LOCUS       NM_014245               2669 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ring finger protein 7 (RNF7), transcript variant 1,
            mRNA.
ACCESSION   NM_014245
VERSION     NM_014245.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2669)
  AUTHORS   Chang,Y., Chen,Q., Li,H., Xu,J., Tan,M., Xiong,X. and Sun,Y.
  TITLE     The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor
            cascade in pancreatic cancer cells
  JOURNAL   Dev Cell 59 (10), 1317-1332 (2024)
   PUBMED   38574733
REFERENCE   2  (bases 1 to 2669)
  AUTHORS   Xu,P., Liu,Y., Liu,C., Guey,B., Li,L., Melenec,P., Ricci,J. and
            Ablasser,A.
  TITLE     The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for
            degradation
  JOURNAL   Nature 627 (8005), 873-879 (2024)
   PUBMED   38418882
REFERENCE   3  (bases 1 to 2669)
  AUTHORS   Hua,H., Xie,H., Zheng,J., Lei,L., Deng,Z. and Yu,C.
  TITLE     RNF7 Facilitated the Tumorigenesis of Pancreatic Cancer by
            Activating PI3K/Akt Signaling Pathway
  JOURNAL   Oxid Med Cell Longev 2023, 1728463 (2023)
   PUBMED   36644576
  REMARK    GeneRIF: RNF7 Facilitated the Tumorigenesis of Pancreatic Cancer by
            Activating PI3K/Akt Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2669)
  AUTHORS   Xiao,C., Zhang,W., Hua,M., Chen,H., Yang,B., Wang,Y. and Yang,Q.
  TITLE     RNF7 inhibits apoptosis and sunitinib sensitivity and promotes
            glycolysis in renal cell carcinoma via the SOCS1/JAK/STAT3 feedback
            loop
  JOURNAL   Cell Mol Biol Lett 27 (1), 36 (2022)
   PUBMED   35562668
  REMARK    GeneRIF: RNF7 inhibits apoptosis and sunitinib sensitivity and
            promotes glycolysis in renal cell carcinoma via the SOCS1/JAK/STAT3
            feedback loop.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2669)
  AUTHORS   Kostrhon,S., Prabu,J.R., Baek,K., Horn-Ghetko,D., von Gronau,S.,
            Klugel,M., Basquin,J., Alpi,A.F. and Schulman,B.A.
  TITLE     CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific
            NEDD8 activation
  JOURNAL   Nat Chem Biol 17 (10), 1075-1083 (2021)
   PUBMED   34518685
REFERENCE   6  (bases 1 to 2669)
  AUTHORS   Sun,Y.
  TITLE     Alterations of SAG mRNA in human cancer cell lines: requirement for
            the RING finger domain for apoptosis protection
  JOURNAL   Carcinogenesis 20 (10), 1899-1903 (1999)
   PUBMED   10506102
REFERENCE   7  (bases 1 to 2669)
  AUTHORS   Swaroop,M., Bian,J., Aviram,M., Duan,H., Bisgaier,C.L., Loo,J.A.
            and Sun,Y.
  TITLE     Expression, purification, and biochemical characterization of SAG,
            a ring finger redox-sensitive protein
  JOURNAL   Free Radic Biol Med 27 (1-2), 193-202 (1999)
   PUBMED   10443936
REFERENCE   8  (bases 1 to 2669)
  AUTHORS   Ohta,T., Michel,J.J., Schottelius,A.J. and Xiong,Y.
  TITLE     ROC1, a homolog of APC11, represents a family of cullin partners
            with an associated ubiquitin ligase activity
  JOURNAL   Mol Cell 3 (4), 535-541 (1999)
   PUBMED   10230407
REFERENCE   9  (bases 1 to 2669)
  AUTHORS   Tan,P., Fuchs,S.Y., Chen,A., Wu,K., Gomez,C., Ronai,Z. and Pan,Z.Q.
  TITLE     Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to
            catalyze the ubiquitination of I kappa B alpha
  JOURNAL   Mol Cell 3 (4), 527-533 (1999)
   PUBMED   10230406
REFERENCE   10 (bases 1 to 2669)
  AUTHORS   Duan,H., Wang,Y., Aviram,M., Swaroop,M., Loo,J.A., Bian,J.,
            Tian,Y., Mueller,T., Bisgaier,C.L. and Sun,Y.
