LOCUS       XM_017006988            8925 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens roundabout guidance receptor 2 (ROBO2),
            transcript variant X6, mRNA.
ACCESSION   XM_017006988
VERSION     XM_017006988.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017006988.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8925
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..8925
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /note="roundabout guidance receptor 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 20 ESTs, 111 long SRA reads, 5 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 4 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:6092"
                     /db_xref="HGNC:HGNC:10250"
                     /db_xref="MIM:602431"
     CDS             409..5019
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /codon_start=1
                     /product="roundabout homolog 2 isoform X6"
                     /protein_id="XP_016862477.1"
                     /db_xref="GeneID:6092"
                     /db_xref="HGNC:HGNC:10250"
                     /db_xref="MIM:602431"
                     /translation="MLSSEKVEKITRLELLFVLMLFLSGPTLSKLTRTPWKGKPWKGG
                     SRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPR
                     SHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQ
                     NPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRK
                     SDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQ
                     PTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVR
                     ARPVAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPN
                     SRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQG
                     PANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRIS
                     DTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVT
                     LSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRA
                     INPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVT
                     WTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVR
                     PYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGI
                     IQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQ
                     PIIIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKR
                     KGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVNNSNSGPNEI
                     GNFGRGDVLPPVPGQGDKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQIL
                     HSNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNKGNNALLYIPDYRLAEGLSN
                     RMPHNQSQDFSTTSSHNSSERSGSLSGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPP
                     PVQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVR
                     GVASSPAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQP
                     PQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSS
                     VTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGM
                     TDDLPPPPDPPPGQGLRQQIGPSQQAGNVENSAERKGSSLERQHASSLEDTKSSLDCP
                     ARTSLEWQRQTQEWISSTERQEDIRKAPHKQGVGSEEALVPYSKPSFPSPGGHSSSGT
                     ASSKGSTGPRKTEVLRAGHQRNASDLLDIGYMGSNSQGQFTE"
ORIGIN      
        1 attaggatca cacaggcagc ctgaaagctg tcagtacaac tgcttctcat ctttttcaca
       61 taatcctgac atcttttccc ttttctgctg gacacagaca ttactgtttt tatcattttc
      121 aatcaagctc acccagaaca ctgaggaata tattcccact gaaagcaaag tggagaacag
      181 aaattatttt atagcttctg gagtagaagc agggctgact gcgtactgag gagaaggagc
