LOCUS       NM_005012               5858 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens receptor tyrosine kinase like orphan receptor 1
            (ROR1), transcript variant 1, mRNA.
ACCESSION   NM_005012
VERSION     NM_005012.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5858)
  AUTHORS   Yamauchi,N., Otsuka,M., Ishikawa,T., Kakeji,Y., Kikuchi,A.,
            Masuda,A., Kodama,Y., Minami,Y. and Kamizaki,K.
  TITLE     Role of Wnt5b-Ror1 signaling in the proliferation of pancreatic
            ductal adenocarcinoma cells
  JOURNAL   Genes Cells 29 (6), 503-511 (2024)
   PUBMED   38531660
  REMARK    GeneRIF: Role of Wnt5b-Ror1 signaling in the proliferation of
            pancreatic ductal adenocarcinoma cells.
REFERENCE   2  (bases 1 to 5858)
  AUTHORS   Kamizaki,K., Minami,Y. and Nishita,M.
  TITLE     Role of the Ror family receptors in Wnt5a signaling
  JOURNAL   In Vitro Cell Dev Biol Anim 60 (5), 489-501 (2024)
   PUBMED   38587578
  REMARK    GeneRIF: Role of the Ror family receptors in Wnt5a signaling.
            Review article
REFERENCE   3  (bases 1 to 5858)
  AUTHORS   de Sousa,F.A., Millan,N.M., Correia,R.P., da Costa Vaz,A.,
            Schimidell,D., Miyamoto,P.C., Passaro,M.S., Nogueira,B.G.,
            Souto,E.X., Bacal,N.S. and Bento,L.C.
  TITLE     ROR1 expression in mature B lymphoid neoplasms by flow cytometry
  JOURNAL   Cytometry B Clin Cytom 106 (1), 74-81 (2024)
   PUBMED   38273649
  REMARK    GeneRIF: ROR1 expression in mature B lymphoid neoplasms by flow
            cytometry.
REFERENCE   4  (bases 1 to 5858)
  AUTHORS   Heabah,N.A.E., Darwish,S.A. and Eid,A.M.
  TITLE     Evaluation of the prognostic significance of receptor tyrosine
            kinase-like orphan receptor 1 (ROR1) in lung carcinoma and its
            relation to lymphangiogenesis and epithelial mesenchymal transition
  JOURNAL   Pathol Res Pract 248, 154703 (2023)
   PUBMED   37481855
  REMARK    GeneRIF: Evaluation of the prognostic significance of receptor
            tyrosine kinase-like orphan receptor 1 (ROR1) in lung carcinoma and
            its relation to lymphangiogenesis and epithelial mesenchymal
            transition.
REFERENCE   5  (bases 1 to 5858)
  AUTHORS   Huang,W., Tang,H., Liu,Y., Li,W., Shimu,A.S., Li,B. and Zhu,C.
  TITLE     ROR1/STAT3 positive feedback loop facilitates cartilage
            degeneration in Osteoarthritis through activation of NF-kappaB
            signaling pathway
  JOURNAL   Int Immunopharmacol 121, 110433 (2023)
   PUBMED   37343369
  REMARK    GeneRIF: ROR1/STAT3 positive feedback loop facilitates cartilage
            degeneration in Osteoarthritis through activation of NF-kappaB
            signaling pathway.
REFERENCE   6  (bases 1 to 5858)
  AUTHORS   Paganoni,S. and Ferreira,A.
  TITLE     Neurite extension in central neurons: a novel role for the receptor
            tyrosine kinases Ror1 and Ror2
  JOURNAL   J Cell Sci 118 (Pt 2), 433-446 (2005)
   PUBMED   15654020
  REMARK    GeneRIF: The ROR1 protein modulates the growth of neurites as well
            as their branching pattern in hippocampal neurons.
REFERENCE   7  (bases 1 to 5858)
  AUTHORS   Nomi,M., Oishi,I., Kani,S., Suzuki,H., Matsuda,T., Yoda,A.,
            Kitamura,M., Itoh,K., Takeuchi,S., Takeda,K., Akira,S., Ikeya,M.,
            Takada,S. and Minami,Y.
