LOCUS       NM_022370               4528 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens roundabout guidance receptor 3 (ROBO3), transcript
            variant 1, mRNA.
ACCESSION   NM_022370 XM_370663
VERSION     NM_022370.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4528)
  AUTHORS   Yi,S., Qin,Z., Zhou,X., Chen,J., Yi,S., Chen,Q., Huang,L.,
            Zhang,Q., Chen,B. and Luo,J.
  TITLE     Early onset horizontal gaze palsy and progressive scoliosis due to
            a noncanonical splicing-site variant and a missense variant in the
            ROBO3 gene
  JOURNAL   Mol Genet Genomic Med 11 (9), e2215 (2023)
   PUBMED   37330975
  REMARK    GeneRIF: Early onset horizontal gaze palsy and progressive
            scoliosis due to a noncanonical splicing-site variant and a
            missense variant in the ROBO3 gene.
            Review article
REFERENCE   2  (bases 1 to 4528)
  AUTHORS   Li,C., Wang,Z., Wei,B., Liu,Z., Li,B., Kang,H., Wang,J., Liu,J.,
            Wang,Q., Guo,H., Wu,X., Liu,N. and Luo,J.
  TITLE     Upregulation of ROBO3 promotes proliferation, migration and
            adhesion of AML cells and affects the survival of AML patients
  JOURNAL   Biochem Biophys Res Commun 661, 1-9 (2023)
   PUBMED   37084487
  REMARK    GeneRIF: Upregulation of ROBO3 promotes proliferation, migration
            and adhesion of AML cells and affects the survival of AML patients.
REFERENCE   3  (bases 1 to 4528)
  AUTHORS   Zhang,Z., Zhang,Z., Shu,L., Meng,Y., Ma,J., Gao,R. and Zhou,X.
  TITLE     A Genetic Variant of the ROBO3 Gene is Associated With Adolescent
            Idiopathic Scoliosis in the Chinese Population
  JOURNAL   Spine (Phila Pa 1976) 48 (2), E20-E24 (2023)
   PUBMED   36149840
  REMARK    GeneRIF: A Genetic Variant of the ROBO3 Gene is Associated With
            Adolescent Idiopathic Scoliosis in the Chinese Population.
REFERENCE   4  (bases 1 to 4528)
  AUTHORS   Cai,M.S., Luo,A.L., Liu,X.P., Jiang,H. and Liu,X.D.
  TITLE     [Expression of ROBO3 and Its Effect on Cell Proliferation and
            Apoptosis in Pediatric Patients with Acute Myeloid Leukemia]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 30 (5), 1324-1330 (2022)
   PUBMED   36208230
  REMARK    GeneRIF: [Expression of ROBO3 and Its Effect on Cell Proliferation
            and Apoptosis in Pediatric Patients with Acute Myeloid Leukemia].
REFERENCE   5  (bases 1 to 4528)
  AUTHORS   Werner,M., Dyas,A., Parfentev,I., Schmidt,G.E., Mieczkowska,I.K.,
            Muller-Kirschbaum,L.C., Muller,C., Kalkhof,S., Reinhardt,O.,
            Urlaub,H., Alves,F., Gallwas,J., Prokakis,E. and Wegwitz,F.
  TITLE     ROBO3s: a novel ROBO3 short isoform promoting breast cancer
            aggressiveness
  JOURNAL   Cell Death Dis 13 (9), 762 (2022)
   PUBMED   36057630
  REMARK    GeneRIF: ROBO3s: a novel ROBO3 short isoform promoting breast
            cancer aggressiveness.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4528)
  AUTHORS   Chan,W.M., Traboulsi,E.I., Arthur,B., Friedman,N., Andrews,C. and
            Engle,E.C.
  TITLE     Horizontal gaze palsy with progressive scoliosis can result from
            compound heterozygous mutations in ROBO3
  JOURNAL   J Med Genet 43 (3), e11 (2006)
   PUBMED   16525029
  REMARK    GeneRIF: Incidence of scoliosis in individuals harbouring
            heterozygous ROBO3 mutations may be greater than in the general
            population.
