LOCUS       XM_011536050            8496 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ROS proto-oncogene 1, receptor tyrosine
            kinase (ROS1), transcript variant X2, mRNA.
ACCESSION   XM_011536050
VERSION     XM_011536050.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011536050.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8496
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..8496
                     /gene="ROS1"
                     /gene_synonym="c-ros-1; MCF3; ROS"
                     /note="ROS proto-oncogene 1, receptor tyrosine kinase;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 1 mRNA, 3 ESTs, 29 long SRA reads, 1
                     Protein, and 98% coverage of the annotated genomic feature
                     by RNAseq alignments, including 6 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:6098"
                     /db_xref="HGNC:HGNC:10261"
                     /db_xref="MIM:165020"
     CDS             287..7357
                     /gene="ROS1"
                     /gene_synonym="c-ros-1; MCF3; ROS"
                     /codon_start=1
                     /product="proto-oncogene tyrosine-protein kinase ROS
                     isoform X2"
                     /protein_id="XP_011534352.1"
                     /db_xref="GeneID:6098"
                     /db_xref="HGNC:HGNC:10261"
                     /db_xref="MIM:165020"
                     /translation="MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQ
                     LDLGTPHNLSEPCIQGCHFWNSVDQKNCALKCNDTYATVCERESCEVGCSSAEGAYEE
                     EVLENADLPTAPFASSIGSHNMTLRWKSANFSGVKYIIQWKYAQLLGSWTYTKTVSRP
                     SYVVKPLHPFTEYIFRVVWIFTAQLQLYSPPSPSYRTHPHGVPETAPLIRNIESSSPD
                     TVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVN
                     EVGEGPEAESSITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNI
                     TGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYF
                     IMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYNGYVFYLLRDGIYRADLPVPSG
                     RCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSASHLILPRIPFADV
                     KSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEFGFGNLVIFGSSSQLHPL
                     PGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFELGPSAWQNWTYEVKVS
                     TQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPWSEPSVGTTLVPAS
                     EPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYSDTKGDVFVWLL
                     NGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLV
                     NDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYW
                     LVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWINGFRIIT
                     TQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEGNAS
                     SFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPY
                     TYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVL
                     TKFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPG
                     PYADVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEM
                     GYYAEGDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFD
                     VDLEHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHR
                     ILQPTATNQQNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQ
                     CWRVITVPAMLAGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSR
                     HILAYSSVMQPFPDKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTP
                     TYLVYYAEVNDRKNSSDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHL
                     PPGKEIWGKTKNGVPEAVQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLA
                     LIPETPLRQSEFPNGRLTLLVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTP
                     EKPYSLVPENTSLQFNWKAPLNVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNIT
                     NLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAE
                     DNGCRITYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAA
                     NNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKS
                     AKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRL
                     LLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHP
                     NILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISK
                     GCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLL
                     PVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLE
                     PPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVI
                     NESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQES
                     ESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDGSD"
ORIGIN      
        1 gcacttctaa gaactaacct ttagtcactg ggtgacttta tgggagtaaa aggaagctgt
       61 tatgaaatag ctcttatgga actgttacaa gctttcaagc attcaaaggt ctaaatgaaa
      121 aaggctaagt attatttcaa aaggcaagta tatcctaata tagcaaaaca aacaaagcaa
      181 aatccatcag ctactcctcc aattgaagtg atgaagccca aataattcat atagcaaaat
      241 ggagaaaatt agaccggcca tctaaaaatc tgccattggt gaagtgatga agaacattta
      301 ctgtcttatt ccgaagcttg tcaattttgc aactcttggc tgcctatgga tttctgtggt
      361 gcagtgtaca gttttaaata gctgcctaaa gtcgtgtgta actaatctgg gccagcagct
      421 tgaccttggc acaccacata atctgagtga accgtgtatc caaggatgtc acttttggaa
      481 ctctgtagat cagaaaaact gtgctttaaa gtgtaatgat acttatgcca ccgtttgtga
      541 gcgggagtcg tgtgaggttg gctgtagcag cgcggaaggt gcatatgaag aggaagtact
      601 ggaaaatgca gacctaccaa ctgctccctt tgcttcttcc attggaagcc acaatatgac
      661 attacgatgg aaatctgcaa acttctctgg agtaaaatac atcattcagt ggaaatatgc
      721 acaacttctg ggaagctgga cttatactaa gactgtgtcc agaccgtcct atgtggtcaa
      781 gcccctgcac cccttcactg agtacatttt ccgagtggtt tggatcttca cagcgcagct
      841 gcagctctac tcccctccaa gtcccagtta caggactcat cctcatggag ttcctgaaac
      901 tgcacctttg attaggaata ttgagagctc aagtcccgac actgtggaag tcagctggga
      961 tccacctcaa ttcccaggtg gacctatttt gggttataac ttaaggctga tcagcaaaaa
     1021 tcaaaaatta gatgcaggga cacagagaac cagtttccag ttttactcca ctttaccaaa
     1081 tactatctac aggttttcta ttgcagcagt aaatgaagtt ggtgagggtc cagaagcaga
     1141 atctagtatt accacttcat cttcagcagt tcaacaagag gaacagtggc tctttttatc
     1201 cagaaaaact tctctaagaa agagatcttt aaaacattta gtagatgaag cacattgcct
     1261 tcggttggat gctatatacc ataatattac aggaatatct gttgatgtcc accagcaaat
     1321 tgtttatttc tctgaaggaa ctctcatatg ggcgaagaag gctgccaaca tgtctgatgt
     1381 atctgacctg agaatttttt acagaggttc aggattaatt tcttctatct ccatagattg
     1441 gctttatcaa agaatgtatt tcatcatgga tgaactggta tgtgtctgtg atttagagaa
     1501 ctgctcaaac atcgaggaaa ttactccacc ctctattagt gcacctcaaa aaattgtggc
     1561 tgattcatac aatgggtatg tcttttacct cctgagagat ggcatttata gagcagacct
     1621 tcctgtacca tctggccggt gtgcagaagc tgtgcgtatt gtggagagtt gcacgttaaa
     1681 ggactttgca atcaagccac aagccaagcg aatcatttac ttcaatgaca ctgcccaagt
     1741 cttcatgtca acatttctgg atggctctgc ttcccatctc atcctacctc gcatcccctt
     1801 tgctgatgtg aaaagttttg cttgtgaaaa caatgacttt cttgtcacag atggcaaggt
     1861 cattttccaa caggatgctt tgtcttttaa tgaattcatc gtgggatgtg acctgagtca
     1921 catagaagaa tttgggtttg gtaacttggt catctttggc tcatcctccc agctgcaccc
     1981 tctgccaggc cgcccgcagg agctttcggt gctgtttggc tctcaccagg ctcttgttca
     2041 atggaagcct cctgcccttg ccataggagc caatgtcatc ctgatcagtg atattattga
     2101 actctttgaa ttaggccctt ctgcctggca gaactggacc tatgaggtga aagtatccac
     2161 ccaagaccct cctgaagtca ctcatatttt cttgaacata agtggaacca tgctgaatgt
     2221 acctgagctg cagagtgcta tgaaatacaa ggtttctgtg agagcaagtt ctccaaagag