      241 cggatccgtg agaaatgtag cttggctcag ggctacatca ggaagctgct acttcagctg
      301 ttaaagatgg caaaacaaca cctacctcag gtttttcaat gattaatgct attttcataa
      361 ccaggaggga agaggatgtg agaaattttg tgaaattaac ttgtggaaat gttatcatca
      421 gagaaagtgg agaaaattac taggcttgaa cttctcttcg ttttgatgct cttcctctct
      481 ggaccaactc tgagcaagct gacccggacc ccctggaaag gaaaaccttg gaagggggga
      541 tcgcgtcttc gccaggagga ctttcccccg cggattgtgg agcatccttc cgatgtcatc
      601 gtctctaagg gcgagcccac gactctgaac tgcaaggcgg agggccggcc aacgcccacc
      661 attgagtggt acaaagatgg ggagcgagtg gagactgaca aggacgatcc ccggtcccac
      721 aggatgcttc tgcccagcgg atccttattc ttcttgcgca tcgtgcacgg gcgcaggagt
      781 aaacctgatg aaggaagcta cgtttgtgtt gcgaggaact atcttggtga agcagtgagt
      841 cgaaatgcgt ctctggaagt ggcattgtta cgagatgact tccgacaaaa ccccacagat
      901 gttgtagtgg cagctggaga gcctgcaatc ctggagtgcc agcctccccg gggacaccca
      961 gaacccacca tctactggaa aaaagacaaa gttcgaattg atgacaagga agaaagaata
     1021 agtatccgtg gtggaaaact gatgatctcc aataccagga aaagtgatgc agggatgtat
     1081 acttgtgttg gtaccaatat ggtgggagaa agggacagtg acccagcaga gctgactgtc
     1141 tttgaacgac ccacatttct caggaggcca attaaccagg tggtactgga ggaagaagct
     1201 gtagaatttc gttgtcaagt ccaaggagat cctcaaccaa ctgtgaggtg gaaaaaggat
     1261 gatgcagact tgccaagagg aaggtatgac atcaaagacg attacacact aagaattaaa
     1321 aagaccatga gtacagatga aggcacctat atgtgtattg ctgagaatcg ggttggaaaa
     1381 atggaagcct ctgctacact caccgtccga gctcgccctg ttgctccccc acagtttgtg
     1441 gttcggccaa gagatcagat tgttgctcaa ggtcgaacag tgacatttcc ctgtgaaact
     1501 aaaggaaacc cacagccagc tgttttttgg cagaaagaag gcagccagaa cctacttttc
     1561 ccaaaccaac cccagcagcc caacagtaga tgctcagtgt caccaactgg agacctcaca
     1621 atcaccaaca ttcaacgttc cgacgcgggt tactacatct gccaggcttt aactgtggca
     1681 ggaagcattt tagcaaaagc tcaactggag gttactgatg ttttgacaga tagacctcca
     1741 cctataattc tacaaggccc agccaaccaa acgctggcag tggatggtac agcgttactg
     1801 aaatgtaaag ccactggtga tcctcttcct gtaattagct ggttaaagga gggatttact
     1861 tttccgggta gagatccaag agcaacaatt caagagcaag gcacactgca gattaagaat
     1921 ttacggattt ctgatactgg cacttatact tgtgtggcta caagttcaag tggagagact
     1981 tcctggagtg cagtgctgga tgtgacagag tctggagcaa caatcagtaa aaactatgat
     2041 ttaagtgacc tgccagggcc accatccaaa ccgcaggtca ctgatgttac taagaacagt
     2101 gtcaccttgt cctggcagcc aggtacccct ggaacccttc cagcaagtgc atatatcatt
     2161 gaggctttca gccaatcagt gagcaacagc tggcagaccg tggcaaacca tgtaaagacc
     2221 accctctata ctgtaagagg actgcggccc aatacaatct acttattcat ggtcagagcg
     2281 atcaaccccc aaggtctcag tgacccaagt cccatgtcag atcctgtgcg cacacaagat
     2341 atcagcccac cagcacaagg agtggaccac aggcaagtgc agaaagagct aggagatgtc
     2401 cttgtccgtc ttcataatcc agttgtgctg actcccacca cggttcaggt cacatggacg
     2461 gttgatcgcc aaccccagtt tatccaaggc taccgagtga tgtatcgtca gacttcaggt
     2521 ctgcaggcga catcttcgtg gcagaattta gatgccaaag tcccgactga acgaagtgct
     2581 gtcttagtca acctgaaaaa gggggtgact tatgaaatta aagtacggcc atattttaat
     2641 gagttccaag gaatggatag tgaatctaaa acggttcgta ctactgaaga agccccaagt
     2701 gccccaccac agtctgtcac tgtactgaca gttggaagct acaatagcac aagtattagt
     2761 gtttcctggg atcctcctcc tccagatcac cagaatggaa ttatccaaga atacaagatc
     2821 tggtgtctag gaaatgaaac gcgattccat atcaacaaaa ctgtggatgc agccattcgg
     2881 tccgtaataa ttggtggatt attcccaggt attcaatacc gggtagaggt tgcagctagt
     2941 accagtgcag gggttggagt aaagagtgag ccacagccaa taataatcgg gagacgcaat
     3001 gaagttgtca ttactgaaaa caataacagc ataactgagc aaatcactga tgtggtgaag
     3061 caaccagcct ttatagctgg tattggtggt gcctgctggg taattctgat gggttttagc
