LOCUS       NM_031916               1061 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens rhophilin associated tail protein 1 like (ROPN1L),
            transcript variant 1, mRNA.
ACCESSION   NM_031916
VERSION     NM_031916.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1061)
  AUTHORS   Wang,J., Cai,X., Zhang,L. and Lei,D.
  TITLE     Linc01513 inhibits the malignant potential of Nasopharyngeal
            carcinoma by binding to PTBP1
  JOURNAL   J Cancer 12 (24), 7380-7389 (2021)
   PUBMED   35003358
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1061)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1061)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1061)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1061)
  AUTHORS   Ding,Y., Yang,D.Z., Zhai,Y.N., Xue,K., Xu,F., Gu,X.Y. and Wang,S.M.
  TITLE     Microarray expression profiling of long non-coding RNAs in
            epithelial ovarian cancer
  JOURNAL   Oncol Lett 14 (2), 2523-2530 (2017)
   PUBMED   28781691
REFERENCE   6  (bases 1 to 1061)
  AUTHORS   Xu,G., Chen,J., Pan,Q., Huang,K., Pan,J., Zhang,W., Chen,J., Yu,F.,
            Zhou,T. and Wang,Y.
  TITLE     Long noncoding RNA expression profiles of lung adenocarcinoma
            ascertained by microarray analysis
  JOURNAL   PLoS One 9 (8), e104044 (2014)
   PUBMED   25089627
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1061)
  AUTHORS   Wang,K.S., Liu,X., Zheng,S., Zeng,M., Pan,Y. and Callahan,K.
  TITLE     A novel locus for body mass index on 5p15.2: a meta-analysis of two
            genome-wide association studies
  JOURNAL   Gene 500 (1), 80-84 (2012)
   PUBMED   22446040
REFERENCE   8  (bases 1 to 1061)
  AUTHORS   Sehrawat,B., Sridharan,M., Ghosh,S., Robson,P., Cass,C.E.,
            Mackey,J.R., Greiner,R. and Damaraju,S.
  TITLE     Potential novel candidate polymorphisms identified in genome-wide
            association study for breast cancer susceptibility
  JOURNAL   Hum Genet 130 (4), 529-537 (2011)
   PUBMED   21424380
  REMARK    GeneRIF: Single nucleotide polymorphisms in ROPN1L gene is
            associated with breast cancer.
REFERENCE   9  (bases 1 to 1061)
  AUTHORS   Newell,A.E., Fiedler,S.E., Ruan,J.M., Pan,J., Wang,P.J.,
            Deininger,J., Corless,C.L. and Carr,D.W.
  TITLE     Protein kinase A RII-like (R2D2) proteins exhibit differential
            localization and AKAP interaction
  JOURNAL   Cell Motil Cytoskeleton 65 (7), 539-552 (2008)
   PUBMED   18421703
REFERENCE   10 (bases 1 to 1061)
  AUTHORS   Carr,D.W., Fujita,A., Stentz,C.L., Liberty,G.A., Olson,G.E. and
            Narumiya,S.
  TITLE     Identification of sperm-specific proteins that interact with
            A-kinase anchoring proteins in a manner similar to the type II
            regulatory subunit of PKA
  JOURNAL   J Biol Chem 276 (20), 17332-17338 (2001)
   PUBMED   11278869
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092336.2, AK098642.1 and
            BC014607.2.
            
            On Nov 22, 2018 this sequence version replaced NM_031916.4.