REFERENCE   7  (bases 1 to 4528)
  AUTHORS   Camurri,L., Mambetisaeva,E., Davies,D., Parnavelas,J.,
            Sundaresan,V. and Andrews,W.
  TITLE     Evidence for the existence of two Robo3 isoforms with divergent
            biochemical properties
  JOURNAL   Mol Cell Neurosci 30 (4), 485-493 (2005)
   PUBMED   16226035
  REMARK    GeneRIF: Here we describe and compare two human Robo3 isoforms,
            Robo3A and Robo3B, which differ by the insertion of 26 amino acids
            at the N-terminus, and these forms appear to be evolutionary
            conserved
REFERENCE   8  (bases 1 to 4528)
  AUTHORS   Bosley,T.M., Salih,M.A., Jen,J.C., Lin,D.D., Oystreck,D.,
            Abu-Amero,K.K., MacDonald,D.B., al Zayed,Z., al Dhalaan,H.,
            Kansu,T., Stigsby,B. and Baloh,R.W.
  TITLE     Neurologic features of horizontal gaze palsy and progressive
            scoliosis with mutations in ROBO3
  JOURNAL   Neurology 64 (7), 1196-1203 (2005)
   PUBMED   15824346
  REMARK    GeneRIF: The major clinical characteristics of patients with
            mutated ROBO3 were horizontal gaze palsy, progressive scoliosis,
            and brainstem malformations.
REFERENCE   9  (bases 1 to 4528)
  AUTHORS   Jen,J.C., Chan,W.M., Bosley,T.M., Wan,J., Carr,J.R., Rub,U.,
            Shattuck,D., Salamon,G., Kudo,L.C., Ou,J., Lin,D.D., Salih,M.A.,
            Kansu,T., Al Dhalaan,H., Al Zayed,Z., MacDonald,D.B., Stigsby,B.,
            Plaitakis,A., Dretakis,E.K., Gottlob,I., Pieh,C., Traboulsi,E.I.,
            Wang,Q., Wang,L., Andrews,C., Yamada,K., Demer,J.L., Karim,S.,
            Alger,J.R., Geschwind,D.H., Deller,T., Sicotte,N.L., Nelson,S.F.,
            Baloh,R.W. and Engle,E.C.
  TITLE     Mutations in a human ROBO gene disrupt hindbrain axon pathway
            crossing and morphogenesis
  JOURNAL   Science 304 (5676), 1509-1513 (2004)
   PUBMED   15105459
  REMARK    GeneRIF: identified mutations in the ROBO3 gene in patients
            affected with horizontal gaze palsy with progressive scoliosis
            (HGPPS);ROBO3 is required for hindbrain axon midline crossing
            GeneRIF: mutations in the ROBO3 gene, which shares homology with
            roundabout genes important in axon guidance in developing
            Drosophila, zebrafish, and mouse.
REFERENCE   10 (bases 1 to 4528)
  AUTHORS   Jen,J., Coulin,C.J., Bosley,T.M., Salih,M.A., Sabatti,C.,
            Nelson,S.F. and Baloh,R.W.
  TITLE     Familial horizontal gaze palsy with progressive scoliosis maps to
            chromosome 11q23-25
  JOURNAL   Neurology 59 (3), 432-435 (2002)
   PUBMED   12177379
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY509035.1 and N80769.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022370.3.
            
            Summary: This gene is a member of the Roundabout (ROBO) gene family
            that controls neurite outgrowth, growth cone guidance, and axon
            fasciculation. ROBO proteins are a subfamily of the immunoglobulin
            transmembrane receptor superfamily. SLIT proteins 1-3, a family of
            secreted chemorepellants, are ligands for ROBO proteins and
            SLIT/ROBO interactions regulate myogenesis, leukocyte migration,
            kidney morphogenesis, angiogenesis, and vasculogenesis in addition
            to neurogenesis. This gene, ROBO3, has a putative extracellular
            domain with five immunoglobulin (Ig)-like loops and three
            fibronectin (Fn) type III motifs, a transmembrane segment, and a
            cytoplasmic tail with three conserved signaling motifs: CC0, CC2,
            and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family
            members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal
            navigation at the ventral midline of the neural tube. In mouse,
            loss of Robo3 results in a complete failure of commissural axons to
            cross the midline throughout the spinal cord and the hindbrain.
