LOCUS       NM_020216               2399 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens arginyl aminopeptidase (RNPEP), transcript variant 1,
            mRNA.
ACCESSION   NM_020216
VERSION     NM_020216.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2399)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   2  (bases 1 to 2399)
  AUTHORS   Malinauskas,M., Wallenius,V., Fandriks,L. and Casselbrant,A.
  TITLE     Local expression of AP/AngIV/IRAP and effect of AngIV on
            glucose-induced epithelial transport in human jejunal mucosa
  JOURNAL   J Renin Angiotensin Aldosterone Syst 16 (4), 1101-1108 (2015)
   PUBMED   26311161
  REMARK    GeneRIF: The substrate Angiotensin II, the enzymes
            aminopeptidases-A, B, M as well as IRAP were detected in the
            jejunal mucosa.
REFERENCE   3  (bases 1 to 2399)
  AUTHORS   Fernandez-Atucha,A., Echevarria,E., Larrinaga,G., Gil,J.,
            Martinez-Cengotitabengoa,M., Gonzalez-Pinto,A.M., Irazusta,J. and
            Seco,J.
  TITLE     Plasma peptidases as prognostic biomarkers in patients with
            first-episode psychosis
  JOURNAL   Psychiatry Res 228 (2), 197-202 (2015)
   PUBMED   25997998
  REMARK    GeneRIF: these results suggest a pathophysiological involvement of
            plasma peptidases and indicate that aminopeptidase activity can
            predict the course of first-episode psychosis patients, acting as a
            prognostic indicator
REFERENCE   4  (bases 1 to 2399)
  AUTHORS   Perez,I., Blanco,L., Sanz,B., Errarte,P., Ariz,U., Beitia,M.,
            Fernandez,A., Loizate,A., Candenas,M.L., Pinto,F.M., Gil,J.,
            Lopez,J.I. and Larrinaga,G.
  TITLE     Altered Activity and Expression of Cytosolic Peptidases in
            Colorectal Cancer
  JOURNAL   Int J Med Sci 12 (6), 458-467 (2015)
   PUBMED   26078706
  REMARK    GeneRIF: cytosolic peptidases(puromycin-sensitive aminopeptidase
            (PSA), aminopeptidase B (APB) and pyroglutamyl-peptidase I (PGI) )
            may be involved in colorectal carcinogenesis
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2399)
  AUTHORS   Cadel,S., Darmon,C., Pernier,J., Herve,G. and Foulon,T.
  TITLE     The M1 family of vertebrate aminopeptidases: role of evolutionarily
            conserved tyrosines in the enzymatic mechanism of aminopeptidase B
  JOURNAL   Biochimie 109, 67-77 (2015)
   PUBMED   25530263
  REMARK    GeneRIF: Data indicate that the importance of hydrogen bonds in
            aminopeptidase B (Ap-B) is verified by the Y229H substitution,
            which preserves the enzyme activity.
REFERENCE   6  (bases 1 to 2399)
  AUTHORS   Foulon,T., Cadel,S. and Cohen,P.
  TITLE     Aminopeptidase B (EC 3.4.11.6)
  JOURNAL   Int J Biochem Cell Biol 31 (7), 747-750 (1999)
   PUBMED   10467730
  REMARK    Review article
REFERENCE   7  (bases 1 to 2399)
  AUTHORS   Balogh,A., Cadel,S., Foulon,T., Picart,R., Der Garabedian,A.,
            Rousselet,A., Tougard,C. and Cohen,P.
  TITLE     Aminopeptidase B: a processing enzyme secreted and associated with
            the plasma membrane of rat pheochromocytoma (PC12) cells
  JOURNAL   J Cell Sci 111 (Pt 2), 161-169 (1998)
   PUBMED   9405297
REFERENCE   8  (bases 1 to 2399)
  AUTHORS   Aurich-Costa,J., Cadel,S., Gouzy,C., Foulon,T., Cherif,D. and
            Cohen,P.
  TITLE     Assignment of the aminopeptidase B gene (RNPEP) to human chromosome
            1 band q32 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 79 (1-2), 143-144 (1997)
   PUBMED   9533033
REFERENCE   9  (bases 1 to 2399)
  AUTHORS   Gress,T.M., Muller-Pillasch,F., Geng,M., Zimmerhackl,F.,
            Zehetner,G., Friess,H., Buchler,M., Adler,G. and Lehrach,H.
  TITLE     A pancreatic cancer-specific expression profile
  JOURNAL   Oncogene 13 (8), 1819-1830 (1996)
   PUBMED   8895530
REFERENCE   10 (bases 1 to 2399)
  AUTHORS   Belhacene,N., Mari,B., Rossi,B. and Auberger,P.
