LOCUS       NM_001173524            8291 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens Ro60, Y RNA binding protein (RO60), transcript variant
            5, mRNA.
ACCESSION   NM_001173524
VERSION     NM_001173524.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8291)
  AUTHORS   Song,Y., Wei,F., Liu,Y., Han,F., Ma,L., Zhuang,Y., Pan,C., Jia,Z.
            and Gong,A.
  TITLE     IL-33/ST2 Activation Is involved in Ro60-Regulated Photosensitivity
            in Cutaneous Lupus Erythematosus
  JOURNAL   Mediators Inflamm 2022, 4955761 (2022)
   PUBMED   35909659
  REMARK    GeneRIF: IL-33/ST2 Activation Is involved in Ro60-Regulated
            Photosensitivity in Cutaneous Lupus Erythematosus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8291)
  AUTHORS   Lee,A.Y.S., Beroukas,D., Brown,L., Lucchesi,C., Kaur,A., Gyedu,L.,
            Hughes,N., Ng,Y.H., Saran,O., Gordon,T.P. and Wang,J.J.
  TITLE     Identification of a unique anti-Ro60 subset with restricted
            serological and molecular profiles
  JOURNAL   Clin Exp Immunol 203 (1), 13-21 (2021)
   PUBMED   32852779
  REMARK    GeneRIF: Identification of a unique anti-Ro60 subset with
            restricted serological and molecular profiles.
REFERENCE   3  (bases 1 to 8291)
  AUTHORS   Leng,Y., Sim,S., Magidson,V. and Wolin,S.L.
  TITLE     Noncoding Y RNAs regulate the levels, subcellular distribution and
            protein interactions of their Ro60 autoantigen partner
  JOURNAL   Nucleic Acids Res 48 (12), 6919-6930 (2020)
   PUBMED   32469055
  REMARK    GeneRIF: Noncoding Y RNAs regulate the levels, subcellular
            distribution and protein interactions of their Ro60 autoantigen
            partner.
REFERENCE   4  (bases 1 to 8291)
  AUTHORS   Chen,S., Zhao,Y., Jin,H., Qi,X., He,J., Huang,J., Ding,Y., Chen,W.,
            Wu,C., Ding,X., Chen,S., Zhang,H., Shang,Y., Du,D. and Zhao,J.
  TITLE     TROVE2 strengthens the anti-inflammatory effect via macrophage
            polarization by estrogen induction in abdominal aortic aneurysm
  JOURNAL   Life Sci 242, 117207 (2020)
   PUBMED   31863777
  REMARK    GeneRIF: strengthens the anti-inflammatory effect via macrophage
            polarization by estrogen induction in abdominal aortic aneurysm
REFERENCE   5  (bases 1 to 8291)
  AUTHORS   Barcellos,K.S., Nonogaki,S., Enokihara,M.M., Teixeira,M.S. and
            Andrade,L.E.
  TITLE     Differential expression of Ro/SSA 60 kDa and La/SSB, but not Ro/SSA
            52 kDa, mRNA and protein in minor salivary glands from patients
            with primary Sjogren's syndrome
  JOURNAL   J Rheumatol 34 (6), 1283-1292 (2007)
   PUBMED   17552056
  REMARK    GeneRIF: Increased Ro/SSA 60 and La/SSB mRNA expression in minor
            salivary glands in primary Sjogren's syndrome (pSS) suggest that
            these 2 autoantigens, but not Ro/SSA 52, are involved in
            tissue-specific autoimmune response in pSS.
REFERENCE   6  (bases 1 to 8291)
  AUTHORS   Pruijn,G.J., Slobbe,R.L. and van Venrooij,W.J.
  TITLE     Analysis of protein--RNA interactions within Ro ribonucleoprotein
            complexes
  JOURNAL   Nucleic Acids Res 19 (19), 5173-5180 (1991)
   PUBMED   1833722
REFERENCE   7  (bases 1 to 8291)
  AUTHORS   Jitsukawa,T., Nakajima,S., Usui,J. and Watanabe,H.