     3121 atatggttgt attggcgaag aaagaagagg aagggactca gtaattatgc tgttacgttt
     3181 caaagaggag atggaggact aatgagcaat ggaagccgtc caggtcttct caatgctggt
     3241 gatcccagct atccatggct tgctgattct tggccagcca cgagcttgcc agtaaataat
     3301 agcaacagtg gcccaaatga gattggaaat tttggccgtg gagatgtgct gccaccagtt
     3361 ccaggccaag gggataaaac agcaacgatg ctctcagatg gagccattta tagtagcatt
     3421 gacttcacta ccaaaaccag ttacaacagt tccagccaaa taacacaggc taccccatat
     3481 gccacgacac agatcttgca ttccaacagc atacatgaat tggctgtcga tctgcctgat
     3541 ccacaatgga aaagctcaat tcagcaaaaa acagatctga tgggatttgg ttattctcta
     3601 cctgatcaga acaaaggtaa caatgcctta ctttacattc ctgactaccg attggctgag
     3661 ggattgtcta atagaatgcc acacaaccag tctcaggatt tcagcaccac cagctctcac
     3721 aacagctcag aaaggagtgg cagtctctca ggtgggaaag gtggaaaaaa gaagaaaaat
     3781 aaaaactctt ctaaaccaca gaaaaacaat ggatccactt gggccaatgt ccctctacct
     3841 ccccccccag tccagcccct tcctggcacg gagctggaac actatgcagt ggaacaacaa
     3901 gaaaatggct atgacagtga tagctggtgc ccaccattgc cagtacaaac ttacttacac
     3961 caaggtctgg aagatgaact ggaagaagat gatgataggg tcccaacacc tcctgttcga
     4021 ggcgtggctt cttctcctgc tatctccttt ggacagcagt ccactgcaac tcttactcca
     4081 tccccacggg aagagatgca acccatgctg caggctcacc tggatgagtt gacaagagcc
     4141 tatcagtttg atatagcaaa acaaacatgg cacattcaaa gcaataatca acctccacag
     4201 cctccagttc caccgttagg ttatgtgtct ggagccttga tttctgattt ggaaacggat
     4261 gttgcagatg atgatgccga cgacgaagag gaagctttag aaatccccag gcccctgaga
     4321 gcactggacc agactcctgg atccagcatg gacaatctag acagctctgt gacaggaaaa
     4381 gcctttacct cctctcaaag acctcgacct accagcccat tttctactga cagtaacacc
     4441 agtgcagccc tgagtcaaag tcagaggcct cggcccacta aaaaacacaa gggagggcgg
     4501 atggaccaac aaccagcatt gcctcatcga agggaaggaa tgacagatga tcttccacca
     4561 ccaccagatc ccccgccagg tcagggttta aggcagcaaa taggcccgag ccagcaggct
     4621 ggtaacgtgg aaaactcagc agagagaaaa ggaagctctc tagagagaca acatgcatcc
     4681 agcttagaag acacaaagag ctcattggat tgtccagcta gaacctccct agagtggcag
     4741 cgacaaaccc aggaatggat aagctccaca gaacgacaag aagatatacg gaaagcccca
     4801 cacaaacaag gtgtcggatc agaggaggcc ttggtgccct atagcaagcc cagtttccca
     4861 tctccaggtg gccacagctc atcaggaaca gcttcttcta agggatccac tggacctagg
     4921 aaaaccgagg tgttgagagc aggccaccag cgcaatgcca gcgaccttct tgacatagga
     4981 tatatgggct ccaacagtca aggacagttt acagagtaaa tgagaggaga catacaaagc
     5041 tgctctgaag gaccatcagg tccggactca tggaagtgat gactctaaac agtgcaatga
     5101 acaatttatt tatgtactat taaaagaact gtaaatgcaa tgtaaagaca cacagccaca
     5161 catatcccac agatattttc attgtgttct tctcttaagt acaccaccca ccttaactct
     5221 ttcttgtcag gagtatataa aaaagaaaga aaacaaaact cgccctacag gaagaaaagg
     5281 attctcctct gtatataatt tcttttgtgc attgctatgc aagctcactc tttttagctc
     5341 tgctcatatt attgtctgtt cttattggtc tgttgtacta tatgtgaatt aataggctgt
     5401 ggtgccatat attaactttt aattgtgtaa cttttatgtt taaattttgc actgcaattt
     5461 tatttggtga taagcacaaa tctctactcc tcatgacatg aagaaaaaga ctgaatgtga
     5521 agggagtttc tgtactgtaa gctagattgg ataatgatgg ctgtaacaaa tcatgttaga
     5581 tggttttcag ttggggtgta gaaataggaa gatgcaaagg aacaatggtg ttggcaaagt
     5641 cttctttgaa tatcagggac tgagtcaata aaaaaaatag tagaaaggtg gcttttacta
     5701 ttgacaaaag ccggggtcaa aaaaagtagt ttaagtctta agactgaata tgcattaaag
     5761 tatgcaggta gcaaagatgt aataaatttg cttaaaaaaa gaaattaaag ttttatttag
     5821 aatcaatttt acctgtcatt gtaattgacc catctgagaa ttacaataag caagaggaaa
     5881 ttaaggtgtt ttgcaagagc tgtatttata ttacagtttt ttaaaaacat tttctgaatt
     5941 atcgtaatta agctctccaa ctcgttaagt cagaatataa tatgaagttc cccaaggaaa
     6001 cgaacaaaat gaactctaga atatctagca aatagttaaa gaagcaattt attattaggg
