LOCUS       NM_134261              10827 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens RAR related orphan receptor A (RORA), transcript
            variant 1, mRNA.
ACCESSION   NM_134261
VERSION     NM_134261.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10827)
  AUTHORS   Wang,M., Zeng,R., Zheng,S. and Qian,Y.
  TITLE     Retinoic acid receptor-related orphan receptor alpha and synthetic
            RORalpha agonist against invasion and metastasis in tongue squamous
            cell carcinoma
  JOURNAL   Biochem Biophys Res Commun 733, 150421 (2024)
   PUBMED   39047426
  REMARK    GeneRIF: Retinoic acid receptor-related orphan receptor alpha and
            synthetic RORalpha agonist against invasion and metastasis in
            tongue squamous cell carcinoma.
REFERENCE   2  (bases 1 to 10827)
  AUTHORS   Sanchez-Martin,S., Altuna-Coy,A., Arreaza-Gil,V., Bernal-Escote,X.,
            Fontgivell,J.F.G., Ascaso-Til,H., Segarra-Tomas,J., Ruiz-Plazas,X.
            and Chacon,M.R.
  TITLE     Tumoral periprostatic adipose tissue exovesicles-derived miR-20a-5p
            regulates prostate cancer cell proliferation and inflammation
            through the RORA gene
  JOURNAL   J Transl Med 22 (1), 661 (2024)
   PUBMED   39010137
  REMARK    GeneRIF: Tumoral periprostatic adipose tissue exovesicles-derived
            miR-20a-5p regulates prostate cancer cell proliferation and
            inflammation through the RORA gene.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10827)
  AUTHORS   Akula,M., McNamee,S.M., Love,Z., Nasraty,N., Chan,N.P.M.,
            Whalen,M., Avola,M.O., Olivares,A.M., Leehy,B.D., Jelcick,A.S.,
            Singh,P., Upadhyay,A.K., Chen,D.F. and Haider,N.B.
  TITLE     Retinoic acid related orphan receptor alpha is a genetic modifier
            that rescues retinal degeneration in a mouse model of Stargardt
            disease and Dry AMD
  JOURNAL   Gene Ther 31 (7-8), 413-421 (2024)
   PUBMED   38755404
  REMARK    GeneRIF: Retinoic acid related orphan receptor alpha is a genetic
            modifier that rescues retinal degeneration in a mouse model of
            Stargardt disease and Dry AMD.
REFERENCE   4  (bases 1 to 10827)
  AUTHORS   Li,M., Guo,H., Wang,B., Han,Z., Wu,S., Liu,J., Huang,H., Zhu,J.,
            An,F., Lin,Z., Mo,K., Tan,J., Liu,C., Wang,L., Deng,X., Li,G.,
            Ji,J. and Ouyang,H.
  TITLE     The single-cell transcriptomic atlas and RORA-mediated 3D
            epigenomic remodeling in driving corneal epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 256 (2024)
   PUBMED   38177186
  REMARK    GeneRIF: The single-cell transcriptomic atlas and RORA-mediated 3D
            epigenomic remodeling in driving corneal epithelial
            differentiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10827)
  AUTHORS   Chen,Y., Zhang,S.P., Gong,W.W., Zheng,Y.Y., Shen,J.R., Liu,X.,
            Gu,Y.H., Shi,J.H. and Meng,G.L.
  TITLE     Novel Therapeutic Potential of Retinoid-Related Orphan Receptor
            alpha in Cardiovascular Diseases
  JOURNAL   Int J Mol Sci 24 (4), 3462 (2023)
   PUBMED   36834872
  REMARK    GeneRIF: Novel Therapeutic Potential of Retinoid-Related Orphan
            Receptor alpha in Cardiovascular Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10827)
  AUTHORS   Giguere,V., Beatty,B., Squire,J., Copeland,N.G. and Jenkins,N.A.
  TITLE     The orphan nuclear receptor ROR alpha (RORA) maps to a conserved
            region of homology on human chromosome 15q21-q22 and mouse
            chromosome 9
  JOURNAL   Genomics 28 (3), 596-598 (1995)
   PUBMED   7490103
REFERENCE   7  (bases 1 to 10827)
  AUTHORS   Steinhilber,D., Brungs,M., Werz,O., Wiesenberg,I., Danielsson,C.,
            Kahlen,J.P., Nayeri,S., Schrader,M. and Carlberg,C.
