LOCUS       NM_001395656            9018 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens roundabout guidance receptor 2 (ROBO2), transcript
            variant 23, mRNA.
ACCESSION   NM_001395656
VERSION     NM_001395656.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9018)
  AUTHORS   Ordonez-Razo,R.M., Gutierrez-Lopez,Y., Araujo-Solis,M.A.,
            Benitez-King,G., Ramirez-Sanchez,I. and Galicia,G.
  TITLE     Overexpression of miR-25 Downregulates the Expression of ROBO2 in
            Idiopathic Intellectual Disability
  JOURNAL   Int J Mol Sci 25 (7), 3953 (2024)
   PUBMED   38612763
  REMARK    GeneRIF: Overexpression of miR-25 Downregulates the Expression of
            ROBO2 in Idiopathic Intellectual Disability.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9018)
  AUTHORS   Jiang,Y. and Tang,Y.
  TITLE     SALL4 advances the proliferation and tumor cell stemness of colon
            cancer cells through the transcription and regulation of ROBO2
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 43 (3), 249-263 (2024)
   PUBMED   37660281
  REMARK    GeneRIF: SALL4 advances the proliferation and tumor cell stemness
            of colon cancer cells through the transcription and regulation of
            ROBO2.
REFERENCE   3  (bases 1 to 9018)
  AUTHORS   Miyaguchi,M., Nakanishi,Y., Maturana,A.D., Mizutani,K. and Niimi,T.
  TITLE     Conformational Change of the Hairpin-like-structured Robo2
            Ectodomain Allows NELL1/2 Binding
  JOURNAL   J Mol Biol 434 (19), 167777 (2022)
   PUBMED   35940226
  REMARK    GeneRIF: Conformational Change of the Hairpin-like-structured Robo2
            Ectodomain Allows NELL1/2 Binding.
REFERENCE   4  (bases 1 to 9018)
  AUTHORS   Quiat,D., Kim,S.W., Zhang,Q., Morton,S.U., Pereira,A.C.,
            DePalma,S.R., Willcox,J.A.L., McDonough,B., DeLaughter,D.M.,
            Gorham,J.M., Curran,J.J., Tumblin,M., Nicolau,Y., Artunduaga,M.A.,
            Quintanilla-Dieck,L., Osorno,G., Serrano,L., Hamdan,U., Eavey,R.D.,
            Seidman,C.E. and Seidman,J.G.
  TITLE     An ancient founder mutation located between ROBO1 and ROBO2 is
            responsible for increased microtia risk in Amerindigenous
            populations
  JOURNAL   Proc Natl Acad Sci U S A 119 (21), e2203928119 (2022)
   PUBMED   35584116
  REMARK    GeneRIF: An ancient founder mutation located between ROBO1 and
            ROBO2 is responsible for increased microtia risk in Amerindigenous
            populations.
REFERENCE   5  (bases 1 to 9018)
  AUTHORS   Prescott,J., Thompson,D.J., Kraft,P., Chanock,S.J., Audley,T.,
            Brown,J., Leyland,J., Folkerd,E., Doody,D., Hankinson,S.E.,
            Hunter,D.J., Jacobs,K.B., Dowsett,M., Cox,D.G., Easton,D.F. and De
            Vivo,I.
  TITLE     Genome-wide association study of circulating estradiol,
            testosterone, and sex hormone-binding globulin in postmenopausal
            women
  JOURNAL   PLoS One 7 (6), e37815 (2012)
   PUBMED   22675492
REFERENCE   6  (bases 1 to 9018)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 9018)
  AUTHORS   Lu,W., van Eerde,A.M., Fan,X., Quintero-Rivera,F., Kulkarni,S.,
            Ferguson,H., Kim,H.G., Fan,Y., Xi,Q., Li,Q.G., Sanlaville,D.,
            Andrews,W., Sundaresan,V., Bi,W., Yan,J., Giltay,J.C., Wijmenga,C.,
            de Jong,T.P., Feather,S.A., Woolf,A.S., Rao,Y., Lupski,J.R.,
            Eccles,M.R., Quade,B.J., Gusella,J.F., Morton,C.C. and Maas,R.L.
