LOCUS       NM_018226               5761 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens arginyl aminopeptidase like 1 (RNPEPL1), mRNA.
ACCESSION   NM_018226
VERSION     NM_018226.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5761)
  AUTHORS   Ohnishi,A. and Tsujimoto,M.
  TITLE     Characterization of the enzymatic properties of human
            RNPEPL1/aminopeptidase Z
  JOURNAL   J Biochem 173 (4), 307-316 (2023)
   PUBMED   36545750
  REMARK    GeneRIF: Characterization of the enzymatic properties of human
            RNPEPL1/aminopeptidase Z.
            Erratum:[J Biochem. 2023 May 29;173(6):497. doi:
            10.1093/jb/mvad027.. PMID: 37021591]
REFERENCE   2  (bases 1 to 5761)
  AUTHORS   Thompson,M.W., Beasley,K.A., Schmidt,M.D. and Seipelt,R.L.
  TITLE     Arginyl aminopeptidase-like 1 (RNPEPL1) is an alternatively
            processed aminopeptidase with specificity for methionine,
            glutamine, and citrulline residues
  JOURNAL   Protein Pept Lett 16 (10), 1256-1266 (2009)
   PUBMED   19508204
  REMARK    GeneRIF: RT-PCR analysis of RNPEPL1 expression revealed a
            ubiquitous tissue distribution, consistent with a general
            housekeeping function, but also revealed alternative splicing of
            the mRNA in all tissues examined.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124862.4, BC082975.1 and BC017301.2.
            
            On Nov 23, 2018 this sequence version replaced NM_018226.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on partial human transcript alignments
            and on full-length homologous transcript and protein alignments
            with mouse NP_852070.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082975.1, AF300795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270357.10/ ENSP00000270357.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AC124862.4         66721-66923         c
            204-2741            BC082975.1         1-2538
            2742-2742           AC124862.4         57054-57054         c
            2743-3116           BC082975.1         2540-2913
            3117-3121           BC017301.2         2166-2170
            3122-5761           AC124862.4         54035-56674         c
FEATURES             Location/Qualifiers
     source          1..5761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..5761
                     /gene="RNPEPL1"
                     /note="arginyl aminopeptidase like 1"
                     /db_xref="GeneID:57140"
                     /db_xref="HGNC:HGNC:10079"
                     /db_xref="MIM:605287"
     exon            1..631
                     /gene="RNPEPL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..2281
                     /gene="RNPEPL1"
                     /EC_number="3.4.11.18"
                     /note="argininyl aminopeptidase-like 1; RNPEP-like 1;
                     arginyl aminopeptidase (aminopeptidase B)-like 1;
                     aminopeptidase B-like 1; methionyl aminopeptidase"
                     /codon_start=1
                     /product="aminopeptidase RNPEPL1"
                     /protein_id="NP_060696.4"
                     /db_xref="GeneID:57140"
                     /db_xref="HGNC:HGNC:10079"