  TITLE     The nuclear receptor for melatonin represses 5-lipoxygenase gene
            expression in human B lymphocytes
  JOURNAL   J Biol Chem 270 (13), 7037-7040 (1995)
   PUBMED   7706239
REFERENCE   8  (bases 1 to 10827)
  AUTHORS   Forman,B.M., Chen,J., Blumberg,B., Kliewer,S.A., Henshaw,R.,
            Ong,E.S. and Evans,R.M.
  TITLE     Cross-talk among ROR alpha 1 and the Rev-erb family of orphan
            nuclear receptors
  JOURNAL   Mol Endocrinol 8 (9), 1253-1261 (1994)
   PUBMED   7838158
REFERENCE   9  (bases 1 to 10827)
  AUTHORS   Giguere,V., Tini,M., Flock,G., Ong,E., Evans,R.M. and
            Otulakowski,G.
  TITLE     Isoform-specific amino-terminal domains dictate DNA-binding
            properties of ROR alpha, a novel family of orphan hormone nuclear
            receptors
  JOURNAL   Genes Dev 8 (5), 538-553 (1994)
   PUBMED   7926749
REFERENCE   10 (bases 1 to 10827)
  AUTHORS   Becker-Andre,M., Andre,E. and DeLamarter,J.F.
  TITLE     Identification of nuclear receptor mRNAs by RT-PCR amplification of
            conserved zinc-finger motif sequences
  JOURNAL   Biochem Biophys Res Commun 194 (3), 1371-1379 (1993)
   PUBMED   7916608
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107905.5, AC009560.10,
            KC877553.1 and AC087385.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_134261.2.
            
            Summary: The protein encoded by this gene is a member of the NR1
            subfamily of nuclear hormone receptors. It can bind as a monomer or
            as a homodimer to hormone response elements upstream of several
            genes to enhance the expression of those genes. The encoded protein
            has been shown to interact with NM23-2, a nucleoside diphosphate
            kinase involved in organogenesis and differentiation, as well as
            with NM23-1, the product of a tumor metastasis suppressor candidate
            gene. Also, it has been shown to aid in the transcriptional
            regulation of some genes involved in circadian rhythm. Four
            transcript variants encoding different isoforms have been described
            for this gene. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1), also called RORalpha1,
            utilizes a different 5' exon than the other variants and encodes
            isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.257716.1,
                                           SRR1803617.53621.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335670.11/ ENSP00000335087.6
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AC107905.5         30389-30638         c
            251-280             AC009560.10        113464-113493       c
            281-366             KC877553.1         133-218             c
            367-508             AC087385.5         4763-4904
            509-904             AC087385.5         7899-8294
            905-1026            AC087385.5         13891-14012
            1027-1159           AC087385.5         15853-15985
            1160-1267           AC087385.5         16653-16760
            1268-1378           AC087385.5         18451-18561
            1379-1491           AC087385.5         19516-19628
            1492-10827          AC087385.5         21901-31236
FEATURES             Location/Qualifiers
     source          1..10827
