LOCUS       NM_080748                366 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens reactive oxygen species modulator 1 (ROMO1), mRNA.
ACCESSION   NM_080748
VERSION     NM_080748.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 366)
  AUTHORS   Tsoneva,E., Dimitrova,P.D., Metodiev,M., Shivarov,V.,
            Vasileva-Slaveva,M. and Yordanov,A.
  TITLE     The effects of ROMO1 on cervical cancer progression
  JOURNAL   Pathol Res Pract 248, 154561 (2023)
   PUBMED   37285738
  REMARK    GeneRIF: The effects of ROMO1 on cervical cancer progression.
REFERENCE   2  (bases 1 to 366)
  AUTHORS   Chen,W.Y., Thuy Dung,P.V., Yeh,H.L., Chen,W.H., Jiang,K.C.,
            Li,H.R., Chen,Z.Q., Hsiao,M., Huang,J., Wen,Y.C. and Liu,Y.N.
  TITLE     Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine
            differentiation of castration-resistant prostate cancer
  JOURNAL   Redox Biol 62, 102686 (2023)
   PUBMED   36963289
  REMARK    GeneRIF: Targeting PKLR/MYCN/ROMO1 signaling suppresses
            neuroendocrine differentiation of castration-resistant prostate
            cancer.
REFERENCE   3  (bases 1 to 366)
  AUTHORS   Wang,L., Liu,X., Liu,Z., Wang,Y., Fan,M., Yin,J., Zhang,Y., Ma,Y.,
            Luo,J., Li,R., Zhao,X., Zhang,P., Zhao,L., Fan,J., Chen,Y., Lu,W.
            and Song,X.
  TITLE     Network models of prostate cancer immune microenvironments identify
            ROMO1 as heterogeneity and prognostic marker
  JOURNAL   Sci Rep 12 (1), 192 (2022)
   PUBMED   34996995
  REMARK    GeneRIF: Network models of prostate cancer immune microenvironments
            identify ROMO1 as heterogeneity and prognostic marker.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 366)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 366)
  AUTHORS   Tibaut,M., Mankoc Ramus,S. and Petrovic,D.
  TITLE     The C allele of the reactive oxygen species modulator 1 (ROMO1)
            polymorphism rs6060566 is a biomarker predicting coronary artery
            stenosis in Slovenian subjects with type 2 diabetes mellitus
  JOURNAL   BMC Med Genomics 13 (1), 184 (2020)
   PUBMED   33302957
  REMARK    GeneRIF: The C allele of the reactive oxygen species modulator 1
            (ROMO1) polymorphism rs6060566 is a biomarker predicting coronary
            artery stenosis in Slovenian subjects with type 2 diabetes
            mellitus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 366)
  AUTHORS   Sha,J., Zhao,G., Chen,X., Guan,W., He,Y. and Wang,Z.
  TITLE     Antibacterial potential of hGlyrichin encoded by a human gene
  JOURNAL   J Pept Sci 18 (2), 97-104 (2012)
   PUBMED   22083756
  REMARK    GeneRIF: A 19 amino acid peptide (pCM19) at positions 42-60 of
            hGlyrichin is crucial for its antibacterial activity.
REFERENCE   7  (bases 1 to 366)
  AUTHORS   Hwang,I.T., Chung,Y.M., Kim,J.J., Chung,J.S., Kim,B.S., Kim,H.J.,
            Kim,J.S. and Yoo,Y.D.
  TITLE     Drug resistance to 5-FU linked to reactive oxygen species modulator
            1
  JOURNAL   Biochem Biophys Res Commun 359 (2), 304-310 (2007)
   PUBMED   17537404
  REMARK    GeneRIF: cellular adaptive response to Romo1-induced ROS is a
            mechanism of drug resistance to 5-FU
REFERENCE   8  (bases 1 to 366)
  AUTHORS   Chung,Y.M., Kim,J.S. and Yoo,Y.D.
