LOCUS       NM_002941               6927 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens roundabout guidance receptor 1 (ROBO1), transcript
            variant 1, mRNA.
ACCESSION   NM_002941
VERSION     NM_002941.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6927)
  AUTHORS   Liu,X., Li,B., Wang,S., Zhang,E., Schultz,M., Touma,M., Monteiro Da
            Rocha,A., Evans,S.M., Eichmann,A., Herron,T., Chen,R., Xiong,D.,
            Jaworski,A., Weiss,S. and Si,M.S.
  TITLE     Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure
            Overload-Induced Cardiac Hypertrophy
  JOURNAL   Circ Res 134 (7), 913-930 (2024)
   PUBMED   38414132
  REMARK    GeneRIF: Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates
            Pressure Overload-Induced Cardiac Hypertrophy.
REFERENCE   2  (bases 1 to 6927)
  AUTHORS   Jin,J.C., Chen,B.Y., Deng,C.H., Chen,J.N., Xu,F., Tao,Y., Hu,C.L.,
            Xu,C.H., Chang,B.H., Wang,Y., Fei,M.Y., Liu,P., Yu,P.C., Li,Z.J.,
            Li,X.Y., Chen,S.B., Jiang,Y.L., Chen,X.C., Zong,L.J., Zhang,J.Y.,
            Ren,Y.Y., Xu,F.H., Liu,Q., Huang,X.H., Guo,J., He,Q., Song,L.X.,
            Zhou,L.Y., Su,J.Y., Xiao,C., Zhang,Y.M., Yan,M., Zhang,Z., Wu,D.,
            Chang,C.K., Li,X., Wang,L. and Wu,L.Y.
  TITLE     ROBO1 deficiency impairs HSPC homeostasis and erythropoiesis via
            CDC42 and predicts poor prognosis in MDS
  JOURNAL   Sci Adv 9 (48), eadi7375 (2023)
   PUBMED   38019913
  REMARK    GeneRIF: ROBO1 deficiency impairs HSPC homeostasis and
            erythropoiesis via CDC42 and predicts poor prognosis in MDS.
REFERENCE   3  (bases 1 to 6927)
  AUTHORS   Yu,R., Zhao,R., Sun,X., Zhang,Z., Wang,S., Gao,X., Sun,Z., Xue,H.
            and Li,G.
  TITLE     MicroRNA-588 regulates the invasive, migratory and vasculogenic
            mimicry-forming abilities of hypoxic glioma cells by targeting
            ROBO1
  JOURNAL   Mol Biol Rep 50 (2), 1333-1347 (2023)
   PUBMED   36459288
  REMARK    GeneRIF: MicroRNA-588 regulates the invasive, migratory and
            vasculogenic mimicry-forming abilities of hypoxic glioma cells by
            targeting ROBO1.
REFERENCE   4  (bases 1 to 6927)
  AUTHORS   Wang,L., Yang,L., Zhuang,T. and Shi,X.
  TITLE     Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in Pancreatic
            Cancer by Silencing ROBO1 and SRGAP2
  JOURNAL   J Immunol Res 2022, 4769385 (2022)
   PUBMED   36277474
  REMARK    GeneRIF: Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in
            Pancreatic Cancer by Silencing ROBO1 and SRGAP2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6927)
  AUTHORS   Williams,R.V., Huang,C., Moremen,K.W., Amster,I.J. and
            Prestegard,J.H.
  TITLE     NMR analysis suggests the terminal domains of Robo1 remain extended
            but are rigidified in the presence of heparan sulfate
  JOURNAL   Sci Rep 12 (1), 14769 (2022)
   PUBMED   36042257
  REMARK    GeneRIF: NMR analysis suggests the terminal domains of Robo1 remain
            extended but are rigidified in the presence of heparan sulfate.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6927)
  AUTHORS   Bashaw,G.J., Kidd,T., Murray,D., Pawson,T. and Goodman,C.S.
  TITLE     Repulsive axon guidance: Abelson and Enabled play opposing roles
            downstream of the roundabout receptor
  JOURNAL   Cell 101 (7), 703-715 (2000)
   PUBMED   10892742
REFERENCE   7  (bases 1 to 6927)
  AUTHORS   Yuan,W., Zhou,L., Chen,J.H., Wu,J.Y., Rao,Y. and Ornitz,D.M.