  TITLE     SAG, a novel zinc RING finger protein that protects cells from
            apoptosis induced by redox agents
  JOURNAL   Mol Cell Biol 19 (4), 3145-3155 (1999)
   PUBMED   10082581
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG742338.1, AC112771.6 and
            AW150174.1.
            
            On Nov 25, 2018 this sequence version replaced NM_014245.4.
            
            Summary: The protein encoded by this gene is a highly conserved
            ring finger protein. It is an essential subunit of
            SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part
            of the protein degradation machinery important for cell cycle
            progression and signal transduction. This protein interacts with,
            and is a substrate of, casein kinase II (CSNK2A1/CKII). The
            phosphorylation of this protein by CSNK2A1 has been shown to
            promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and
            p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding
            distinct isoforms have been reported. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.52654.1,
                                           SRR1660809.23122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273480.4/ ENSP00000273480.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-472               BG742338.1         90-561
            473-1860            AC112771.6         32527-33914
            1861-1912           AW150174.1         10-61               c
            1913-2669           AC112771.6         33967-34723
FEATURES             Location/Qualifiers
     source          1..2669
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..2669
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
                     /note="ring finger protein 7"
                     /db_xref="GeneID:9616"
                     /db_xref="HGNC:HGNC:10070"
                     /db_xref="MIM:603863"
     exon            1..219
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..386
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
                     /EC_number="2.3.2.27"
                     /EC_number="2.3.2.32"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sensitive to apoptosis, zinc RING finger protein SAG,
                     regulator of cullins 2; RING-box protein 2; CKII
                     beta-binding protein 1; sensitive to apoptosis zinc RING
                     finger protein SAG; sensitive to apoptosis gene protein"
                     /codon_start=1
                     /product="RING-box protein 2 isoform 1"
                     /protein_id="NP_055060.1"
                     /db_xref="CCDS:CCDS3118.1"
                     /db_xref="GeneID:9616"
                     /db_xref="HGNC:HGNC:10070"
                     /db_xref="MIM:603863"
                     /translation="MADVEDGEETCALASHSGSSGSKSGGDKMFSLKKWNAVAMWSWD
                     VECDTCAICRVQVMDACLRCQAENKQEDCVVVWGECNHSFHNCCMSLWVKQNNRCPLC
                     QQDWVVQRIGK"
     exon            220..267
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
                     /inference="alignment:Splign:2.1.0"
     exon            268..2669
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      788..793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
                     /note="hexamer: AATAAA"
     polyA_site      811
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
                     /note="major polyA site"
     regulatory      921..926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
                     /note="hexamer: AATAAA"
     polyA_site      949
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
     regulatory      1484..1489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
                     /note="hexamer: AATAAA"
     polyA_site      1510
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
     regulatory      1554..1559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
                     /note="hexamer: AGTAAA"
     polyA_site      1582
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
     regulatory      1614..1619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
                     /note="hexamer: AATAAA"
     polyA_site      1642