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.2"
     gene            1..10827
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /note="RAR related orphan receptor A"
                     /db_xref="GeneID:6095"
                     /db_xref="HGNC:HGNC:10258"
                     /db_xref="MIM:600825"
     exon            1..250
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1656
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /note="isoform a is encoded by transcript variant 1;
                     retinoic acid receptor-related orphan receptor alpha;
                     transcription factor RZR-alpha; ROR-alpha; nuclear
                     receptor ROR-alpha; retinoid-related orphan receptor
                     alpha; nuclear receptor RZR-alpha; nuclear receptor
                     subfamily 1 group F member 1; RAR-related orphan nuclear
                     receptor alpha"
                     /codon_start=1
                     /product="nuclear receptor ROR-alpha isoform a"
                     /protein_id="NP_599023.1"
                     /db_xref="CCDS:CCDS10177.1"
                     /db_xref="GeneID:6095"
                     /db_xref="HGNC:HGNC:10258"
                     /db_xref="MIM:600825"
                     /translation="MESAPAAPDPAASEPGSSGADAAAGSRETPLNQESARKSEPPAP
                     VRRQSYSSTSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ
                     SNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEV
                     QKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAV
                     SSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHL
                     AQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYV
                     VEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFK
                     SLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQ
                     LALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYK
                     ELFTSEFEPAMQIDG"
     exon            251..280
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /inference="alignment:Splign:2.1.0"
     exon            281..366
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /inference="alignment:Splign:2.1.0"
     exon            367..508
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /inference="alignment:Splign:2.1.0"
     exon            509..904
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1026
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1159
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1267
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1378
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1491
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..10827
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1822..1827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /note="hexamer: AATAAA"
     polyA_site      1851
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
     regulatory      10803..10808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /note="hexamer: AATAAA"
     polyA_site      10827
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /note="major polyA site"
ORIGIN      
        1 gtaccataga gttgctctga aaacagaaga tagagggagt ctcggagctc gccatctcca
       61 gcgatctcta cattgggaaa aaacatggag tcagctccgg cagcccccga ccccgccgcc
      121 agcgagccag gcagcagcgg cgcggacgcg gccgccggct ccagggagac cccgctgaac
