LOCUS       XM_047448677            8514 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens roundabout guidance receptor 2 (ROBO2),
            transcript variant X16, mRNA.
ACCESSION   XM_047448677
VERSION     XM_047448677.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8514
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..8514
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /note="roundabout guidance receptor 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 19 ESTs, 123 long SRA reads, 3 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 4 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:6092"
                     /db_xref="HGNC:HGNC:10250"
                     /db_xref="MIM:602431"
     CDS             409..4608
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /codon_start=1
                     /product="roundabout homolog 2 isoform X16"
                     /protein_id="XP_047304633.1"
                     /db_xref="GeneID:6092"
                     /db_xref="HGNC:HGNC:10250"
                     /db_xref="MIM:602431"
                     /translation="MLSSEKVEKITRLELLFVLMLFLSGPTLSKLTRTPWKGKPWKGG
                     SRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPR
                     SHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQ
                     NPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRK
                     SDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQ
                     PTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVR
                     APPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCS
                     VSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQ
                     TLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGT
                     YTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQ
                     PGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQ
                     GLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVD
                     RQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFN
                     EFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEY
                     KIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIII
                     GRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLS
                     NYAVTFQRGDGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVNNSNSGPNEIGNFG
                     RGDVLPPVPGQGDKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNS
                     IHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNN
                     GSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELE
                     EDDDRVPTPPVRGVASSPAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIA
                     KQTWHIQSNNQPPQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQ
                     TPGSSMDNLDSSVTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMD
                     QQPALPHRREGMTDEEALVPYSKPSFPSPGGHSSSGTASSKGSTGPRKTEVLRAGHQR
                     NASDLLDIGYMGSNSQGQFTE"
ORIGIN      
        1 attaggatca cacaggcagc ctgaaagctg tcagtacaac tgcttctcat ctttttcaca
       61 taatcctgac atcttttccc ttttctgctg gacacagaca ttactgtttt tatcattttc
      121 aatcaagctc acccagaaca ctgaggaata tattcccact gaaagcaaag tggagaacag
      181 aaattatttt atagcttctg gagtagaagc agggctgact gcgtactgag gagaaggagc
      241 cggatccgtg agaaatgtag cttggctcag ggctacatca ggaagctgct acttcagctg
