LOCUS       NM_016125               2122 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ring finger protein, transmembrane 1 (RNFT1), mRNA.
ACCESSION   NM_016125
VERSION     NM_016125.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2122)
  AUTHORS   Tan,P., He,L. and Zhou,Y.
  TITLE     TRIM59 deficiency curtails breast cancer metastasis through
            SQSTM1-selective autophagic degradation of PDCD10
  JOURNAL   Autophagy 15 (4), 747-749 (2019)
   PUBMED   30653426
REFERENCE   2  (bases 1 to 2122)
  AUTHORS   Kaneko,M., Iwase,I., Yamasaki,Y., Takai,T., Wu,Y., Kanemoto,S.,
            Matsuhisa,K., Asada,R., Okuma,Y., Watanabe,T., Imaizumi,K. and
            Nomura,Y.
  TITLE     Genome-wide identification and gene expression profiling of
            ubiquitin ligases for endoplasmic reticulum protein degradation
  JOURNAL   Sci Rep 6, 30955 (2016)
   PUBMED   27485036
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2122)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 2122)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 2122)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB456985.1, BC088365.1 and AC004686.2.
            
            On Nov 22, 2018 this sequence version replaced NM_016125.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.962118.1,
                                           SRR1660809.91897.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305783.13/ ENSP00000304670.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DB456985.1         17-37
            22-2000             BC088365.1         1-1979
            2001-2122           AC004686.2         2909-3030
FEATURES             Location/Qualifiers
     source          1..2122
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.1"
     gene            1..2122
                     /gene="RNFT1"
                     /gene_synonym="PTD016"
                     /note="ring finger protein, transmembrane 1"
                     /db_xref="GeneID:51136"
                     /db_xref="HGNC:HGNC:30206"
                     /db_xref="MIM:615172"
     exon            1..133
                     /gene="RNFT1"
                     /gene_synonym="PTD016"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1385
                     /gene="RNFT1"
                     /gene_synonym="PTD016"
                     /EC_number="2.3.2.27"
                     /note="RING finger and transmembrane domain-containing
                     protein 1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNFT1"
                     /protein_id="NP_057209.3"
                     /db_xref="CCDS:CCDS11622.2"
                     /db_xref="GeneID:51136"
                     /db_xref="HGNC:HGNC:30206"
                     /db_xref="MIM:615172"
                     /translation="MPLFLLSLPTPPSASGHERRQRPEAKTSGSEKKYLRAMQANRSQ
                     LHSPPGTGSSEDASTPQCVHTRLTGEGSCPHSGDVHIQINSIPKECAENASSRNIRSG
                     VHSCAHGCVHSRLRGHSHSEARLTDDTAAESGDHGSSSFSEFRYLFKWLQKSLPYILI
                     LSVKLVMQHITGISLGIGLLTTFMYANKSIVNQVFLRERSSKIQCAWLLVFLAGSSVL
                     LYYTFHSQSLYYSLIFLNPTLDHLSFWEVFWIVGITDFILKFFFMGLKCLILLVPSFI
                     MPFKSKGYWYMLLEELCQYYRTFVPIPVWFRYLISYGEFGNVTRWSLGILLALLYLIL
                     KLLEFFGHLRTFRQVLRIFFTQPSYGVAASKRQCSDVDDICSICQAEFQKPILLICQH
                     IFCEECMTLWFNREKTCPLCRTVISDHINKWKDGATSSHLQIY"
     exon            134..591
                     /gene="RNFT1"
                     /gene_synonym="PTD016"
                     /inference="alignment:Splign:2.1.0"
     exon            592..668
                     /gene="RNFT1"
                     /gene_synonym="PTD016"
                     /inference="alignment:Splign:2.1.0"
     exon            669..769
                     /gene="RNFT1"
                     /gene_synonym="PTD016"
                     /inference="alignment:Splign:2.1.0"
     exon            770..923
                     /gene="RNFT1"
