LOCUS       NM_006914               9581 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RAR related orphan receptor B (RORB), transcript
            variant 1, mRNA.
ACCESSION   NM_006914
VERSION     NM_006914.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9581)
  AUTHORS   Zheng,J., Tang,H., Yang,Y. and Yang,K.
  TITLE     Comprehensive analysis of the prognosis and biological significance
            of RORbeta in head and neck squamous cell carcinoma
  JOURNAL   Environ Toxicol 39 (2), 487-508 (2024)
   PUBMED   37278231
  REMARK    GeneRIF: Comprehensive analysis of the prognosis and biological
            significance of RORbeta in head and neck squamous cell carcinoma.
REFERENCE   2  (bases 1 to 9581)
  AUTHORS   Lehrer,S. and Rheinstein,P.H.
  TITLE     RORB, an Alzheimer's disease susceptibility gene, is associated
            with viral encephalitis, an Alzheimer's disease risk factor
  JOURNAL   Clin Neurol Neurosurg 233, 107984 (2023)
   PUBMED   37734269
  REMARK    GeneRIF: RORB, an Alzheimer's disease susceptibility gene, is
            associated with viral encephalitis, an Alzheimer's disease risk
            factor.
REFERENCE   3  (bases 1 to 9581)
  AUTHORS   Wen,Z., Chen,M., Guo,W., Guo,K., Du,P., Fang,Y., Gao,M. and Wang,Q.
  TITLE     RORbeta suppresses the stemness of gastric cancer cells by
            downregulating the activity of the Wnt signaling pathway
  JOURNAL   Oncol Rep 46 (2) (2021)
   PUBMED   34278502
  REMARK    GeneRIF: RORbeta suppresses the stemness of gastric cancer cells by
            downregulating the activity of the Wnt signaling pathway.
REFERENCE   4  (bases 1 to 9581)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 9581)
  AUTHORS   Sadleir,L.G., de Valles-Ibanez,G., King,C., Coleman,M., Mossman,S.,
            Paterson,S., Nguyen,J., Berkovic,S.F., Mullen,S., Bahlo,M.,
            Hildebrand,M.S., Mefford,H.C. and Scheffer,I.E.
  TITLE     Inherited RORB pathogenic variants: Overlap of photosensitive
            genetic generalized and occipital lobe epilepsy
  JOURNAL   Epilepsia 61 (4), e23-e29 (2020)
   PUBMED   32162308
  REMARK    GeneRIF: Inherited RORB pathogenic variants: Overlap of
            photosensitive genetic generalized and occipital lobe epilepsy.
REFERENCE   6  (bases 1 to 9581)
  AUTHORS   Paravicini,G., Steinmayr,M., Andre,E. and Becker-Andre,M.
  TITLE     The metastasis suppressor candidate nucleotide diphosphate kinase
            NM23 specifically interacts with members of the ROR/RZR nuclear
            orphan receptor subfamily
  JOURNAL   Biochem Biophys Res Commun 227 (1), 82-87 (1996)
   PUBMED   8858107
REFERENCE   7  (bases 1 to 9581)
  AUTHORS   Greiner,E.F., Kirfel,J., Greschik,H., Dorflinger,U., Becker,P.,
            Mercep,A. and Schule,R.
  TITLE     Functional analysis of retinoid Z receptor beta, a brain-specific
            nuclear orphan receptor
  JOURNAL   Proc Natl Acad Sci U S A 93 (19), 10105-10110 (1996)
   PUBMED   8816759
REFERENCE   8  (bases 1 to 9581)
  AUTHORS   Carlberg,C., Hooft van Huijsduijnen,R., Staple,J.K.,
            DeLamarter,J.F. and Becker-Andre,M.
  TITLE     RZRs, a new family of retinoid-related orphan receptors that
            function as both monomers and homodimers
  JOURNAL   Mol Endocrinol 8 (6), 757-770 (1994)
   PUBMED   7935491
REFERENCE   9  (bases 1 to 9581)
  AUTHORS   Giguere,V., Tini,M., Flock,G., Ong,E., Evans,R.M. and
            Otulakowski,G.