      301 ttaaagatgg caaaacaaca cctacctcag gtttttcaat gattaatgct attttcataa
      361 ccaggaggga agaggatgtg agaaattttg tgaaattaac ttgtggaaat gttatcatca
      421 gagaaagtgg agaaaattac taggcttgaa cttctcttcg ttttgatgct cttcctctct
      481 ggaccaactc tgagcaagct gacccggacc ccctggaaag gaaaaccttg gaagggggga
      541 tcgcgtcttc gccaggagga ctttcccccg cggattgtgg agcatccttc cgatgtcatc
      601 gtctctaagg gcgagcccac gactctgaac tgcaaggcgg agggccggcc aacgcccacc
      661 attgagtggt acaaagatgg ggagcgagtg gagactgaca aggacgatcc ccggtcccac
      721 aggatgcttc tgcccagcgg atccttattc ttcttgcgca tcgtgcacgg gcgcaggagt
      781 aaacctgatg aaggaagcta cgtttgtgtt gcgaggaact atcttggtga agcagtgagt
      841 cgaaatgcgt ctctggaagt ggcattgtta cgagatgact tccgacaaaa ccccacagat
      901 gttgtagtgg cagctggaga gcctgcaatc ctggagtgcc agcctccccg gggacaccca
      961 gaacccacca tctactggaa aaaagacaaa gttcgaattg atgacaagga agaaagaata
     1021 agtatccgtg gtggaaaact gatgatctcc aataccagga aaagtgatgc agggatgtat
     1081 acttgtgttg gtaccaatat ggtgggagaa agggacagtg acccagcaga gctgactgtc
     1141 tttgaacgac ccacatttct caggaggcca attaaccagg tggtactgga ggaagaagct
     1201 gtagaatttc gttgtcaagt ccaaggagat cctcaaccaa ctgtgaggtg gaaaaaggat
     1261 gatgcagact tgccaagagg aaggtatgac atcaaagacg attacacact aagaattaaa
     1321 aagaccatga gtacagatga aggcacctat atgtgtattg ctgagaatcg ggttggaaaa
     1381 atggaagcct ctgctacact caccgtccga gctcccccac agtttgtggt tcggccaaga
     1441 gatcagattg ttgctcaagg tcgaacagtg acatttccct gtgaaactaa aggaaaccca
     1501 cagccagctg ttttttggca gaaagaaggc agccagaacc tacttttccc aaaccaaccc
     1561 cagcagccca acagtagatg ctcagtgtca ccaactggag acctcacaat caccaacatt
     1621 caacgttccg acgcgggtta ctacatctgc caggctttaa ctgtggcagg aagcatttta
     1681 gcaaaagctc aactggaggt tactgatgtt ttgacagata gacctccacc tataattcta
     1741 caaggcccag ccaaccaaac gctggcagtg gatggtacag cgttactgaa atgtaaagcc
     1801 actggtgatc ctcttcctgt aattagctgg ttaaaggagg gatttacttt tccgggtaga
     1861 gatccaagag caacaattca agagcaaggc acactgcaga ttaagaattt acggatttct
     1921 gatactggca cttatacttg tgtggctaca agttcaagtg gagagacttc ctggagtgca
     1981 gtgctggatg tgacagagtc tggagcaaca atcagtaaaa actatgattt aagtgacctg
     2041 ccagggccac catccaaacc gcaggtcact gatgttacta agaacagtgt caccttgtcc
     2101 tggcagccag gtacccctgg aacccttcca gcaagtgcat atatcattga ggctttcagc
     2161 caatcagtga gcaacagctg gcagaccgtg gcaaaccatg taaagaccac cctctatact
     2221 gtaagaggac tgcggcccaa tacaatctac ttattcatgg tcagagcgat caacccccaa
     2281 ggtctcagtg acccaagtcc catgtcagat cctgtgcgca cacaagatat cagcccacca
     2341 gcacaaggag tggaccacag gcaagtgcag aaagagctag gagatgtcct tgtccgtctt
     2401 cataatccag ttgtgctgac tcccaccacg gttcaggtca catggacggt tgatcgccaa
     2461 ccccagttta tccaaggcta ccgagtgatg tatcgtcaga cttcaggtct gcaggcgaca
     2521 tcttcgtggc agaatttaga tgccaaagtc ccgactgaac gaagtgctgt cttagtcaac
     2581 ctgaaaaagg gggtgactta tgaaattaaa gtacggccat attttaatga gttccaagga
     2641 atggatagtg aatctaaaac ggttcgtact actgaagaag ccccaagtgc cccaccacag
     2701 tctgtcactg tactgacagt tggaagctac aatagcacaa gtattagtgt ttcctgggat
     2761 cctcctcctc cagatcacca gaatggaatt atccaagaat acaagatctg gtgtctagga
     2821 aatgaaacgc gattccatat caacaaaact gtggatgcag ccattcggtc cgtaataatt
     2881 ggtggattat tcccaggtat tcaataccgg gtagaggttg cagctagtac cagtgcaggg
     2941 gttggagtaa agagtgagcc acagccaata ataatcggga gacgcaatga agttgtcatt
     3001 actgaaaaca ataacagcat aactgagcaa atcactgatg tggtgaagca accagccttt