      181 caggaatccg cccgcaagag cgagccgcct gccccggtgc gcagacagag ctattccagc
      241 accagcagag gtatctcagt aacgaagaag acacatacat ctcaaattga aattattcca
      301 tgcaagatct gtggagacaa atcatcagga atccattatg gtgtcattac atgtgaaggc
      361 tgcaagggct ttttcaggag aagtcagcaa agcaatgcca cctactcctg tcctcgtcag
      421 aagaactgtt tgattgatcg aaccagtaga aaccgctgcc aacactgtcg attacagaaa
      481 tgccttgccg tagggatgtc tcgagatgct gtaaaatttg gccgaatgtc aaaaaagcag
      541 agagacagct tgtatgcaga agtacagaaa caccggatgc agcagcagca gcgcgaccac
      601 cagcagcagc ctggagaggc tgagccgctg acgcccacct acaacatctc ggccaacggg
      661 ctgacggaac ttcacgacga cctcagtaac tacattgacg ggcacacccc tgaggggagt
      721 aaggcagact ccgccgtcag cagcttctac ctggacatac agccttcccc agaccagtca
      781 ggtcttgata tcaatggaat caaaccagaa ccaatatgtg actacacacc agcatcaggc
      841 ttctttccct actgttcgtt caccaacggc gagacttccc caactgtgtc catggcagaa
      901 ttagaacacc ttgcacagaa tatatctaaa tcgcatctgg aaacctgcca atacttgaga
      961 gaagagctcc agcagataac gtggcagacc tttttacagg aagaaattga gaactatcaa
     1021 aacaagcagc gggaggtgat gtggcaattg tgtgccatca aaattacaga agctatacag
     1081 tatgtggtgg agtttgccaa acgcattgat ggatttatgg aactgtgtca aaatgatcaa
     1141 attgtgcttc taaaagcagg ttctctagag gtggtgttta tcagaatgtg ccgtgccttt
     1201 gactctcaga acaacaccgt gtactttgat gggaagtatg ccagccccga cgtcttcaaa
     1261 tccttaggtt gtgaagactt tattagcttt gtgtttgaat ttggaaagag tttatgttct
     1321 atgcacctga ctgaagatga aattgcatta ttttctgcat ttgtactgat gtcagcagat
     1381 cgctcatggc tgcaagaaaa ggtaaaaatt gaaaaactgc aacagaaaat tcagctagct
     1441 cttcaacacg tcctacagaa gaatcaccga gaagatggaa tactaacaaa gttaatatgc
     1501 aaggtgtcta ccttaagagc cttatgtgga cgacatacag aaaagctaat ggcatttaaa
     1561 gcaatatacc cagacattgt gcgacttcat tttcctccat tatacaagga gttgttcact
     1621 tcagaatttg agccagcaat gcaaattgat gggtaaatgt tatcacctaa gcacttctag
     1681 aatgtctgaa gtacaaacat gaaaaacaaa caaaaaaatt aaccgagaca ctttatatgg
     1741 ccctgcacag acctggagcg ccacacactg cacatctttt ggtgatcggg gtcaggcaaa
     1801 ggaggggaaa caatgaaaac aaataaaagt tgaacttgtt tttctcatgc atatgatttc
     1861 cattatgcct acagatatgg accctttttc tgtcttgact tcttgatcat tgacctctgt
     1921 ttacaacagg aggagggtac taaagtcgga ggatttcctt ttcttgtagc tcactgccca
     1981 cagactttct acagagtcac caatctgtca gtaacaacag agagtccagc aataatcggt
     2041 gactggtgtg catagcggag gttgcggcat tactttgcac aactagctct ttgtttcatg
     2101 aaggaagttt ttattttttc accgattatt gccagtccgc aggatggcat gaaaagggtc
     2161 catagcagta gcaacaatag cattataata tattacaggg taaatgggca tgaagactat
     2221 atatagctaa aagagatatt gtttatatat tgttttaagt aatataaaat gtagttactg
     2281 gtgtagcttt tcctgttgaa ttgataaggc actttcattt tgcacctttt tctttaaatt
     2341 aaatgctagc gtgttcactg tcgtgtcgca tgtgcaccag aaacacaagt ttaactgaga
     2401 aggcttggaa ggtacgttgg gaggtattta tgctgctgtt tacaaaatta tttttaagag
     2461 actggctggt catatctaga aatcaccacg ttggattttt tttttaacat gtgaatttgg
     2521 aattagaaac ggaactctcc ctaaattata ctttgctttt tggtaagttt aatgatagat
     2581 gtgtttatgc ttcatacaaa gttgaatgat tgattggcgt ggtggacata taccatcatg
     2641 ctcatttttt ttttttaaag ctttttaaaa tgccacctca tggaggcgag ggggaggaga
     2701 agctcatttt acacaattca gtagttaaat atggactcgg tctcaacttg gaattcttat
     2761 gctttgagaa caaatcaaca accagaatat ttattggaat ctagctttta ttataagaag
