LOCUS       NP_005968                685 aa            linear   PRI 27-APR-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform 1 [Homo sapiens].
ACCESSION   NP_005968
VERSION     NP_005968.1
DBSOURCE    REFSEQ: accession NM_005977.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 685)
  AUTHORS   Deng,B., Deng,W., Zheng,H., Wei,Y., Zhang,J., Zeng,N., He,Y. and
            Guo,R.
  TITLE     Non-adherent culture method affects the proliferation and apoptosis
            of mesenchymal stem cells through inhibiting LINC00707 to promote
            RNF6-mediated QKI ubiquitination
  JOURNAL   Exp Cell Res 434 (1), 113877 (2024)
   PUBMED   38072302
  REMARK    GeneRIF: Non-adherent culture method affects the proliferation and
            apoptosis of mesenchymal stem cells through inhibiting LINC00707 to
            promote RNF6-mediated QKI ubiquitination.
REFERENCE   2  (residues 1 to 685)
  AUTHORS   Sun,W., Hua,X., Gu,Y., Xu,Q., Zhu,S., Lv,T. and Song,Y.
  TITLE     E3 ubiquitin ligase RNF6 promotes antiviral immune responses
            through enhancing the expression of interferon stimulated genes in
            myeloid cells
  JOURNAL   Clin Immunol 242, 109099 (2022)
   PUBMED   35973638
  REMARK    GeneRIF: E3 ubiquitin ligase RNF6 promotes antiviral immune
            responses through enhancing the expression of interferon stimulated
            genes in myeloid cells.
REFERENCE   3  (residues 1 to 685)
  AUTHORS   Sun,Y., Sun,H., Qi,Y., Pan,M., An,N., Leng,X., Liu,Y. and Chen,Z.
  TITLE     Ring finger protein 6 enhances chemo-resistance by
            transcriptionally activating proliferating cell nuclear antigen
            expression and attenuating DNA damage in lung adenocarcinoma
  JOURNAL   Cancer Lett 534, 215609 (2022)
   PUBMED   35278611
  REMARK    GeneRIF: Ring finger protein 6 enhances chemo-resistance by
            transcriptionally activating proliferating cell nuclear antigen
            expression and attenuating DNA damage in lung adenocarcinoma.
REFERENCE   4  (residues 1 to 685)
  AUTHORS   Chai,Y., Jiao,S., Peng,X., Gan,Q., Chen,L., Hu,X., Hao,L., Zhang,S.
            and Tao,Q.
  TITLE     RING-Finger Protein 6 promotes Drug Resistance in Retinoblastoma
            via JAK2/STAT3 Signaling Pathway
  JOURNAL   Pathol Oncol Res 28, 1610273 (2022)
   PUBMED   35369571
  REMARK    GeneRIF: RING-Finger Protein 6 promotes Drug Resistance in
            Retinoblastoma via JAK2/STAT3 Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 685)
  AUTHORS   Xu,H., Wong,C.C., Li,W., Zhou,Y., Li,Y., Wang,L., Liu,L. and Yu,J.
  TITLE     RING-finger protein 6 promotes colorectal tumorigenesis by
            transcriptionally activating SF3B2
  JOURNAL   Oncogene 40 (47), 6513-6526 (2021)
   PUBMED   34611311
  REMARK    GeneRIF: RING-finger protein 6 promotes colorectal tumorigenesis by
            transcriptionally activating SF3B2.
REFERENCE   6  (residues 1 to 685)
  AUTHORS   Zhu,L., Tong,G., Chen,J., Wang,Y., Wang,S., Zhao,M., Li,J. and
            Ma,J.
  TITLE     Cloning and identification of a novel RNF6 transcriptional splice
            variant Spg2 in human development
  JOURNAL   Sci China C Life Sci 51 (4), 302-307 (2008)
   PUBMED   18368307
  REMARK    GeneRIF: Results describe thet cloning and identification of a
            novel RNF6 transcriptional splice variant, Spg2, in human
            development.
REFERENCE   7  (residues 1 to 685)
  AUTHORS   Tursun,B., Schluter,A., Peters,M.A., Viehweger,B., Ostendorff,H.P.,
            Soosairajah,J., Drung,A., Bossenz,M., Johnsen,S.A., Schweizer,M.,
            Bernard,O. and Bach,I.
