LOCUS       NM_003799               6236 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens RNA guanine-7 methyltransferase (RNMT), transcript
            variant 2, mRNA.
ACCESSION   NM_003799
VERSION     NM_003799.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6236)
  AUTHORS   Perveen,S., Yazdi,A.K., Hajian,T., Li,F. and Vedadi,M.
  TITLE     Kinetic characterization of human mRNA guanine-N7 methyltransferase
  JOURNAL   Sci Rep 14 (1), 4509 (2024)
   PUBMED   38402266
  REMARK    GeneRIF: Kinetic characterization of human mRNA guanine-N7
            methyltransferase.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6236)
  AUTHORS   Osborne,M.J., Volpon,L., Memarpoor-Yazdi,M., Pillay,S.,
            Thambipillai,A., Czarnota,S., Culjkovic-Kraljacic,B., Trahan,C.,
            Oeffinger,M., Cowling,V.H. and Borden,K.L.B.
  TITLE     Identification and Characterization of the Interaction Between the
            Methyl-7-Guanosine Cap Maturation Enzyme RNMT and the Cap-Binding
            Protein eIF4E
  JOURNAL   J Mol Biol 434 (5), 167451 (2022)
   PUBMED   35026230
  REMARK    GeneRIF: Identification and Characterization of the Interaction
            Between the Methyl-7-Guanosine Cap Maturation Enzyme RNMT and the
            Cap-Binding Protein eIF4E.
REFERENCE   3  (bases 1 to 6236)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 6236)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 6236)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 6236)
  AUTHORS   Pillutla,R.C., Shimamoto,A., Furuichi,Y. and Shatkin,A.J.
  TITLE     Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT)
            map to 6q16 and 18p11.22-p11.23, respectively
  JOURNAL   Genomics 54 (2), 351-353 (1998)
   PUBMED   9828141
REFERENCE   7  (bases 1 to 6236)
  AUTHORS   Tsukamoto,T., Shibagaki,Y., Niikura,Y. and Mizumoto,K.
  TITLE     Cloning and characterization of three human cDNAs encoding mRNA
            (guanine-7-)-methyltransferase, an mRNA cap methylase
  JOURNAL   Biochem Biophys Res Commun 251 (1), 27-34 (1998)
   PUBMED   9790902
REFERENCE   8  (bases 1 to 6236)
  AUTHORS   Pillutla,R.C., Yue,Z., Maldonado,E. and Shatkin,A.J.
  TITLE     Recombinant human mRNA cap methyltransferase binds capping
            enzyme/RNA polymerase IIo complexes
  JOURNAL   J Biol Chem 273 (34), 21443-21446 (1998)
   PUBMED   9705270
REFERENCE   9  (bases 1 to 6236)
  AUTHORS   Yamada-Okabe,T., Doi,R., Shimmi,O., Arisawa,M. and Yamada-Okabe,H.
  TITLE     Isolation and characterization of a human cDNA for mRNA 5'-capping
            enzyme
  JOURNAL   Nucleic Acids Res 26 (7), 1700-1706 (1998)
   PUBMED   9512541
REFERENCE   10 (bases 1 to 6236)
  AUTHORS   Langberg,S.R. and Moss,B.
  TITLE     Post-transcriptional modifications of mRNA. Purification and
            characterization of cap I and cap II RNA
            (nucleoside-2'-)-methyltransferases from HeLa cells
  JOURNAL   J Biol Chem 256 (19), 10054-10060 (1981)
   PUBMED   7275966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA634865.1, AF067791.1, AP001525.6 and AB022605.1.