  TITLE     Disruption of ROBO2 is associated with urinary tract anomalies and
            confers risk of vesicoureteral reflux
  JOURNAL   Am J Hum Genet 80 (4), 616-632 (2007)
   PUBMED   17357069
  REMARK    GeneRIF: Disruption of ROBO2 is associated with urinary tract
            anomalies and confers risk of vesicoureteral reflux.
REFERENCE   8  (bases 1 to 9018)
  AUTHORS   Yue,Y., Grossmann,B., Galetzka,D., Zechner,U. and Haaf,T.
  TITLE     Isolation and differential expression of two isoforms of the
            ROBO2/Robo2 axon guidance receptor gene in humans and mice
  JOURNAL   Genomics 88 (6), 772-778 (2006)
   PUBMED   16829019
  REMARK    GeneRIF: two differentially expressed isoforms were isolated and
            identified. Exons 1 and 2 of human ROBO2a lie in an inherently
            unstable DNA segment at human chromosome 3p12.3.
REFERENCE   9  (bases 1 to 9018)
  AUTHORS   Hivert,B., Liu,Z., Chuang,C.Y., Doherty,P. and Sundaresan,V.
  TITLE     Robo1 and Robo2 are homophilic binding molecules that promote
            axonal growth
  JOURNAL   Mol Cell Neurosci 21 (4), 534-545 (2002)
   PUBMED   12504588
REFERENCE   10 (bases 1 to 9018)
  AUTHORS   Kidd,T., Brose,K., Mitchell,K.J., Fetter,R.D., Tessier-Lavigne,M.,
            Goodman,C.S. and Tear,G.
  TITLE     Roundabout controls axon crossing of the CNS midline and defines a
            novel subfamily of evolutionarily conserved guidance receptors
  JOURNAL   Cell 92 (2), 205-215 (1998)
   PUBMED   9458045
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC117515.8, AC117516.5 and
            AC133040.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene belongs to the ROBO
            family, part of the immunoglobulin superfamily of proteins that are
            highly conserved from fly to human. The encoded protein is a
            transmembrane receptor for the slit homolog 2 protein and functions
            in axon guidance and cell migration. Mutations in this gene are
            associated with vesicoureteral reflux, characterized by the
            backward flow of urine from the bladder into the ureters or the
            kidney. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Feb 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2142363,
                              SAMEA2144333 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000696593.1/ ENSP00000512738.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-748               AC117515.8         91159-91906         c
            749-1075            AC117515.8         33665-33991         c
            1076-1233           AC117516.5         43125-43282         c
            1234-1354           AC117516.5         39477-39597         c
            1355-1493           AC117516.5         27314-27452         c
            1494-1621           AC133040.3         2084-2211
            1622-1633           AC133040.3         6712-6723
            1634-1758           AC133040.3         25647-25771
            1759-1930           AC133040.3         30127-30298
            1931-2136           AC133040.3         37253-37458
            2137-2218           AC133040.3         41960-42041
            2219-2381           AC133040.3         42476-42638
            2382-2548           AC133040.3         44263-44429
            2549-2670           AC133040.3         47622-47743
            2671-2902           AC133040.3         53808-54039
            2903-3027           AC133040.3         56799-56923