  TITLE     Detection of anti-nuclear antibodies from patients with systemic
            rheumatic diseases by ELISA using HEp-2 cell nuclei
  JOURNAL   J Clin Lab Anal 5 (1), 49-53 (1991)
   PUBMED   1999763
REFERENCE   8  (bases 1 to 8291)
  AUTHORS   James,J.A., Dickey,W.D., Fujisaku,A., O'Brien,C.A., Deutscher,S.L.,
            Keene,J.D. and Harley,J.B.
  TITLE     Antigenicity of a recombinant Ro (SS-A) fusion protein
  JOURNAL   Arthritis Rheum 33 (1), 102-106 (1990)
   PUBMED   1689160
REFERENCE   9  (bases 1 to 8291)
  AUTHORS   Ben-Chetrit,E., Gandy,B.J., Tan,E.M. and Sullivan,K.F.
  TITLE     Isolation and characterization of a cDNA clone encoding the 60-kD
            component of the human SS-A/Ro ribonucleoprotein autoantigen
  JOURNAL   J Clin Invest 83 (4), 1284-1292 (1989)
   PUBMED   2649513
REFERENCE   10 (bases 1 to 8291)
  AUTHORS   Deutscher,S.L., Harley,J.B. and Keene,J.D.
  TITLE     Molecular analysis of the 60-kDa human Ro ribonucleoprotein
  JOURNAL   Proc Natl Acad Sci U S A 85 (24), 9479-9483 (1988)
   PUBMED   3200833
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136370.4, AK314594.1, M25077.1 and BC036658.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001173524.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR, the 3'
            coding region and the 3' UTR, compared to variant 1. The resulting
            isoform (2) has a distinct C-terminus and is longer than isoform 1.
            Variants 2 and 5 encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.170185.1,
                                           SRR1660803.201087.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400968.7/ ENSP00000383752.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AL136370.4         61985-62007         c
            24-791              AK314594.1         1-768
            792-792             M25077.1           790-790
            793-1803            AK314594.1         770-1780
            1804-2095           BC036658.2         1830-2121
            2096-2096           AL136370.4         36595-36595         c
            2097-2426           BC036658.2         2123-2452
            2427-2427           AL136370.4         36264-36264         c
            2428-3029           BC036658.2         2454-3055
            3030-3030           AL136370.4         35661-35661         c
            3031-3057           BC036658.2         3057-3083
            3058-8291           AL136370.4         30400-35633         c
FEATURES             Location/Qualifiers
     source          1..8291
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.2"
     gene            1..8291
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
                     /note="Ro60, Y RNA binding protein"
                     /db_xref="GeneID:6738"
                     /db_xref="HGNC:HGNC:11313"
                     /db_xref="MIM:600063"
     exon            1..165
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            166..766
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1803
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
                     /note="isoform 2 is encoded by transcript variant 5;
                     Sjogren syndrome antigen A2 (60kD, ribonucleoprotein
                     autoantigen SS-A/Ro); gastric cancer multi-drug resistance