     2821 gacccaaaga ttatatcctg agcaaatgca cactccccat gtgaggacat gaagtattta
     2881 ctttgtgaat gtttatgttc ttggtataat ctaggaaccc tatgagttta tctcagagtg
     2941 aactaattct agatttgttg tcaatagatg ctataattca agaatgttgc tctccatatt
     3001 tgaaaaacga tggataggag ggtgagggaa gcatacaatg ttgaaccagt ttctcttatt
     3061 taaatattaa atactttaag cctttaaagt gaagttgatg ctagctgcaa acatttactc
     3121 ttgtatttat cttcactagg aaactgtgga ctgtaattta ttttattaaa tatttagaag
     3181 attatttggc ttgtgtgttc aggtgagaaa tactgagttg tttttgttta atttcatggt
     3241 tttttttttt ttaatgatcc ctagtggggg aaggggaaag gaatagtctg ataaacagat
     3301 gtgcatattt taaaaacaag tgaccttttg ggaatgtagg catttagacg atgattttag
     3361 tcgcactagg ggtgggattc aaactactgg tcaaagacca ttttgtacag aaaagggaac
     3421 atctccgatg ggtgttaagg taggagtttc catgcagccc tttatgtctg agaaatagtc
     3481 tcctctgcca ttggggtccc tgcggaatct tctacaggaa ttgcagctct tcacgtcatg
     3541 ctaggttacc agcatgggct tcccagagca cttcactctg tttctaactc cactgacttt
     3601 tctgacttgt ttcttgaggg acttggaaaa ggggaaggta ttattcacac agatgtgtgt
     3661 atgaagccta aataacatcc aacttttttt ccaaaaacat agtaagagtt taaccataaa
     3721 tagaagagta atattccttt aaatttctta caggcatgta aaattttatg tgtttataga
     3781 gagatgctaa ctgtcagcat atagtattta tattggggca agaagggtta aatcaaatct
     3841 ttaatttaag taagcatagt tcctttaaag atcagtagta tttatactct gaaaagagta
     3901 ccaagcttag ttcagttatt tattcatcca ttttttttct attgtttctc ctctgggggg
     3961 aaatggtgtt ttgtttttgt ttgagttttg tgttttagtt ttttggtttt ggttttgttt
     4021 tgtttttttg tcattcagat tcactaaatt tggggatggt tttattaaag tatattaact
     4081 tctttttaac caaagctttc tgaatatgac cagcctcagg tgctagcgca ttaaagagca
     4141 actaaaccta attccagtgt cgatttgtga aataataaaa gctaattgaa tttctctaag
     4201 ggtgagagag aacataatga tgaacttaaa aagaaattcc ttttcccaga agggattctg
     4261 catgtaccta caaacaatca tgctctaacc acagtaatag tcatgccatg gtgacattgc
     4321 ttttacggta aaccaagata ggtaatatga tgcttcttcc caggtgtttc tgaaagaaaa
     4381 gcagcggtgg agcttaagag ccaagtccac tgattgacat aataggatgg aattgtagac
     4441 agagacatgc tccatgaaac aaggaaacaa ctgactacta tttggatcta agttgggatc
     4501 tgatgttaaa caataaattc agtttaaaaa aaatatggag ctcagaaaag gatgtgaaaa
     4561 actttgcatt ttcctttctt cattattaca aaaacaccta tgtgatgaca taaaatactt
     4621 gggtgatatc agaacaatta tccttaatag tttttataat taaagtttcc taaacttcag
     4681 tctccaatag tcttttaagg attggaacca catcactgtc agccccgctg ctacaatgcc
     4741 tttgtacaat ttttttacat aaggcaaata aggcttttgt acaaagcctg aataccttct
     4801 gttccaatgg tgtccaaatg gttattatat tgtgaaaaac ctggccttgg tcacaatgca
     4861 aacaaaagta cagatgaaag tgctttttgg acagtttgca aattgtgtta aagctacgga
     4921 ttttttttaa agtgttcagc atcttaacgt gtattaaagc tatggatttt tttttaaagt
     4981 cttcagcatc ctaattcacc ctttctaact taagaaaaac atgacttaag acactgcttc
     5041 taagtttggt tgttctttat agtgtggata cccagttatc tgtgagcgta tgggggtggg
     5101 ctgagggtca ggtgaggaag gagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     5161 gatttgcatg tgtatgatgt gtgtgcgtcg gaccgcttct aggctactaa gtgtcaatgg
     5221 aaaagaaaat gtattcaaaa tacttaaatc aaaactagaa gatggggaaa aaaagattta
     5281 ttctatacaa agccttgtct ggaccacttt agagagactt ctattttttt aacccttcta
     5341 taaatatttg atggcacttg aaatattcct gcaataaaat gtgatttgtg taaagaaaaa
     5401 aagattttgt aatgtgaaac aaagaaagaa agtaatgtaa ttttctaaaa aaaaaaatac
     5461 aaacaaacaa actttgtatt attttcttga tggaatttgt ctatctgtct ttggaaaact