  TITLE     The mouse SLIT family: secreted ligands for ROBO expressed in
            patterns that suggest a role in morphogenesis and axon guidance
  JOURNAL   Dev Biol 212 (2), 290-306 (1999)
   PUBMED   10433822
REFERENCE   8  (bases 1 to 6927)
  AUTHORS   Sundaresan,V., Chung,G., Heppell-Parton,A., Xiong,J., Grundy,C.,
            Roberts,I., James,L., Cahn,A., Bench,A., Douglas,J., Minna,J.,
            Sekido,Y., Lerman,M., Latif,F., Bergh,J., Li,H., Lowe,N.,
            Ogilvie,D. and Rabbitts,P.
  TITLE     Homozygous deletions at 3p12 in breast and lung cancer
  JOURNAL   Oncogene 17 (13), 1723-1729 (1998)
   PUBMED   9796701
REFERENCE   9  (bases 1 to 6927)
  AUTHORS   Sundaresan,V., Roberts,I., Bateman,A., Bankier,A., Sheppard,M.,
            Hobbs,C., Xiong,J., Minna,J., Latif,F., Lerman,M. and Rabbitts,P.
  TITLE     The DUTT1 gene, a novel NCAM family member is expressed in
            developing murine neural tissues and has an unusually broad pattern
            of expression
  JOURNAL   Mol Cell Neurosci 11 (1-2), 29-35 (1998)
   PUBMED   9608531
REFERENCE   10 (bases 1 to 6927)
  AUTHORS   Kidd,T., Brose,K., Mitchell,K.J., Fetter,R.D., Tessier-Lavigne,M.,
            Goodman,C.S. and Tear,G.
  TITLE     Roundabout controls axon crossing of the CNS midline and defines a
            novel subfamily of evolutionarily conserved guidance receptors
  JOURNAL   Cell 92 (2), 205-215 (1998)
   PUBMED   9458045
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC125624.6, DR003097.1,
            AF040990.1 and AK025535.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002941.3.
            
            Summary: Bilateral symmetric nervous systems have special midline
            structures that establish a partition between the two mirror image
            halves. Some axons project toward and across the midline in
            response to long-range chemoattractants emanating from the midline.
            The product of this gene is a member of the immunoglobulin gene
            superfamily and encodes an integral membrane protein that functions
            in axon guidance and neuronal precursor cell migration. This
            receptor is activated by SLIT-family proteins, resulting in a
            repulsive effect on glioma cell guidance in the developing brain. A
            related gene is located at an adjacent region on chromosome 3.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF040990.1 [ECO:0000331]
            RNAseq introns       :: mixed/partial sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000464233.6/ ENSP00000420321.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AC125624.6         28628-28716         c
            90-297              DR003097.1         8-215
            298-5253            AF040990.1         1-4956
            5254-6927           AK025535.1         920-2593
FEATURES             Location/Qualifiers
     source          1..6927
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p12.3"
     gene            1..6927
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /note="roundabout guidance receptor 1"
                     /db_xref="GeneID:6091"
                     /db_xref="HGNC:HGNC:10249"
                     /db_xref="MIM:602430"
     exon            1..247
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            248..385
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..5253
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; deleted in U twenty twenty; roundabout, axon
                     guidance receptor, homolog 1"
                     /codon_start=1
                     /product="roundabout homolog 1 isoform a precursor"
                     /protein_id="NP_002932.1"
                     /db_xref="CCDS:CCDS54611.1"
                     /db_xref="GeneID:6091"
                     /db_xref="HGNC:HGNC:10249"
                     /db_xref="MIM:602430"
                     /translation="MKWKHVPFLVMISLLSLSPNHLFLAQLIPDPEDVERGNDHGTPI
                     PTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWY
                     KGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHN
                     ASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERI
                     TIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVD
                     DSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN
                     MVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNL
                     LFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA
                     DRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG
                     VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSK
                     PEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGL
                     KPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHN
                     PTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD
                     LRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSW
                     QPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAAST
                     GAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVF
                     SIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAA
                     QPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNL
                     MLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMN
                     NGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNT
                     GGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNI
                     SVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTAT
                     LTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVS
                     DMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSAS
                     EEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQ
                     CPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPT
                     AQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPRE
                     AQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSR
                     GSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES"
     exon            386..469
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            470..796
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            797..954
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1075
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1214
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1342
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1467
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1639
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1845
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1927
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2096
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2263
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2385
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2617
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2739
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2911
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3109
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3136
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3179
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3334
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..3670
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3778
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            3779..3923
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            3924..4172
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            4173..4579
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            4580..4732
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            4733..5041
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            5042..5238
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     exon            5239..6927
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6906..6911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /note="hexamer: ATTAAA"
     polyA_site      6927
                     /gene="ROBO1"
                     /gene_synonym="CPHD8; DUTT1; NORS; NYS8; SAX3"
                     /note="major polyA site"
ORIGIN      
        1 gcattaatag taatacagat aacgggtttg aaagaattct ctactgaaga aggattgaat
       61 ttttccaggg tgctgataca gagaagaaac ccgacttcac tctctcccta tttccccact
      121 cttaggttta aaagtctgtc acctttcgct tggtttaaac tcggaaaggt ctcagtgcac
