LOCUS       NM_005060               2996 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens RAR related orphan receptor C (RORC), transcript
            variant 1, mRNA.
ACCESSION   NM_005060
VERSION     NM_005060.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2996)
  AUTHORS   Erice,P.A., Huang,X., Seasock,M.J., Robertson,M.J., Tung,H.Y.,
            Perez-Negron,M.A., Lotlikar,S.L., Corry,D.B., Kheradmand,F. and
            Rodriguez,A.
  TITLE     Downregulation of Mirlet7 miRNA family promotes Tc17
            differentiation and emphysema via de-repression of RORgammat
  JOURNAL   Elife 13, 92879 (2024)
   PUBMED   38722677
  REMARK    GeneRIF: Downregulation of Mirlet7 miRNA family promotes Tc17
            differentiation and emphysema via de-repression of RORgammat.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2996)
  AUTHORS   Wiche Salinas,T.R., Zhang,Y., Sarnello,D., Zhyvoloup,A.,
            Marchand,L.R., Fert,A., Planas,D., Lodha,M., Chatterjee,D.,
            Karwacz,K., Oxenford,S., Routy,J.P., Irlbeck,D., Amrine-Madsen,H.,
            Ancuta,P. and Fassati,A.
  TITLE     Th17 cell master transcription factor RORC2 regulates HIV-1 gene
            expression and viral outgrowth
  JOURNAL   Proc Natl Acad Sci U S A 118 (48) (2021)
   PUBMED   34819367
  REMARK    GeneRIF: Th17 cell master transcription factor RORC2 regulates
            HIV-1 gene expression and viral outgrowth.
REFERENCE   3  (bases 1 to 2996)
  AUTHORS   Strutzenberg,T.S., Zhu,Y., Novick,S.J., Garcia-Ordonez,R.D.,
            Doebelin,C., He,Y., Chang,M.R., Kamenecka,T.M., Edwards,D.P. and
            Griffin,P.R.
  TITLE     Conformational Changes of RORgamma During Response Element
            Recognition and Coregulator Engagement
  JOURNAL   J Mol Biol 433 (22), 167258 (2021)
   PUBMED   34547329
  REMARK    GeneRIF: Conformational Changes of RORgamma During Response Element
            Recognition and Coregulator Engagement.
REFERENCE   4  (bases 1 to 2996)
  AUTHORS   Gholamipoor,Z., Rahimzadeh,M., Montazerghaem,H. and Naderi,N.
  TITLE     RORC gene polymorphism is associated with acute kidney injury
            following cardiac surgery
  JOURNAL   Acta Anaesthesiol Scand 65 (10), 1397-1403 (2021)
   PUBMED   34252205
  REMARK    GeneRIF: RORC gene polymorphism is associated with acute kidney
            injury following cardiac surgery.
REFERENCE   5  (bases 1 to 2996)
  AUTHORS   Wilson,P.A., Santos Franco,S., He,L., Galwey,N.W., Meakin,J.,
            McIntyre,R., McHugh,S.M., Nolan,M.A., Spain,S.L., Carlson,T.,
            Lobera,M., Rubio,J.P., Davis,B. and McCarthy,L.C.
  TITLE     Transcriptomic effects of rs4845604, an IBD and allergy-associated
            RORC variant, in stimulated ex vivo CD4+ T cells
  JOURNAL   PLoS One 16 (10), e0258316 (2021)
   PUBMED   34673799
  REMARK    GeneRIF: Transcriptomic effects of rs4845604, an IBD and
            allergy-associated RORC variant, in stimulated ex vivo CD4+ T
            cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2996)
  AUTHORS   Kurebayashi,S., Ueda,E., Sakaue,M., Patel,D.D., Medvedev,A.,
            Zhang,F. and Jetten,A.M.
  TITLE     Retinoid-related orphan receptor gamma (RORgamma) is essential for
            lymphoid organogenesis and controls apoptosis during thymopoiesis
  JOURNAL   Proc Natl Acad Sci U S A 97 (18), 10132-10137 (2000)
   PUBMED   10963675
REFERENCE   7  (bases 1 to 2996)
  AUTHORS   Sun,Z., Unutmaz,D., Zou,Y.R., Sunshine,M.J., Pierani,A.,
            Brenner-Morton,S., Mebius,R.E. and Littman,D.R.
  TITLE     Requirement for RORgamma in thymocyte survival and lymphoid organ
            development
  JOURNAL   Science 288 (5475), 2369-2373 (2000)
   PUBMED   10875923
REFERENCE   8  (bases 1 to 2996)
  AUTHORS   Villey,I., de Chasseval,R. and de Villartay,J.P.
  TITLE     RORgammaT, a thymus-specific isoform of the orphan nuclear receptor
            RORgamma / TOR, is up-regulated by signaling through the pre-T cell
            receptor and binds to the TEA promoter
  JOURNAL   Eur J Immunol 29 (12), 4072-4080 (1999)
   PUBMED   10602018
REFERENCE   9  (bases 1 to 2996)
  AUTHORS   Medvedev,A., Chistokhina,A., Hirose,T. and Jetten,A.M.