     2281 gccaggcccc tggtcagagc cctcagtggg tactaccctg gtgccagcta gtgaaccacc
     2341 atttatcatg gctgtgaaag aagatgggct ttggagtaaa ccattaaata gctttggccc
     2401 aggagagttc ttatcctctg atataggaaa tgtgtcagac atggattggt ataacaacag
     2461 cctctactac agtgacacga aaggcgacgt ttttgtgtgg ctgctgaatg ggacggatat
     2521 ctcagagaat tatcacctac ccagcattgc aggagcaggg gctttagctt ttgagtggct
     2581 gggtcacttt ctctactggg ctggaaagac atatgtgata caaaggcagt ctgtgttgac
     2641 gggacacaca gacattgtta cccacgtgaa gctattggtg aatgacatgg tggtggattc
     2701 agttggtgga tatctctact ggaccacact ctattcagtg gaaagcacca gactaaatgg
     2761 ggaaagttcc cttgtactac agacacagcc ttggttttct gggaaaaagg taattgctct
     2821 aactttagac ctcagtgatg ggctcctgta ttggttggtt caagacagtc aatgtattca
     2881 cctgtacaca gctgttcttc ggggacagag cactggggat accaccatca cagaatttgc
     2941 agcctggagt acttctgaaa tttcccagaa tgcactgatg tactatagtg gtcggctgtt
     3001 ctggatcaat ggctttagga ttatcacaac tcaagaaata ggtcagaaaa ccagtgtctc
     3061 tgttttggaa ccagccagat ttaatcagtt cacaattatt cagacatccc ttaagcccct
     3121 gccagggaac ttttccttta cccctaaggt tattccagat tctgttcaag agtcttcatt
     3181 taggattgaa ggaaatgctt caagttttca aatcctgtgg aatggtcccc ctgcggtaga
     3241 ctggggtgta gttttctaca gtgtagaatt tagtgctcat tctaagttct tggctagtga
     3301 acaacactct ttacctgtat ttactgtgga aggactggaa ccttatgcct tatttaatct
     3361 ttctgtcact ccttatacct actggggaaa gggccccaaa acatctctgt cacttcgagc
     3421 acctgaaaca gttccatcag caccagagaa ccccagaata tttatattac caagtggaaa
     3481 atgctgcaac aagaatgaag ttgtggtgga atttaggtgg aacaaaccta agcatgaaaa
     3541 tggggtgtta acaaaatttg aaattttcta caatatatcc aatcaaagta ttacaaacaa
     3601 aacatgtgaa gactggattg ctgtcaatgt cactccctca gtgatgtctt ttcaacttga
     3661 aggcatgagt cccagatgct ttattgcctt ccaggttagg gcctttacat ctaaggggcc
     3721 aggaccatat gctgacgttg taaagtctac aacatcagaa atcaacccat ttcctcacct
     3781 cataactctt cttggtaaca agatagtttt tttagatatg gatcaaaatc aagttgtgtg
     3841 gacgttttca gcagaaagag ttatcagtgc cgtttgctac acagctgata atgagatggg
     3901 atattatgct gaaggggact cactctttct tctgcacttg cacaatcgct ctagctctga
     3961 gcttttccaa gattcactgg tttttgatat cacagttatt acaattgact ggatttcaag
     4021 gcacctctac tttgcactga aagaatcaca aaatggaatg caagtatttg atgttgatct
     4081 tgaacacaag gtgaaatatc ccagagaggt gaagattcac aataggaatt caacaataat
     4141 ttctttttct gtatatcctc ttttaagtcg cttgtattgg acagaagttt ccaattttgg
     4201 ctaccagatg ttctactaca gtattatcag tcacaccttg caccgaattc tgcaacccac
     4261 agctacaaac caacaaaaca aaaggaatca atgttcttgt aatgtgactg aatttgagtt
     4321 aagtggagca atggctattg atacctctaa cctagagaaa ccattgatat actttgccaa
     4381 agcacaagag atctgggcaa tggatctgga aggctgtcag tgttggagag ttatcacagt
     4441 acctgctatg ctcgcaggaa aaacccttgt tagcttaact gtggatggag atcttatata
     4501 ctggatcatc acagcaaagg acagcacaca gatttatcag gcaaagaaag gaaatggggc
     4561 catcgtttcc caggtgaagg ccctaaggag taggcatatc ttggcttaca gttcagttat
     4621 gcagcctttt ccagataaag cgtttctgtc tctagcttca gacactgtgg aaccaactat
     4681 acttaatgcc actaacacta gcctcacaat cagattacct ctggccaaga caaacctcac
     4741 atggtatggc atcaccagcc ctactccaac atacctggtt tattatgcag aagttaatga
     4801 caggaaaaac agctctgact tgaaatatag aattctggaa tttcaggaca gtatagctct
     4861 tattgaagat ttacaaccat tttcaacata catgatacag atagctgtaa aaaattatta
     4921 ttcagatcct ttggaacatt taccaccagg aaaagagatt tggggaaaaa ctaaaaatgg
     4981 agtaccagag gcagtgcagc tcattaatac aactgtgcgg tcagacacca gcctcattat
     5041 atcttggaga gaatctcaca agccaaatgg acctaaagaa tcagtccgtt atcagttggc
     5101 aatctcacac ctggccctaa ttcctgaaac tcctctaaga caaagtgaat ttccaaatgg
     5161 aaggctcact ctccttgtta ctagactgtc tggtggaaat atttatgtgt taaaggttct
     5221 tgcctgccac tctgaggaaa tgtggtgtac agagagtcat cctgtcactg tggaaatgtt
     5281 taacacacca gagaaacctt attccttggt tccagagaac actagtttgc aatttaattg
     5341 gaaggctcca ttgaatgtta acctcatcag attttgggtt gagctacaga agtggaaata