            Mutations ROBO3 result in horizontal gaze palsy with progressive
            scoliosis (HGPPS); an autosomal recessive disorder characterized by
            congenital absence of horizontal gaze, progressive scoliosis, and
            failure of the corticospinal and somatosensory axon tracts to cross
            the midline in the medulla. [provided by RefSeq, May 2019].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY509035.1, AK291045.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397801.6/ ENSP00000380903.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4523              AY509035.1         47-4569
            4524-4528           N80769.1           6-10                c
FEATURES             Location/Qualifiers
     source          1..4528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..4528
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /note="roundabout guidance receptor 3"
                     /db_xref="GeneID:64221"
                     /db_xref="HGNC:HGNC:13433"
                     /db_xref="MIM:608630"
     exon            1..306
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..4307
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; retinoblastoma inhibiting gene 1; roundabout,
                     axon guidance receptor, homolog 3; roundabout homolog 3;
                     roundabout-like protein 3"
                     /codon_start=1
                     /product="roundabout homolog 3 isoform a precursor"
                     /protein_id="NP_071765.2"
                     /db_xref="CCDS:CCDS44755.1"
                     /db_xref="GeneID:64221"
                     /db_xref="HGNC:HGNC:13433"
                     /db_xref="MIM:608630"
                     /translation="MLRYLLKTLLQMNLFADSLAGDISNSSELLLGFNSSLAALNHTL
                     LPPGDPSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGA
                     RVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLE
                     VAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRG
                     GKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVT
                     FLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGR
                     AEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPS
                     QSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLP
                     PVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYI
                     ANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTE
                     ITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTI
                     YLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLG
                     PRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQI
                     QIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQ
                     QNGVITEYQIWCLGNESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVP
                     SAPVLVQLPSPPDLEPGLEVGAGLAVRLARVLREPAFLAGSGAACGALLLGLCAALYW
                     RRKQRKELSHYTASFAYTPAVSFPHSEGLSGASSRPPMGLGPAPYSWLADSWPHPSRS
                     PSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGTAAPGEGPVYSTIDPAGEELQ
                     TFHGGFPQHPSGDLGPWSQYAPPEWSQGDSGAKGGKVKLLGKPVQMPSLNWPEALPPP
                     PPSCELSCLEGPEEELEGSSEPEEWCPPMPERSHLTEPSSSGGCLVTPSRRETPSPTP
                     SYGQQSTATLTPSPPDPPQPPTDMPHLHQMPRRVPLGPSSPLSVSQPMLGIREARPAG
                     LGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKALPYRREN
                     SPGDLPPPPLPPPEEEASWALELRAAGSMSSLERERSGERKAVQAVPLAAQRVLHPDE
                     EAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQSRSQSQRPG
                     QKRREEPR"
     exon            307..633
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..791
