LOCUS       XM_017006982            6852 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens roundabout guidance receptor 1 (ROBO1),
            transcript variant X5, mRNA.
ACCESSION   XM_017006982
VERSION     XM_017006982.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017006982.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6852
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..6852
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /note="roundabout guidance receptor 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 4 mRNAs, 60 ESTs, 1317 long SRA reads, 1 Protein, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 9 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:6091"
                     /db_xref="HGNC:HGNC:10249"
                     /db_xref="MIM:602430"
     CDS             298..5178
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /codon_start=1
                     /product="roundabout homolog 1 isoform X4"
                     /protein_id="XP_016862471.1"
                     /db_xref="GeneID:6091"
                     /db_xref="HGNC:HGNC:10249"
                     /db_xref="MIM:602430"
                     /translation="MKWKHVPFLVMISLLSLSPNHLFLAQLIPGSRLRQEDFPPRIVE
                     HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL
                     RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAV
                     MECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV
                     GERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK
                     SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRD
                     QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN
                     VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS
                     CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE
                     ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP
                     TSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS
                     DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGY
                     KILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEI
                     KFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETR
                     YHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPE
                     DQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVP
                     SFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTA
                     GNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNS
                     PNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQ
                     YNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGART
                     PKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDE
                     LEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQH
                     QPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRR
                     LLLRGLEQTPASSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADF
                     AQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPA
                     KKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTD
                     RSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKT
                     HLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGG
                     YERGEDNNEELEETES"
ORIGIN      
        1 gcattaatag taatacagat aacgggtttg aaagaattct ctactgaaga aggattgaat
       61 ttttccaggg tgctgataca gagaagaaac ccgacttcac tctctcccta tttccccact
      121 cttaggttta aaagtctgtc acctttcgct tggtttaaac tcggaaaggt ctcagtgcac
      181 agcaaagttg cagggctgcg tctgcactac ggagcctcta gattgctgaa aacagtctta
      241 tggaaggata acacattgtc tgtcactggc tggttgtaat gcaaggaagg gacaaagatg
      301 aaatggaaac atgttccttt tttggtcatg atatcactcc tcagcttatc cccaaatcac
      361 ctgtttctgg cccagcttat tccaggctcc cgtcttcgtc aggaagattt tccacctcgc
      421 attgttgaac acccttcaga cctgattgtc tcaaaaggag aacctgcaac tttgaactgc