            3028-3199           AC133040.3         59256-59427
            3200-3382           AC133040.3         68060-68242
            3383-3425           AC133040.3         74451-74493
            3426-3553           AC133040.3         75932-76059
            3554-3835           AC133040.3         81519-81800
            3836-3992           AC133040.3         87107-87263
            3993-4253           AC133040.3         96822-97082
            4254-4459           AC133040.3         101536-101741
            4460-4633           AC133040.3         114179-114352
            4634-4906           AC133040.3         121980-122252
            4907-5107           AC133040.3         124013-124213
            5108-9018           AC133040.3         125363-129273
FEATURES             Location/Qualifiers
     source          1..9018
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p12.3"
     gene            1..9018
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /note="roundabout guidance receptor 2"
                     /db_xref="GeneID:6092"
                     /db_xref="HGNC:HGNC:10250"
                     /db_xref="MIM:602431"
     exon            1..748
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             688..5109
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /note="isoform 23 precursor is encoded by transcript
                     variant 23; roundabout, axon guidance receptor, homolog 2"
                     /codon_start=1
                     /product="roundabout homolog 2 isoform 23 precursor"
                     /protein_id="NP_001382585.1"
                     /db_xref="CCDS:CCDS93319.1"
                     /db_xref="GeneID:6092"
                     /db_xref="HGNC:HGNC:10250"
                     /db_xref="MIM:602431"
                     /translation="MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSK
                     GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSK
                     PDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGH
                     PEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAE
                     LTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDY
                     TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRARPVAPPQFVVRPRDQIVAQGRT
                     VTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGY
                     YICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPL
                     PVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLD
                     VTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQ
                     SVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISP
                     PAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGL
                     QATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAP
                     SAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDA
                     AIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQI
                     TDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSR
                     PGLLNAGDPSYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATML
                     SDGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQ
                     KTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPPVQPLPG
                     TELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASSPA
                     ISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPP
                     LGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFT
                     SSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDDLPPP
                     PDPPPGQGLRQQIGPSQQAGNVENSAERKGSSLERQHASSLEDTKSSLDCPARTSLEW
                     QRQTQEWISSTERQEDIRKAPHKQGVGSEEALVPYSKPSFPSPGGHSSSGTASSKGST
                     GPRKTEVLRAGHQRNASDLLDIGYMGSNSQGQFTGEL"
     exon            749..1075
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1233
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1354
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1493
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1621
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1633
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1758
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1930
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2136
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2218
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2381
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2548
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2670
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2902
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..3027
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3199
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3382
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3425
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            3426..3553
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3835
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            3836..3992
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            3993..4253
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            4254..4459
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            4460..4633
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            4634..4906
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            4907..5107
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            5108..9018
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6536..6541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /note="hexamer: AATAAA"
     polyA_site      6566
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /note="major polyA site"
     regulatory      9000..9005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /note="hexamer: AATATA"
     polyA_site      9018
                     /gene="ROBO2"
                     /gene_synonym="SAX3"
                     /note="major polyA site"
ORIGIN      
        1 cgtaggagtt cggattctcc acccgaatcg tcctgatttc ccttctcctc tcttttggaa
       61 accggagagg tggagggagg gcaacaccgc tgcaaaggag aggcccgcca agtctgcccg
      121 cctgcaaagt gttgctttga cacattctta ttatggaagt taagtaaaaa tatagacata
      181 ttaaaaaata actccggacg tggagctgct acggagaagg aaaccggggg aaagaaaacc
      241 agtaggcagg ccaatggttt ttcggcagcg cgctggcaag tttgtggaac actttctagg
      301 aattaggtct tttcctcccc cttcatcatc ttgacttctg aaggaagaac ttggctttgg
      361 attgcagtgg agcctaagga gagagggtta gacacactcg aataatccct ctggctgggc
      421 tgaatttgtg ggaatttagg aagccagagt gctggaaata cagcagcctt tgaagtaccc
      481 tctgttaatt tggatggatc tcagtgtgcc ccgttcgaga cctctccacc aaccccttct
      541 gatcttgcga tttgctcttc ttgactttaa ttagtatcta ggaaagtcta aactttggac
      601 ctacctcttt ttttgatact catttttgta cttttgctct ctgggattgg tttcttaaag
      661 aatctggatc ctttttaata tgtcaaaatg agtctgctga tgtttacaca actactgctc