  TITLE     Isoform-specific amino-terminal domains dictate DNA-binding
            properties of ROR alpha, a novel family of orphan hormone nuclear
            receptors
  JOURNAL   Genes Dev 8 (5), 538-553 (1994)
   PUBMED   7926749
REFERENCE   10 (bases 1 to 9581)
  AUTHORS   Beeson,W.M., Perry,T.W. and Zurcher,T.D.
  TITLE     Effect of supplemental zinc on growth and on hair and blood serum
            levels of beef cattle
  JOURNAL   J Anim Sci 45 (1), 160-165 (1977)
   PUBMED   885817
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355674.10, AL691650.1,
            BC051830.1, BC093772.1, BX647070.1, AL137018.9 and AL158833.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006914.3.
            
            Summary: The protein encoded by this gene is a member of the NR1
            subfamily of nuclear hormone receptors. It is a DNA-binding protein
            that can bind as a monomer or as a homodimer to hormone response
            elements upstream of several genes to enhance the expression of
            those genes. The encoded protein has been shown to interact with
            NM23-2, a nucleoside diphosphate kinase involved in organogenesis
            and differentiation, and to help regulate the expression of some
            genes involved in circadian rhythm. [provided by RefSeq, Feb 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.76239.1,
                                           SRR1803613.194400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376896.8/ ENSP00000366093.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL355674.10        140322-140322
            2-13                AL691650.1         2-13
            14-893              BC051830.1         1-880
            894-2063            BC093772.1         327-1496
            2064-2887           BC051830.1         2051-2874
            2888-3605           BX647070.1         2328-3045
            3606-5359           AL137018.9         155415-157168
            5360-9581           AL158833.13        101-4322
FEATURES             Location/Qualifiers
     source          1..9581
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.13"
     gene            1..9581
                     /gene="RORB"
                     /gene_synonym="bA133M9.1; EIG15; NR1F2; ROR-BETA; RORbeta;
                     RZR-BETA; RZRB"
                     /note="RAR related orphan receptor B"
                     /db_xref="GeneID:6096"
                     /db_xref="HGNC:HGNC:10259"
                     /db_xref="MIM:601972"
     exon            1..649
                     /gene="RORB"
                     /gene_synonym="bA133M9.1; EIG15; NR1F2; ROR-BETA; RORbeta;
                     RZR-BETA; RZRB"
                     /inference="alignment:Splign:2.1.0"
     CDS             643..2022
                     /gene="RORB"
                     /gene_synonym="bA133M9.1; EIG15; NR1F2; ROR-BETA; RORbeta;
                     RZR-BETA; RZRB"
                     /note="isoform 1 is encoded by transcript variant 1;
                     retinoic acid-binding receptor beta; nuclear receptor
                     RZR-beta; nuclear receptor ROR-beta; RAR-related orphan