     5521 ttttatttca ttgaatgtgc catagtagaa atgtgtgttt ttagttttag actaaggaat
     5581 agctagttgt tgtgttccga cattccaaaa tgcaaaacaa cctagtagta tctttcatga
     5641 aaaggtttaa gtagtatgta agcttctctc attgttgctt ttttgcacat gttcttcatt
     5701 cctctctagt gcaatatgta catagagcac ttgcgggtgt accttgatcc ctcagggaaa
     5761 aatacatatt tgtacagttt tttggggttt ttttgttttt tggttttttt tgttttgcct
     5821 tttgtttttg gctaaggaat gtcgatcgaa tcacttgtta ttgttgaggg gcagccagat
     5881 aataatccta aagccactgt ttccaacatt gattgtttaa atcatatgtc cttccaatgc
     5941 tattatttta agataataat aaaaagttat tttctgacag ttctttgtgc tgactggtga
     6001 aaaacaaggg taaataagca ccttataatt gacttactgt gaatgacaat ccatcttggt
     6061 atcaacgata gaagccctat cattttggag ttggggttaa gagtcagaaa caatgtgctc
     6121 agggatctcc taaaactctt aaaacagggt ggccagtact actgggacaa attgtgtttt
     6181 ttattattaa taataatgat aataatacta tccctccaag gcacaagtga actatataga
     6241 actgcgtgtg tgtaaactct ttactctcgt ctcattttgt tgagtttaga acttgatgtg
     6301 ctcgtcagtc ttgtgtttca aaacactgaa taacttccaa agcaaagtta tgccagtgtg
     6361 ttcaaaagat aaattaataa tgtaccagca aagagcatca ttcaaagtat agtccttgca
     6421 tattccagtt accatttctc taataattaa aatattcatg ataaatatat atatagcatc
     6481 atatgttaaa aactatttca aattctacat attaaggatg aaaattttaa aatccagtaa
     6541 taagaggaga gacctgccta tcagtacagt gatataggta aaagatgaaa tatgttttta
     6601 aaataccagc aattaactat tgttttcatg ggttctcctc tagaagcaaa ccaaaaattc
     6661 cttcatggaa aacaattctt acttctacat gtgtagttta tatctgatgc attacaagag
     6721 ctaatgttta aagacaaaac aaaacctgcc tgtatgacag cagcaactcg agccaacatt
     6781 tagtgttaca tgttatattt ttgaaatacc gttttgttat catattccac atattacttt
     6841 ccataaagtc agagaagttc aatgtaattg ttggctctga ttcttccacc ttgggataca
     6901 cattcacaag aagatttata tattttctta ctatgataga ggaacataat ctgggaaaac
     6961 ttcccatgtc tgtaagatga aaaggatacc tttaccatgt tgtttttgat aataaagaat
     7021 atggaaaatg gtagaaatct ctcctctcta tgtgtatttg tatatgtgtg tatacacaca
     7081 cacgttgaca tttttacata acatgtgatt gccacttctt ataaagttat gatatagaac
     7141 cccatgaaaa caactttata ttatagatca aataatgtgc ccagaaacgc aattgcaaca
     7201 gtaaatcttg atctattggt aagagtctat gatacaggtc ttcattctat ccctaaacat
     7261 aatgttagta aagaggttcc atcagattgt attatagaga ccttcctatt gctatttatt
     7321 tttaagagat gagaagactg actagcaatg tctccacagt gcaattggtt tcacttctgg
     7381 gtctgtctgt ctgtttgtgt aggtgagatc agtgttgtca ggctctcaga ataattttta
     7441 aaagaatcca gaagcctgac ttcacaccaa gtagccatcc tagatgggcg ggggggatct
     7501 ccatgttcaa ccaaaccctc agaacttaga gcaataaata cattcagtca tttatttata
     7561 aatgaatgac agaatattca atccaaatag aaacaacctt ttgtcagtga tgcaacataa
     7621 catggagtct tatattgaga aagtgaatat gaatatttta aatagatgcc taggaaatct
     7681 gtgtttgctg tttacattta atgtactttg ccacattagc agtaccacac ttcttttact
     7741 ttcatccttc taagaactaa tgaaagatag cttgctatta gctttgacat gttgcacatg
     7801 ccattatgtt gttctctaag aacaactaaa ttctctccag tgttcatgtg tgattccttt
     7861 ttcatcatta ttactttaat gtggatgaat actatttcta ggaacttgat tatcactgaa
     7921 cagattgcat atgtaaatgc agataattct tgagcaatat agtgaaaatg atttcacaaa
     7981 aaaaatccat atgtactgta tacatcttcc tgaatccaaa attctcctgt tatccacaca
     8041 gtttgaaatc tcatattaaa cagtggtaaa tttttaaaca ttaggacatt agctggctgc
     8101 ttctataaat gtacctgtat tgtctgcctg ctccttttgt ggagatgtgt ttttgtattg