      721 tgtggatttt tatatgttcg ggttgatgga tcgcgtcttc gccaggagga ctttcccccg
      781 cggattgtgg agcatccttc cgatgtcatc gtctctaagg gcgagcccac gactctgaac
      841 tgcaaggcgg agggccggcc aacgcccacc attgagtggt acaaagatgg ggagcgagtg
      901 gagactgaca aggacgatcc ccggtcccac aggatgcttc tgcccagcgg atccttattc
      961 ttcttgcgca tcgtgcacgg gcgcaggagt aaacctgatg aaggaagcta cgtttgtgtt
     1021 gcgaggaact atcttggtga agcagtgagt cgaaatgcgt ctctggaagt ggcattgtta
     1081 cgagatgact tccgacaaaa ccccacagat gttgtagtgg cagctggaga gcctgcaatc
     1141 ctggagtgcc agcctccccg gggacaccca gaacccacca tctactggaa aaaagacaaa
     1201 gttcgaattg atgacaagga agaaagaata agtatccgtg gtggaaaact gatgatctcc
     1261 aataccagga aaagtgatgc agggatgtat acttgtgttg gtaccaatat ggtgggagaa
     1321 agggacagtg acccagcaga gctgactgtc tttgaacgac ccacatttct caggaggcca
     1381 attaaccagg tggtactgga ggaagaagct gtagaatttc gttgtcaagt ccaaggagat
     1441 cctcaaccaa ctgtgaggtg gaaaaaggat gatgcagact tgccaagagg aaggtatgac
     1501 atcaaagacg attacacact aagaattaaa aagaccatga gtacagatga aggcacctat
     1561 atgtgtattg ctgagaatcg ggttggaaaa atggaagcct ctgctacact caccgtccga
     1621 gctcgccctg ttgctccccc acagtttgtg gttcggccaa gagatcagat tgttgctcaa
     1681 ggtcgaacag tgacatttcc ctgtgaaact aaaggaaacc cacagccagc tgttttttgg
     1741 cagaaagaag gcagccagaa cctacttttc ccaaaccaac cccagcagcc caacagtaga
     1801 tgctcagtgt caccaactgg agacctcaca atcaccaaca ttcaacgttc cgacgcgggt
     1861 tactacatct gccaggcttt aactgtggca ggaagcattt tagcaaaagc tcaactggag
     1921 gttactgatg ttttgacaga tagacctcca cctataattc tacaaggccc agccaaccaa
     1981 acgctggcag tggatggtac agcgttactg aaatgtaaag ccactggtga tcctcttcct
     2041 gtaattagct ggttaaagga gggatttact tttccgggta gagatccaag agcaacaatt
     2101 caagagcaag gcacactgca gattaagaat ttacggattt ctgatactgg cacttatact
     2161 tgtgtggcta caagttcaag tggagagact tcctggagtg cagtgctgga tgtgacagag
     2221 tctggagcaa caatcagtaa aaactatgat ttaagtgacc tgccagggcc accatccaaa
     2281 ccgcaggtca ctgatgttac taagaacagt gtcaccttgt cctggcagcc aggtacccct
     2341 ggaacccttc cagcaagtgc atatatcatt gaggctttca gccaatcagt gagcaacagc
     2401 tggcagaccg tggcaaacca tgtaaagacc accctctata ctgtaagagg actgcggccc
     2461 aatacaatct acttattcat ggtcagagcg atcaaccccc aaggtctcag tgacccaagt
     2521 cccatgtcag atcctgtgcg cacacaagat atcagcccac cagcacaagg agtggaccac
     2581 aggcaagtgc agaaagagct aggagatgtc cttgtccgtc ttcataatcc agttgtgctg
     2641 actcccacca cggttcaggt cacatggacg gttgatcgcc aaccccagtt tatccaaggc
     2701 taccgagtga tgtatcgtca gacttcaggt ctgcaggcga catcttcgtg gcagaattta
     2761 gatgccaaag tcccgactga acgaagtgct gtcttagtca acctgaaaaa gggggtgact
     2821 tatgaaatta aagtacggcc atattttaat gagttccaag gaatggatag tgaatctaaa
     2881 acggttcgta ctactgaaga agccccaagt gccccaccac agtctgtcac tgtactgaca
     2941 gttggaagct acaatagcac aagtattagt gtttcctggg atcctcctcc tccagatcac
     3001 cagaatggaa ttatccaaga atacaagatc tggtgtctag gaaatgaaac gcgattccat
     3061 atcaacaaaa ctgtggatgc agccattcgg tccgtaataa ttggtggatt attcccaggt
     3121 attcaatacc gggtagaggt tgcagctagt accagtgcag gggttggagt aaagagtgag
     3181 ccacagccaa taataatcgg gagacgcaat gaagttgtca ttactgaaaa caataacagc
     3241 ataactgagc aaatcactga tgtggtgaag caaccagcct ttatagctgg tattggtggt
     3301 gcctgctggg taattctgat gggttttagc atatggttgt attggcgaag aaagaagagg
     3361 aagggactca gtaattatgc tgttacgttt caaagaggag atggaggact aatgagcaat
     3421 ggaagccgtc caggtcttct caatgctggt gatcccagct atccatggct tgctgattct