      481 aaagctgaag gccgccccac acccactatt gaatggtaca aagggggaga gagagtggag
      541 acagacaaag atgaccctcg ctcacaccga atgttgctgc cgagtggatc tttatttttc
      601 ttacgtatag tacatggacg gaaaagtaga cctgatgaag gagtctatgt ctgtgtagca
      661 aggaattacc ttggagaggc tgtgagccac aatgcatcgc tggaagtagc catacttcgg
      721 gatgacttca gacaaaaccc ttcggatgtc atggttgcag taggagagcc tgcagtaatg
      781 gaatgccaac ctccacgagg ccatcctgag cccaccattt catggaagaa agatggctct
      841 ccactggatg ataaagatga aagaataact atacgaggag gaaagctcat gatcacttac
      901 acccgtaaaa gtgacgctgg caaatatgtt tgtgttggta ccaatatggt tggggaacgt
      961 gagagtgaag tagccgagct gactgtctta gagagaccat catttgtgaa gagacccagt
     1021 aacttggcag taactgtgga tgacagtgca gaatttaaat gtgaggcccg aggtgaccct
     1081 gtacctacag tacgatggag gaaagatgat ggagagctgc ccaaatccag atatgaaatc
     1141 cgagatgatc ataccttgaa aattaggaag gtgacagctg gtgacatggg ttcatacact
     1201 tgtgttgcag aaaatatggt gggcaaagct gaagcatctg ctactctgac tgttcaagtt
     1261 gggtctgaac ctccacattt tgttgtgaaa ccccgtgacc aggttgttgc tttgggacgg
     1321 actgtaactt ttcagtgtga agcaaccgga aatcctcaac cagctatttt ctggaggaga
     1381 gaagggagtc agaatctact tttctcatat caaccaccac agtcatccag ccgattttca
     1441 gtctcccaga ctggcgacct cacaattact aatgtccagc gatctgatgt tggttattac
     1501 atctgccaga ctttaaatgt tgctggaagc atcatcacaa aggcatattt ggaagttaca
     1561 gatgtgattg cagatcggcc tcccccagtt attcgacaag gtcctgtgaa tcagactgta
     1621 gccgtggatg gcactttcgt cctcagctgt gtggccacag gcagtccagt gcccaccatt
     1681 ctgtggagaa aggatggagt cctcgtttca acccaagact ctcgaatcaa acagttggag
     1741 aatggagtac tgcagatccg atatgctaag ctgggtgata ctggtcggta cacctgcatt
     1801 gcatcaaccc ccagtggtga agcaacatgg agtgcttaca ttgaagttca agaatttgga
     1861 gttccagttc agcctccaag acctactgac ccaaatttaa tccctagtgc cccatcaaaa
     1921 cctgaagtga cagatgtcag cagaaataca gtcacattat cgtggcaacc aaatttgaat
     1981 tcaggagcaa ctccaacatc ttatattata gaagccttca gccatgcatc tggtagcagc
     2041 tggcagaccg tagcagagaa tgtgaaaaca gaaacatctg ccattaaagg actcaaacct
     2101 aatgcaattt accttttcct tgtgagggca gctaatgcat atggaattag tgatccaagc
     2161 caaatatcag atccagtgaa aacacaagat gtcctaccaa caagtcaggg ggtggaccac
     2221 aagcaggtcc agagagagct gggaaatgct gttctgcacc tccacaaccc caccgtcctt
     2281 tcttcctctt ccatcgaagt gcactggaca gtagatcaac agtctcagta tatacaagga
     2341 tataaaattc tctatcggcc atctggagcc aaccacggag aatcagactg gttagttttt
     2401 gaagtgagga cgccagccaa aaacagtgtg gtaatccctg atctcagaaa gggagtcaac
     2461 tatgaaatta aggctcgccc tttttttaat gaatttcaag gagcagatag tgaaatcaag
     2521 tttgccaaaa ccctggaaga agcacccagt gccccacccc aaggtgtaac tgtatccaag
     2581 aatgatggaa acggaactgc aattctagtt agttggcagc cacctccaga agacactcaa
     2641 aatggaatgg tccaagagta taaggtttgg tgtctgggca atgaaactcg ataccacatc
     2701 aacaaaacag tggatggttc caccttttcc gtggtcattc cctttcttgt tcctggaatc
     2761 cgatacagtg tggaagtggc agccagcact ggggctgggt ctggggtaaa gagtgagcct
     2821 cagttcatcc agctggatgc ccatggaaac cctgtgtcac ctgaggacca agtcagcctc
     2881 gctcagcaga tttcagatgt ggtgaagcag ccggccttca tagcaggtat tggagcagcc
     2941 tgttggatca tcctcatggt cttcagcatc tggctttatc gacaccgcaa gaagagaaac
     3001 ggacttacta gtacctacgc gggtatcaga aaagtcccgt cttttacctt cacaccaaca
     3061 gtaacttacc agagaggagg cgaagctgtc agcagtggag ggaggcctgg acttctcaac
     3121 atcagtgaac ctgccgcgca gccatggctg gcagacacgt ggcctaatac tggcaacaac
     3181 cacaatgact gctccatcag ctgctgcacg gcaggcaatg gaaacagcga cagcaacctc
     3241 actacctaca gtcgcccagc tgattgtata gcaaattata acaaccaact ggataacaaa
     3301 caaacaaatc tgatgctccc tgagtcaact gtttatggtg atgtggacct tagtaacaaa
     3361 atcaatgaga tgaaaacctt caatagccca aatctgaagg atgggcgttt tgtcaatcca
     3421 tcagggcagc ctactcctta cgccaccact cagctcatcc agtcaaacct cagcaacaac
     3481 atgaacaatg gcagcgggga ctctggcgag aagcactgga aaccactggg acagcagaaa
     3541 caagaagtgg caccagttca gtacaacatc gtggagcaaa acaagctgaa caaagattat
     3601 cgagcaaatg acacagttcc tccaactatc ccatacaacc aatcatacga ccagaacaca