  TITLE     The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in
            axonal growth cones
  JOURNAL   Genes Dev 19 (19), 2307-2319 (2005)
   PUBMED   16204183
  REMARK    GeneRIF: Rnf6 controls cellular LIMK1 concentrations and indicate a
            new function for the ubiquitin/proteasome system in regulating
            local growth cone actin dynamics
            Erratum:[Genes Dev. 2005 Nov 1;19(21):2643]
REFERENCE   8  (residues 1 to 685)
  AUTHORS   Lo,H.S., Hu,N., Gere,S., Lu,N., Su,H., Goldstein,A.M., Taylor,P.R.
            and Lee,M.P.
  TITLE     Identification of somatic mutations of the RNF6 gene in human
            esophageal squamous cell carcinoma
  JOURNAL   Cancer Res 62 (15), 4191-4193 (2002)
   PUBMED   12154016
REFERENCE   9  (residues 1 to 685)
  AUTHORS   Lopez,P., Vidal,F., Martin,L., Lopez-Fernandez,L.A., Rual,J.F.,
            Rosen,B.S., Cuzin,F. and Rassoulzadegan,M.
  TITLE     Gene control in germinal differentiation: RNF6, a transcription
            regulatory protein in the mouse sertoli cell
  JOURNAL   Mol Cell Biol 22 (10), 3488-3496 (2002)
   PUBMED   11971979
  REMARK    GeneRIF: Functional anaylysis of the mouse homolog
REFERENCE   10 (residues 1 to 685)
  AUTHORS   Macdonald,D.H., Lahiri,D., Sampath,A., Chase,A., Sohal,J. and
            Cross,N.C.
  TITLE     Cloning and characterization of RNF6, a novel RING finger gene
            mapping to 13q12
  JOURNAL   Genomics 58 (1), 94-97 (1999)
   PUBMED   10331950
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL138966.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene contains a RING-H2 finger
            motif. Deletions and mutations in this gene were detected in
            esophageal squamous cell carcinoma (ESCC), suggesting that this
            protein may be a potential tumor suppressor. Studies of the mouse
            counterpart suggested a role of this protein in the transcription
            regulation that controls germinal differentiation. Multiple
            alternatively spliced transcript variants encoding the same protein
            are observed. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1, 3, and 4
            all encode the same isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.874903.1,
                                           SRR1660803.258130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149876 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381588.9/ ENSP00000371000.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..685
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.13"
     Protein         1..685
                     /product="E3 ubiquitin-protein ligase RNF6 isoform 1"
                     /EC_number="2.3.2.27"
                     /note="RING-H2 protein RNF-6; E3 ubiquitin-protein ligase
                     RNF6; ring finger protein (C3H2C3 type) 6; RING-type E3
                     ubiquitin transferase RNF6"
                     /calculated_mol_wt=77960
     Region          1..29
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y252.1)"
     Region          81..107
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y252.1)"
     Region          121..142
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y252.1)"
     Region          168..273
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y252.1)"
     Region          286..345
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y252.1)"
     Region          499..576
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y252.1)"
     Region          630..681
                     /region_name="RING-H2_RNF6"
                     /note="RING finger, H2 subclass, found in E3
                     ubiquitin-protein ligase RNF6 and similar proteins;
                     cd16673"
                     /db_xref="CDD:438335"
     CDS             1..685
                     /gene="RNF6"
                     /coded_by="NM_005977.4:414..2471"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS9316.1"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mnqsrsrsdg gseetlpqdh nhhenerrwq qerlhreeay yqfinelnde dyrlmrdhnl
       61 lgtpgeitse elqqrldgvk eqlasqpdlr dgtnyrdsev presshedsl lewlntfrrt
      121 gnatrsgqng nqtwravsrt npnngefrfs leihvnhenr gfeihgedyt diplsdsnrd
      181 htanrqqrst spvarrtrsq tsvnfngsss niprtrlasr gqnpaegsfs tlgrlrngig
      241 gaagiprana srtnfsshtn qsggselrqr egqrfgaahv wengarsnvt vrntnqrlep
      301 irlrstsnsr srspiqrqsg tvyhnsqres rpvqqttrrs vrrrgrtrvf leqdrererr
      361 gtaytpfsns rlvsritvee geessrssta vrrhptitld lqvrrirpge nrdrdsianr
      421 trsrvglaen tvtiesnsgg frrtisrler sgirtyvsti tvplrrisen elvepssval
      481 rsilrqimtg fgelsslmea dseselqrng qhlpdmhsel snlgtdnnrs qhregssqdr
      541 qaqgdstemh genettqpht rnsdsrggrq lrnpnnlvet gtlpilrlah ffllnesddd
      601 drirgltkeq idnlstrhye hnsidselgk icsvcisdyv tgnklrqlpc mhefhihcid
      661 rwlsenctcp icrqpvlgsn ianng
//