                     receptor beta; retinoid-related orphan receptor beta;
                     nuclear receptor subfamily 1 group F member 2; retinoid Z
                     receptor beta"
                     /codon_start=1
                     /product="nuclear receptor ROR-beta isoform 1"
                     /protein_id="NP_008845.2"
                     /db_xref="CCDS:CCDS6646.1"
                     /db_xref="GeneID:6096"
                     /db_xref="HGNC:HGNC:10259"
                     /db_xref="MIM:601972"
                     /translation="MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASY
                     SCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQ
                     RLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDS
                     GQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQN
                     IIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEF
                     AKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALG
                     SDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFAL
                     QHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELF
                     NPDCATGCK"
     exon            650..735
                     /gene="RORB"
                     /gene_synonym="bA133M9.1; EIG15; NR1F2; ROR-BETA; RORbeta;
                     RZR-BETA; RZRB"
                     /inference="alignment:Splign:2.1.0"
     exon            736..877
                     /gene="RORB"
                     /gene_synonym="bA133M9.1; EIG15; NR1F2; ROR-BETA; RORbeta;
                     RZR-BETA; RZRB"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1279
                     /gene="RORB"
                     /gene_synonym="bA133M9.1; EIG15; NR1F2; ROR-BETA; RORbeta;
                     RZR-BETA; RZRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1401
                     /gene="RORB"
                     /gene_synonym="bA133M9.1; EIG15; NR1F2; ROR-BETA; RORbeta;
                     RZR-BETA; RZRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1534
                     /gene="RORB"
                     /gene_synonym="bA133M9.1; EIG15; NR1F2; ROR-BETA; RORbeta;
                     RZR-BETA; RZRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1642
                     /gene="RORB"
                     /gene_synonym="bA133M9.1; EIG15; NR1F2; ROR-BETA; RORbeta;
                     RZR-BETA; RZRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1753
                     /gene="RORB"
                     /gene_synonym="bA133M9.1; EIG15; NR1F2; ROR-BETA; RORbeta;
                     RZR-BETA; RZRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1866
                     /gene="RORB"
                     /gene_synonym="bA133M9.1; EIG15; NR1F2; ROR-BETA; RORbeta;
                     RZR-BETA; RZRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..9581
                     /gene="RORB"
                     /gene_synonym="bA133M9.1; EIG15; NR1F2; ROR-BETA; RORbeta;
                     RZR-BETA; RZRB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9559..9564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RORB"