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..912
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1051
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1179
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1304
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1476
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1682
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1764
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1930
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2097
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2219
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2445
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2567
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2739
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2925
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..2949
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..2992
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3132
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3327
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3466
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3679
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3680..3831
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3832..3942
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3943..4104
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            4105..4295
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     exon            4296..4528
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4503..4508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /note="hexamer: AATAAA"
     polyA_site      4528
                     /gene="ROBO3"
                     /gene_synonym="HGPPS; HGPPS1; HGPS; RBIG1; RIG1"
                     /note="major polyA site"
ORIGIN      
        1 gtacccaggc gcaccggcag gagagcggca ccgtggctgc cgcagcgcgc agaggctgtg
       61 gaggggctta cggctcccag cccacgggtc tcagacccag gggctgggcc cccagccccc
      121 agtcccgatc ccagctgggt cgagccatgc tgcgctacct gctgaaaacg ctgctgcaga
      181 tgaacttgtt cgcggactct ctggccgggg acatctccaa ctccagcgag ctgctcttgg
      241 gcttcaactc ctcgctggcg gcgctcaacc acaccctgct gcctcccggc gatccctctc
      301 tcaacgggtc aagggtagga ccggaggacg ctatgccccg catcgtggag cagccgccag
      361 atctgctggt ctcccgaggc gagcccgcca cgttgccctg ccgcgctgaa ggccgacccc
      421 gacccaacat tgagtggtac aagaacgggg cgcgtgtggc cactgtgcgg gaggatccgc
      481 gtgcgcaccg cctgctgctg cccagcggcg ccctcttctt cccgcgcatc gtgcacgggc
      541 gccgcgcgcg gccggacgaa ggtgtctaca cttgcgtggc tcgcaactac ctgggggcag
      601 cagcgagcag aaacgcctcg ctggaagtgg cagtcctccg tgatgatttc cggcagtctc
      661 ctggaaacgt ggtggtggca gtgggggagc cagcagtact ggaatgcgtg cccccccgcg
      721 gccacccgga gccttccgtg tcctggagga aggacggtgc aagactcaag gaagaggaag
      781 gaaggatcac gatccgtgga gggaagctga tgatgtcaca tacactcaag agcgatgcag
      841 gcatgtatgt gtgcgtagcc tccaacatgg cgggagaacg ggagagtgcg gcagctgaag
      901 tcatggtact ggagcgtccc tcattcctgc gcagaccagt gaatcaggtg gtcctggctg
      961 atgcccctgt gactttccta tgtgaggtga agggggatcc cccacctcgt ctacgctggc
     1021 gcaaggagga tggggaactg cccacaggca ggtatgagat ccggagtgac cacagccttt
     1081 ggattgggca tgtgagtgcc gaagatgagg gaacgtacac ctgtgtggcg gagaacagtg
     1141 tgggccgcgc tgaagcatct ggctccctca gtgttcacgt cccaccccag ttggtgaccc
     1201 agccccagga ccagatggca gctcctggag agagcgtggc tttccagtgc gagaccaaag
     1261 gaaacccccc acctgccatc ttctggcaga aggaggggag tcaggtcctg cttttcccca
     1321 gtcagtcact tcagccgacg gggcgcttct cagtgtctcc aagaggccaa cttaacatca
     1381 ccgcggtgca gcgtggggat gctgggtact acgtgtgcca ggctgtcagt gtggctggca
     1441 gcatcctggc caaggccctg ctggagataa aaggagcctc tttggatggg ctgcctcctg
     1501 tcatcctcca gggaccagcc aatcagacgc tggtgcttgg ctcctccgtg tggctgccct