                     protein; TROVE domain family member 2; 60 kDa
                     ribonucleoprotein Ro; sjoegren syndrome type A antigen;
                     Ro/SSA 60kDa; ro60 autoantigen; RNA-binding protein RO60"
                     /codon_start=1
                     /product="RNA-binding protein RO60 isoform 2"
                     /protein_id="NP_001166995.1"
                     /db_xref="CCDS:CCDS1379.1"
                     /db_xref="GeneID:6738"
                     /db_xref="HGNC:HGNC:11313"
                     /db_xref="MIM:600063"
                     /translation="MEESVNQMQPLNEKQIANSQDGYVWQVTDMNRLHRFLCFGSEGG
                     TYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTTKQEPMLFALAICSQC
                     SDISTKQAAFKAVSEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAIADWYNEKG
                     GMALALAVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHELYKEKAL
                     SVETEKLLKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWKALLQEM
                     PLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHILIALETYKTG
                     HGLRGKLKWRPDEEILKALDAAFYKTFKTVEPTGKRFLLAVDVSASMNQRVLGSILNA
                     STVAAAMCMVVTRTEKDSYVVAFSDEMVPCPVTTDMTLQQVLMAMSQIPAGGTDCSLP
                     MIWAQKTNTPADVFIVFTDNETFAGGVHPAIALREYRKKMDIPAKLIVCGMTSNGFTI
                     ADPDDRGMLDMCGFDTGALDVIRNFTLDMI"
     exon            767..987
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1134
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1272
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1389
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1503
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1650
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..8291
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3033..3038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
                     /note="hexamer: ATTAAA"
     polyA_site      3057
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
                     /note="major polyA site"
     regulatory      4320..4325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
                     /note="hexamer: AATAAA"
     polyA_site      4339
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
     regulatory      7702..7707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
                     /note="hexamer: TATAAA"
     polyA_site      7721
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
     regulatory      7773..7778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
                     /note="hexamer: AATAAA"
     polyA_site      7810
                     /gene="RO60"
                     /gene_synonym="RORNP; SSA2; TROVE2"
ORIGIN      
        1 actcgttccc gggaaccgaa cctggaatcc ccggcggcag tggggctgtt gctgttgctg
       61 tggctgtcgc tgcccgtcag gctgccttct tttgtcgttt cccagcgctg cgcaggactt
      121 ctcctggcgg cgctgcggat ccagggggtc ggctgccagg tacaggtttc ctaaagacaa
      181 aaaaaaatgg aggaatctgt aaaccaaatg cagccactga atgagaagca gatagccaat
      241 tctcaggatg gatatgtatg gcaagtcact gacatgaatc gactacaccg gttcttatgt
      301 ttcggttctg aaggtgggac ttattatatc aaagaacaga agttgggcct tgaaaatgct
      361 gaagctttaa ttagattgat tgaagatggc agaggatgtg aagtgataca agaaataaag
