LOCUS       NM_001031709            2409 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens renalase, FAD dependent amine oxidase (RNLS),
            transcript variant 1, mRNA.
ACCESSION   NM_001031709
VERSION     NM_001031709.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2409)
  AUTHORS   Shen,H., Yang,J., Xue,W., Wei,Z., Li,L., Guan,J., Li,X. and Wu,X.
  TITLE     Renalase rs2296545 variant improve hypertension susceptibility by
            modifying binding affinity to catecholamines in obstructive sleep
            apnea
  JOURNAL   Hypertens Res 47 (11), 3200-3213 (2024)
   PUBMED   39232213
  REMARK    GeneRIF: Renalase rs2296545 variant improve hypertension
            susceptibility by modifying binding affinity to catecholamines in
            obstructive sleep apnea.
REFERENCE   2  (bases 1 to 2409)
  AUTHORS   Zorawik,A., Hajdusianek,W., Markiewicz-Gorka,I., Jaremkow,A.,
            Pawlas,K., Martynowicz,H., Mazur,G., Poreba,R. and Gac,P.
  TITLE     Coexistence of Cardiovascular Risk Factors and Blood Renalase
            Concentration
  JOURNAL   Int J Mol Sci 24 (23), 16666 (2023)
   PUBMED   38068986
  REMARK    GeneRIF: Coexistence of Cardiovascular Risk Factors and Blood
            Renalase Concentration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2409)
  AUTHORS   Yang,J.D., Xue,W.J., Wei,Z.C., Hou,C.Q., Li,X.Y., Xu,H.H., Wu,X.L.,
            Feng,Y.H. and Yin,S.K.
  TITLE     [The association of renalase single-nucleotide polymorphisms
            rs2576178 and rs10887800 with hypertension in patients with
            obstructive sleep apnea]
  JOURNAL   Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 58 (10), 966-973
            (2023)
   PUBMED   37840161
  REMARK    GeneRIF: [The association of renalase single-nucleotide
            polymorphisms rs2576178 and rs10887800 with hypertension in
            patients with obstructive sleep apnea].
REFERENCE   4  (bases 1 to 2409)
  AUTHORS   Stojanovic,D., Stojanovic,M., Milenkovic,J., Velickov,A.,
            Ignjatovic,A. and Milojkovic,M.
  TITLE     The Multi-Faceted Nature of Renalase for Mitochondrial Dysfunction
            Improvement in Cardiac Disease
  JOURNAL   Cells 12 (12), 1607 (2023)
   PUBMED   37371077
  REMARK    GeneRIF: The Multi-Faceted Nature of Renalase for Mitochondrial
            Dysfunction Improvement in Cardiac Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2409)
  AUTHORS   Ersak,B., Ozaksit,G., Tugrul,D., Doganay,M., Ustun,Y. and
            Kokanali,M.K.
  TITLE     Role of serum renalase levels in predicting the presence of
            metabolic syndrome in patients with polycystic ovary syndrome
  JOURNAL   Taiwan J Obstet Gynecol 62 (3), 417-422 (2023)
   PUBMED   37188446
  REMARK    GeneRIF: Role of serum renalase levels in predicting the presence
            of metabolic syndrome in patients with polycystic ovary syndrome.
REFERENCE   6  (bases 1 to 2409)
  AUTHORS   Rampersaud,E., Damcott,C.M., Fu,M., Shen,H., McArdle,P., Shi,X.,
            Shelton,J., Yin,J., Chang,Y.P., Ott,S.H., Zhang,L., Zhao,Y.,
            Mitchell,B.D., O'Connell,J. and Shuldiner,A.R.
  TITLE     Identification of novel candidate genes for type 2 diabetes from a
            genome-wide association scan in the Old Order Amish: evidence for
            replication from diabetes-related quantitative traits and from
            independent populations
  JOURNAL   Diabetes 56 (12), 3053-3062 (2007)
   PUBMED   17846126
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2409)
  AUTHORS   Zhao,Q., Fan,Z., He,J., Chen,S., Li,H., Zhang,P., Wang,L., Hu,D.,
            Huang,J., Qiang,B. and Gu,D.
  TITLE     Renalase gene is a novel susceptibility gene for essential
            hypertension: a two-stage association study in northern Han Chinese
            population
  JOURNAL   J Mol Med (Berl) 85 (8), 877-885 (2007)
   PUBMED   17216203
  REMARK    GeneRIF: Renalase gene is a novel susceptibility gene for essential
            hypertension: a two-stage association study in northern Han Chinese
            population.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2409)
  AUTHORS   Xu,J. and Desir,G.V.