     8161 gatgtttggg ccaatgggag gcttcaagct acaacatatt ttcccacttt aaataatatt
     8221 taacatatga caaaccccag acaaggcttt taatatgtat aaagaactgc agtgttaggt
     8281 ggtttatttg caaactgttt tcagtgttgt ccatttttat ggcaccttta acaatattct
     8341 tgtttccaaa gtacaaaaaa aataggttaa ataatctagc cataactgaa tgtcaagcaa
     8401 taaaacaaat gacttttgtg catagactta aaaaatacaa attttagaca tctgcatgta
     8461 aatgcaatct cttgtttact gctttcttca acttgagcaa tcgattcctt atttactatt
     8521 aacttaagaa cttgtaacgg cctgtaaaca ttttctctct tactcttctt tcaaatttac
     8581 ctgtccctgc ttttgagtca taatatttaa tgttgttctg cacatctcta tacagttaac
     8641 tttttggctt tcattctgta tagataagaa aatgttatat tataaacagc ctactcagtg
     8701 caaatattta tctgtttatc aaatccacaa tatgctgtat aataccggtt ttactatata
     8761 atctatttta gacatagctg tttagaacta gagtgtgcta tttttgtgtt tttctgatgt
     8821 gtggtgctag acaagttact tttgtgaaca acaaaaatta tcccttttat tcctagacaa
     8881 taccaccttt gggtcttgtt aatttcactg agtataacta tatatttgta tatatataca
     8941 tatatatata tatctaccta tgcccaactg gcagctgtat cagagtgctg gatttgggac
     9001 atgcttttct ctttaaatac ataatatcat tatataaatt attctagagt gtatttaatt
     9061 aggataaaat tacttcctta gtatggatat ttgacatcta tagggtgaat ttgtttataa
     9121 atatggctat atggaaactt attagcattt actttatgtt tgctacttgg ctttacagca
     9181 tatctcctaa gctgaaaaat aatttgccag gccttcaaga tcctaaagaa acttgtttaa
     9241 tggagtaata tacttttttt tcttattaag gaattgtatt actggcacct aacacagttg
     9301 tattcttagc tcctattata gataatgggc atttacataa aatatcctag atggcttgat
     9361 ggcagaataa acctttcccc tcctacctga gtcatgagaa ggatggagac gtcctctgcc
     9421 ataacatggg ccataaagca aattcgacat gggatgttct gtttcagtat gacctcaacc
     9481 agttccatga actgagtgaa ggaccttcat tttcaaagtt atttaataag tagcttaatt
     9541 aagcctttct acccattctc ccaagatcta ctggcattat tgaaaagcaa agtttatcaa
     9601 atatctaact aaggatgtag ttaaccttat taaatattga ttagaattgt tctgtaatat
     9661 tactgaattt gtaagatctt tagcaaagat ttttgagcaa tttataaatg tagagcaaat
     9721 gtttctgttt actgcacttt ttgtaactga aggtgataaa ttctcaagcc atgattattg
     9781 gcttccatgc actgcaatat ttatccacaa ttctagacat tttccatttt tgtggaagag
     9841 ttgctgttac cttaattata aatgcaattg tgtggttaat gagagctaat gctagtagtt
     9901 aaccttttaa agtggattgg ctacagttga gggagaaatc tcttttaata taaatcacat
     9961 cattccttaa ctgcctctct tggaaagaga ttgaaacctt ttttttaaag cacgatttag
    10021 catcctaagc ttcctgaggg tagagattgt atctttttgc gtctgcacaa tggctagcac
    10081 atgtcagcat ttgacaattg ttaaatgata acaagtgtgc cccaattaaa acgtttttcc
    10141 tgggttgttt tgttaaattt acaaagtaag ccaagcctta cggttaacat tctcctctac
    10201 aaccaagtat taaagccaca tttaaaaaga ccacatgaaa tgctgattct aattgtgtgt
    10261 aggtcttgag gattaagcac acaaatttca caaacttctg tttgagtaaa caaactcagc
    10321 cttctgtaaa tatacatgca agtttggaaa cagtaatact gtacctataa atatatgctg
    10381 tctgttttgt gtacagtatg taaaaactcc ttttctgcca cactaaaaat gcaagccatt
    10441 tatgggaatc ctaaaactag tattgaacta aaactttgct aatgatcttt attagaggat
    10501 cgtccaactt ttcacttacc ttgggttttc ttttcaattc actcttacac tagtctgctt
    10561 atttccagct gtttatttta ttgagtcctg aatttaaaaa aaaaatattt tgattcattt
    10621 tgtaaataca agctgtacaa aaaagagaga tttaatgttg tcttttaaat actccaattt
    10681 tcattctaat atgaatgttg ttatattgta cttagaaact gtacctttaa tattacatta
    10741 cctttattaa aagtgcattg aacacatcaa ttttagatgt gctttatgta ctgttatcct
    10801 ataataaaac ttcagcttct aatggaa
//