      181 agcaaagttg cagggctgcg tctgcactac ggagcctcta gattgctgaa aacagtctta
      241 tggaaggata acacattgtc tgtcactggc tggttgtaat gcaaggaagg gacaaagatg
      301 aaatggaaac atgttccttt tttggtcatg atatcactcc tcagcttatc cccaaatcac
      361 ctgtttctgg cccagcttat tccagaccct gaagatgtag agagggggaa cgaccacggg
      421 acgccaatcc ccacctctga taacgatgac aattcgctgg gctatacagg ctcccgtctt
      481 cgtcaggaag attttccacc tcgcattgtt gaacaccctt cagacctgat tgtctcaaaa
      541 ggagaacctg caactttgaa ctgcaaagct gaaggccgcc ccacacccac tattgaatgg
      601 tacaaagggg gagagagagt ggagacagac aaagatgacc ctcgctcaca ccgaatgttg
      661 ctgccgagtg gatctttatt tttcttacgt atagtacatg gacggaaaag tagacctgat
      721 gaaggagtct atgtctgtgt agcaaggaat taccttggag aggctgtgag ccacaatgca
      781 tcgctggaag tagccatact tcgggatgac ttcagacaaa acccttcgga tgtcatggtt
      841 gcagtaggag agcctgcagt aatggaatgc caacctccac gaggccatcc tgagcccacc
      901 atttcatgga agaaagatgg ctctccactg gatgataaag atgaaagaat aactatacga
      961 ggaggaaagc tcatgatcac ttacacccgt aaaagtgacg ctggcaaata tgtttgtgtt
     1021 ggtaccaata tggttgggga acgtgagagt gaagtagccg agctgactgt cttagagaga
     1081 ccatcatttg tgaagagacc cagtaacttg gcagtaactg tggatgacag tgcagaattt
     1141 aaatgtgagg cccgaggtga ccctgtacct acagtacgat ggaggaaaga tgatggagag
     1201 ctgcccaaat ccagatatga aatccgagat gatcatacct tgaaaattag gaaggtgaca
     1261 gctggtgaca tgggttcata cacttgtgtt gcagaaaata tggtgggcaa agctgaagca
     1321 tctgctactc tgactgttca agaacctcca cattttgttg tgaaaccccg tgaccaggtt
     1381 gttgctttgg gacggactgt aacttttcag tgtgaagcaa ccggaaatcc tcaaccagct
     1441 attttctgga ggagagaagg gagtcagaat ctacttttct catatcaacc accacagtca
     1501 tccagccgat tttcagtctc ccagactggc gacctcacaa ttactaatgt ccagcgatct
     1561 gatgttggtt attacatctg ccagacttta aatgttgctg gaagcatcat cacaaaggca
     1621 tatttggaag ttacagatgt gattgcagat cggcctcccc cagttattcg acaaggtcct
     1681 gtgaatcaga ctgtagccgt ggatggcact ttcgtcctca gctgtgtggc cacaggcagt
     1741 ccagtgccca ccattctgtg gagaaaggat ggagtcctcg tttcaaccca agactctcga
     1801 atcaaacagt tggagaatgg agtactgcag atccgatatg ctaagctggg tgatactggt
     1861 cggtacacct gcattgcatc aacccccagt ggtgaagcaa catggagtgc ttacattgaa
     1921 gttcaagaat ttggagttcc agttcagcct ccaagaccta ctgacccaaa tttaatccct
     1981 agtgccccat caaaacctga agtgacagat gtcagcagaa atacagtcac attatcgtgg
     2041 caaccaaatt tgaattcagg agcaactcca acatcttata ttatagaagc cttcagccat
     2101 gcatctggta gcagctggca gaccgtagca gagaatgtga aaacagaaac atctgccatt
     2161 aaaggactca aacctaatgc aatttacctt ttccttgtga gggcagctaa tgcatatgga
     2221 attagtgatc caagccaaat atcagatcca gtgaaaacac aagatgtcct accaacaagt
     2281 cagggggtgg accacaagca ggtccagaga gagctgggaa atgctgttct gcacctccac
     2341 aaccccaccg tcctttcttc ctcttccatc gaagtgcact ggacagtaga tcaacagtct
     2401 cagtatatac aaggatataa aattctctat cggccatctg gagccaacca cggagaatca
     2461 gactggttag tttttgaagt gaggacgcca gccaaaaaca gtgtggtaat ccctgatctc
     2521 agaaagggag tcaactatga aattaaggct cgcccttttt ttaatgaatt tcaaggagca
     2581 gatagtgaaa tcaagtttgc caaaaccctg gaagaagcac ccagtgcccc accccaaggt
     2641 gtaactgtat ccaagaatga tggaaacgga actgcaattc tagttagttg gcagccacct
     2701 ccagaagaca ctcaaaatgg aatggtccaa gagtataagg tttggtgtct gggcaatgaa
     2761 actcgatacc acatcaacaa aacagtggat ggttccacct tttccgtggt cattcccttt
     2821 cttgttcctg gaatccgata cagtgtggaa gtggcagcca gcactggggc tgggtctggg
     2881 gtaaagagtg agcctcagtt catccagctg gatgcccatg gaaaccctgt gtcacctgag
     2941 gaccaagtca gcctcgctca gcagatttca gatgtggtga agcagccggc cttcatagca
     3001 ggtattggag cagcctgttg gatcatcctc atggtcttca gcatctggct ttatcgacac
     3061 cgcaagaaga gaaacggact tactagtacc tacgcgggta tcagaaaagt cccgtctttt
     3121 accttcacac caacagtaac ttaccagaga ggaggcgaag ctgtcagcag tggagggagg
     3181 cctggacttc tcaacatcag tgaacctgcc gcgcagccat ggctggcaga cacgtggcct
     3241 aatactggca acaaccacaa tgactgctcc atcagctgct gcacggcagg caatggaaac
     3301 agcgacagca acctcactac ctacagtcgc ccagctgatt gtatagcaaa ttataacaac
     3361 caactggata acaaacaaac aaatctgatg ctccctgagt caactgttta tggtgatgtg
     3421 gaccttagta acaaaatcaa tgagatgaaa accttcaata gcccaaatct gaaggatggg
     3481 cgttttgtca atccatcagg gcagcctact ccttacgcca ccactcagct catccagtca