      421 tcatttagtc aagaaggcag aaccacaaag caagagccta tgctctttgc acttgccatt
      481 tgttcccagt gctccgacat aagcacaaaa caagcagcat ttaaagctgt ttctgaagtt
      541 tgtcgcattc ctacccatct ctttactttt atccagttta agaaagatct gaaggaaagc
      601 atgaaatgtg gcatgtgggg tcgtgccctc cggaaggcta tagcggactg gtacaatgag
      661 aaaggtggca tggcccttgc tctggcagtt acaaaatata aacagagaaa tggctggtct
      721 cacaaagatc tattaagatt gtcacatctt aaaccttcca gtgaaggact tgcaattgtg
      781 accaaatata ttacaaaggg ctggaaagaa gttcatgaat tgtataaaga aaaagcactc
      841 tctgtggaga ctgaaaaatt attaaagtat ctggaggctg tagagaaagt gaagcgcaca
      901 agagatgagc tagaagtcat tcatctaata gaagaacata gattagttag agaacatctt
      961 ttaacaaatc acttaaagtc taaagaggta tggaaggctt tgttacaaga aatgccgctt
     1021 actgcattac taaggaatct aggaaagatg actgctaatt cagtacttga accaggaaat
     1081 tcagaagtat ctttagtatg tgaaaaactg tgtaatgaaa aactattaaa aaaggctcgt
     1141 atacatccat ttcatatttt gatcgcatta gaaacttaca agacaggtca tggtctcaga
     1201 gggaaactga agtggcgccc tgatgaagaa attttgaaag cattggatgc tgctttttat
     1261 aaaacattta agacagttga accaactgga aaacgtttct tactagctgt tgatgtcagt
     1321 gcttctatga accaaagagt tttgggtagt atactcaacg ctagtacagt tgctgcagca
     1381 atgtgcatgg ttgtcacacg aacagaaaaa gattcttatg tagttgcttt ttccgatgaa
     1441 atggtaccat gtccagtgac tacagatatg accttacaac aggttttaat ggctatgagt
     1501 cagatcccag caggtggaac tgattgctct cttccaatga tctgggctca gaagacaaac
     1561 acacctgctg atgtcttcat tgtattcact gataatgaga cctttgctgg aggtgtccat
     1621 cctgctattg ctctgaggga gtatcgaaag aaaatggata ttccagctaa attgattgtt
     1681 tgtggaatga catcaaatgg tttcaccatt gcagacccag atgatagagg catgttggat
     1741 atgtgcggct ttgatactgg agctctggat gtaattcgaa atttcacatt agatatgatt
     1801 taaccataag cagcagcacg atccagagat ccattgccat cagtgatctc actaaaaata
     1861 tacagctact tcccagctaa tctccaccca atgaatgatg atggtatagt atgtgcataa
     1921 tggaaagtta ccttactgaa aaaaaaaaaa gaaggaaaaa taagatgggc ccaaaggtct
     1981 atctactaaa ctagctcttg gggaaatagc ttcaggatac tgtagtttcc tctatctaat
     2041 agagaacttt ttgttaacag acactgtaaa atagttttgc tttgttgaat aatacgtgtg
     2101 tacctaaaag aggtaagagc aaaaagtgta attccacatc atgttacttg agaagtgctt
     2161 aacgttttct taaatgtttt cattgggaaa ggacagcttt gataatgtcc aaatactctg
     2221 aaatgcacta gaccatataa ctgtgatgaa atatgaaact catctgtaaa cttttatacc
     2281 aagggggtaa aaaaaaaaac taaggcattt gattaaatta tgaatgagtt ttacaaattc
     2341 ctttcagagt tttactaaga tcacacaaat aacagctttc ttattcagtg aaaaagatat
     2401 tttatttctg atgttttatt tgcacttgtg gaatatgtta ccattaatca gaaacatcat
     2461 ggcaacccct aagaatagac taagtttgtg ttggctgagg gattctattt ggtttgcttt
     2521 tttttttttg ctttgttata ttttattgct acaaggggtg tgacttgata atgatttcct
     2581 ctgaattata ataacatagc cagatgtagt ctcacactgt ttttcatact cttaagtgta
     2641 aataatataa aatgtttcaa gcgcttaact ccccctcatt cacaaagtat aacaattaaa
     2701 atctcaacta taaccagttt agctttttcc ttacttttaa aataaaattt tttactttta
     2761 actatttttt tagttaatat ttttaaaagt atacatgtca atggcctctt tgtccattat
     2821 tcattttgtg gcaaaatatt cttctttgat agtgtaaaca aataataaag caatctaggt
     2881 cctttaggtt tgaaaggcaa tttttgagta gcatattacc agctagccag tcactaggaa
     2941 tttttttcag tattatttgt atgtattaaa cttttcatta cactaaagtg cattatttta
     3001 ttgagcaagt atccttcatt gtgaggttta acattaaagc aatctgttga aatgccatta