  TITLE     Characterization and purification of T lymphocyte aminopeptidase B:
            a putative marker of T cell activation
  JOURNAL   Eur J Immunol 23 (8), 1948-1955 (1993)
   PUBMED   8344358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099676.2.
            
            On Nov 23, 2018 this sequence version replaced NM_020216.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001064.2, SRR1163657.562267.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295640.9/ ENSP00000295640.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               AC099676.2         83294-83759
            467-607             AC099676.2         89550-89690
            608-756             AC099676.2         90029-90177
            757-873             AC099676.2         96793-96909
            874-1109            AC099676.2         97965-98200
            1110-1223           AC099676.2         100548-100661
            1224-1336           AC099676.2         102022-102134
            1337-1445           AC099676.2         102305-102413
            1446-1670           AC099676.2         103883-104107
            1671-1813           AC099676.2         105000-105142
            1814-2399           AC099676.2         106204-106789
FEATURES             Location/Qualifiers
     source          1..2399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2399
                     /gene="RNPEP"
                     /gene_synonym="AP-B; APB"
                     /note="arginyl aminopeptidase"
                     /db_xref="GeneID:6051"
                     /db_xref="HGNC:HGNC:10078"
                     /db_xref="MIM:602675"
     exon            1..466
                     /gene="RNPEP"
                     /gene_synonym="AP-B; APB"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1972
                     /gene="RNPEP"
                     /gene_synonym="AP-B; APB"
                     /EC_number="3.4.11.6"
                     /note="isoform a is encoded by transcript variant 1;
                     aminopeptidase B; arginine aminopeptidase"
                     /codon_start=1
                     /product="aminopeptidase B isoform a"
                     /protein_id="NP_064601.3"
                     /db_xref="CCDS:CCDS1418.1"
                     /db_xref="GeneID:6051"
                     /db_xref="HGNC:HGNC:10078"
                     /db_xref="MIM:602675"
                     /translation="MASGEHSPGSGAARRPLHSAQAVDVASASNFRAFELLHLHLDLR
                     AEFGPPGPGAGSRGLSGTAVLDLRCLEPEGAAELRLDSHPCLEVTAAALRRERPGSEE
                     PPAEPVSFYTQPFSHYGQALCVSFPQPCRAAERLQVLLTYRVGEGPGVCWLAPEQTAG
                     KKKPFVYTQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFTAVMSASTWEKRGPNKF
                     FFQMCQPIPSYLIALAIGDLVSAEVGPRSRVWAEPCLIDAAKEEYNGVIEEFLATGEK
                     LFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGN
                     LVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMDITGEENPL
                     NKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVGDQDQFDSFLKAYVHEFKFRSI
                     LADDFLDFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEEL
                     AQLWAAEELDMKAIEAVAISPWKTYQLVYFLDKILQKSPLPPGNVKKLGDTYPSISNA
                     RNAELRLRWGQIVLKNDHQEDFWKVKEFLHNQGKQKYTLPLYHAMMGGSEVAQTLAKE
                     TFASTASQLHSNVVNYVQQIVAPKGS"
     exon            467..607
                     /gene="RNPEP"
                     /gene_synonym="AP-B; APB"
                     /inference="alignment:Splign:2.1.0"
     exon            608..756
                     /gene="RNPEP"
                     /gene_synonym="AP-B; APB"
                     /inference="alignment:Splign:2.1.0"
     exon            757..873
                     /gene="RNPEP"
                     /gene_synonym="AP-B; APB"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1109
                     /gene="RNPEP"
                     /gene_synonym="AP-B; APB"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1223
                     /gene="RNPEP"