            
            On Jun 2, 2019 this sequence version replaced NM_003799.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF067791.1, AB007858.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383314.7/ ENSP00000372804.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DA634865.1         14-45
            33-1970             AF067791.1         1-1938
            1971-5334           AP001525.6         98022-101385
            5335-6235           AF067791.1         5303-6203
            6236-6236           AB022605.1         4078-4078
FEATURES             Location/Qualifiers
     source          1..6236
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.21"
     gene            1..6236
                     /gene="RNMT"
                     /gene_synonym="cm1p; CMT1; CMT1c; hCMT1; hMet; Met; MET;
                     N7-MTase; RG7MT1"
                     /note="RNA guanine-7 methyltransferase"
                     /db_xref="GeneID:8731"
                     /db_xref="HGNC:HGNC:10075"
                     /db_xref="MIM:603514"
     exon            1..57
                     /gene="RNMT"
                     /gene_synonym="cm1p; CMT1; CMT1c; hCMT1; hMet; Met; MET;
                     N7-MTase; RG7MT1"
                     /inference="alignment:Splign:2.1.0"
     exon            58..186
                     /gene="RNMT"
                     /gene_synonym="cm1p; CMT1; CMT1c; hCMT1; hMet; Met; MET;
                     N7-MTase; RG7MT1"
                     /inference="alignment:Splign:2.1.0"
     exon            187..645
                     /gene="RNMT"
                     /gene_synonym="cm1p; CMT1; CMT1c; hCMT1; hMet; Met; MET;
                     N7-MTase; RG7MT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1659
                     /gene="RNMT"
                     /gene_synonym="cm1p; CMT1; CMT1c; hCMT1; hMet; Met; MET;
                     N7-MTase; RG7MT1"
                     /EC_number="2.1.1.56"
                     /note="isoform 2 is encoded by transcript variant 2; mRNA
                     cap guanine-N7 methyltransferase; mRNA
                     (guanine-7-)methyltransferase; mRNA cap methyltransferase;
                     mRNA (guanine-N(7)-)-methyltransferase; RNA (guanine-7-)
                     methyltransferase; hcm1p; mRNA cap guanine-N(7)
                     methyltransferase"
                     /codon_start=1
                     /product="mRNA cap guanine-N(7) methyltransferase isoform
                     2"
                     /protein_id="NP_003790.1"
                     /db_xref="CCDS:CCDS11867.1"
                     /db_xref="GeneID:8731"
                     /db_xref="HGNC:HGNC:10075"
                     /db_xref="MIM:603514"
                     /translation="MANSAKAEEYEKMSLEQAKASVNSETESSFNINENTTASGTGLS
                     EKTSVCRQVDIARKRKEFEDDLVKESSSCGKDTPSKKRKLDPEIVPEEKDCGDAEGNS
                     KKRKRETEDVPKDKSSTGDGTQNKRKIALEDVPEKQKNLEEGHSSTVAAHYNELQEVG
                     LEKRSQSRIFYLRNFNNWMKSVLIGEFLEKVRQKKKRDITVLDLGCGKGGDLLKWKKG
                     RINKLVCTDIADVSVKQCQQRYEDMKNRRDSEYIFSAEFITADSSKELLIDKFRDPQM
                     CFDICSCQFVCHYSFESYEQADMMLRNACERLSPGGYFIGTTPNSFELIRRLEASETE
                     SFGNEIYTVKFQKKGDYPLFGCKYDFNLEGVVDVPEFLVYFPLLNEMAKKYNMKLVYK
                     KTFLEFYEEKIKNNENKMLLKRMQALEPYPANESSKLVSEKVDDYEHAAKYMKNSQVR
                     LPLGTLSKSEWEATSIYLVFAFEKQQ"