  TITLE     Renalase, a new renal hormone: its role in health and disease
  JOURNAL   Curr Opin Nephrol Hypertens 16 (4), 373-378 (2007)
   PUBMED   17565281
  REMARK    GeneRIF: renalase pathway is a previously unrecognized mechanism
            for regulating circulating catecholamines & cardiac function, and
            blood pressure. Abnormalities in the renalase pathway are evident
            in animal models of chronic kidney disease and hypertension[review]
            Review article
REFERENCE   9  (bases 1 to 2409)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 2409)
  AUTHORS   Xu,J., Li,G., Wang,P., Velazquez,H., Yao,X., Li,Y., Wu,Y.,
            Peixoto,A., Crowley,S. and Desir,G.V.
  TITLE     Renalase is a novel, soluble monoamine oxidase that regulates
            cardiac function and blood pressure
  JOURNAL   J Clin Invest 115 (5), 1275-1280 (2005)
   PUBMED   15841207
  REMARK    GeneRIF: secreted by the kidney, circulates in blood, and modulates
            cardiac function and systemic blood pressure
            GeneRIF: Renalase regulates cardiac function and blood pressure.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP332262.1, BC005364.1, BM978857.1, AL353149.10 and AA854849.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001031709.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.101895.1,
                                           SRR1163655.64493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331772.9/ ENSP00000332530.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               BP332262.1         8-246
            240-1178            BC005364.1         135-1073
            1179-1479           BM978857.1         81-381              c
            1480-1552           BC005364.1         1375-1447
            1553-2005           AL353149.10        32814-33266         c
            2006-2409           AA854849.1         5-408               c
FEATURES             Location/Qualifiers
     source          1..2409
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     gene            1..2409
                     /gene="RNLS"
                     /gene_synonym="C10orf59; RENALASE"
                     /note="renalase, FAD dependent amine oxidase"
                     /db_xref="GeneID:55328"
                     /db_xref="HGNC:HGNC:25641"
                     /db_xref="MIM:609360"
     exon            1..246
                     /gene="RNLS"
                     /gene_synonym="C10orf59; RENALASE"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1157
                     /gene="RNLS"
                     /gene_synonym="C10orf59; RENALASE"
                     /EC_number="1.6.3.5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; MAO-C; monoamine oxidase-C; alpha-NAD(P)H
                     oxidase/anomerase"
                     /codon_start=1
                     /product="renalase isoform 1 precursor"
                     /protein_id="NP_001026879.2"
                     /db_xref="CCDS:CCDS31239.1"
                     /db_xref="GeneID:55328"
                     /db_xref="HGNC:HGNC:25641"
                     /db_xref="MIM:609360"
                     /translation="MAQVLIVGAGMTGSLCAALLRRQTSGPLYLAVWDKAEDSGGRMT
                     TACSPHNPQCTADLGAQYITCTPHYAKKHQRFYDELLAYGVLRPLSSPIEGMVMKEGD
                     CNFVAPQGISSIIKHYLKESGAEVYFRHRVTQINLRDDKWEVSKQTGSPEQFDLIVLT
                     MPVPEILQLQGDITTLISECQRQQLEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSN
                     PCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENILPG
                     LPQPIATKCQKWRHSQVTNAAANCPGQMTLHHKPFLACGGDGFTQSNFDGCITSALCV
                     LEALKNYI"
     exon            247..352
                     /gene="RNLS"
                     /gene_synonym="C10orf59; RENALASE"
                     /inference="alignment:Splign:2.1.0"
     exon            353..495
                     /gene="RNLS"
                     /gene_synonym="C10orf59; RENALASE"
                     /inference="alignment:Splign:2.1.0"
     exon            496..654
                     /gene="RNLS"
                     /gene_synonym="C10orf59; RENALASE"
                     /inference="alignment:Splign:2.1.0"