  TITLE     Genomic structure and chromosomal mapping of the nuclear orphan
            receptor ROR gamma (RORC) gene
  JOURNAL   Genomics 46 (1), 93-102 (1997)
   PUBMED   9403063
REFERENCE   10 (bases 1 to 2996)
  AUTHORS   Hirose,T., Smith,R.J. and Jetten,A.M.
  TITLE     ROR gamma: the third member of ROR/RZR orphan receptor subfamily
            that is highly expressed in skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1976-1983 (1994)
   PUBMED   7811290
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U16997.1, BC031554.1,
            AL834219.1 and CB161467.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005060.3.
            
            Summary: The protein encoded by this gene is a DNA-binding
            transcription factor and is a member of the NR1 subfamily of
            nuclear hormone receptors. The specific functions of this protein
            are not known; however, studies of a similar gene in mice have
            shown that this gene may be essential for lymphoid organogenesis
            and may play an important regulatory role in thymopoiesis. In
            addition, studies in mice suggest that the protein encoded by this
            gene may inhibit the expression of Fas ligand and IL2. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.236256.1,
                                           SRR1803617.46160.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318247.7/ ENSP00000327025.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                U16997.1           32-43
            13-2068             BC031554.1         1-2056
            2069-2848           AL834219.1         2109-2888
            2849-2890           CB161467.1         454-495
            2891-2996           AL834219.1         2931-3036
FEATURES             Location/Qualifiers
     source          1..2996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2996
                     /gene="RORC"
                     /gene_synonym="IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR"
                     /note="RAR related orphan receptor C"
                     /db_xref="GeneID:6097"
                     /db_xref="HGNC:HGNC:10260"
                     /db_xref="MIM:602943"
     exon            1..78
                     /gene="RORC"
                     /gene_synonym="IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1595
                     /gene="RORC"
                     /gene_synonym="IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR"
                     /note="isoform a is encoded by transcript variant 1;
                     nuclear receptor ROR-gamma; retinoic acid-binding receptor
                     gamma; retinoid-related orphan receptor gamma; nuclear
                     receptor RZR-gamma; nuclear receptor subfamily 1 group F
                     member 3"
                     /codon_start=1
                     /product="nuclear receptor ROR-gamma isoform a"
                     /protein_id="NP_005051.2"
                     /db_xref="CCDS:CCDS1004.1"
                     /db_xref="GeneID:6097"
                     /db_xref="HGNC:HGNC:10260"
                     /db_xref="MIM:602943"
                     /translation="MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYG
                     VITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVK
                     FGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPL
                     GSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFY
                     STGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQS
                     VCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEF
                     AKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALG
                     CSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAF
                     HHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFST
                     ETESPVGLSK"
     exon            79..108
                     /gene="RORC"
                     /gene_synonym="IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR"
                     /inference="alignment:Splign:2.1.0"
     exon            109..194
                     /gene="RORC"
                     /gene_synonym="IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR"
                     /inference="alignment:Splign:2.1.0"
     exon            195..336
                     /gene="RORC"
                     /gene_synonym="IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR"
                     /inference="alignment:Splign:2.1.0"
     exon            337..849
                     /gene="RORC"
                     /gene_synonym="IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR"
                     /inference="alignment:Splign:2.1.0"
     exon            850..971
                     /gene="RORC"