     exon            646..781
                     /gene="RNMT"
                     /gene_synonym="cm1p; CMT1; CMT1c; hCMT1; hMet; Met; MET;
                     N7-MTase; RG7MT1"
                     /inference="alignment:Splign:2.1.0"
     exon            782..907
                     /gene="RNMT"
                     /gene_synonym="cm1p; CMT1; CMT1c; hCMT1; hMet; Met; MET;
                     N7-MTase; RG7MT1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1020
                     /gene="RNMT"
                     /gene_synonym="cm1p; CMT1; CMT1c; hCMT1; hMet; Met; MET;
                     N7-MTase; RG7MT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1202
                     /gene="RNMT"
                     /gene_synonym="cm1p; CMT1; CMT1c; hCMT1; hMet; Met; MET;
                     N7-MTase; RG7MT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1367
                     /gene="RNMT"
                     /gene_synonym="cm1p; CMT1; CMT1c; hCMT1; hMet; Met; MET;
                     N7-MTase; RG7MT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1485
                     /gene="RNMT"
                     /gene_synonym="cm1p; CMT1; CMT1c; hCMT1; hMet; Met; MET;
                     N7-MTase; RG7MT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1587
                     /gene="RNMT"
                     /gene_synonym="cm1p; CMT1; CMT1c; hCMT1; hMet; Met; MET;
                     N7-MTase; RG7MT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1621
                     /gene="RNMT"
                     /gene_synonym="cm1p; CMT1; CMT1c; hCMT1; hMet; Met; MET;
                     N7-MTase; RG7MT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..6236
                     /gene="RNMT"
                     /gene_synonym="cm1p; CMT1; CMT1c; hCMT1; hMet; Met; MET;
                     N7-MTase; RG7MT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6212..6217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNMT"
                     /gene_synonym="cm1p; CMT1; CMT1c; hCMT1; hMet; Met; MET;
                     N7-MTase; RG7MT1"
                     /note="hexamer: AATAAA"
     polyA_site      6236
                     /gene="RNMT"
                     /gene_synonym="cm1p; CMT1; CMT1c; hCMT1; hMet; Met; MET;
                     N7-MTase; RG7MT1"
                     /note="major polyA site"
ORIGIN      
        1 agacacgcgt ggcgcgggcc gccgtttccg caaacagaat cgcgtttggc tgtgctggat
       61 gtgtgaacct attgggtact gtacaacttc aagcctcgaa atcagatagg caccaccaac
      121 ctcatttcct gtttcacctt gattttctgt gataccaaaa tctcagcttc acaaagtcat
      181 tgaaagtgtt ggttcatgaa gttttaccat caattcaagt aatcataaat ggcaaattct
      241 gcaaaagcag aagaatatga aaagatgtct cttgaacagg caaaagcgtc agtgaattct
      301 gaaacagagt cttcattcaa tattaatgaa aacacaacag cttctgggac tgggctttct
      361 gaaaagactt ctgtctgtag gcaagtagac atagcaagaa agagaaaaga gtttgaagat
      421 gatcttgtaa aggaaagttc tagttgtggg aaagacactc catccaagaa gagaaaactt
      481 gatcctgaaa ttgtcccaga ggaaaaagat tgtggtgatg ctgaaggcaa ttcaaagaaa
      541 agaaaaagag aaactgagga tgttccaaaa gataaatctt ctactggaga tggcactcaa
      601 aataagagaa aaatagcact tgaggatgtt cctgaaaagc agaaaaatct ggaagaagga
      661 cacagctcaa cagtggctgc ccattacaat gaacttcagg aagttggttt ggagaagcgt
      721 agtcaaagtc gtatttttta cctaagaaac tttaataatt ggatgaaaag tgttctcatt
      781 ggagaatttt tggaaaaggt acgacagaag aaaaaacgtg atatcactgt tttggacctg