  TITLE     Loss of mRor1 enhances the heart and skeletal abnormalities in
            mRor2-deficient mice: redundant and pleiotropic functions of mRor1
            and mRor2 receptor tyrosine kinases
  JOURNAL   Mol Cell Biol 21 (24), 8329-8335 (2001)
   PUBMED   11713269
REFERENCE   8  (bases 1 to 5858)
  AUTHORS   Reddy,U.R., Phatak,S., Allen,C., Nycum,L.M., Sulman,E.P.,
            White,P.S. and Biegel,J.A.
  TITLE     Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32
            by fluorescence in situ hybridization and somatic cell hybrid
            analysis
  JOURNAL   Genomics 41 (2), 283-285 (1997)
   PUBMED   9143508
REFERENCE   9  (bases 1 to 5858)
  AUTHORS   Reddy,U.R., Phatak,S. and Pleasure,D.
  TITLE     Human neural tissues express a truncated Ror1 receptor tyrosine
            kinase, lacking both extracellular and transmembrane domains
  JOURNAL   Oncogene 13 (7), 1555-1559 (1996)
   PUBMED   8875995
REFERENCE   10 (bases 1 to 5858)
  AUTHORS   Masiakowski,P. and Carroll,R.D.
  TITLE     A novel family of cell surface receptors with tyrosine kinase-like
            domain
  JOURNAL   J Biol Chem 267 (36), 26181-26190 (1992)
   PUBMED   1334494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161742.7, AK308088.1,
            M97675.1, AL137859.3, AL445205.14 and AK000776.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005012.3.
            
            Summary: This gene encodes a receptor tyrosine kinase-like orphan
            receptor that modulates neurite growth in the central nervous
            system. The encoded protein is a glycosylated type I membrane
            protein that belongs to the ROR subfamily of cell surface
            receptors. It is a pseudokinase that lacks catalytic activity and
            may interact with the non-canonical Wnt signalling pathway. This
            gene is highly expressed during early embryonic development but
            expressed at very low levels in adult tissues. Increased expression
            of this gene is associated with B-cell chronic lymphocytic
            leukaemia. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jun
            2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M97675.1, AK308088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371079.6/ ENSP00000360120.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL161742.7         25243-25244
            3-26                AK308088.1         7-30
            27-580              M97675.1           1-554
            581-581             AL137859.3         81283-81283
            582-1563            M97675.1           556-1537
            1564-1575           AL445205.14        47011-47022
            1576-1753           M97675.1           1550-1727
            1754-1754           AL445205.14        63531-63531
            1755-1952           M97675.1           1729-1926
            1953-1955           AL445205.14        81965-81967
            1956-3384           M97675.1           1930-3358
            3385-5787           AL445205.14        83397-85799
            5788-5858           AK000776.1         1804-1874
FEATURES             Location/Qualifiers
     source          1..5858
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..5858
                     /gene="ROR1"
                     /gene_synonym="dJ537F10.1; NTRKR1"
                     /note="receptor tyrosine kinase like orphan receptor 1"
                     /db_xref="GeneID:4919"
                     /db_xref="HGNC:HGNC:10256"
                     /db_xref="MIM:602336"
     exon            1..492
                     /gene="ROR1"
                     /gene_synonym="dJ537F10.1; NTRKR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..3215
                     /gene="ROR1"