                     /db_xref="MIM:605287"
                     /translation="MAAQCCCRQAPGAEAAPVRPPPEPPPALDVASASSAQLFRLRHL
                     QLGLELRPEARELAGCLVLELCALRPAPRALVLDAHPALRLHSAAFRRAPAAAAETPC
                     AFAFSAPGPGPAPPPPLPAFPEAPGSEPACCPLAFRVDPFTDYGSSLTVTLPPELQAH
                     QPFQVILRYTSTDAPAIWWLDPELTYGCAKPFVFTQGHSVCNRSFFPCFDTPAVKCTY
                     SAVVKAPSGVQVLMSATRSAYMEEEGVFHFHMEHPVPAYLVALVAGDLKPADIGPRSR
                     VWAEPCLLPTATSKLSGAVEQWLSAAERLYGPYMWGRYDIVFLPPSFPIVAMENPCLT
                     FIISSILESDEFLVIDVIHEVAHSWFGNAVTNATWEEMWLSEGLATYAQRRITTETYG
                     AAFTCLETAFRLDALHRQMKLLGEDSPVSKLQVKLEPGVNPSHLMNLFTYEKGYCFVY
                     YLSQLCGDPQRFDDFLRAYVEKYKFTSVVAQDLLDSFLSFFPELKEQSVDCRAGLEFE
                     RWLNATGPPLAEPDLSQGSSLTRPVEALFQLWTAEPLDQAAASASAIDISKWRTFQTA
                     LFLDRLLDGSPLPQEVVMSLSKCYSSLLDSMNAEIRIRWLQIVVRNDYYPDLHRVRRF
                     LESQMSRMYTIPLYEDLCTGALKSFALEVFYQTQGRLHPNLRRAIQQILSQGLGSSTE
                     PASEPSTELGKAEADTDSDAQALLLGDEAPSSAISLRDVNVSA"
     exon            632..772
                     /gene="RNPEPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            773..924
                     /gene="RNPEPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1041
                     /gene="RNPEPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1277
                     /gene="RNPEPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1391
                     /gene="RNPEPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1504
                     /gene="RNPEPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1613
                     /gene="RNPEPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1844
                     /gene="RNPEPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1987
                     /gene="RNPEPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..5761
                     /gene="RNPEPL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3096..3101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNPEPL1"
                     /note="hexamer: ATTAAA"
     polyA_site      3116
                     /gene="RNPEPL1"
                     /note="major polyA site"
     regulatory      5743..5748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNPEPL1"
                     /note="hexamer: AATAAA"
     polyA_site      5761
                     /gene="RNPEPL1"
ORIGIN      
        1 gacttcctgt tgtgcccgcg ccccgccgcc gccgccgccc ggcgcccctc gcccgcggcc
       61 cggcgcggcc gccgcccatg gatttcacct agtgccggcg gccatggccg cgcagtgctg
      121 ctgccgccag gcgcccggcg ccgaggccgc gcccgtccgc ccgccgcccg agccgccgcc
      181 cgccctggac gtggcctcgg cctccagcgc gcagctcttc cgcctccgcc acctgcagct
      241 gggcctggag ctgcggcccg aggcgcgcga gttggccggc tgcctggtgc tcgagctgtg
      301 cgcgctgcgg cccgcgcccc gcgcgctcgt gctcgacgcg cacccggctc tgcgcctgca
      361 ctcagccgcc ttccgtcgcg cccccgccgc cgccgccgag acgccctgcg ccttcgcctt
      421 ctccgccccc gggccggggc ccgcgccgcc gcccccgctg cccgccttcc ccgaggcgcc
      481 cggctccgag cccgcctgct gtccgctggc cttcagggtg gacccgttca ccgactacgg
      541 ctcctcgctc accgtcacgc tgccgcccga gctgcaggcg caccagccct tccaggtcat