      841 ggatgtggta aaggtggaga tttgctgaaa tggaaaaaag gaagaattaa caagctagtt
      901 tgtactgata ttgccgatgt ttctgtcaaa cagtgtcagc agcggtatga ggacatgaaa
      961 aatcgtcgtg atagtgaata tattttcagt gcagaattta taactgctga cagctcaaag
     1021 gaacttctga ttgacaaatt tcgtgaccca caaatgtgtt ttgacatctg cagttgtcag
     1081 tttgtctgtc attactcatt tgagtcttat gagcaggctg acatgatgct gagaaatgcg
     1141 tgtgagagac ttagccctgg gggctatttt attggtacta ctcccaatag ctttgaattg
     1201 ataagacgcc ttgaagcttc agaaacagaa tcatttggaa atgaaatata tactgtgaaa
     1261 tttcagaaga aaggagatta tcctttattt ggctgcaaat atgacttcaa cttggaaggt
     1321 gttgtggatg ttcctgaatt cttggtctat tttccattgc taaatgaaat ggcaaagaag
     1381 tacaatatga aactagtcta caaaaaaaca tttctggaat tctacgaaga aaagattaag
     1441 aacaatgaaa ataaaatgct cttaaaacga atgcaggcct tggagccata tcctgcaaat
     1501 gagagttcta aacttgtctc tgagaaggtg gatgactatg aacatgcagc aaagtacatg
     1561 aagaacagtc aagtaaggtt acctttggga accttaagta aatcagaatg ggaagctaca
     1621 agtatttact tggtgtttgc ctttgagaaa cagcagtgag cacataggca gtagtcccag
     1681 aggggccgtg ttctgtcctg cacaaatttg aacaactcat ctcgatatat ttgatatttc
     1741 tctgtctgtt gattttaatt ctaaatgtgc aggatgctgc cagaaactcc aatgtagaaa
     1801 ttcaacattt gctgtctgtg acagatgaac ttttgcatgt gtatataaga atgagttggg
     1861 acctctgtct ttaaaaatct atttttaggt aatgttctaa gaattccatt tgcctctatg
     1921 atcttagctc ataaaaatat aatatgactt gataaagcaa ctaaactctt tccacagtgt
     1981 tcagatttgt cctgtgtgtg tttacagtat tcaatttatt gcagttatag aattggtcag
     2041 agagcatttt catagtgtgc tcatttctat ggttttgtta tatagcattt ttcaacattt
     2101 aatggtctgt acagttgaat gtaagtgttc aatatgtatt gctgaagtta taagtttaaa
     2161 actcaatttc agatgctcat aaaagttact tagctaaaat tttagcaatt tattgcattt
     2221 tgaaataatc attaacatgc tgcaattcag gagctggtta gaacatttta agtggcagca
     2281 tagaattttg gaattttggg gctttctttt cagaaattgc taccatagta attaatgttt
     2341 ccagttatca agattgtgat tagacacatt tacctttctt cattgaacaa atggtgccat
     2401 agttattttt ctcaaaattt agtgaaaatc cctcccatgt agacatgttg cacatttttt
     2461 ccaaatttat acatggaact gcagtaggaa tattctcacc atctgatgcc atgtacccac
     2521 ttcagaaata agcaatactt gttcctctgt tacaacctca gcactttgca ccgtaggagc
     2581 cattgttaaa gttgtcactt gtgtaactga ctgcttttcc aaaactggta cttatgtgaa
     2641 ctgttgtcct tgctttacac caccatttgg aaaacttacc agtttttaga tgtagatgta
     2701 gtgaaaaact tcaagaatga agcagagcaa ttgagtattc ttttttaaat tattaagcca
     2761 tgatttacaa aaacattact ttctgtaatt cacaatactt gttttaaaaa catagtgtct
     2821 tcattagtgt gcatctatta actgttcatg gtgttagagt tgcaaacttt ttagcaagaa
     2881 aatatggatt tcctcatttc agttccttct gcagcctgtg aatctccaca aagtgttacc
     2941 agtttacaaa aataagtctt tttgccttaa gtcattttgg aaataagtaa tactgcatct
     3001 gactctggtg gctgtattag ctaggaaagg tttgtaaatg gtgtcagtga ggtggggaaa
     3061 ggaagtcttc ctgtcacata tgcaggttcg ttttcattct agggcagtgc caggaagtat
     3121 attgatagct ttgtaggtac aggaaaaaca tcatcattat ttcctctgtt cacatttact
     3181 ggtcttaatt aacaggtaat aataatacat gtacttttag cctgaaacct cttccacgcc
     3241 atgggtaact tgggggagag aagaatcctc caaacgatgg agtagccagt ggtaatacaa
     3301 agcagggaga acagaaaggt agagttacta aggccttcag tgaacagaaa ggagcagaga
     3361 gcaagattag atctgagaag atgctctggg gactgagccc actgttgttg gtgtcaggga
     3421 ggcttactgg agccacacct gcaggcgctg tgttcaggca ccaccttcct ccttgagctt
     3481 tgcctgtctc ttgccttatc agttcttcct ccaccaccct acacccccct ccccccggcc