     3481 tggccagcca cgagcttgcc agtaaataat agcaacagtg gcccaaatga gattggaaat
     3541 tttggccgtg gagatgtgct gccaccagtt ccaggccaag gggataaaac agcaacgatg
     3601 ctctcagatg gagccattta tagtagcatt gacttcacta ccaaaaccag ttacaacagt
     3661 tccagccaaa taacacaggc taccccatat gccacgacac agatcttgca ttccaacagc
     3721 atacatgaat tggctgtcga tctgcctgat ccacaatgga aaagctcaat tcagcaaaaa
     3781 acagatctga tgggatttgg ttattctcta cctgatcaga acaaaggtaa caatggtggg
     3841 aaaggtggaa aaaagaagaa aaataaaaac tcttctaaac cacagaaaaa caatggatcc
     3901 acttgggcca atgtccctct acctcccccc ccagtccagc cccttcctgg cacggagctg
     3961 gaacactatg cagtggaaca acaagaaaat ggctatgaca gtgatagctg gtgcccacca
     4021 ttgccagtac aaacttactt acaccaaggt ctggaagatg aactggaaga agatgatgat
     4081 agggtcccaa cacctcctgt tcgaggcgtg gcttcttctc ctgctatctc ctttggacag
     4141 cagtccactg caactcttac tccatcccca cgggaagaga tgcaacccat gctgcaggct
     4201 cacctggatg agttgacaag agcctatcag tttgatatag caaaacaaac atggcacatt
     4261 caaagcaata atcaacctcc acagcctcca gttccaccgt taggttatgt gtctggagcc
     4321 ttgatttctg atttggaaac ggatgttgca gatgatgatg ccgacgacga agaggaagct
     4381 ttagaaatcc ccaggcccct gagagcactg gaccagactc ctggatccag catggacaat
     4441 ctagacagct ctgtgacagg aaaagccttt acctcctctc aaagacctcg acctaccagc
     4501 ccattttcta ctgacagtaa caccagtgca gccctgagtc aaagtcagag gcctcggccc
     4561 actaaaaaac acaagggagg gcggatggac caacaaccag cattgcctca tcgaagggaa
     4621 ggaatgacag atgatcttcc accaccacca gatcccccgc caggtcaggg tttaaggcag
     4681 caaataggcc cgagccagca ggctggtaac gtggaaaact cagcagagag aaaaggaagc
     4741 tctctagaga gacaacatgc atccagctta gaagacacaa agagctcatt ggattgtcca
     4801 gctagaacct ccctagagtg gcagcgacaa acccaggaat ggataagctc cacagaacga
     4861 caagaagata tacggaaagc cccacacaaa caaggtgtcg gatcagagga ggccttggtg
     4921 ccctatagca agcccagttt cccatctcca ggtggccaca gctcatcagg aacagcttct
     4981 tctaagggat ccactggacc taggaaaacc gaggtgttga gagcaggcca ccagcgcaat
     5041 gccagcgacc ttcttgacat aggatatatg ggctccaaca gtcaaggaca gtttacaggt
     5101 gaattatagt aaatgagagg agacatacaa agctgctctg aaggaccatc aggtccggac
     5161 tcatggaagt gatgactcta aacagtgcaa tgaacaattt atttatgtac tattaaaaga
     5221 actgtaaatg caatgtaaag acacacagcc acacatatcc cacagatatt ttcattgtgt
     5281 tcttctctta agtacaccac ccaccttaac tctttcttgt caggagtata taaaaaagaa
     5341 agaaaacaaa actcgcccta caggaagaaa aggattctcc tctgtatata atttcttttg
     5401 tgcattgcta tgcaagctca ctctttttag ctctgctcat attattgtct gttcttattg
     5461 gtctgttgta ctatatgtga attaataggc tgtggtgcca tatattaact tttaattgtg
     5521 taacttttat gtttaaattt tgcactgcaa ttttatttgg tgataagcac aaatctctac
     5581 tcctcatgac atgaagaaaa agactgaatg tgaagggagt ttctgtactg taagctagat
     5641 tggataatga tggctgtaac aaatcatgtt agatggtttt cagttggggt gtagaaatag
     5701 gaagatgcaa aggaacaatg gtgttggcaa agtcttcttt gaatatcagg gactgagtca
     5761 ataaaaaaaa tagtagaaag gtggctttta ctattgacaa aagccggggt caaaaaaagt
     5821 agtttaagtc ttaagactga atatgcatta aagtatgcag gtagcaaaga tgtaataaat
     5881 ttgcttaaaa aaagaaatta aagttttatt tagaatcaat tttacctgtc attgtaattg
     5941 acccatctga gaattacaat aagcaagagg aaattaaggt gttttgcaag agctgtattt
     6001 atattacagt tttttaaaaa cattttctga attatcgtaa ttaagctctc caactcgtta
     6061 agtcagaata taatatgaag ttccccaagg aaacgaacaa aatgaactct agaatatcta
     6121 gcaaatagtt aaagaagcaa tttattatta gggcatactc gggctgtttc caaatataaa
     6181 ctctattgca atatcttatt tcatctttct aatacatgta cagtgcacac tagaggatag