     3061 tctttgctca taattttatt atggccgtct aaggtagctt acacataaaa cctgtttgcg
     3121 tatctgttgt tctctaaata ttaattgaag atttactgag gatttgtaag gtccttctcg
     3181 ctgttatgtg aaaagtcaaa ctgtagttaa tgtaaattat agccttttag gtgcttgggg
     3241 gttagagggt ttatgttttt tgggaaaggg ggactttagt agtctgagga tttctgtaca
     3301 tattttcttc tgttttatgt gaaatttggg ctctgggaat aagaaaatat tcctttcaaa
     3361 tttatttgac atattaatgc tggttttgat atgtacccat tccttcaagg caactggtat
     3421 cagtttttaa gtgtgattta cctgagatat ttttgttcag caaagctcat agcaccctca
     3481 cccccactcc agacatgcat tgcttctgat gttgttcacg tttttaaccc tgtcaagcat
     3541 tgaactgaat atattagcta cttttgacac attaaaatat tacgttcaga ttgaatttaa
     3601 agtttaaaga aactaataga attacgtaat agttattgaa ttgtttaagt aaacccaaga
     3661 tcttaaaaat tataacatga tcattttatt cctaatagaa atgttaaata gaatatagta
     3721 caaaagtgca ttaccttcag ttgtgtacta tttccataat acttttagac aaatatatct
     3781 ataagttaat attaaatcca tcaaggatac aagattggat ggatatgacc tttctgaagt
     3841 atttaggtag gtctaattaa atggactagg gtaacattta agaaagaaag gataagtagg
     3901 agaagctacc acagaaggta acttttcaaa tcatggcata tttgagctgg aagaaacctt
     3961 agaaacctaa aagctaattt tttaaatttt tgttagagag ctgaggtcca agacagagtg
     4021 tgattttgaa gtactataac ctagaaatct tggtctcttc attcctgtgc cagaatttat
     4081 ttccccacaa catgggaata catggtctca gaagagtaga ggataaaata aaattattta
     4141 agacttttac cttattgagt tattaggaaa taatgtatat acgattgctt taggagtaga
     4201 aaaatagaat gggaacatgt ataatcttgt aattcatagg aatcctcaag cacaattaac
     4261 ctgtgttgct atatatatct acatatatag agaaaaaaca aaaactttac ctcattatga
     4321 ataaaatgta ctgaagtgat aagtttttta tttcctgagt tacttttagg attactgtta
     4381 aattaatatt tgggaaaata ctgcttttaa aaacaatcct gcaagaataa acaaacttta
     4441 tttcctaggt agtatgtaaa tagttccagg atatagttgt aattagtaaa acaaaaacta
     4501 atcttataat cccacccttt attagttgaa agttcttgga aattccattt attaatactt
     4561 atattattta gtaatctatc ttatgagagt gttagtgagg caagatgcta gtgaatggaa
     4621 tttagtgtta ccctttgaca cctcctttgc tttatctaac ttactgtgtg actgtagaca
     4681 accagtttaa cctaagtgat ttgattattt ttatccttaa aaagtaacat atctgtgctt
     4741 ggatcataga agaatcagtg atttaatatt tgtataaaaa ttgaaactgg gaagagggct
     4801 tgcaatacaa gttagaattc tttttttttt tggttaaaaa cattcttgtt aataagatac
     4861 gtatttcaaa agataaaatg ttttagaaaa atagctcact caataggcct aacagtgttt
     4921 taaaacattc ctgttcagag tagaaaaatt tagaagaaaa attttcacag ctaaagtatt
     4981 acccaaaaag tcactattct ctactgaaga gggagaaaaa atatactcca agatcttctt
     5041 ggacagacct agaaaaacaa gcttatactc tgaggaaatg ctgttaacaa actttttttt
     5101 ttgagacagg ctatccctct gtcacccagg ctggagtggc atgatcacag ctcactgcag
     5161 ccttgacctc ccaagttcaa gtgatcttcc caagtagcca ggaacactgg tgtgcactgc
     5221 actaccacgc ctgctttttt tttttttttt tttttttttt tttttaagag acaacgtctc
     5281 actgtgttgc ccaggctggt gtcaaactcc tgggctcaag ggatcttcct gccttggcct
     5341 cccgaagtgc tggaattaga ggcatgagcc actgcaccca gccagcaaac attctcttaa
     5401 tcttttaaag taaccagtaa atctacaaat agtaaagtac tattttcatc agggattttt
     5461 tttttcttat tttctagatt ttacagaaac aatgtgaaat tattttggaa agataaggta
     5521 ggattcttga ataaatctga aggtctcaca attaagtgag aaacaccttt aaaagcatag
     5581 taaagctaca cctaaataac taaagcctaa atcattgtaa tgttttgttg gacttacttt
     5641 aacttgacct gttgtagcca caaataacaa atttcttggt aactgatgct attacagtag