                     /gene_synonym="AP-B; APB"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1336
                     /gene="RNPEP"
                     /gene_synonym="AP-B; APB"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1445
                     /gene="RNPEP"
                     /gene_synonym="AP-B; APB"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1670
                     /gene="RNPEP"
                     /gene_synonym="AP-B; APB"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1813
                     /gene="RNPEP"
                     /gene_synonym="AP-B; APB"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..2399
                     /gene="RNPEP"
                     /gene_synonym="AP-B; APB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2375..2380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNPEP"
                     /gene_synonym="AP-B; APB"
                     /note="hexamer: AATAAA"
     polyA_site      2399
                     /gene="RNPEP"
                     /gene_synonym="AP-B; APB"
                     /note="major polyA site"
ORIGIN      
        1 gagcaacggc tctgcggcca tggcgagcgg cgagcattcc cccggcagcg gcgcggcccg
       61 gcggccgctg cactccgcgc aggctgtgga cgtggcctcg gcctccaact tccgggcctt
      121 tgagctgctg cacttgcacc tggacctgcg ggctgagttc gggcctccag ggcccggcgc
      181 agggagccgg gggctgagcg gcaccgcggt cctggacctg cgctgcctgg agcccgaggg
      241 cgccgccgag ctgcggctgg actcgcaccc gtgcctggag gtgacggcgg cggcgctgcg
      301 gcgggagcgg cccggctcgg aggagccgcc tgcggagccc gtgagcttct acacgcagcc
      361 cttctcgcac tatggccagg ccctgtgcgt gtccttcccg cagccctgcc gcgccgccga
      421 gcgcctccag gtgctgctca cctaccgcgt cggggaggga cccggggttt gctggttggc
      481 tcccgagcag acagcaggaa agaagaagcc cttcgtgtac acccagggcc aggctgtcct
      541 aaaccgggcc ttcttccctt gcttcgacac gcctgctgtt aaatacaagt attcagctct
      601 tattgaggtc ccagatggct tcacagctgt gatgagtgct agcacctggg agaagagagg
      661 tccaaataag ttcttcttcc agatgtgtca gcccatcccc tcctatctga tagctttggc
      721 catcggagat ctggtttcgg ctgaagttgg acccaggagc cgggtgtggg ctgagccctg
      781 cctgattgat gctgccaagg aggagtacaa cggggtgata gaagaatttt tggcaacagg
      841 agagaagctt tttggacctt atgtttgggg aaggtatgac ttgctcttca tgccaccgtc
      901 ctttccattt ggaggaatgg agaacccttg tctgaccttt gtcaccccct gcctgctagc
      961 tggggaccgc tccttggcag atgtcatcat ccatgagatc tcccacagtt ggtttgggaa
     1021 cctggtcacc aacgccaact ggggtgaatt ctggctcaat gaaggtttca ccatgtacgc
     1081 ccagaggagg atctccacca tcctctttgg cgctgcgtac acctgcttgg aggctgcaac
     1141 ggggcgggct ctgctgcgtc agcacatgga catcactgga gaggaaaacc cactcaacaa
     1201 gctccgcgtg aagattgaac caggcgttga cccggacgac acctataatg agacccccta
     1261 cgagaaaggt ttctgctttg tttcatacct ggcccacttg gtgggtgatc aggatcagtt
     1321 tgacagtttt ctcaaggcct atgtgcatga attcaaattc cgaagcatct tagccgatga
     1381 ctttctggac ttctacttgg aatatttccc tgagcttaag aaaaagagag tggatatcat
     1441 tccaggtttt gagtttgatc gatggctgaa tacccccggc tggcccccgt acctccctga
     1501 tctctcccct ggggactcac tcatgaagcc tgctgaagag ctagcccaac tgtgggcagc
     1561 cgaggagctg gacatgaagg ccattgaagc cgtggccatc tctccctgga agacctacca
     1621 gctggtctac ttcctggata agatcctcca gaaatcccct ctccctcctg ggaatgtgaa
     1681 aaaacttgga gacacatacc caagtatctc aaatgcccgg aatgcagagc tccggctgcg
     1741 atggggccaa atcgtcctta agaacgacca ccaggaagat ttctggaaag tgaaggagtt
     1801 cctgcataac caggggaagc agaagtatac acttccgctg taccacgcaa tgatgggtgg
     1861 cagtgaggtg gcccagaccc tcgccaagga gacttttgca tccaccgcct cccagctcca
     1921 cagcaatgtt gtcaactatg tccagcagat cgtggcaccc aagggcagtt agaggctcgt
     1981 gtgcatggcc cctgcctctt caggctctcc aggctttcag aataattgtt tgttcccaaa
     2041 ttcctgttcc ctgatcaact tcctggagtt tatatcccct caggataatc tattctctag
     2101 cttaggtatc tgtgactctt gggcctctgc tctggtggga acttacttct ctatagccca
     2161 ctgagccccg agacagagaa cctgcccaca gctctccccg ctacaggctg caggcactgc
     2221 agggcagcgg gtattctcct ccccacctaa gtctctggga agaagtggag aggactgatg
     2281 ctcttctttt ttctctttct gtcctttttc ttgctgattt tatgcaaagg gctggcattc
     2341 tgattgttct tttttcaggt ttaatcctta ttttaataaa gttttcaagc aaaaattaa
//