     6241 agctgcatca cttaaattca tgacttaaaa aataatacag tttatataca acttgttttt
     6301 tatttgatta agaagtgaag tttacgccac ccaatgtata gccaaattgt acgtgcttaa
     6361 aaaacagtgc cgagagtatg ttcagttcgc agtaagtaga tttattggaa taaatattct
     6421 atggtacatt ctcagaaatt ggcttccaac taaaatacgt ttgacccatt ttgaataagg
     6481 aaattgaaaa gaaaaattta aaaggagaaa aaaatgcatg tttataaact ttttaaataa
     6541 aaccagacct tgtaagtgga cattaataat tgtcctgcct catttgtttt cacgactttg
     6601 acaacaagaa gttcctgaac attagtcatg tatgctcaga ataaatgtga ctttgaaata
     6661 tatgttagct actgtacatg tatagtcagt caagtagaag aggaccttcc tgaaattccc
     6721 acttgtgaca ttttcccatg ggtttcctac acaatcttaa attttatttc tgtctatact
     6781 ttctcaaatt tttcctatga taagttcagt tgttggtact cttctaaaaa tattcaacgt
     6841 gattaggatc agttctaaaa tacgggaccc ctttgagtga caattcgcac tccatgcatt
     6901 attggctcag tagccaattt ttgtcacgtc gttataacaa ggagatgaca taattaaaca
     6961 tttccatcct ttctattccc tgagactgca tcagcacagg caagtataga atgtaatgtt
     7021 cttcatgggc cccaccagct ttttggtgcc atgtaattta tttcttcgct gaagagaaaa
     7081 agaattctga gacacagtta ttaaaccctt tatcaacttt ctaccatcag tgcctgaatt
     7141 ctaatgcagt gtgatttctc tgggacaaag agactgagga agatgaaaag tttcttcaaa
     7201 gagtgaatac atacttattc acaactctag gatgtgagga ctttaaatat ctctttatga
     7261 agttccctgc ctaacctctt tctatttaaa ggcaaacaaa tttcgaagag gttttgtgtt
     7321 ccctctttat gtttctctat gacccagttt agtctaaaac cttagttcat tacatataca
     7381 acacatagcc tttgatccct ggtaactggc aggtgttggt gattaataaa ccaaggcttc
     7441 aaagtgaagt atgtgtgtgc agatgacttt tggaataacg tgggcatagc atcatacctt
     7501 cctgattgtc ttcagcatat aaaaattaac tgttgtagtt aaaattatgt cagtgcagag
     7561 cttgtggtta cttggaatgt tctttcagaa tagtccatgt tgcctattaa acctagtttt
     7621 aaacacattg ggcagtcaat ttatgcaccc aaaatatcac cctcaggtag attgagggca
     7681 agataaaatg ctgtatgtag ctatacaaag gaattcagaa acattactgg aaagcaaagc
     7741 ctttgtcagc ttgctactga caaagtagta aaaagctact aatcagtgtt gagtcagatg
     7801 tcaacagaaa aatacaaata cctatgagag ccacagcagt ttctcgtttc atagccgatt
     7861 caatgaatat gattagaaat tcactgagct cactcttgca ggtttaaatg gaggcctgca
     7921 taaggactgc aagaggaaat ctgggtggga gagaatgtaa tctgatcttg cactcatagg
     7981 caatgctgca atgcaatcat gtccaataca agcacagctt cattcataac aggaaacgtc
     8041 ttctttggga aaatagctct attggtgccc aaactcaggt atgccagtgt atgcaggtgg
     8101 agtcgcccta cccctcttcc aaacatgtcc tgtgagattt ttaaaataag atgggatagt
     8161 acaggggcat gaaaagaatt gattccttca caggatttga atccagttca agggagaatg
     8221 tagaaaattc aaaaccaaca tataaggtat cacacaacca agaaaagtaa aaccattgca
     8281 agtttacttg cgttgagtac aaaacagatt taatggtgtt ctatgtcata gtttaatgct
     8341 ctgggtattt aaatatgttt tcaacaggat ttgagttgaa agtttgtaat gtgctttgat
     8401 ggaacacctc tcaatttcta ttcaataaac ttatgtaatt gtccattgac aatataatga
     8461 taacagtacc attgaactct aaactgtggt ttatcttcac tactgggaag caactgtgca
     8521 tcagtattaa agatatgcag aaacataata ttcactaatt tgttcatctg cttctgtata
     8581 ttgtttatgg aattacatgg caagaactgt tctaaagcaa catgtctttc cacattattt
     8641 tagaggtgaa attacttttg ttttgcttct ctataatgtg tacttcaaat gaaacaccat
     8701 acttttttct aaaaaaagat gttcaattta ctaatttttt taaatctcat aatttaaaaa
     8761 gcatttgttg tgattttaaa gtgttgcaag aaaagggatt ttgtggccgt gggtagactt
     8821 tttatacttt gttttataga tggatttttt ttaactgtag tttgtttaag tcaccaagca
     8881 gcatccaaaa tcttaatgtg tttcatttga tgttgttaga tcagagaaga aattggcata
     8941 aaatcggtta atagtattgt caaagaattg tgtattgtgt actcactggg aaaaaataaa
     9001 atatattcac atttcaaa
//