     5701 gtaatcaaaa atgaaaaatt ctagtcttat atactgcagg tttggggtga ttgttaaggc
     5761 actatcccct ctggagaaat gtcatatggc atcagtgtaa acatgcacaa gaaagaattt
     5821 gtaaaaaaaa atgacaggtt aatcaatgaa attagttgta tttactgttt ggattttatt
     5881 tagtgtttcc ttgatgtctg tttcctcatc tcttatttgt tggaagatta cttttctacc
     5941 tctttttttt cttttaaaat tcctttctta catttctgtt gtttcttttt ctagtccttc
     6001 tctatctgga taataaaatg aatgacagga aagtcaccca catagaggtt tgggatgaac
     6061 cttttgcaga ttgctttttg tttcatacaa gtataagatc atattttctt tttcaactta
     6121 gtaataggca ggcttcttgg aacaataagt agattgatac actcctcccc aaatcaaatt
     6181 atattgtata tcttttatat tagatgtttg cagaaattct gtggccttta agatcagtta
     6241 ttcagccttt gtaattatgt tatctagcta tgttgaaaag ataagtgctt actatataag
     6301 cactcttaga aaaataatta actgattact ctttcagaaa atagcaggtg tctcaatgct
     6361 ttttttccat aattataaag accattgtca aaatctttgg tttactaaat atttcactga
     6421 gcatatatag agatacgttg cttgtggcat aaaaagtctt gtagataact tactcacatt
     6481 tggctttttt ttaattggtg cattttttaa tttgcttttt tgaaaattat gaagttaaaa
     6541 tttaattcta aggtagtatt tttcatgtat aaaactaata atgtagttaa gcatactgtt
     6601 tgaataaaat tataataaat ggcacaattc cttaaaccct gaaaatacca agttatattg
     6661 gaaaatagtg gaaagaaaaa actagtggag aacatcttag aaaattctat tgtggaaatt
     6721 acgatgatta ttttcagtga gaatgaattt atatatacaa caaaaatata caaaagctaa
     6781 ccttctcatc ctaaaaagat ttttcccttt gcttctgttt tatttagccc tgccatgcac
     6841 cacattaatt ttatgaacat aaatgatatt taacttttct tttttttttt ttttttgaga
     6901 cagagtctca ctccgtcacc aggctggagt gcggtggcgc gatctcagct cactgcaacc
     6961 tccatttccc aggttcaagc aattctcctg cctcagcctc ccaagtagct gggattacag
     7021 gcacgcgcca ccacgcccac ctaatttttg tatttttagt agagacgggg tttcaccatg
     7081 ttggtcaggc tggcctcgat ctcgtgacct cgtgatctgt ccgcctcggc cttccaaagt
     7141 gctaggatta caggcgtgag ccaccgcacc tggccaactt ttcatcttaa gttgtttaaa
     7201 tttatgcact tttagatatc agaatatatg cttgaacaaa ggaaatagta aattagctat
     7261 atgtctgctg gtttcacttc gatgtggata tggatatgtg gataaagaca gtaaatgaaa
     7321 ttaaaaccct gctgttttaa atatcattac cagatataat tgagggaata ttatatcaac
     7381 aaacatattg aaacttggct ttatttgtaa cgtaaactat atataatcca tacgtagcca
     7441 aattagattt aaaatataca attaatgaat agtactcaaa gtgtttttgt tgcactgtta
     7501 ctctgaatat ggactctcta tatctggtat ggcgtgactg ggcataactt ctgtaatgta
     7561 tttcagttat atgtttttcc ttttattgcc agcttctgat aatgaaattt tccaaaggga
     7621 tgagatataa gaatcatctt ttataaaaac cagtggggag tggggtatta taatctagtt
     7681 ctaaactgtc catttgcttt atataaaggc tttgatttca ataactgacc atttgatgaa
     7741 tatttaaatt acacagaata atgtctacat agaataaact taagtattca agagccttaa
     7801 agtgaaaaaa tgaacctttt gactgcctta aaatactact tgctctgtaa ttcaggcata
     7861 ctagttactt tccttggggt ctgtttaaat aatgccttaa tagtgttcta atgtttctga
     7921 aatacagaac tcaaagggtc ttttagagct tttaatttta catagtgaat ggaaatttaa
     7981 gtattacatt ttaaaacctg attgtacatt ggtaatttaa acatccaata acaggaaaat
     8041 ctagatacag tgatgtgtta tacatacatg actgttaaca tcagtaatat tttatgatag
     8101 tttaaggttt tttattgttt tctataacaa gttatccaac aggttggact ttgtaacatg
     8161 atatccaagg accaagttgc atatttaaca tcgaatgaaa atgtagttgt acagttccaa
     8221 aaataattaa ttttttaagg gaatttttca agacaaaagg caaatatttt gtttcaaacc
     8281 tacaagcaaa t
//