     3061 atagctggta ttggtggtgc ctgctgggta attctgatgg gttttagcat atggttgtat
     3121 tggcgaagaa agaagaggaa gggactcagt aattatgctg ttacgtttca aagaggagat
     3181 ggaggactaa tgagcaatgg aagccgtcca ggtcttctca atgctggtga tcccagctat
     3241 ccatggcttg ctgattcttg gccagccacg agcttgccag taaataatag caacagtggc
     3301 ccaaatgaga ttggaaattt tggccgtgga gatgtgctgc caccagttcc aggccaaggg
     3361 gataaaacag caacgatgct ctcagatgga gccatttata gtagcattga cttcactacc
     3421 aaaaccagtt acaacagttc cagccaaata acacaggcta ccccatatgc cacgacacag
     3481 atcttgcatt ccaacagcat acatgaattg gctgtcgatc tgcctgatcc acaatggaaa
     3541 agctcaattc agcaaaaaac agatctgatg ggatttggtt attctctacc tgatcagaac
     3601 aaaggtaaca atggtgggaa aggtggaaaa aagaagaaaa ataaaaactc ttctaaacca
     3661 cagaaaaaca atggatccac ttgggccaat gtccctctac ctcccccccc agtccagccc
     3721 cttcctggca cggagctgga acactatgca gtggaacaac aagaaaatgg ctatgacagt
     3781 gatagctggt gcccaccatt gccagtacaa acttacttac accaaggtct ggaagatgaa
     3841 ctggaagaag atgatgatag ggtcccaaca cctcctgttc gaggcgtggc ttcttctcct
     3901 gctatctcct ttggacagca gtccactgca actcttactc catccccacg ggaagagatg
     3961 caacccatgc tgcaggctca cctggatgag ttgacaagag cctatcagtt tgatatagca
     4021 aaacaaacat ggcacattca aagcaataat caacctccac agcctccagt tccaccgtta
     4081 ggttatgtgt ctggagcctt gatttctgat ttggaaacgg atgttgcaga tgatgatgcc
     4141 gacgacgaag aggaagcttt agaaatcccc aggcccctga gagcactgga ccagactcct
     4201 ggatccagca tggacaatct agacagctct gtgacaggaa aagcctttac ctcctctcaa
     4261 agacctcgac ctaccagccc attttctact gacagtaaca ccagtgcagc cctgagtcaa
     4321 agtcagaggc ctcggcccac taaaaaacac aagggagggc ggatggacca acaaccagca
     4381 ttgcctcatc gaagggaagg aatgacagat gaggaggcct tggtgcccta tagcaagccc
     4441 agtttcccat ctccaggtgg ccacagctca tcaggaacag cttcttctaa gggatccact
     4501 ggacctagga aaaccgaggt gttgagagca ggccaccagc gcaatgccag cgaccttctt
     4561 gacataggat atatgggctc caacagtcaa ggacagttta cagagtaaat gagaggagac
     4621 atacaaagct gctctgaagg accatcaggt ccggactcat ggaagtgatg actctaaaca
     4681 gtgcaatgaa caatttattt atgtactatt aaaagaactg taaatgcaat gtaaagacac
     4741 acagccacac atatcccaca gatattttca ttgtgttctt ctcttaagta caccacccac
     4801 cttaactctt tcttgtcagg agtatataaa aaagaaagaa aacaaaactc gccctacagg
     4861 aagaaaagga ttctcctctg tatataattt cttttgtgca ttgctatgca agctcactct
     4921 ttttagctct gctcatatta ttgtctgttc ttattggtct gttgtactat atgtgaatta
     4981 ataggctgtg gtgccatata ttaactttta attgtgtaac ttttatgttt aaattttgca
     5041 ctgcaatttt atttggtgat aagcacaaat ctctactcct catgacatga agaaaaagac
     5101 tgaatgtgaa gggagtttct gtactgtaag ctagattgga taatgatggc tgtaacaaat
     5161 catgttagat ggttttcagt tggggtgtag aaataggaag atgcaaagga acaatggtgt
     5221 tggcaaagtc ttctttgaat atcagggact gagtcaataa aaaaaatagt agaaaggtgg
     5281 cttttactat tgacaaaagc cggggtcaaa aaaagtagtt taagtcttaa gactgaatat
     5341 gcattaaagt atgcaggtag caaagatgta ataaatttgc ttaaaaaaag aaattaaagt
     5401 tttatttaga atcaatttta cctgtcattg taattgaccc atctgagaat tacaataagc
     5461 aagaggaaat taaggtgttt tgcaagagct gtatttatat tacagttttt taaaaacatt
     5521 ttctgaatta tcgtaattaa gctctccaac tcgttaagtc agaatataat atgaagttcc
     5581 ccaaggaaac gaacaaaatg aactctagaa tatctagcaa atagttaaag aagcaattta
     5641 ttattagggc atactcgggc tgtttccaaa tataaactct attgcaatat cttatttcat
     5701 ctttctaata catgtacagt gcacactaga ggatagagct gcatcactta aattcatgac