                     /gene_synonym="bA133M9.1; EIG15; NR1F2; ROR-BETA; RORbeta;
                     RZR-BETA; RZRB"
                     /note="hexamer: ATTAAA"
     polyA_site      9581
                     /gene="RORB"
                     /gene_synonym="bA133M9.1; EIG15; NR1F2; ROR-BETA; RORbeta;
                     RZR-BETA; RZRB"
                     /note="major polyA site"
ORIGIN      
        1 atctctcccc tctctttctc tctcgctgct cccttcctcc ctgtaactga acagtgaaaa
       61 ttcacattgt ggatccgcta acaggcacag atgtcatgtg aaaacgcaca tgctctgcca
      121 tccacaccgc ctttctttct tttctttctg tttccttttt tcccccttgt tccttctccc
      181 tcttctttgt aactaacaaa accaccacca actcctcctc ctgctgctgc ccttcctcct
      241 cctcctcagt ccaagtgatc acaaaagaaa tcttctgagc cggaggcggt ggcatttttt
      301 aaaaagcaag cacattggag agaaagaaaa agaaaaacaa aaccaaaaca aaacccaggc
      361 accagacagc cagaacattt ttttttcacc cttcctgaaa acaaacaaac aaacaaacaa
      421 tcatcaaaac agtcaccacc aacatcaaaa ctgttaacat agcggcggcg gcggcaaacg
      481 tcaccctgca gccacggcgt ccgcctaaag ggatggtttt ctcggcagag cagctcttcg
      541 ccgaccacct tcttcactcg tgctgagcgg gatttttggg ctctccgggg ttcgggctgg
      601 gagcagcttc atgactacgc ggagcgggag agcggccaca ccatgcgagc acaaattgaa
      661 gtgataccat gcaaaatttg tggcgataag tcctctggga tccactacgg agtcatcaca
      721 tgtgaaggct gcaagggatt ctttaggagg agccagcaga acaatgcttc ttattcctgc
      781 ccaaggcaga gaaactgttt aattgacaga acgaacagaa accgttgcca acactgccga
      841 ctgcagaagt gtcttgccct aggaatgtca agagatgctg tgaagtttgg gaggatgtcc
      901 aagaagcaaa gggacagcct gtatgctgag gtgcagaagc accagcagcg gctgcaggaa
      961 cagcggcagc agcagagtgg ggaggcagaa gcccttgcca gggtgtacag cagcagcatt
     1021 agcaacggcc tgagcaacct gaacaacgag accagcggca cttatgccaa cgggcacgtc
     1081 attgacctgc ccaagtctga gggttattac aacgtcgatt ccggtcagcc gtcccctgat
     1141 cagtcaggac ttgacatgac tggaatcaaa cagataaagc aagaacctat ctatgacctc
     1201 acatccgtac ccaacttgtt tacctatagc tctttcaaca atgggcagtt agcaccaggg
     1261 ataaccatga ctgaaatcga ccgaattgca cagaacatca ttaagtccca tttggagaca
     1321 tgtcaataca ccatggaaga gctgcaccag ctggcgtggc agacccacac ctatgaagaa
     1381 attaaagcat atcaaagcaa gtccagggaa gcactgtggc aacaatgtgc catccagatc
     1441 actcacgcca tccaatacgt ggtggagttt gcaaagcgga taacaggctt catggagctc
     1501 tgtcaaaatg atcaaattct acttctgaag tcaggttgct tggaagtggt tttagtgaga
     1561 atgtgccgtg ccttcaaccc attaaacaac actgttctgt ttgaaggaaa atatggagga
     1621 atgcaaatgt tcaaagcctt aggttctgat gacctagtga atgaagcatt tgactttgca
     1681 aagaatttgt gttccttgca gctgaccgag gaggagatcg ctttgttctc atctgctgtt
     1741 ctgatatctc cagaccgagc ctggcttata gaaccaagga aagtccagaa gcttcaggaa
     1801 aaaatttatt ttgcacttca acatgtgatt cagaagaatc acctggatga tgagaccttg
     1861 gcaaagttaa tagccaagat accaaccatc acggcagttt gcaacttgca cggggagaag
     1921 ctgcaggtat ttaagcaatc tcatccagag atagtgaata cactgtttcc tccgttatac
     1981 aaggagctct ttaatcctga ctgtgccacc ggctgcaaat gaaggggaca agagaactgt
     2041 ctcatagtca tggaatgcat caccattaag acaaaagcaa tgtgttcatg aagacttaag