                     /gene_synonym="PTD016"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1082
                     /gene="RNFT1"
                     /gene_synonym="PTD016"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1148
                     /gene="RNFT1"
                     /gene_synonym="PTD016"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1250
                     /gene="RNFT1"
                     /gene_synonym="PTD016"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..2122
                     /gene="RNFT1"
                     /gene_synonym="PTD016"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1982..1987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNFT1"
                     /gene_synonym="PTD016"
                     /note="hexamer: AATAAA"
     polyA_site      2000
                     /gene="RNFT1"
                     /gene_synonym="PTD016"
                     /note="major polyA site"
     regulatory      2101..2106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNFT1"
                     /gene_synonym="PTD016"
                     /note="hexamer: AATAAT"
     polyA_site      2122
                     /gene="RNFT1"
                     /gene_synonym="PTD016"
                     /note="major polyA site"
ORIGIN      
        1 gccgttgccg ccgggctgag agaagagctt gcggggtttg cggttgatgg ccccgactga
       61 agggctggag gcggtgtatg ccgctgttct tgctgtcgct cccgacacct ccgtccgctt
      121 ctggtcatga gaggagacag aggcctgaag caaagacatc tgggtcagag aaaaagtatt
      181 taagggccat gcaagccaat cgtagccaac tgcacagtcc tccaggaact ggaagcagtg
      241 aggatgcctc aacccctcag tgtgtccaca caagattgac aggagagggt tcttgccctc
      301 attctggaga tgttcatatc cagataaact ccatacctaa agaatgtgca gaaaatgcaa
      361 gctccagaaa tataaggtca ggtgtccata gctgtgccca tggatgtgta cacagtcgct
      421 tacggggtca ctcccacagt gaagcaaggc tgactgatga tactgccgca gaatctggag
      481 atcatggtag tagctccttc tcagaattcc gctatctctt caagtggctg caaaaaagtc
      541 ttccatatat tttgattctg agcgtcaaac ttgttatgca gcatataaca ggaatttctc
      601 ttggaattgg gctgctaaca acttttatgt atgcaaacaa aagcattgta aatcaggttt
      661 ttctaagaga aaggtcctca aagattcagt gtgcttggtt actggtattc ttagcaggat
      721 cttctgttct tttatattac acctttcatt ctcagtcact ttattacagc ttaatttttt
      781 taaatcctac tttggaccat ttgagcttct gggaagtatt ttggattgtt ggaattacag
      841 acttcattct gaaattcttt ttcatgggct taaaatgcct tattttattg gtgccttctt
      901 tcatcatgcc ttttaaatct aagggttact ggtatatgct tttagaagaa ttgtgtcaat
      961 actaccgaac ttttgttccc ataccagttt ggtttcgcta ccttataagc tatggggagt
     1021 ttggtaacgt aactagatgg agtcttggga tactgctggc tttactctac ctcatattaa
     1081 aacttttgga attttttggg catctgagaa ctttcagaca ggttttacga atatttttta
     1141 cacaaccaag ttatggagtg gctgccagca agagacagtg ttcagatgtg gatgatattt
     1201 gttcaatatg tcaagctgaa tttcagaagc caattcttct catttgtcag catatatttt
     1261 gtgaagagtg catgacctta tggtttaaca gagagaaaac atgtccactc tgcagaactg
     1321 tgatttcaga ccatataaac aaatggaagg atggagccac ttcatcacac cttcaaatat
     1381 attaagttgt ataaactatc aaggccacaa aatactaatg tcatttggtc ataatgacta
     1441 ctgataaggc atcagaatgg attttcaggg ctaccagaaa aatgtttcca gatggtttta
     1501 gaatgtagga cttatgatcc aattcaccaa aagattaaat gaaaccaccc tgtgttttaa
     1561 aatatatata atgttcaacc taatgtatat gcaacattta ttctattcta attatttgac
     1621 aggtaactgc agtgttaaat tgtaaatgtg ttttctttat gttaccaaaa cagcaatttg
     1681 aaattagaac tagtggtttt agagaactca ggtattcttt cctgacattg ttttcagaat
     1741 aaagaatatt tttcataata ttttaagata catactatct aaaagtagaa ttttgttcag
     1801 cattgacttt tataattccc atcctaaaaa ttcttaatat tttcataaaa tttgtatttt
     1861 taaatgaaaa ttctaaatgt tgtattttat cagtaacatt ttctaagtga agattaattt
     1921 actgaggatg atacattata gtattgtatt attctctgta gtaagattag taataagtga
     1981 aaataaatga tttaaattca ttttgtctct ggacgtcata aattcttcct gccatcagct
     2041 ttaatgttca tgatcatgct ttttgtatag taccatggag tatctcgaag taactattaa
     2101 aataattcat gtggattata aa
//