            
            Summary: This gene encodes a member of the ropporin family. The
            encoded protein is present in sperm and interacts with A-kinase
            anchoring protein, AKAP3, through the amphipathic helix region of
            AKAP3. Alternatively spliced transcript variants have been found
            for this gene. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014607.2, SRR5189667.99632.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274134.5/ ENSP00000274134.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AC092336.2         67294-67486         c
            194-1060            AK098642.1         100-966
            1061-1061           BC014607.2         1039-1039
FEATURES             Location/Qualifiers
     source          1..1061
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.2"
     gene            1..1061
                     /gene="ROPN1L"
                     /gene_synonym="ASP; LINC01513; RSPH11; TCONS_00009352"
                     /note="rhophilin associated tail protein 1 like"
                     /db_xref="GeneID:83853"
                     /db_xref="HGNC:HGNC:24060"
                     /db_xref="MIM:611756"
     exon            1..420
                     /gene="ROPN1L"
                     /gene_synonym="ASP; LINC01513; RSPH11; TCONS_00009352"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..982
                     /gene="ROPN1L"
                     /gene_synonym="ASP; LINC01513; RSPH11; TCONS_00009352"
                     /note="AKAP-associated sperm protein; radial spoke head 11
                     homolog; ROPN1-like protein; long intergenic non-protein
                     coding RNA 1513"
                     /codon_start=1
                     /product="ropporin-1-like protein"
                     /protein_id="NP_114122.2"
                     /db_xref="CCDS:CCDS3879.1"
                     /db_xref="GeneID:83853"
                     /db_xref="HGNC:HGNC:24060"
                     /db_xref="MIM:611756"
                     /translation="MPLPDTMFCAQQIHIPPELPDILKQFTKAAIRTQPADVLRWSAG
                     YFSALSRGDPLPVKDRMEMPTATQKTDTGLTQGLLKVLHKQCHHKRYVELTDLEQKWK
                     NLCLPKEKFKALLQLDPCENKIKWINFLALGCSMLGGSLNTALKHLCEILTDDPEGGP
                     ARIPFKTFSYVYRYLARLDSDVSPLETESYLASLKENIDARKNGMIGLSDFFFPKRKL
                     LESIENSEDVGH"
     exon            421..544
                     /gene="ROPN1L"
                     /gene_synonym="ASP; LINC01513; RSPH11; TCONS_00009352"
                     /inference="alignment:Splign:2.1.0"
     exon            545..706
                     /gene="ROPN1L"
                     /gene_synonym="ASP; LINC01513; RSPH11; TCONS_00009352"
                     /inference="alignment:Splign:2.1.0"
     exon            707..882
                     /gene="ROPN1L"
                     /gene_synonym="ASP; LINC01513; RSPH11; TCONS_00009352"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1061
                     /gene="ROPN1L"
                     /gene_synonym="ASP; LINC01513; RSPH11; TCONS_00009352"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1039..1044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ROPN1L"
                     /gene_synonym="ASP; LINC01513; RSPH11; TCONS_00009352"
                     /note="hexamer: AATACA"
     polyA_site      1061
                     /gene="ROPN1L"
                     /gene_synonym="ASP; LINC01513; RSPH11; TCONS_00009352"
                     /note="major polyA site"
ORIGIN      
        1 gcgtcccggg tgcctggata ccgagcgcgt ccgtagtggc ggctggcgct agggaactgc
       61 agggtctagg gtgttgtcgg agtggcagtt ggtccgaatt tctcccgaag cccgcggagg
      121 agcgggtaag agccccgcga atccggcccc aacctcggga acgggatggg aggcggccct
      181 ggccgcaagc cccgcgctgc tagcgggtcc accgcgtcgt agccgacagc cgcccttctt
      241 cctcgcagcg cgccgcgatt caccagcctg gtcccttctg cggagagcga tgccgcttcc
      301 cgacaccatg ttctgcgctc agcagatcca cattcccccg gagctgccgg acatcctgaa
      361 gcaattcacc aaggctgcca tccgcaccca gccggccgac gtgctgcggt ggtccgcggg
      421 ctatttttca gctctgtcga gaggagatcc acttcctgta aaggacagaa tggaaatgcc
      481 cacggcaacc cagaaaacag acacaggcct gactcaagga ctcctgaaag ttttgcacaa
      541 gcagtgtcac cacaagcggt atgtggaatt aacagatctt gagcagaagt ggaagaactt
      601 gtgcctgccg aaggaaaaat tcaaagcgct cttacaactg gatccttgtg aaaacaaaat
      661 caagtggata aactttttag cgcttggatg cagcatgctt ggtgggtcct tgaacactgc
      721 gctgaagcac ctgtgcgaga tcctcacgga cgatccggag ggcgggcccg ctcgcatccc
      781 cttcaagacg ttttcctacg tttaccgcta cttggccaga ttagactcag atgtgtctcc
      841 cttggagacg gaatcctacc ttgcctctct aaaggaaaat atagacgcca ggaagaacgg
      901 catgataggt ctttcagatt tcttctttcc aaagaggaaa cttttagaaa gcattgaaaa
      961 ctctgaagat gtaggccatt aatacagaga agaatacatt ttaatgtcaa aatagtgctc
     1021 tttaaaattc tggcaccaaa tacaacttac cctgaatcac a
//