     6061 catactcggg ctgtttccaa atataaactc tattgcaata tcttatttca tctttctaat
     6121 acatgtacag tgcacactag aggatagagc tgcatcactt aaattcatga cttaaaaaat
     6181 aatacagttt atatacaact tgttttttat ttgattaaga agtgaagttt acgccaccca
     6241 atgtatagcc aaattgtacg tgcttaaaaa acagtgccga gagtatgttc agttcgcagt
     6301 aagtagattt attggaataa atattctatg gtacattctc agaaattggc ttccaactaa
     6361 aatacgtttg acccattttg aataaggaaa ttgaaaagaa aaatttaaaa ggagaaaaaa
     6421 atgcatgttt ataaactttt taaataaaac cagaccttgt aagtggacat taataattgt
     6481 cctgcctcat ttgttttcac gactttgaca acaagaagtt cctgaacatt agtcatgtat
     6541 gctcagaata aatgtgactt tgaaatatat gttagctact gtacatgtat agtcagtcaa
     6601 gtagaagagg accttcctga aattcccact tgtgacattt tcccatgggt ttcctacaca
     6661 atcttaaatt ttatttctgt ctatactttc tcaaattttt cctatgataa gttcagttgt
     6721 tggtactctt ctaaaaatat tcaacgtgat taggatcagt tctaaaatac gggacccctt
     6781 tgagtgacaa ttcgcactcc atgcattatt ggctcagtag ccaatttttg tcacgtcgtt
     6841 ataacaagga gatgacataa ttaaacattt ccatcctttc tattccctga gactgcatca
     6901 gcacaggcaa gtatagaatg taatgttctt catgggcccc accagctttt tggtgccatg
     6961 taatttattt cttcgctgaa gagaaaaaga attctgagac acagttatta aaccctttat
     7021 caactttcta ccatcagtgc ctgaattcta atgcagtgtg atttctctgg gacaaagaga
     7081 ctgaggaaga tgaaaagttt cttcaaagag tgaatacata cttattcaca actctaggat
     7141 gtgaggactt taaatatctc tttatgaagt tccctgccta acctctttct atttaaaggc
     7201 aaacaaattt cgaagaggtt ttgtgttccc tctttatgtt tctctatgac ccagtttagt
     7261 ctaaaacctt agttcattac atatacaaca catagccttt gatccctggt aactggcagg
     7321 tgttggtgat taataaacca aggcttcaaa gtgaagtatg tgtgtgcaga tgacttttgg
     7381 aataacgtgg gcatagcatc ataccttcct gattgtcttc agcatataaa aattaactgt
     7441 tgtagttaaa attatgtcag tgcagagctt gtggttactt ggaatgttct ttcagaatag
     7501 tccatgttgc ctattaaacc tagttttaaa cacattgggc agtcaattta tgcacccaaa
     7561 atatcaccct caggtagatt gagggcaaga taaaatgctg tatgtagcta tacaaaggaa
     7621 ttcagaaaca ttactggaaa gcaaagcctt tgtcagcttg ctactgacaa agtagtaaaa
     7681 agctactaat cagtgttgag tcagatgtca acagaaaaat acaaatacct atgagagcca
     7741 cagcagtttc tcgtttcata gccgattcaa tgaatatgat tagaaattca ctgagctcac
     7801 tcttgcaggt ttaaatggag gcctgcataa ggactgcaag aggaaatctg ggtgggagag
     7861 aatgtaatct gatcttgcac tcataggcaa tgctgcaatg caatcatgtc caatacaagc
     7921 acagcttcat tcataacagg aaacgtcttc tttgggaaaa tagctctatt ggtgcccaaa
     7981 ctcaggtatg ccagtgtatg caggtggagt cgccctaccc ctcttccaaa catgtcctgt
     8041 gagattttta aaataagatg ggatagtaca ggggcatgaa aagaattgat tccttcacag
     8101 gatttgaatc cagttcaagg gagaatgtag aaaattcaaa accaacatat aaggtatcac
     8161 acaaccaaga aaagtaaaac cattgcaagt ttacttgcgt tgagtacaaa acagatttaa
     8221 tggtgttcta tgtcatagtt taatgctctg ggtatttaaa tatgttttca acaggatttg
     8281 agttgaaagt ttgtaatgtg ctttgatgga acacctctca atttctattc aataaactta
     8341 tgtaattgtc cattgacaat ataatgataa cagtaccatt gaactctaaa ctgtggttta
     8401 tcttcactac tgggaagcaa ctgtgcatca gtattaaaga tatgcagaaa cataatattc
     8461 actaatttgt tcatctgctt ctgtatattg tttatggaat tacatggcaa gaactgttct
     8521 aaagcaacat gtctttccac attattttag aggtgaaatt acttttgttt tgcttctcta
     8581 taatgtgtac ttcaaatgaa acaccatact tttttctaaa aaaagatgtt caatttacta
     8641 atttttttaa atctcataat ttaaaaagca tttgttgtga ttttaaagtg ttgcaagaaa
     8701 agggattttg tggccgtggg tagacttttt atactttgtt ttatagatgg atttttttta
     8761 actgtagttt gtttaagtca ccaagcagca tccaaaatct taatgtgttt catttgatgt
     8821 tgttagatca gagaagaaat tggcataaaa tcggttaata gtattgtcaa agaattgtgt
     8881 attgtgtact cactgggaaa aaataaaata tattcacatt tcaaa
//