     1561 gcagagtgac tgggaaccct caacccagtg tccgatggaa gaaggatggg cagtggctgc
     1621 agggggatga cctccagttc aagacaatgg ccaacggtac cctgtacatc gccaatgtgc
     1681 aggagatgga catgggcttc tacagctgcg tggccaagag ttccacaggg gaagccacat
     1741 ggagcggctg gcttaagatg cgggaagact ggggagtatc accagacccc cctacagaac
     1801 ccagttcccc tccgggggct ccctctcagc cagtggtcac tgagatcacc aagaacagca
     1861 ttaccctgac ctggaagccc aacccacaaa ctggggctgc agtcacgtct tatgtgatag
     1921 aggccttcag cccagcagct ggcaacacat ggcgtactgt ggcagatggc gtgcagctgg
     1981 agacacacac agtcagcggt ctgcagccca ataccatcta cctgtttctg gttcgagcag
     2041 tgggagcctg gggcctcagt gagcccagcc ccgtctctga gcctgtccgt acacaggata
     2101 gcagcccctc taggccagtg gaggacccat ggagaggcca gcagggactg gcggaagtgg
     2161 ctgtgcgcct gcaggagccc atagtcctgg gaccccggac cctgcaggtg tcctggactg
     2221 tggatggccc agtccagctg gtgcaaggtt tccgggtgtc ttggagggta gcaggccctg
     2281 agggaggaag ctggacaatg ttggacctac agtccccaag ccagcaaagt actgtgctaa
     2341 gaggactccc tccagggacc caaatccaga tcaaggtgca agcccaaggc caggaggggc
     2401 tgggggctga aagcctctct gtgaccagga gcattcctga ggaggccccc agtggccccc
     2461 cacagggagt ggcggtggcc ttggggggtg atggcaacag cagtatcact gtgtcctggg
     2521 aacctccact cccctcccag caaaatgggg tcatcacgga ataccagatc tggtgcctgg
     2581 gcaatgagag ccgctttcac ctcaatcgat ctgcagcagg ctgggcacgc tccgcaatgc
     2641 tccgaggact ggtgcccggt ctcctctatc gaaccctggt cgcggcggcc accagcgcag
     2701 gcgtgggcgt gcccagtgcc ccagtgctgg tgcagctgcc gtccccgccg gacctggagc
     2761 ccgggctgga ggtgggcgcg gggctggcgg tgcggctggc gagggtgctg cgggagcccg
     2821 ccttcctcgc gggcagcggc gcagcctgcg gggcgctgct tctcgggctc tgcgccgccc
     2881 tctactggcg ccggaaacag cgcaaagagc tcagccacta cacggcctct tttgcctaca
     2941 caccggcagt gtccttcccg cactcagagg gcctctctgg agccagttcc aggccaccca
     3001 tgggccttgg ccccgccccc tactcatggc tggcagattc gtggccccac ccatctcgaa
     3061 gcccctcggc ccaggaaccc aggggaagct gctgccctag caatcctgac ccggacgaca
     3121 gatattacaa cgaagcggga atctccctgt atctagctca gacggccagg ggcacggccg
     3181 cccctggcga gggtcctgtc tatagcacca ttgacccagc gggggaggag ctgcagacct
     3241 tccatggggg cttcccccaa catccctcag gagatctggg tccctggagc cagtacgctc
     3301 ctccagagtg gagccagggg gacagtggag ccaagggagg caaagtgaag cttctgggga
     3361 aacctgtgca gatgccctct ctgaactggc cagaagccct gcccccacct cctccttctt
     3421 gtgaactgag ctgcctagaa gggccggagg aggagctgga gggcagctca gagccagagg
     3481 agtggtgccc gccaatgcct gagagaagtc acctgacgga gcccagctcc agtggagggt
     3541 gcctggtcac cccatcccga agggaaaccc cctctcccac accttcctat ggacagcagt
     3601 ccacagccac tcttacaccc tcacctcctg accctcccca gcccccaact gacatgcccc
     3661 atctccatca gatgcccagg agggtgcccc ttgggccgag ttcccctctc agtgtatccc
     3721 agcccatgct gggcatccgt gaagcgaggc ctgctggctt gggtgctggc cctgcagcct
     3781 caccccacct cagccccagt cctgccccta gcacagccag cagtgcccca ggcagaacct
     3841 ggcaggggaa tggggagatg actcccccac ttcaaggacc ccgtgctcga ttccggaaga
     3901 aacccaaggc tcttccctac aggagggaga acagtcctgg ggacttgccc ccaccaccct
     3961 tgccaccgcc agaggaagag gcgagctggg ccctagagct gagggcagca ggcagcatgt
     4021 cctccctgga gcgggagcgc agtggggaga ggaaagcggt ccaggccgtg cccctggcag
     4081 cccagcgggt gctccaccca gatgaagagg cctggctccc atacagcaga ccaagcttcc
     4141 tgtcccgggg ccagggcacc agcacatgtt ccacggccgg cagcaactct tccaggggct
     4201 ccagcagctc taggggctcc cggggccctg gccggagccg gagtcggagt cagagccgga
     4261 gccagagcca aaggccagga cagaaacgcc gagaggaacc aagatgaccc ttgttggggc
     4321 attgagaata tcatgagtgc cacggggaag gggagtaggg atgtcttttc ccccccagca
     4381 gtgatgagtg gggctagctg aagcccattg gtttccacga tttcaattgg ctgagaaggc
     4441 agagagctag ctcctccctt tctttctttt tccacctgag acttgtttat aaaaaacaaa
     4501 acaataaaaa gagtctgatc agagccca
//