     2101 aaaaatgtca ctactgcaac attaggaatg tcctgcactt aatagaatta tttttcaccg
     2161 ctacagtttg aagaatgtaa atatgcacct gagtggggct cttttatttg tttgtttgtt
     2221 tttgaaatga ccataaatat acaaatatag gacactgggt gttatccttt ttttaatttt
     2281 attcgggtat gttttgggag acaactgttt atagaatttt attgtagata tatacaagaa
     2341 aagagcggta ctttacatga ttacttttcc tgttgattgt tcaaatataa tttaagaaaa
     2401 ttccacttaa taggcttacc tatttctatg tttttaggta gttgatgcat gtgtaaattt
     2461 gtagctgtct tggaaagtac tgtgcatgta tgtaataagt atataatatg tgagaatatt
     2521 atatatgact attacttata catgcacatg cactgtggct taaataccat acctactagc
     2581 aatggaggtt cagtcaggct ctcttctatg atttaccttc tgtgttatat gttaccttta
     2641 tgttagacaa tcaggatttt gttttcccag ccagagtttt catctatagt caatggcagg
     2701 acggtaccaa ctcagagtta agtctacaaa ggaataaaca taatgtgtgg cctctatata
     2761 caaactctat ttctgtcaat gacatcaaag ccttgtcaag atggttcata ttgggaagga
     2821 gacagtattt taagccattt tcctgtttca agaattaggc cacagataac attgcaaggt
     2881 ccaagacttt tttgaccaaa cagtagatat tttctatttt tcaccagaac acataaaaac
     2941 actttttttc ttttggattt ctggttgtga aacaagcttg atttcagtgc ttattgtgtc
     3001 ttcaactgaa aaatacaatc tgtggattat gactaccagc aatttttttc taggaaagtt
     3061 aaaagaataa atcagaaccc agggcaacaa tgccatttca tgtaaacatt ttctctctca
     3121 ccatgttttg gcaagaaaag gtagaaagag aagacccaga gtgaagaagt aattctttat
     3181 attcctttct ttaatgtatt tgttaggaaa agtggcaata aagggggagg catattataa
     3241 aatgctataa tataaaaatg tagcaaaaac ttgacagact agaaaaaaaa agatctgtgt
     3301 tattctaggg aactaatgta ccccaaagcc aaaactaatt cctgtgaagt ttacagttac
     3361 atcatccatt taccctagaa ttattttttt agcaactttt agaaataaag aatacaactg
     3421 tgacattagg atcagagatt ttagacttcc ttgtacaaat tctcacttct ccacctgctc
     3481 accaatgaaa ttaatcataa gaaaagcata tattccaaga aatttgttct gcctgtgtcc
     3541 tggaggccta tacctctgtt attttctgat acaaaataaa acttaaaaaa aagaaaacaa
     3601 gctaagagag aagtttgtgt ataagacaat gaaaattatg gtctcctgta agtatatccc
     3661 agccaccaac tcctaaagaa ctgccctttt ctccatatta aacacacaca cacttacaca
     3721 cacacacata caaacccctg ctttgtaaag tttccatcag tggaaacttt gatttctttt
     3781 tttaatctct tatgctctcc tgaagttcat ggttgagcac catctccaag ataccacaga
     3841 actcttgatt gatgatcaaa acagtagtgt catcttttcc ttttagaaaa cggaacattt
     3901 tctcacctca tgattgatga attctaaacc aatggggaaa aacaaaaagg ctttaaaata
     3961 atgaatctgt ttctcaacta ctgttatatt caattaattt aactacattg aaccaaatta
     4021 cctttggttc taagaagaca gctgtagact gcttattatg ctgctacagg gactcaattc
     4081 tttttggtgt aaatgtcact cctgctagct ctttgtataa agaattaatt cccagagtca
     4141 tatttccttc taatggaaag attactctac tgattgctag gaaaacaggg taatggaagg
     4201 cactcaatta aaccaagccg tttccaaatg caatgtatgt tttatgattg gcttgtgata
     4261 ggcgatgctt catgtgtcta cttggtgttt ccctttgagc tttgaactta tgtcaaactt
     4321 tgttttcatt gttctgttgg cctagtgttt tccattgtca gcctgtaatt cctgctcagt
     4381 tgcagaggga attatttatt tcctccaatt taccttagag gatttaaatt ggctcaattg
     4441 atgaagtggc tcagaatttt ttcctccctt ttcccatggg tgatatagga aaaagattgt
     4501 tccccacatt taccttggga ggtactgctt tgaatttgtg ttgtttccac tagcgttaag
     4561 catttcactg ggacggcatg gaccttttga agctgggagg aaggaaacag agctagcatc