     5401 caatgagttt taccatgtta aaacttcatg cagccaaggt cctgcttatg tctgtaatat
     5461 cacaaatcta caaccttata cttcatataa tgtcagagta gtggtggttt ataagacggg
     5521 agaaaatagc acctcacttc cagaaagctt taagacaaaa gctggagtcc caaataaacc
     5581 aggcattccc aaattactag aagggagtaa aaattcaata cagtgggaga aagctgaaga
     5641 taatggatgt agaattacat actatatcct tgagataaga aagagcactt caaataattt
     5701 acagaaccag aatttaaggt ggaagatgac atttaatgga tcctgcagta gtgtttgcac
     5761 atggaagtcc aaaaacctga aaggaatatt tcagttcaga gtagtagctg caaataatct
     5821 agggtttggt gaatatagtg gaatcagtga gaatattata ttagttggag atgatttttg
     5881 gataccagaa acaagtttca tacttactat tatagttgga atatttctgg ttgttacaat
     5941 cccactgacc tttgtctggc atagaagatt aaagaatcaa aaaagtgcca aggaaggggt
     6001 gacagtgctt ataaacgaag acaaagagtt ggctgagctg cgaggtctgg cagccggagt
     6061 aggcctggct aatgcctgct atgcaataca tactcttcca acccaagagg agattgaaaa
     6121 tcttcctgcc ttccctcggg aaaaactgac tctgcgtctc ttgctgggaa gtggagcctt
     6181 tggagaagtg tatgaaggaa cagcagtgga catcttagga gttggaagtg gagaaatcaa
     6241 agtagcagtg aagactttga agaagggttc cacagaccag gagaagattg aattcctgaa
     6301 ggaggcacat ctgatgagca aatttaatca tcccaacatt ctgaagcagc ttggagtttg
     6361 tctgctgaat gaaccccaat acattatcct ggaactgatg gagggaggag accttcttac
     6421 ttatttgcgt aaagcccgga tggcaacgtt ttatggtcct ttactcacct tggttgacct
     6481 tgtagacctg tgtgtagata tttcaaaagg ctgtgtctac ttggaacgga tgcatttcat
     6541 tcacagggat ctggcagcta gaaattgcct tgtttccgtg aaagactata ccagtccacg
     6601 gatagtgaag attggagact ttggactcgc cagagacatc tataaaaatg attactatag
     6661 aaagagaggg gaaggcctgc tcccagttcg gtggatggct ccagaaagtt tgatggatgg
     6721 aatcttcact actcaatctg atgtatggtc ttttggaatt ctgatttggg agattttaac
     6781 tcttggtcat cagccttatc cagctcattc caaccttgat gtgttaaact atgtgcaaac
     6841 aggagggaga ctggagccac caagaaattg tcctgatgat ctgtggaatt taatgaccca
     6901 gtgctgggct caagaacccg accaaagacc tacttttcat agaattcagg accaacttca
     6961 gttattcaga aattttttct taaatagcat ttataagtcc agagatgaag caaacaacag
     7021 tggagtcata aatgaaagct ttgaaggtga agatggcgat gtgatttgtt tgaattcaga
     7081 tgacattatg ccagttgctt taatggaaac gaagaaccga gaagggttaa actatatggt
     7141 acttgctaca gaatgtggcc aaggtgaaga aaagtctgag ggtcctctag gctcccagga
     7201 atctgaatct tgtggtctga ggaaagaaga gaaggaacca catgcagaca aagatttctg
     7261 ccaagaaaaa caagtggctt actgcccttc tggcaagcct gaaggcctga actatgcctg
     7321 tctcactcac agtggatatg gagatgggtc tgattaatag cgttgtttgg gaaatagaga
     7381 gttgagataa acactctcat tcagtagtta ctgaaagaaa actctgctag aatgataaat
     7441 gtcatggtgg tctataactc caaataaaca atgcaacgtt cctgatttct aatcttggtt
     7501 ctgagagcca tttggtttca gttgtagcaa tccccatacc agctgcctga ctttcagtag
     7561 aattatgaga tgaacactaa gcatgtggaa agcttaggaa gactcagaag tctggaaggg
     7621 aaacactgct ctcccttctc ccttgaggtg ctttaggctc ttacccacct ttcagtttgg
     7681 gctgtaataa aaatatcttg gccacatgtt tagagacaga ataggtgtgt tcagcgatat
     7741 aaagaagagg ctaaggagta ggctcagggg ggtcaactga actacagata atctcaaatg
     7801 ggaccaagga aatgagaaat aatttcacac atacagaaga aaccagcacc tgtgacttga
     7861 gaaatcactt ggaaagctgt tactgcaatg atatatatat tatctttttt taattttttt
     7921 tttttttttt tgagacgaag tcttgctctg ttgcccaggc tggagttcaa tggcacgatc
     7981 tcggcactgc aaactccacc tcctgggttc aagcaattct cgtgcctcag cctcctaagt
     8041 agctgggatt acaggcgtgt gccaccacgc ccggctaatt tttgtatttt tagtagagat
     8101 gaggtttcac catattggcc aggctggtct agaactcctg acctcgggat ccacctgcct
     8161 tggcctccca aagtgctgga ttacaggtgt gagccaccat gcctagccga tatatattgt
     8221 ctttaatcac tactgtaaaa tattttgtag ttttgaggct tacaacagta gattcagtca
     8281 tgttgaaaat aagactgtga agatctttta agtcctgaag ttttgcattc tgtaatcttc
     8341 agttgtataa aatcactctg acttgtgtgc tattatggaa attaactagt ataaagattg
     8401 ctatttgcca tatctatttt atgtataaaa tacttaagat tacattttgt atcaaattat
     8461 gcttaaaatt aaatataaat gattatacaa tgttaa
//