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
     regulatory      1891..1896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
                     /note="hexamer: ATTAAA"
     polyA_site      1912
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
     regulatory      2562..2567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
                     /note="hexamer: AGTAAA"
     polyA_site      2581
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
     regulatory      2601..2606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
                     /note="hexamer: TATAAA"
     polyA_site      2625
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
     regulatory      2648..2653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
                     /note="hexamer: AATATA"
     polyA_site      2669
                     /gene="RNF7"
                     /gene_synonym="CKBBP1; rbx2; ROC2; SAG"
ORIGIN      
        1 cttccccaag ccaacgtctc cgccgtcggc tccgcggcgc cgccatggcc gacgtggaag
       61 acggagagga aacctgcgcc ctggcctctc actccgggag ctcaggctcc aagtcgggag
      121 gcgacaagat gttctccctc aagaagtgga acgcggtggc catgtggagc tgggacgtgg
      181 agtgcgatac gtgcgccatc tgcagggtcc aggtgatgga tgcctgtctt agatgtcaag
      241 ctgaaaacaa acaagaggac tgtgttgtgg tctggggaga atgtaatcat tccttccaca
      301 actgctgcat gtccctgtgg gtgaaacaga acaatcgctg ccctctctgc cagcaggact
      361 gggtggtcca aagaatcggc aaatgagagt ggttagaagg cttcttagcg cagttgttca
      421 gagccctggt ggatcttgta atccagtgcc ctacaaaggc tagaacacta caggggatga
      481 attcttcaaa taggagccga tggatctgtg gtcctttggg actcatcaaa gccttggttt
      541 agcattttgt cagttttatc ttcagaaatt ctctgcgatt aagaagataa tttattaaag
      601 gtggtccttc ctacctctgt ggtgtgtgtc gcgcacacag cttagaagtg ctataaaaaa
      661 ggaaagagct ccaaattgaa tcacctttat aatttaccca tttctataca acaggcagtg
      721 gaagcagttt cagagaactt tttgcatgct tatggttgat cagttaaaaa agaatgttac
      781 agtaacaaat aaagtgcagt ttaaaaccca actcttactc ttaatttgtt cctaatacgt
      841 atttttggca gggagaggga acggtccatg aaatctttat gtgatataag gattttaagt
      901 ttgggccagt gaacagggta aataaaattt aacttttgag catatggaat tttgattgcc
      961 tttaaagtta ctattctgta tcattgattc atcaagaaaa cctagatctg cactcacctc
     1021 actgttcaat cattgagtgg taaaggacag aagtattttc tagttctggt cagatgatat
     1081 aatttttttt tttttttttt gtgggggtga agtcttgctc tgccacccag gctggagtgc
     1141 agtggcatga tgtcaactca ctgcaacctc cgcctcccgg gttcaagtga ttctcctgcc
     1201 tcagcctccc gagtagctgg gattacaggt gtgtgccacc acacccggct aatttttgta
     1261 tttttagtag agacgggatt tccccatgtt ggccaggctg gtctcaaact cctgacctca
     1321 ggtgattcgc ccacctcagc ctcccaaagt gctgggatta caggtgtggg ccactgcacc
     1381 tggcccagat gatataattt aactgtgttt taggtaacat gttaatgagg gaaaatgttt
     1441 accagtgtag cattggatca aaaagtttat cacacagtgt tttaataaat ggtttattct
     1501 gcttacctta tttgaattgt cattataatt ttatatgcaa ccttaatttg tcaagtaaat
     1561 actttcattt aatttgaaag aattcatatt catttgctct ttcatttgac aataataaaa
     1621 tttaaggttt attacctgga aagagtgcaa gaaaatacta aacaacttta tcaaactgat
     1681 tcacactgag gggaggttat tttgtaacaa ataatggacc acaagttcat tttgtattct
     1741 tctgtagtag aggctactga tatgaattta agaaaaaacc ttagaatctt aacttttcac
     1801 atctgcagat gcagtgtgcc attctgaatt tttcaatcta agggatgtgg atacatagaa
     1861 tgtttaaaaa gataacaatt agaatgaaaa attaaaatta tgtatgcttt tatatgggtt
     1921 actttttatt gatcacattt ctctggaaat ttttctttat attttttcac agttgtcttt
     1981 ctagctactg aaaaaattat acaaatatct ttggccattt aaatgtttat cattgtgcag
     2041 tgaactgttt tagtaacttt ctgtttgacc tttttagaag gttgcatcct taaaatgtga
     2101 accagataca tggctttgca ttgaagagga aagcagtaga atgtcaggtt actttaggca
     2161 gtgtgacagt atataaatga aatgtggagg atggtggtaa caatttgatt ttccacacag
     2221 caaaaccaca gtcccgccac ctaacaaagc cctgtttatg ccacacacca gcatctgagg
     2281 gaagaggagg cactgtgaca aagcagcgct gatgctgctc agcctgcgat gattacagct
     2341 catctgcaca gccatctgaa agtttaatac atactcatca gagggaacat gccgggacaa
     2401 ttttgggttc caatacaaaa gttaagcatc aaacaggttt ttctttccat ttgattaaat
     2461 gtgctgattt tattttactg ttgcattaga aacaaacaag ttatctttcg ctatttaatt
     2521 ttccctctat gcaaattgtg ttattacagc tgaccgctat cagtaaatct taattctgtc
     2581 agtcccattg cttccttttt tataaaaata ctgtgtcccc ctttactgtc atgaagtgaa
     2641 attcataaat atatttccta cacatataa
//