     3541 ccaagcccct gtgtctcctt gttacaatta agtttctgga tattgactta agaactgtta
     3601 ggaagaggac tagaaaaggc ttcccctgcc tatcctctcc gatcaccaag gtggaaggga
     3661 gctagtagga ctcttccttg acacaccttg tcgtctaaat gttcggtatt ctattcagga
     3721 cttacggtaa ctattatgag ggaggcatgg ctttccaccg tcgggccagg aagagcacct
     3781 gttgctgcaa gctcagtgaa gtggggcact cccagacctg ccatgcagtt tatcctctga
     3841 gaatggaatt ggaaatgaag acctaaccag ctattggtgg gaatgacgga actggggatt
     3901 gcgatgattg atctgggaac atggctggat tgtgatttaa ccaagaatgc tgatgttgaa
     3961 ttctttgggc ctagaatata cttgagaaag cactagtggc ttgtgttcag ggagaggagc
     4021 tggcagtttt taaccacttc tgtgggagcc gtgttctaac ctgtggaaag tattgcaatt
     4081 ctgtgagagt gactctgcag agtcactgca ccatcaggct tggccctgct gtgccttcag
     4141 tacccagcca ggttctctgg gtccagggtg actctccaaa gaaattggcc ttcagctgga
     4201 gaaaacattg ggtggagact ctcacttatg ttaatgcaat cttgaaatga ctgaaaggta
     4261 gattgccagc acagtgagtt tcccagcctg ctcccccatc cacacttgga aattgaggga
     4321 gcatgaccgc tctctgactt cacatgttaa tagaggatca gagcagagtt gggagtatat
     4381 tggtcaggat catagaaaag aagacaaagc ttgctcagcc atgagatggc caggtatcca
     4441 gttttgttaa ctctctttgg gaatttcttt ttcagcctgt tttttagctt agtgccatta
     4501 tgtcattttg atttgtattc aagtactctt caagtatctt tgtaatgaag gtttggctac
     4561 ttgtataggt ctgcctgcag ggtgaaaatg ccagtgtgaa tattctagct accaaacatt
     4621 gttttttgtt gaaaaactga ctttctgttg tctacctcag gccttgtgca tttgggttat
     4681 ctcaagccag tcaccacaga gggtctctag ggtctgcaaa atagaggcca aatccaggga
     4741 ccaggcccta ataatagaag ttgtaccaaa atgcctgtgg tacttgatgg cctgttggtc
     4801 aaataggaag tacaagtgtg tgatgttaga acctccctag ttgctgctat atcaaacact
     4861 gcacacttga caagtgtttt cattccccgc cctctgacag aacaacattc ctaattcttt
     4921 gaaggcaacc agtgcaaagg ctactacact tgtgtaatga tatttagcag atgcatacag
     4981 gactggatcc cagggcactg tcagttcttc cctccctctc gtgctgctca gtttgtcctc
     5041 tgctcccatg taggcctaaa gtcaccccac tccttagtgc ctgcacctca ccacgatatt
     5101 gaggaagcac aggacatcca agggtactct ccagtttggc tgtggagact tgagcaagcc
     5161 ctaaagtccc ctgctccctg gacttctcct gggttgtgct tttttggggg caacatacct
     5221 tggacaaagc tgagctgaca gctaatgttt attagcctcc tacctaagtc agtcactttg
     5281 ctaaattctt cacctgtggt aactcatttt gattgttata acatctcagc accgttattc
     5341 ccattttaat gatgaggaaa ctgagtcata gaggatacag acttgcccaa aggagagcca
     5401 ggattttcac accccctcct caagctgggc ctgccctcca agtgcttgtt atatacctcc
     5461 acgggtgtca gcccagatga ctcctcaccc atccaccacc tgcagcttga gatgttaact
     5521 attagagctc cattcttttg gttcaaaacg ttgatactta cttagatgtt ccctgagagg
     5581 agtgtttatt tctgagtaag gggctttgtt gaaagagggg gttagagaga gcaagacagc
     5641 acttgagtgc actggcagga agcagagata agacttgaat ttcagtttgg tagaccacct
     5701 tctttagcag cccaacctgt agcaaatcta gtttagcctg catggcaggg agagggattc
     5761 tcttcccacc ctcaccattt gcaagtggca ggagctgaga atgccagtac gagagtgtag
     5821 ccaaagtgag aggctgagag caaaggagac atttttttca gttttgagtc gagtatccag
     5881 acagaggcaa atcattttgt ttaacttttt attaaagtgt aactatagaa acacatcaat
     5941 gatttttcac aagtggagca cgtgcataca atcggcaccc cagaagcccc ccgtcagatt
     6001 cccttccagt taactacctc tccaagggaa accactatcc tgagttctaa gcgcatagat
     6061 tagttctgtc tggtttgggg agatatataa atggaattat gcattcttcg tatctggttt
     6121 cttttcacca atattatgtt tgtgagattt ttgttgcatg tatttgtaca tggattttca
     6181 ttctcatggt tgtataatat ttcattgtgt gaataaacca catactgttt atctga
//