                     /gene_synonym="IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1104
                     /gene="RORC"
                     /gene_synonym="IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1212
                     /gene="RORC"
                     /gene_synonym="IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1323
                     /gene="RORC"
                     /gene_synonym="IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1433
                     /gene="RORC"
                     /gene_synonym="IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..2996
                     /gene="RORC"
                     /gene_synonym="IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2975..2980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RORC"
                     /gene_synonym="IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR"
                     /note="hexamer: TATAAA"
     polyA_site      2996
                     /gene="RORC"
                     /gene_synonym="IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR"
                     /note="major polyA site"
ORIGIN      
        1 agccagggca gccaggacgg caccaaggga gctgccccat ggacagggcc ccacagagac
       61 agcaccgagc ctcacgggag ctgctggctg caaagaagac ccacacctca caaattgaag
      121 tgatcccttg caaaatctgt ggggacaagt cgtctgggat ccactacggg gttatcacct
      181 gtgaggggtg caagggcttc ttccgccgga gccagcgctg taacgcggcc tactcctgca
      241 cccgtcagca gaactgcccc atcgaccgca ccagccgaaa ccgatgccag cactgccgcc
      301 tgcagaaatg cctggcgctg ggcatgtccc gagatgctgt caagttcggc cgcatgtcca
      361 agaagcagag ggacagcctg catgcagaag tgcagaaaca gctgcagcag cggcaacagc
      421 agcaacagga accagtggtc aagacccctc cagcaggggc ccaaggagca gataccctca
      481 cctacacctt ggggctccca gacgggcagc tgcccctggg ctcctcgcct gacctgcctg
      541 aggcttctgc ctgtccccct ggcctcctga aagcctcagg ctctgggccc tcatattcca
      601 acaacttggc caaggcaggg ctcaatgggg cctcatgcca ccttgaatac agccctgagc
      661 ggggcaaggc tgagggcaga gagagcttct atagcacagg cagccagctg acccctgacc
      721 gatgtggact tcgttttgag gaacacaggc atcctgggct tggggaactg ggacagggcc
      781 cagacagcta cggcagcccc agtttccgca gcacaccgga ggcaccctat gcctccctga
      841 cagagataga gcacctggtg cagagcgtct gcaagtccta cagggagaca tgccagctgc
      901 ggctggagga cctgctgcgg cagcgctcca acatcttctc ccgggaggaa gtgactggct
      961 accagaggaa gtccatgtgg gagatgtggg aacggtgtgc ccaccacctc accgaggcca
     1021 ttcagtacgt ggtggagttc gccaagaggc tctcaggctt tatggagctc tgccagaatg
     1081 accagattgt gcttctcaaa gcaggagcaa tggaagtggt gctggttagg atgtgccggg
     1141 cctacaatgc tgacaaccgc acggtctttt ttgaaggcaa atacggtggc atggagctgt
     1201 tccgagcctt gggctgcagc gagctcatca gctccatctt tgacttctcc cactccctaa
     1261 gtgccttgca cttttccgag gatgagattg ccctctacac agcccttgtt ctcatcaatg
     1321 cccatcggcc agggctccaa gagaaaagga aagtagaaca gctgcagtac aatctggagc
     1381 tggcctttca tcatcatctc tgcaagactc atcgccaaag catcctggca aagctgccac
     1441 ccaaggggaa gcttcggagc ctgtgtagcc agcatgtgga aaggctgcag atcttccagc
     1501 acctccaccc catcgtggtc caagccgctt tccctccact ctacaaggag ctcttcagca
     1561 ctgaaaccga gtcacctgtg gggctgtcca agtgacctgg aagagggact ccttgcctct
     1621 ccctatggcc tgctggccca cctccctgga ccccgttcca ccctcaccct tttcctttcc
     1681 catgaaccct ggagggtggt ccccaccagc tctttggaag tgagcagatg ctgcggctgg
     1741 ctttctgtca gcaggccggc ctggcagtgg gacaatcgcc agagggtggg gctggcagaa
     1801 caccatctcc agcctcagct ttgacctgtc tcatttccca tattccttca cacccagctt
     1861 ctggaaggca tggggtggct gggatttaag gacttctggg ggaccaagac atcctcaaga
     1921 aaacaggggc atccagggct ccctggatga atagaatgca attcattcag aagctcagaa
     1981 gctaagaata agcctttgaa atacctcatt gcatttccct ttgggcttcg gcttggggag
     2041 atggatcaag ctcagagact ggcagtgaga gcccagaagg acctgtataa aatgaatctg
     2101 gagctttaca ttttctgcct ctgccttcct cccagctcag caaggaagta tttgggcacc
     2161 ctacccttta cctggggtct aaccaaaaat ggatgggatg aggatgagag gctggagata
     2221 attgttttat gggatttggg tgtgggacta gggtacaatg aaggccaaga gcatctcaga
     2281 catagagtta aaactcaaac ctcttatgtg cactttaaag atagacttta ggggctggca
     2341 caaatctgat cagagacaca tatccataca caggtgaaac acatacagac tcaacagcaa
     2401 tcatgcagtt ccagagacac atgaacctga cacaatctct cttatccttg aggccacagc
     2461 ttggaggagc ctagaggcct caggggaaag tcccaatcct gagggaccct cccaaacatt
     2521 tccatggtgc tccagtccac tgatcttggg tctggggtga tccaaatacc accccagctc
     2581 cagctgtctt ctaccactag aagacccaag agaagcagaa gtcgctcgca ctggtcagtc
     2641 ggaaggcaag atcagatcct ggaggacttt cctggcctgc ccgccagccc tgctcttgtt
     2701 gtggagaagg aagcagatgt gatcacatca ccccgtcatt gggcaccgct gactccagca
     2761 tggaggacac cagggagcag ggcctgggcc tgtttcccca gctgtgatct tgcccagaac
     2821 ctctcttggc ttcataaaca gctgtgaacc ctcccctgag ggattaacag caatgatggg
     2881 cagtcgtgga gttggggggg ttgggggtgg gattgtgtcc tctaagggga cgggttcatc
     2941 tgagtaaaca taaaccccaa cttgtgccat tctttataaa atgattttaa aggcaa
//