     4621 tgaaccagag caaaacaatg gcaaccagga catactcatc ccacttagtt gagagaagag
     4681 atttctagtt tgggttacag ttgcccaacc ttccctttaa agagaatcca gtcatgtttt
     4741 caatggtaaa aagccttaaa aagctgccct tcgaagatct cctatgactg catgtcaagg
     4801 tattttgtac ctacaatccc agaacttggt tccttcccca tgaggactaa caaatgttca
     4861 caacaatcat gatcaagtgt gcactggaag aaaaaatcca caatctgggc ttctcacttc
     4921 gtgcttcata aatgacaatc actgcttgat gcagatgttg cactgtatcc actcagggat
     4981 gtttccttaa aaaaaaaaaa tacatcaaga aggaggaaaa aattaaaaac aggaaaatga
     5041 caacaaaatg tgaatggtat aaattaaata tgttgctgag agcacctctc tgacaaggct
     5101 ttcagaccaa caagcagtaa cttcatgtca taaactagat tgacttattt ggacttgctg
     5161 aaaagttgca cccaagtaag gacaacttgg tctcattttc taaactctgc taagagccaa
     5221 ataatctagc tgtcccattc agaggaattt ttatctccct gcaaatccaa actttctata
     5281 caaatcctga acaaggaaaa tacagaaatc taactggcat tagataaaat ggacaaggga
     5341 ggtgaaaccg ggtgaattca aacttcagtg tatttgtggt ccataaaaag aaagggaaat
     5401 tttggaggga aaataggaca ggaaaggatt ccaaatctgg tttgacaccc gtatatgccc
     5461 gtactgtcca tgactcaact aatctctttg cccctttttc tgtggctcct tttttgtttt
     5521 gagacagatc ttgttcaaca tgttgctcag gctggagtgc agtggcatga gatcttggct
     5581 cgctgcaatc tctgcctcct gggttcaagc gattctcctg cttcagcctc ctgagtagct
     5641 gggattacag gcacacgccc ccacacccgg ctaatttttg tattttaggt agagatgggg
     5701 tttcaccatg ttggccaggc tggtcctgaa ctcctgacct caagtgatcc acccgccttg
     5761 gcctcccaaa gtgcaaggat tacaggcctg agccactgcg ccctgccttc agtggctctt
     5821 ttatccccca aagactgaaa gctgaaggtg gagatgttct ccacaaacat accctttctg
     5881 aatttccctt gttttagcac tgtgttcagg gctctggact aaagtacctc tgagtaggta
     5941 aaatcagaga atataacgat ctcctgagtg attagatttc tttggtagat tccaagagat
     6001 cttaaatcat aataaactct gaatattaac aagaggtgcc agggaggtgt cagtacattt
     6061 cctatcatag ctgccttgtt caaagcataa tctcagagca gtcaagctaa actgtttgta
     6121 gaaaaccatg aagatcaact catgctcact ctctacaatg caatgtgtac gaggcttgaa
     6181 ggcaaaaaca attcttgggt cccaaggaca acctaaaact taccagcttt tttcaaaaac
     6241 aacaatcaga tgcaaataat ggcagtgttg ttctatgttc tttgtttctg ttcattatag
     6301 aagcaaggaa aaattctatt tctattggaa attagaagaa ataatttctt cctgactctt
     6361 tttttttcta taaactttta tttccaagga agctgctaca atttgcagtc aattcaggcc
     6421 atggacgtct gtgccctaac agaagcaccg ttcaatagaa cagcaataac cttaaagtgt
     6481 gcatctgtag tgaaactctg cacaaagtcc cctgcataaa gaagagagga aagcctacca
     6541 tctgctttag acgaagtgtt atttgatgtt ctgtttccaa ctgtcagtat aagcagcaac
     6601 tagagtaaag gcctgatgtg ggaaactatg gggggtcttt caaaaaaaag ctgacactct
     6661 attcattttt gggtctcagg accagagggt acagggtaga gggtagttta ccatttaaag
     6721 caggggttga aaattcgaaa gcctaaaagg gccagggggc ttaatgcaaa tgggtgaagc
     6781 agcccagggg caagctggcc aggaaatgcc ctgtggaaaa agggacatcc acgatttacc
     6841 tgaaactgaa tgctgctaga gcttctgaat tttataaaat ctctgaaatt atacatgatg
     6901 gcagttgatt cagagcttag tgcagaccaa acaaatacat cactgagcag aagagggccc
     6961 atagatcgtc agcttgcagc ctctggttta aagcaaaatc gcatctgggg ccagctcaac
     7021 tgcagcaagt ctggtcagat tcaaccctgg acgatattag aatgatatta gttttggaag
