataagaaaca tagttctcta gatgattttg
     4381 aaaattgttc actaaggaag tttcaggatg aaaatgcata tacttccttt gatatggaag
     4441 aaccacggac ttctgaagaa ccaggctcaa taaccaacag catgacatca agtgaaagaa
     4501 acatttcaga attggaatct tttgaagaat tagaaaacca tgacactgat atctttaata
     4561 cagtggtaaa tggaggagag caagccactg aagaattaat ccaagaagag gtagaggcta
     4621 gtaaaacttt agaattgata gacatctcta gtaagaatat tatggaagaa aaaagaatga
     4681 acggtataat ttatgaaata atcagtaaga ggctggcaac accaccatct ttagattttt
     4741 gctatgattc taagcaaaat agtgaaaagg agaccaatga aggagaaact aagatggtaa
     4801 aaatgatggt gaaaactatg gaaactggaa gttattcaga gtcctctcct gatttaaaaa
     4861 aatgcatcaa aagtccagtg acttctgatt ggtcagacta tcggcctgac agtgacagtg
     4921 agcagccata taaaacatcc agtgatgatc ccaatgacag tggcgaactt acccaagaga
     4981 aagaatataa cataggattt gttaaaaggg caatagaaaa actgtacggt aaagcagata
     5041 ttatcaaacc atcttttttt cctgggtcta cccgcaaatc tcaggtttgt ccttataatt
     5101 ctgtggaatt tcagtgttcc aggaaagcaa gtctttatga ttctgaaggg cagtcatttg
     5161 gctcttctga acaggtatct agtagttcat ctatgttgca ggaattccag gaggaaagac
     5221 aagataagtg tgatgttagt gctgtgaggg acaattattg taggggtgac attgtagaac
     5281 ctggtacaaa acaaaatgat gatagcagaa tcctcacaga catagaggaa ggagtactga
     5341 ttgacaaagg caaatggctt ctgaaagaaa atcatttgct aaggatgtca tctgaaaatc
     5401 ctggcatgtg tggcaatgca gacaccacat cagtggacac cctacttgat aataacagca
     5461 gtgaggtacc atattcacat tttggtaatt tggccccagg cccaacgatg gatgaactct
     5521 cctcttcaga actcgaggaa ctgactcaac cccttgaact aaaatgcaat tactttaaca
     5581 tgcctcatgg tagtgactca gaaccttttc atgaggactt gctggatgtt cgcaatgaaa
     5641 cctgtgccaa ggaaagaata gcaaatcatc atacagagga gaagggtagt catcagtcag
     5701 aaagagtatg cacatctgtc actcattcct ttatttctgc tggtaacaaa gtctaccctg
     5761 tctctgatga tgctattaaa aaccaaccat tgcctggcag taatatgatt catggtacac
     5821 ttcaggaagc tgactctttg gataaactgt atgctctttg tggtcaacat tgcccaatac
     5881 taactgttat tatccaaccc atgaatgagg aagaccgagg atttgcatat cgcaaagaat
     5941 ctgatattga aaatttcttg ggtttttatt tatggatgaa aatacaccca tatttacttc
     6001 agacagacaa aaatgtgttc agggaagaga acaataaagc aagtatgaga caaaatctta
     6061 ttgataatgc cattggtgat atatttgatc agttttattt cagtaacaca tttgacttga
     6121 tgggtaaaag aagaaaacaa aaaagaatta acttcttggg gttagaggaa gaaggtaatt
     6181 taaagaaatt tcaaccagat ttgaaggaaa ggttttgtat gaatttcttg cacacatcat
     6241 tgttagttgt gggtaatgtg gattcaaata cacaagacct cagcggtcag acaaatgaaa
     6301 tctttaaagc agtcgatgag aataacaact tattaaataa cagattccag ggctcaagaa
     6361 caaatctcaa ccaagtagta agagaaaata tcaactgtca ttacttcttt gaaatgcttg
     6421 gtcaagcttg cctcttagat atttgccaag ttgagacctc cttaaatatt agcaacagaa
     6481 atattttaga actttgtatg tttgagggtg aaaatctttt catttgggaa gaggaagaca
     6541 tattaaattt aactgatctt gaaagcagta gagaacaaga agatttataa tttcaatatc
     6601 agcacactca ttctttgtca attcattttt tcccatgaga tgaagcacat gtgacgaata
     6661 cggactagat aacctctaag aattttccac ttcttcaaaa tgaacttact ctagaaagct
     6721 tacccttgga taaccagttt gactttcata atgtctctgt tttttgtttt tccaacaatt
     6781 acagactcag gttctcttat tttggaagtt tctatctggt tttgttctga acttacattt
     6841 tttttttttt tggtatctat gatttttttt gctcagggca tcaaaatgtg ctaaggacaa
     6901 gaattatatc ctttttaaaa aatgttgtta gcttggtgta aaatgtatat tgactgtatt
     6961 ggtgaataaa ttgaatagac ataacctcaa agtacttcac ttattctttt taactactga
     7021 tttgataaaa agtatgatta taagatatcc acgacaatct catagtttct t
//