  TITLE     A novel protein, Romo1, induces ROS production in the mitochondria
  JOURNAL   Biochem Biophys Res Commun 347 (3), 649-655 (2006)
   PUBMED   16842742
REFERENCE   9  (bases 1 to 366)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 366)
  AUTHORS   Bauer,M.F., Gempel,K., Reichert,A.S., Rappold,G.A., Lichtner,P.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     Genetic and structural characterization of the human mitochondrial
            inner membrane translocase
  JOURNAL   J Mol Biol 289 (1), 69-82 (1999)
   PUBMED   10339406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC105281.1 and AK000548.1.
            
            On Nov 22, 2018 this sequence version replaced NM_080748.2.
            
            Summary: The protein encoded by this gene is a mitochondrial
            membrane protein that is responsible for increasing the level of
            reactive oxygen species (ROS) in cells. The protein also has
            antimicrobial activity against a variety of bacteria by inducing
            bacterial membrane breakage. [provided by RefSeq, Nov 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000548.1, BU851902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 16842742; reported by
                                                  MitoCarta
            MANE Ensembl match                 :: ENST00000374077.8/
                                                  ENSP00000363190.3
            Protein has antimicrobial activity :: PMID: 22083756
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               BC105281.1         5-350
            347-366             AK000548.1         347-366
FEATURES             Location/Qualifiers
     source          1..366
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..366
                     /gene="ROMO1"
                     /gene_synonym="bA353C18.2; C20orf52; MTGM; MTGMP"
                     /note="reactive oxygen species modulator 1"
                     /db_xref="GeneID:140823"
                     /db_xref="HGNC:HGNC:16185"
                     /db_xref="MIM:618894"
     exon            1..52
                     /gene="ROMO1"
                     /gene_synonym="bA353C18.2; C20orf52; MTGM; MTGMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..292
                     /gene="ROMO1"
                     /gene_synonym="bA353C18.2; C20orf52; MTGM; MTGMP"
                     /note="mitochondrial targeting GXXXG protein; ROS
                     modulator 1; protein MGR2 homolog; glyrichin; epididymis
                     tissue protein Li 175; mitochondrial targeting GxxxG motif
                     protein; PCM19"
                     /codon_start=1
                     /product="reactive oxygen species modulator 1"
                     /protein_id="NP_542786.1"
                     /db_xref="CCDS:CCDS13264.1"
                     /db_xref="GeneID:140823"
                     /db_xref="HGNC:HGNC:16185"
                     /db_xref="MIM:618894"
                     /translation="MPVAVGPYGQSQPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLR
                     IGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC"
     exon            53..183
                     /gene="ROMO1"
                     /gene_synonym="bA353C18.2; C20orf52; MTGM; MTGMP"
                     /inference="alignment:Splign:2.1.0"
     exon            184..366
                     /gene="ROMO1"
                     /gene_synonym="bA353C18.2; C20orf52; MTGM; MTGMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      345..350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ROMO1"
                     /gene_synonym="bA353C18.2; C20orf52; MTGM; MTGMP"
                     /note="hexamer: AATAAA"
     polyA_site      366
                     /gene="ROMO1"
                     /gene_synonym="bA353C18.2; C20orf52; MTGM; MTGMP"
                     /note="major polyA site"
ORIGIN      
        1 gttttccgtg agagacgtag agctgagcga cccagcccgc gagcgaggtg agatgccggt
       61 ggccgtgggt ccctacggac agtcccagcc aagctgcttc gaccgtgtca aaatgggctt
      121 cgtgatgggt tgcgccgtgg gcatggcggc cggggcgctc ttcggcacct tttcctgtct
      181 caggatcgga atgcggggtc gagagctgat gggcggcatt gggaaaacca tgatgcagag
      241 tggcggcacc tttggcacat tcatggccat tgggatgggc atccgatgct aaccatggtt
      301 gccaactaca tctgtccctt cccatcaatc ccagcccatg tactaataaa agaaagtctt
      361 tgagta
//