     exon            655..828
                     /gene="RNLS"
                     /gene_synonym="C10orf59; RENALASE"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1004
                     /gene="RNLS"
                     /gene_synonym="C10orf59; RENALASE"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..2409
                     /gene="RNLS"
                     /gene_synonym="C10orf59; RENALASE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1527..1532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNLS"
                     /gene_synonym="C10orf59; RENALASE"
                     /note="hexamer: AATAAT"
     polyA_site      1550
                     /gene="RNLS"
                     /gene_synonym="C10orf59; RENALASE"
                     /note="major polyA site"
     regulatory      2381..2386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNLS"
                     /gene_synonym="C10orf59; RENALASE"
                     /note="hexamer: AATAAA"
     polyA_site      2409
                     /gene="RNLS"
                     /gene_synonym="C10orf59; RENALASE"
ORIGIN      
        1 agggcccagg tcggcccagg gagcacggaa ccaaagagcg ctagcgccgg ttcggccgcc
       61 tttccagaaa gcccgggccg aacggccccg ccgcagagac tcagcgcgga tcgctgctcc
      121 ctctcgccat ggcgcaggtg ctgatcgtgg gcgccgggat gacaggaagc ttgtgcgctg
      181 cgctgctgag gaggcagacg tccggtccct tgtaccttgc tgtgtgggac aaggctgagg
      241 actcaggggg aagaatgact acagcctgca gtcctcataa tcctcagtgc acagctgact
      301 tgggtgctca gtacatcacc tgcactcctc attatgccaa aaaacaccaa cgtttttatg
      361 atgaactgtt agcctatggc gttttgaggc ctctaagctc gcctattgaa ggaatggtga
      421 tgaaagaagg agactgtaac tttgtggcac ctcaaggaat ttcttcaatt attaagcatt
      481 acttgaaaga atcaggtgca gaagtctact tcagacatcg tgtgacacag atcaacctaa
      541 gagatgacaa atgggaagta tccaaacaaa caggctcccc tgagcagttt gatcttattg
      601 ttctcacaat gccagttcct gagattctgc agcttcaagg tgacatcacc accttaatta
      661 gtgaatgcca aaggcagcaa ctggaggctg tgagctactc ctctcgatat gctctgggcc
      721 tcttttatga agctggtacg aagattgatg tcccttgggc tgggcagtac atcaccagta
      781 atccctgcat acgcttcgtc tccattgata ataagaagcg caatatagag tcatcagaaa
      841 ttgggccttc cctcgtgatt cacaccactg tcccatttgg agttacatac ttggaacaca
      901 gcattgagga tgtgcaagag ttagtcttcc agcagctgga aaacattttg ccgggtttgc
      961 ctcagccaat tgctaccaaa tgccaaaaat ggagacattc acaggttaca aatgctgctg
     1021 ccaactgtcc tggccaaatg actctgcatc acaaaccttt ccttgcatgt ggaggggatg
     1081 gatttactca gtccaacttt gatggctgca tcacttctgc cctatgtgtt ctggaagctt
     1141 taaagaatta tatttagtgc ctatatcctt attctctaca tgtgtattgg gtttttattt
     1201 tcacaatttt ctgttattga ttattttgtt ttctattttg ctaagaaaaa ttactggaaa
     1261 attgttcttc acttattatc atttttcatg tggagtataa aatcaatttt gtaattttga
     1321 tagttacaac ccatgctaga atggaaattc ctcacacctt gcaccttccc tacttttctg
     1381 aattgctatg actactcctt gttggaggaa aagtggtact taaaaaataa caaacgactc
     1441 tctcaaaaaa attacattaa atcacaataa cagtttgtgt gccaaaaact tgattatcct
     1501 tatgaaaatt tcaattctga ataaagaata atcacattat caaagcccca tcttaagtct
     1561 tcggatgtgt ccttgaatca atatttttgc aaattataca aaacaagatt tttccaaaat
     1621 gtaggtaaca gagtgtaatt cttatttctc atttatcccc caagttatta agtgatcctg
     1681 aattgtaggt catatatgtc atcatcttag tgtggagggc aacttgactg ataaagagac
     1741 cttccttcag attttcagaa agtataagat tccacatgat tttcccagcc acacagtact
     1801 ttttaacttt caaacaaatt ccagtcctaa tatgaaagat aaaaattaaa tagaaacaga
     1861 gagaaagtat atcgatcctt accttttgct atattttata gctgttgctg ttactttatg
     1921 ggttctccag tatgtgctgt ggcatttaga ctgtgtcgag tttaatgaat ttaacacaac
     1981 aaaaaattta ctgaaccaga aaatagatgc acttaaaata gttcaatatt tgccaagttg
     2041 gtggttcagc atatcaccca catgcttcag tgacctgacc ccacgacttg ctagctggag
     2101 agaaatcaat ctccagcctt ccaaaccagc tacctgttgc taatttgaaa agcaaaatga
     2161 tgagttctat ttcagcattt tgaaaggaga aaaatcattg cagcctctca aactaacaaa
     2221 agttcaacaa aagacttctt actgtaatag tgtttaaagt ttcacactta catgtccact
     2281 gtcatacata cacatacaca ggcacaggca gaacttgctt ctatagctgc aaagtgggtt
     2341 ttatgaccct atagcatatt attatatgtt tcctcttagc aataaattgg tgaaaaactt
     2401 aaatgccaa
//