      601 cctgcggtac acctcgaccg acgcccccgc catctggtgg ctggacccag agctgaccta
      661 tggctgcgcc aagcccttcg tcttcaccca gggccactcc gtgtgcaacc gctccttctt
      721 cccgtgcttc gacacacctg ccgtgaagtg cacctactct gccgtcgtca aggcgccatc
      781 gggggtgcag gtgctgatga gtgccacccg gagtgcatac atggaggaag aaggcgtctt
      841 ccacttccac atggagcacc ccgtgcccgc ctacctcgtg gccctggtgg ccggagacct
      901 caagccggca gacatcgggc ccaggagccg cgtgtgggcc gagccatgcc tcctgcccac
      961 ggccaccagc aagctgtcgg gcgcagtgga gcagtggctg agtgcagctg agcggctgta
     1021 tgggccctac atgtggggca ggtacgacat tgtcttcctg ccaccctcct tccccatcgt
     1081 ggccatggag aacccctgcc tcaccttcat catctcctcc atcctggaga gcgatgagtt
     1141 cctggtcatc gatgtcatcc acgaggtggc ccacagttgg ttcggcaacg ctgtcaccaa
     1201 cgccacgtgg gaagagatgt ggctgagcga gggcctggcc acctatgccc agcgccgtat
     1261 caccaccgag acctacggtg ctgccttcac ctgcctggag actgccttcc gcctggacgc
     1321 cctgcaccgg cagatgaagc ttctgggaga ggacagcccg gtcagcaaac tgcaggtcaa
     1381 gctggagcca ggagtgaatc ccagccacct gatgaacctg ttcacctacg agaagggcta
     1441 ctgcttcgtg tactacctgt cccagctctg cggagaccca cagcgctttg atgactttct
     1501 ccgagcctat gtggagaagt acaagttcac cagcgtggtg gcccaggacc tgctggactc
     1561 cttcctgagc ttcttcccgg agctgaagga gcagagcgtg gactgccggg cagggctgga
     1621 attcgagcgc tggctcaatg ccacaggccc gccgctggct gagccggacc tgtctcaggg
     1681 atccagcctg acccggcccg tggaggccct tttccagctg tggaccgcag aacctctgga
     1741 ccaggcagct gcctcggcca gcgccattga catctccaag tggaggacct tccagacagc
     1801 actcttcctg gaccggctcc tggatgggtc cccgctgccg caggaggtgg tgatgagcct
     1861 gtccaagtgc tactcctccc tgctggactc gatgaacgct gagatccgca tccgctggct
     1921 gcagattgtg gtccgcaacg actactatcc tgacctccac agggtgcggc gcttcctgga
     1981 gagccagatg tcacgcatgt acaccatccc gctgtacgag gacctctgca ccggtgccct
     2041 caagtccttc gcgctggagg tcttctacca gacgcagggc cggctgcacc ccaacctgcg
     2101 cagagccatc cagcagatcc tgtcccaggg cctgggctcc agcacagagc ccgcctcaga
     2161 gcccagcacg gagctgggca aggctgaagc agacacagac tcggacgcac aggccctgct
     2221 gcttggggac gaggccccca gcagtgccat ctctctcagg gacgtcaatg tgtctgccta
     2281 gccctgttgg cgggctgacc ctcgacctcc cagacaccac aattgtgcct tctgtgggcc
     2341 aggcctgcca tgactgcgtc tcggctctgg ccatgagctc tgcccaggcc cacaagcccc
     2401 tcccctgggc tctcccaggc agggagaatg gggagaggga cctccttgtg tctggcagag
     2461 acctgtggac ctggcctccc cactcccagc tctcttgcac tgcaggccct ggggccagcc
     2521 cgcacacacc atgcctcctg tctcaacact gacagctgtg cctagccccg gatgccagca
     2581 cctgccaggt gccgccccgg ggcaagggcc ccagcagccc tatggtgacc gccacactgt
     2641 gccttaatgt ctgccggggg cccaggctgt gctgtccctg cagcacgcct ccttgcaggg
     2701 atctgagcca ccctccccgc acagccctgc accccgcccc tggggttggc agcctcagtt
     2761 ggcccctggc agaggaacaa ggacacagac attccctcag tgtggggggc aggggacaca
     2821 gggagaggat ggttgtccct ggggagggcc ctctggcccc aggcaacctt agcccctcag
     2881 aacagggagt cccaggaccc agggagagtg tggggacagg acagcctgtc tcttgtagct
     2941 tcctggggtg ggaggcacag gggcaaagca ataccccagg gaaagtggga ggtggtgctg
     3001 gtgctctctc caggcccacc atgctgggag aggcggccag agcctggggc ctccagcctg
     3061 ggactgctgt gatggggtat cacggtgatg gtcccattaa acttccactc tgcaaacctg
     3121 atctcctgcg ctctttctcg cgactcttgt cctctgcatc ttcctggctg tgtagggtgg