                     /gene_synonym="dJ537F10.1; NTRKR1"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; neurotrophic tyrosine kinase, receptor-related
                     1; inactive tyrosine-protein kinase transmembrane receptor
                     ROR1"
                     /codon_start=1
                     /product="inactive tyrosine-protein kinase transmembrane
                     receptor ROR1 isoform 1 precursor"
                     /protein_id="NP_005003.2"
                     /db_xref="CCDS:CCDS626.1"
                     /db_xref="GeneID:4919"
                     /db_xref="HGNC:HGNC:10256"
                     /db_xref="MIM:602336"
                     /translation="MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTS
                     SWNISSELNKDSYLTLDEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEP
                     RRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGY
                     SDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDK
                     CSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMILMR
                     LKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQC
                     QPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACD
                     SKDSKEKNKMEILYILVPSVAIPLAIALLFFFICVCRNNQKSSSAPVQRQPKHVRGQN
                     VEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTL
                     KDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIM
                     RSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIG
                     EQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVL
                     WEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFK
                     DIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRYPNYMFPSQGITP
                     QGQIAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTGPPRVIQHCPPPKSRSP
                     SSASGSTSTGHVTSLPSSGSNQEANIPLLPHMSIPNHPGGMGITVFGNKSQKPYKIDS
                     KQASLLGDANIHGHTESMISAEL"
     exon            493..564
                     /gene="ROR1"
                     /gene_synonym="dJ537F10.1; NTRKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..852
                     /gene="ROR1"
                     /gene_synonym="dJ537F10.1; NTRKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..883
                     /gene="ROR1"
                     /gene_synonym="dJ537F10.1; NTRKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1011
                     /gene="ROR1"
                     /gene_synonym="dJ537F10.1; NTRKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1329
                     /gene="ROR1"
                     /gene_synonym="dJ537F10.1; NTRKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1575
                     /gene="ROR1"
                     /gene_synonym="dJ537F10.1; NTRKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1787
                     /gene="ROR1"
                     /gene_synonym="dJ537F10.1; NTRKR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..5858
                     /gene="ROR1"
                     /gene_synonym="dJ537F10.1; NTRKR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5806..5811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ROR1"
                     /gene_synonym="dJ537F10.1; NTRKR1"
                     /note="hexamer: ATTAAA"
     polyA_site      5825
                     /gene="ROR1"
                     /gene_synonym="dJ537F10.1; NTRKR1"
                     /note="major polyA site"
     regulatory      5837..5842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ROR1"
                     /gene_synonym="dJ537F10.1; NTRKR1"
                     /note="hexamer: ATTAAA"
     polyA_site      5858