     3661 ggaggatcct acaacagctc agaccggggc agtagtacat ctgggagtca ggggcacaag
     3721 aaaggggcaa gaacacccaa ggtaccaaaa cagggtggca tgaactgggc agacctgctt
     3781 cctcctcccc cagcacatcc tcctccacac agcaatagcg aagagtacaa catttctgta
     3841 gatgaaagct atgaccaaga aatgccatgt cccgtgccac cagcaaggat gtatttgcaa
     3901 caagatgaat tagaagagga ggaagatgaa cgaggcccca ctccccctgt tcggggagca
     3961 gcttcttctc cagctgccgt gtcctatagc catcagtcca ctgccactct gactccctcc
     4021 ccacaggaag aactccagcc catgttacag gattgtccag aggagactgg ccacatgcag
     4081 caccagcccg acaggagacg gcagcctgtg agtcctcctc caccaccacg gccgatctcc
     4141 cctccacata cctatggcta catttcagga cccctggtct cagatatgga tacggatgcg
     4201 ccagaagagg aagaagacga agccgacatg gaggtagcca agatgcaaac cagaaggctt
     4261 ttgttacgtg ggcttgagca gacacctgcc tccagtgttg gggacctgga gagctctgtc
     4321 acggggtcca tgatcaacgg ctggggctca gcctcagagg aggacaacat ttccagcgga
     4381 cgctccagtg ttagttcttc ggacggctcc tttttcactg atgctgactt tgcccaggca
     4441 gtcgcagcag cggcagagta tgctggtctg aaagtagcac gacggcaaat gcaggatgct
     4501 gctggccgtc gacattttca tgcgtctcag tgccctaggc ccacaagtcc cgtgtctaca
     4561 gacagcaaca tgagtgccgc cgtaatgcag aaaaccagac cagccaagaa actgaaacac
     4621 cagccaggac atctgcgcag agaaacctac acagatgatc ttccaccacc tcctgtgccg
     4681 ccacctgcta taaagtcacc tactgcccaa tccaagacac agctggaagt acgacctgta
     4741 gtggtgccaa aactcccttc tatggatgca agaacagaca gatcatcaga cagaaaagga
     4801 agcagttaca aggggagaga agtgttggat ggaagacagg ttgttgacat gcgaacaaat
     4861 ccaggtgatc ccagagaagc acaggaacag caaaatgacg ggaaaggacg tggaaacaag
     4921 gcagcaaaac gagaccttcc accagcaaag actcatctca tccaagagga tattctacct
     4981 tattgtagac ctacttttcc aacatcaaat aatcccagag atcccagttc ctcaagctca
     5041 atgtcatcaa gaggatcagg aagcagacaa agagaacaag caaatgtagg tcgaagaaat
     5101 attgcagaaa tgcaggtact tggaggatat gaaagaggag aagataataa tgaagaatta
     5161 gaggaaactg aaagctgaag acaaccaaga ggcttatgag atctaatgtg aaaatcatca
     5221 ctcaagatgc ctcctgtcag atgacacatg acgccagata aaatgttcag tgcaatcaga
     5281 gtgtacaaat tgtcgttttt attcctctta ttgggatatc attttaaaaa ctttattggg
     5341 tttttattgt tgttgtttga tccctaaccc tacaaagagc cttcctattc ccctcgctgt
     5401 tggagcaaac cattatacct tacttccagc aagcaaagtg ctttgacttc ttgcttcagt
     5461 catcagccag caagagggaa caaaactgtt cttttgcatt ttgccgctga gatatggcat
     5521 tgcactgctt atatgccaag ctaatttata gcaagatatt gatcaaatat agaaagttga
     5581 tattcaacct cacaagggct ctcaaagtat aatctttcta tagccaactg ctaatgcaaa
     5641 ttaaaacata tttcatttta acatgatttc aaaatcagtt tttcatacta ccctttgctg
     5701 gaagaaacta aaaatatagc aaatgcagaa ccacaaacaa ttcgaatggg gtagaaacat
     5761 tgtaaatatt tactctttgc aaaccctggt ggtattttat tttggcttca tttcaatcat
     5821 tgaagtatat tcttattgga aatgtacttt tggataagta gggctaagcc agttggatct
     5881 ctggttgtct agtcattgtc ataagtaaac ctagtaaaac cttgttctat ttttcaatca
     5941 tcaaaaagta attataaata cgtattacaa acaagtggat gtttttaatg accaattgag
     6001 taagaacatc cctgtcttaa ctggcctaaa tttcttctgg tagtgtcagt tcaactttca
     6061 gaagtgccac ttaaggaagt ttgatttttg tttttgtaat gcactgtttt taatctctct
     6121 ctcttttttt tttttttttt ggttttaaaa gcacaatcac taaactttat ttgtaaacca
     6181 ttgtaactat taaccttttt tgtcttattg aaaaaaaaaa tgttgagaag cgtttttaac
     6241 ctgttttgtt aatgctctat gtttgtattt ggaatatttg aataatgaca gatggtgaag
     6301 taacatgcat actttattgt gggccatgaa ccaaatggtt cttacttttc ctggacttaa
     6361 agaaaaaaag aggtttaagt ttgttgtggc caatgtcgaa acctacaaga tttccttaaa
     6421 atctctaata gaggcattac ttgctttcaa ttgacaaatg atgccctctg actagtagat
     6481 ttctatgatc cttttttgtc attttatgaa tatcattgat tttataattg gtgctatttg
     6541 aagaaaaaaa tgtacattta ttcatagata gataagtatc aggtctgacc ccagtggaaa
     6601 acaaagccaa acaaaactga accacaaaaa aaaaggctgg tgttcaccaa aaccaaactt
     6661 gttcatttag ataatttgaa aaagttccat agaaaaggcg tgcagtacta agggaacaat
     6721 ccatgtgatt aatgttttca ttatgttcat gtaagaagcc ccttattttt agccataatt
     6781 ttgcatactg aaaatccaat aatcagaaaa gtaattttgt cacattattt attaaaaatg
     6841 ttctcaaata ca
//