     7081 gaggggatgg agatcttccc cttctaatac tcaattttgt tttggtattt gattgtcaca
     7141 actagaggat ataacaggag gtcagtttaa aaaatagcaa acagtctaaa aatgaaaact
     7201 attcaattta gtgatggctt ataaaagaca ctccaacttg tcttgcccaa actcccttct
     7261 tcatagagcc agggggctgg atttcttgcc actttttttc tgaaaggcaa atgcatgact
     7321 tttattcttt tgggtctcag tgtgtttctt gaactgtgtg acttcaatat ctgtgacaag
     7381 tttttatttt cccttagttg tatgtgaaga atttattcta tagtcgtgat catgtagtcc
     7441 tccattgttt ggaagtgcag accatggatt cctatgcagc agatgggggt tgtctgtttg
     7501 tgcacttttt tcctaagctg ctgaaattcc tccgatgtga atgggccata gtaatctttg
     7561 cctcctgcgt gactgtaagc atggcctcca gtggatcaga gaaagcagct cagtgattgt
     7621 tctcatggcc aaaaataaag cacaagggtt accggaattg aatgagccct gttcagggca
     7681 gcacggggca tctgcacccc agctgggcag catgatcctt gtattcaact atactcttct
     7741 ggcagtagtt ggtggcaagc attcgcgtgc ctctgtcaca accatacgta gaaacacatt
     7801 aggtatgtct ggaaagctac aaatcccaca tccaagcaca gtaccgtctg cttcatctga
     7861 ttaacacaca cacaagaaag aaaaattaca cccacagaaa actgagtatg tattgtagaa
     7921 atgtagagga aaaataaaaa tattttttca aatgtaatta cttttaatat atgcttgtgg
     7981 aaggtctaat acaatgtatg ctgtctctgt aatttttgct gtaaataact ggagacggtg
     8041 agtacactga tttttctatg tctctgttta agcataagac tttgtaacaa tttttttaga
     8101 gggggaaaat caacaaagag caaatatgta cttgcttcct ttctgcgtgt tatgtacttc
     8161 tcagtttttt aatggaaact ggttgtaaca gtttaagcat cttgacgggt cattggtgtt
     8221 aagtgtatgc ttctttttgt aatatgactg agaaagggac agggctgtca attaaatctg
     8281 ctccaaagaa tttgtattga agattggcct aagacctgca aactccatct ataactagaa
     8341 aatacgaaaa aggaaaatta aaaaaaaaag ttgcctgagt taagtcatct ttccttgtag
     8401 caaatggctt tgtccaaatc ctttctgcat ggaatagctt aaggaaaaca aactccgctt
     8461 tctgatgaac aagatatttt tgtacacatt tatttcttgt taataacctg aggtcagacc
     8521 actcatttgc tgaagccata actgaccttc accaaataaa tgttgtaaag aacctagggg
     8581 agggttgggg agagactgag agggaggaaa atccaaggtg tcatgagcta tagcaacaca
     8641 ggcaggagca agttgttgaa actgatgctt ttcctgcatc ccaaatatga ctttaaaagg
     8701 ctagtatttt atgatgatcg atttataatg ataaaaagat atttagattt aaatgagaca
     8761 ttccaatatt tttgaaatcc ctaacaatgc ttccttgctt ttaggattga gagaaatgat
     8821 tttcatatac ttccaacatt cagagattta atgtttttac cttagctcca gcctacgctt
     8881 gtaaagtgaa gagtgattct aagtcccgtg aaaccgtggg ctgcctgggg cttggctgtg
     8941 cccactaacc tactgcgcct ggggggcagc atgggagggg tacagtttgc atctcattag
     9001 catgcacacc actgttggca atgcataaaa gttgcattgc cacaagtatg taaaataaaa
     9061 atattcactc taaaaagaat aataattcta cttttttaaa agaataatgt ctcttatagt
     9121 caccattgat ttttctggag tttaattaca ttattaccat gtattcttat tggcctgtag
     9181 aggaaaaagg caaaccacaa ataaacccag tgacatatat agttttaaaa tctacaattt
     9241 tctgatctct ctctccttgt ttaatatata agccctaatt tctgtgtatg tgagtaaaac
     9301 tgcagcctga gtcatttagg aagtaagtat tgagtttttt taatcataaa tatactagaa
     9361 taaaacagca ctccctaaca attaaaaaag agttttatat tactttagaa tgtaataggt
     9421 ttttgtcctt attttatgtc ctgtaaatta ttagttcaat actgttagca ttcccggata
     9481 atgcacacat gatttctgaa tgttttctgt aaatgacaat caatgtttat gaagtttcct
     9541 cctttaatgc tgaacaaaat taaaagaaga aaaagaaaaa a
//