                     /gene="ROR1"
                     /gene_synonym="dJ537F10.1; NTRKR1"
                     /note="major polyA site"
ORIGIN      
        1 aagttgagcg agagagggag cgtggagagc tggagcagcc gccaccgccg ccgccgaggg
       61 agccccggga cggcagcccc tgggcgcagg gtgcgctgtt ctcggagtcc gacccagggc
      121 gactcacgcc cactggtgcg acccggacag cctgggactg acccgccggc ccaggcgagg
      181 ctgcagccag agggctggga agggatcgcg ctcgcggcat ccagaggcgg ccaggcggag
      241 gcgagggagc aggttagagg gacaaagagc tttgcagacg tccccggcgt cctgcgagcg
      301 ccagcggccg ggacgaggcg gccgggagcc cgggaagagc ccgtggatgt tctgcgcgcg
      361 gcctgggagc cgccgccgcc gccgcctcag cgagaggagg aatgcaccgg ccgcgccgcc
      421 gcgggacgcg cccgccgctc ctggcgctgc tggccgcgct gctgctggcc gcacgcgggg
      481 ctgctgccca agaaacagag ctgtcagtca gtgctgaatt agtgcctacc tcatcatgga
      541 acatctcaag tgaactcaac aaagattctt acctgaccct cgatgaacca atgaataaca
      601 tcaccacgtc tctgggccag acagcagaac tgcactgcaa agtctctggg aatccacctc
      661 ccaccatccg ctggttcaaa aatgatgctc ctgtggtcca ggagccccgg aggctctcct
      721 ttcggtccac catctatggc tctcggctgc ggattagaaa cctcgacacc acagacacag
      781 gctacttcca gtgcgtggca acaaacggca aggaggtggt ttcttccact ggagtcttgt
      841 ttgtcaagtt tggcccccct cccactgcaa gtccaggata ctcagatgag tatgaagaag
      901 atggattctg tcagccatac agagggattg catgtgcaag atttattggc aaccgcaccg
      961 tctatatgga gtctttgcac atgcaagggg aaatagaaaa tcagatcaca gctgccttca
     1021 ctatgattgg cacttccagt cacttatctg ataagtgttc tcagttcgcc attccttccc
     1081 tgtgccacta tgccttcccg tactgcgatg aaacttcatc cgtcccaaag ccccgtgact
     1141 tgtgtcgcga tgaatgtgaa atcctggaga atgtcctgtg tcaaacagag tacatttttg
     1201 caagatcaaa tcccatgatt ctgatgaggc tgaaactgcc aaactgtgaa gatctccccc
     1261 agccagagag cccagaagct gcgaactgta tccggattgg aattcccatg gcagatccta
     1321 taaataaaaa tcacaagtgt tataacagca caggtgtgga ctaccggggg accgtcagtg
     1381 tgaccaaatc agggcgccag tgccagccat ggaattccca gtatccccac acacacactt
     1441 tcaccgccct tcgtttccca gagctgaatg gaggccattc ctactgccgc aacccaggga
     1501 atcaaaagga agctccctgg tgcttcacct tggatgaaaa ctttaagtct gatctgtgtg
     1561 acatcccagc gtgcgattca aaggattcca aggagaagaa taaaatggaa atcctgtaca
     1621 tactagtgcc aagtgtggcc attcccctgg ccattgcttt actcttcttc ttcatttgcg
     1681 tctgtcggaa taaccagaag tcatcgtcgg caccagtcca gaggcaacca aaacacgtca
     1741 gaggtcaaaa tgtagagatg tcaatgctga atgcatataa acccaagagc aaggctaaag
     1801 agctacctct ttctgctgta cgctttatgg aagaattggg tgagtgtgcc tttggaaaaa
     1861 tctataaagg ccatctctat ctcccaggca tggaccatgc tcagctggtt gctatcaaga
     1921 ccttgaaaga ctataacaac ccccagcaat ggacggaatt tcaacaagaa gcctccctaa
     1981 tggcagaact gcaccacccc aatattgtct gccttctagg tgccgtcact caggaacaac
     2041 ctgtgtgcat gctttttgag tatattaatc agggggatct ccatgagttc ctcatcatga
     2101 gatccccaca ctctgatgtt ggctgcagca gtgatgaaga tgggactgtg aaatccagcc
     2161 tggaccacgg agattttctg cacattgcaa ttcagattgc agctggcatg gaatacctgt
     2221 ctagtcactt ctttgtccac aaggaccttg cagctcgcaa tattttaatc ggagagcaac
     2281 ttcatgtaaa gatttcagac ttggggcttt ccagagaaat ttactccgct gattactaca
     2341 gggtccagag taagtccttg ctgcccattc gctggatgcc ccctgaagcc atcatgtatg
     2401 gcaaattctc ttctgattca gatatctggt cctttggggt tgtcttgtgg gagattttca
     2461 gttttggact ccagccatat tatggattca gtaaccagga agtgattgag atggtgagaa
     2521 aacggcagct cttaccatgc tctgaagact gcccacccag aatgtacagc ctcatgacag
     2581 agtgctggaa tgagattcct tctaggagac caagatttaa agatattcac gtccggcttc
     2641 ggtcctggga gggactctca agtcacacaa gctctactac tccttcaggg ggaaatgcca
     2701 ccacacagac aacctccctc agtgccagcc cagtgagtaa tctcagtaac cccagatatc
     2761 ctaattacat gttcccgagc cagggtatta caccacaggg ccagattgct ggtttcattg
     2821 gcccgccaat acctcagaac cagcgattca ttcccatcaa tggataccca atacctcctg