     5761 ttaaaaaata atacagttta tatacaactt gttttttatt tgattaagaa gtgaagttta
     5821 cgccacccaa tgtatagcca aattgtacgt gcttaaaaaa cagtgccgag agtatgttca
     5881 gttcgcagta agtagattta ttggaataaa tattctatgg tacattctca gaaattggct
     5941 tccaactaaa atacgtttga cccattttga ataaggaaat tgaaaagaaa aatttaaaag
     6001 gagaaaaaaa tgcatgttta taaacttttt aaataaaacc agaccttgta agtggacatt
     6061 aataattgtc ctgcctcatt tgttttcacg actttgacaa caagaagttc ctgaacatta
     6121 gtcatgtatg ctcagaataa atgtgacttt gaaatatatg ttagctactg tacatgtata
     6181 gtcagtcaag tagaagagga ccttcctgaa attcccactt gtgacatttt cccatgggtt
     6241 tcctacacaa tcttaaattt tatttctgtc tatactttct caaatttttc ctatgataag
     6301 ttcagttgtt ggtactcttc taaaaatatt caacgtgatt aggatcagtt ctaaaatacg
     6361 ggaccccttt gagtgacaat tcgcactcca tgcattattg gctcagtagc caatttttgt
     6421 cacgtcgtta taacaaggag atgacataat taaacatttc catcctttct attccctgag
     6481 actgcatcag cacaggcaag tatagaatgt aatgttcttc atgggcccca ccagcttttt
     6541 ggtgccatgt aatttatttc ttcgctgaag agaaaaagaa ttctgagaca cagttattaa
     6601 accctttatc aactttctac catcagtgcc tgaattctaa tgcagtgtga tttctctggg
     6661 acaaagagac tgaggaagat gaaaagtttc ttcaaagagt gaatacatac ttattcacaa
     6721 ctctaggatg tgaggacttt aaatatctct ttatgaagtt ccctgcctaa cctctttcta
     6781 tttaaaggca aacaaatttc gaagaggttt tgtgttccct ctttatgttt ctctatgacc
     6841 cagtttagtc taaaacctta gttcattaca tatacaacac atagcctttg atccctggta
     6901 actggcaggt gttggtgatt aataaaccaa ggcttcaaag tgaagtatgt gtgtgcagat
     6961 gacttttgga ataacgtggg catagcatca taccttcctg attgtcttca gcatataaaa
     7021 attaactgtt gtagttaaaa ttatgtcagt gcagagcttg tggttacttg gaatgttctt
     7081 tcagaatagt ccatgttgcc tattaaacct agttttaaac acattgggca gtcaatttat
     7141 gcacccaaaa tatcaccctc aggtagattg agggcaagat aaaatgctgt atgtagctat
     7201 acaaaggaat tcagaaacat tactggaaag caaagccttt gtcagcttgc tactgacaaa
     7261 gtagtaaaaa gctactaatc agtgttgagt cagatgtcaa cagaaaaata caaataccta
     7321 tgagagccac agcagtttct cgtttcatag ccgattcaat gaatatgatt agaaattcac
     7381 tgagctcact cttgcaggtt taaatggagg cctgcataag gactgcaaga ggaaatctgg
     7441 gtgggagaga atgtaatctg atcttgcact cataggcaat gctgcaatgc aatcatgtcc
     7501 aatacaagca cagcttcatt cataacagga aacgtcttct ttgggaaaat agctctattg
     7561 gtgcccaaac tcaggtatgc cagtgtatgc aggtggagtc gccctacccc tcttccaaac
     7621 atgtcctgtg agatttttaa aataagatgg gatagtacag gggcatgaaa agaattgatt
     7681 ccttcacagg atttgaatcc agttcaaggg agaatgtaga aaattcaaaa ccaacatata
     7741 aggtatcaca caaccaagaa aagtaaaacc attgcaagtt tacttgcgtt gagtacaaaa
     7801 cagatttaat ggtgttctat gtcatagttt aatgctctgg gtatttaaat atgttttcaa
     7861 caggatttga gttgaaagtt tgtaatgtgc tttgatggaa cacctctcaa tttctattca
     7921 ataaacttat gtaattgtcc attgacaata taatgataac agtaccattg aactctaaac
     7981 tgtggtttat cttcactact gggaagcaac tgtgcatcag tattaaagat atgcagaaac
     8041 ataatattca ctaatttgtt catctgcttc tgtatattgt ttatggaatt acatggcaag
     8101 aactgttcta aagcaacatg tctttccaca ttattttaga ggtgaaatta cttttgtttt
     8161 gcttctctat aatgtgtact tcaaatgaaa caccatactt ttttctaaaa aaagatgttc
     8221 aatttactaa tttttttaaa tctcataatt taaaaagcat ttgttgtgat tttaaagtgt
     8281 tgcaagaaaa gggattttgt ggccgtgggt agacttttta tactttgttt tatagatgga
     8341 ttttttttaa ctgtagtttg tttaagtcac caagcagcat ccaaaatctt aatgtgtttc
     8401 atttgatgtt gttagatcag agaagaaatt ggcataaaat cggttaatag tattgtcaaa
     8461 gaattgtgta ttgtgtactc actgggaaaa aataaaatat attcacattt caaa
//