     3181 gctggcctgc cgggacttgg ggcctggagc tggtcaggag ctgggtgtgg ccccctcctc
     3241 tgatacataa gcccgagagc aggctccccg aatcctgccc agccccttgg ctggaccccc
     3301 tgggcctgag tagcctctgg atgtcacagg aaagccatgt gtcaccttca ctctgggcct
     3361 tcacctgtgg cttaagccaa atcccggcct cagtggtgat cctttcccaa gatgggtaca
     3421 aggtgacagg catgttttgt tttggagaac tgagatttcc attttcccag gcgataggtg
     3481 tcgctgccct tcacagtccc caaggatgtg gcgccaccat ctcagtgcca cgcacacctg
     3541 gccaacatgc cgtggcccag aagcagcacg tctcttctcc caacccgctg gccaggccca
     3601 gtcacagccc cactccacac atggcagcca ggaagtgggg agggcaggag gtgctgggca
     3661 aataaccctg ataccatcac tgtccagtcc ccagtcacca aatgtcccac tcaccctcct
     3721 tcctgttctg gatgccccgc ccctcccctc ccctcccaag gacatatgag tcccctccag
     3781 tggcggtggc aactctggtc tagggtctgg ggccgtctct acatgtgttg cttcatgtac
     3841 cttcttcaca tcaggtctgg gggaggcgcc accccatcca gagacctagg aactagaaga
     3901 ctgccactgc ccctcacacc cagggatagg atgactgcag taacccctgt gaaagcgggt
     3961 atggagggca cctggcagcc cctgctgcat ggccatctaa agtcttgcca ggcaggcaca
     4021 gctagggccc ctgcctggga gtggacaccc cactccccca agtcatgttc tctgtggcct
     4081 ggggctccag ccttgggagg acccctttcc tgtttcttaa ccatgcttga tggtgtcctc
     4141 aaaggagccc tgctcagtgg cagaactgct ttctcagcct cttccccgcc aaggttgttt
     4201 tcaagtccca gcagtcacag actttcatcc tgggctcttc tttcttttgc aattcagctc
     4261 tcgaaatgac tctgtggtct gcgggtgact ccactccacg tgcctacagc cacgcccaca
     4321 gcgccacctc cggacgctgc tgagctgcgc acctgtgcct gacacctggc tttgggaaac
     4381 tcagcagcag tgcccagcgt catgaccctg ggggcaggag ggcatctgga tccaggatgg
     4441 caccctcacc acaatctgtc ttggctctgt gcccgcccgt ggggtacaca ggagggctct
     4501 ttcagcccta agtccttgtg ttcctgacct ttgttcctct tccacccagc ttgcaagtgc
     4561 agaatttttt tttagctcgt cgcttccctg cagtcccttg tccaatgcag cctccggccg
     4621 atactcaggc cagtgttgtt tcccaacctc tccactagat acgcacactt agctcacggt
     4681 ctgcctcatg agtcatccca gttgagcttt accaaatgtt ttgccccacc taacagcctg
     4741 cccacattcc aaatcctggc aggtcgcacg ttttattagc acagcacccc tctcctagcg
     4801 gccagcttct ctattaggcc acgttatgct ccagccacac aactatgaag cgcagacgtc
     4861 tcacacaaca aagctttctc atgctgcagg cccacctcag gctggcaggg gaagggggga
     4921 ttctcttcaa tgtgaccact ctcggacccg taccgatgaa cagagatctc aaatgtttcc
     4981 aggcaccttg ccagggataa gagagctgtt gaggggctca cactggcagt ggaagttcta
     5041 aggggcctac aaccacaggg gctgcaaccc caccatatgc acaaaagcgg gggcagatgg
     5101 caaacagcac taatgacaac gacggagctg aggccagaat gtgagagaga tctgcatttt
     5161 ggggattagg gcctagtcag gcaggtagga gatgatgttc aaaaagggaa aagaagcgtg
     5221 atgaaagact ggtttctaca gagatagatt agaaagctga agcctgaaaa aacagtgaag
     5281 gagacccatg caaatttcta ggccctggag gtccaaataa ggttttctaa gtccctcagg
     5341 ccatgacagg ttcagtccag acttgtctcc cagagtgttt ctctgccatc cctactctaa
     5401 ctgggactta ttggtggtgt ttctctccta aggccagatg ctttgcacag aacattagga
     5461 aactccagat gtaaaggtaa ggcacaactg agaatcacct gcccagggca gcaacacagt
     5521 gtgaaggaaa acaggccact caacccaaac ttacacctga gacagaggca acagaaaaat
     5581 cagaaaagga ctttagaaca catataatca aaatctcaga cctaaagacg acttttgaaa
     5641 taaaccataa catatgaaga ggcacttatg aaacaagaac aggtagttta taaaaaagaa
     5701 ccagtcagag accctggaaa ttttttaaaa agcaattact aaaataaaaa atgaaaactc
     5761 a
//