     2881 gatatgcagc gtttccagct gcccactacc agccaacagg tcctcccaga gtgattcagc
     2941 actgcccacc tcccaagagt cggtccccaa gcagtgccag tgggtcgact agcactggcc
     3001 atgtgactag cttgccctca tcaggatcca atcaggaagc aaatattcct ttactaccac
     3061 acatgtcaat tccaaatcat cctggtggaa tgggtatcac cgtttttggc aacaaatctc
     3121 aaaaacccta caaaattgac tcaaagcaag catctttact aggagacgcc aatattcatg
     3181 gacacaccga atctatgatt tctgcagaac tgtaaaatgc acaacttttg taaatgtggt
     3241 atacaggaca aactagacgg ccgtagaaaa gatttatatt caaatgtttt tattaaagta
     3301 aggttctcat ttagcagaca tcgcaacaag taccttctgt gaagtttcac tgtgtcttac
     3361 caagcaggac agacactcgg ccagaaaaaa aaaaaaaaaa aaaaaacaag caaacaaaaa
     3421 cattgtggga tgtgcactcc attggagtgc atgacatggc attgggattg gaacatgtgg
     3481 tttcgagcac tgaaagctgc aaaccagtga agaggaaaag aaccttgtga ttaaatataa
     3541 aaccaaaagt caaatggtgc tttgtgtttt agccttcagt caccatgact ggtctctccc
     3601 ccagatgtat atataccata gcatttgtct acctgctgtc ttttcttcag gacagatgtt
     3661 caggaattat attgattgaa tttagactct gtgcatgttc ttatggaaat gatgttcaga
     3721 atccatgaag aaacttcagg ccaaatttga aaccctggag ggaaatgagc cataagggaa
     3781 gtataacaag ccctgaagcc ttttatgtcg ttgtgcttct ttgggaaggt gtagagtgtg
     3841 cctttttgtg aatcctcctc tgatcatgag ggtctttccc acagtttctc acagtgtgtt
     3901 tacactgccc ttggaataac acagcgcatc agaccataag aaggctagat gtggatgcta
     3961 gaattgattg ttggttgata gttctctttg ctggattagg aatgaggcgc caaaggaagc
     4021 acagccagga aaatggcccc acagcctaga tcagcatctg tgggaaagga aaaagggttc
     4081 ccatggggac agcccccata ggagttttct ggaaccagta acactgaaaa ataagtgtgt
     4141 ggctacagat gagcacgccc accccttgca actccctgtt tacaagttgt ccgaggcatt
     4201 ggagtgctta tggtcaatgg gctctaggga agtaggaaac tccatcatga tacaaatgtc
     4261 tagtaatttt aaagtttctt tccctttttt tctgtgctgg aaatgttcac agatttgatt
     4321 cccgccccaa gaattacaac aatgtattca tacagtcagt tggaatccaa aggcaattaa
     4381 ttctattttg caaaatatga tggtcttcct aaaaaacaag tactgagttc tcatttcaaa
     4441 agttaccaag aactgaattc tttaaactag caaaccgaag taacatgacc atttttgcct
     4501 tagtgggagg tttcaaatgt gcagctcatg gcatttacct gccgaccatc ttttgccaag
     4561 tttagaattc ttatgcgttt caagttctat atagaaagta attttacttt tgatttttct
     4621 cttgttaaaa aaaaactcct ttattctaag aacaatgtct caaagtctca tttttacttt
     4681 aaaggtataa gagacttcta aagagactta cgggatataa aagtaattcc tggaaatgat
     4741 atttgatgag gagaatgtaa gagaatgaaa aacacattga tgttttcatt tttaaaaaat
     4801 acaactagca tgagaaatca agaaaatatg tttaccaaaa tgcattgcaa ttttcccaaa
     4861 cctgagtctt caaataacaa acatgaactt ataggtactg tgaactagaa gaattggtta
     4921 tatccagatt tctgggagat aaattaaaac atatttttgt ggcataaata agctgattca
     4981 gaagttacat ttcttaactt taggtagagg agaatatttg tatccttttg ttgctatgca
     5041 actgtttaat gatgaagctt caaaccacaa ttttgtatat catatgacaa tcaattgttt
     5101 tccaagaata tttattattt taagtacaca atttcagtga atcttgagtt tttctaggag
     5161 tcccttaaag ggaaattagc attccatgag ccagtaaaat acctactctg gtaaaacatt
     5221 attatggtta aaaagtaaat tcaagttagt tttttataaa gaactataac atttatttta
     5281 aacattttat aataactgaa aacattaaag tgagcaaatg aaatttcaaa accacttgta
     5341 ataatgtatt ttataatcgc actgtgatac tatataacac agtctctttt gtattaaaat
     5401 agtatttttt tcacaagctg aaaaatatct tttcctttgt tgacaatgtt ttgtaagatg
     5461 actttatttt cagatctttt tctccttttt tgcacaaaac tatgcttatg gtttgtgtca
     5521 cagaagtgaa aatatatctt tgcattttta tatctggtct gtttttcttg tttcctttgt
     5581 ttttaacttg atatagattt tcttcaaata tataatggca attttcagat atctcacctt
     5641 accatatctt tccttatttt cactgcatgc atttaatcac tgtattactt aatgtttgat
     5701 ttgttattat gggcatttca aataggcaag cattgaattg taatgacaaa aaggctattt
     5761 tatattaagg atatatgcat ttgtatttca cacaccagag atgatattaa acactgatta
     5821 ttttatgctg ctgtttatta aaaatgttta ctataaaa
//