     3541 aacctcagca acaacatgaa caatggcagc ggggactctg gcgagaagca ctggaaacca
     3601 ctgggacagc agaaacaaga agtggcacca gttcagtaca acatcgtgga gcaaaacaag
     3661 ctgaacaaag attatcgagc aaatgacaca gttcctccaa ctatcccata caaccaatca
     3721 tacgaccaga acacaggagg atcctacaac agctcagacc ggggcagtag tacatctggg
     3781 agtcaggggc acaagaaagg ggcaagaaca cccaaggtac caaaacaggg tggcatgaac
     3841 tgggcagacc tgcttcctcc tcccccagca catcctcctc cacacagcaa tagcgaagag
     3901 tacaacattt ctgtagatga aagctatgac caagaaatgc catgtcccgt gccaccagca
     3961 aggatgtatt tgcaacaaga tgaattagaa gaggaggaag atgaacgagg ccccactccc
     4021 cctgttcggg gagcagcttc ttctccagct gccgtgtcct atagccatca gtccactgcc
     4081 actctgactc cctccccaca ggaagaactc cagcccatgt tacaggattg tccagaggag
     4141 actggccaca tgcagcacca gcccgacagg agacggcagc ctgtgagtcc tcctccacca
     4201 ccacggccga tctcccctcc acatacctat ggctacattt caggacccct ggtctcagat
     4261 atggatacgg atgcgccaga agaggaagaa gacgaagccg acatggaggt agccaagatg
     4321 caaaccagaa ggcttttgtt acgtgggctt gagcagacac ctgcctccag tgttggggac
     4381 ctggagagct ctgtcacggg gtccatgatc aacggctggg gctcagcctc agaggaggac
     4441 aacatttcca gcggacgctc cagtgttagt tcttcggacg gctccttttt cactgatgct
     4501 gactttgccc aggcagtcgc agcagcggca gagtatgctg gtctgaaagt agcacgacgg
     4561 caaatgcagg atgctgctgg ccgtcgacat tttcatgcgt ctcagtgccc taggcccaca
     4621 agtcccgtgt ctacagacag caacatgagt gccgccgtaa tgcagaaaac cagaccagcc
     4681 aagaaactga aacaccagcc aggacatctg cgcagagaaa cctacacaga tgatcttcca
     4741 ccacctcctg tgccgccacc tgctataaag tcacctactg cccaatccaa gacacagctg
     4801 gaagtacgac ctgtagtggt gccaaaactc ccttctatgg atgcaagaac agacagatca
     4861 tcagacagaa aaggaagcag ttacaagggg agagaagtgt tggatggaag acaggttgtt
     4921 gacatgcgaa caaatccagg tgatcccaga gaagcacagg aacagcaaaa tgacgggaaa
     4981 ggacgtggaa acaaggcagc aaaacgagac cttccaccag caaagactca tctcatccaa
     5041 gaggatattc taccttattg tagacctact tttccaacat caaataatcc cagagatccc
     5101 agttcctcaa gctcaatgtc atcaagagga tcaggaagca gacaaagaga acaagcaaat
     5161 gtaggtcgaa gaaatattgc agaaatgcag gtacttggag gatatgaaag aggagaagat
     5221 aataatgaag aattagagga aactgaaagc tgaagacaac caagaggctt atgagatcta
     5281 atgtgaaaat catcactcaa gatgcctcct gtcagatgac acatgacgcc agataaaatg
     5341 ttcagtgcaa tcagagtgta caaattgtcg tttttattcc tcttattggg atatcatttt
     5401 aaaaacttta ttgggttttt attgttgttg tttgatccct aaccctacaa agagccttcc
     5461 tattcccctc gctgttggag caaaccatta taccttactt ccagcaagca aagtgctttg
     5521 acttcttgct tcagtcatca gccagcaaga gggaacaaaa ctgttctttt gcattttgcc
     5581 gctgagatat ggcattgcac tgcttatatg ccaagctaat ttatagcaag atattgatca
     5641 aatatagaaa gttgatattc aacctcacaa gggctctcaa agtataatct ttctatagcc
     5701 aactgctaat gcaaattaaa acatatttca ttttaacatg atttcaaaat cagtttttca
     5761 tactaccctt tgctggaaga aactaaaaat atagcaaatg cagaaccaca aacaattcga
     5821 atggggtaga aacattgtaa atatttactc tttgcaaacc ctggtggtat tttattttgg
     5881 cttcatttca atcattgaag tatattctta ttggaaatgt acttttggat aagtagggct
     5941 aagccagttg gatctctggt tgtctagtca ttgtcataag taaacctagt aaaaccttgt
     6001 tctatttttc aatcatcaaa aagtaattat aaatacgtat tacaaacaag tggatgtttt
     6061 taatgaccaa ttgagtaaga acatccctgt cttaactggc ctaaatttct tctggtagtg
     6121 tcagttcaac tttcagaagt gccacttaag gaagtttgat ttttgttttt gtaatgcact
     6181 gtttttaatc tctctctctt tttttttttt tttttggttt taaaagcaca atcactaaac
     6241 tttatttgta aaccattgta actattaacc ttttttgtct tattgaaaaa aaaaatgttg
     6301 agaagcgttt ttaacctgtt ttgttaatgc tctatgtttg tatttggaat atttgaataa
     6361 tgacagatgg tgaagtaaca tgcatacttt attgtgggcc atgaaccaaa tggttcttac
     6421 ttttcctgga cttaaagaaa aaaagaggtt taagtttgtt gtggccaatg tcgaaaccta
     6481 caagatttcc ttaaaatctc taatagaggc attacttgct ttcaattgac aaatgatgcc
     6541 ctctgactag tagatttcta tgatcctttt ttgtcatttt atgaatatca ttgattttat
     6601 aattggtgct atttgaagaa aaaaatgtac atttattcat agatagataa gtatcaggtc
     6661 tgaccccagt ggaaaacaaa gccaaacaaa actgaaccac aaaaaaaaag gctggtgttc
     6721 accaaaacca aacttgttca tttagataat ttgaaaaagt tccatagaaa aggcgtgcag
     6781 tactaaggga acaatccatg tgattaatgt tttcattatg ttcatgtaag aagcccctta
     6841 tttttagcca taattttgca tactgaaaat ccaataatca gaaaagtaat tttgtcacat
     6901 tatttattaa aaatgttctc aaataca
//
