LOCUS       NM_006913               1117 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ring finger protein 5 (RNF5), mRNA.
ACCESSION   NM_006913
VERSION     NM_006913.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1117)
  AUTHORS   Wei,G., Chen,X., Ruan,T., Ma,X., Zhu,X., Wen,W., He,D., Tao,K. and
            Wu,C.
  TITLE     Human gastric cancer progression and stabilization of ATG2B through
            RNF5 binding facilitated by autophagy-associated CircDHX8
  JOURNAL   Cell Death Dis 15 (6), 410 (2024)
   PUBMED   38866787
  REMARK    GeneRIF: Human gastric cancer progression and stabilization of
            ATG2B through RNF5 binding facilitated by autophagy-associated
            CircDHX8.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1117)
  AUTHORS   Li,X., Wang,F., Huang,L., Yang,M. and Kuang,E.
  TITLE     Downregulation of EphA2 stability by RNF5 limits its
            tumor-suppressive function in HER2-negative breast cancers
  JOURNAL   Cell Death Dis 14 (10), 662 (2023)
   PUBMED   37816703
  REMARK    GeneRIF: Downregulation of EphA2 stability by RNF5 limits its
            tumor-suppressive function in HER2-negative breast cancers.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1117)
  AUTHORS   Li,Z., Hao,P., Zhao,Z., Gao,W., Huan,C., Li,L., Chen,X., Wang,H.,
            Jin,N., Luo,Z.Q., Li,C. and Zhang,W.
  TITLE     The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting
            its envelope protein for degradation
  JOURNAL   Signal Transduct Target Ther 8 (1), 53 (2023)
   PUBMED   36737599
  REMARK    GeneRIF: The E3 ligase RNF5 restricts SARS-CoV-2 replication by
            targeting its envelope protein for degradation.
            Erratum:[Signal Transduct Target Ther. 2023 Feb 27;8(1):85. doi:
            10.1038/s41392-023-01374-y.. PMID: 36849529]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1117)
  AUTHORS   Li,X., Wang,F., Zhang,X., Sun,Q. and Kuang,E.
  TITLE     Suppression of KSHV lytic replication and primary effusion lymphoma
            by selective RNF5 inhibition
  JOURNAL   PLoS Pathog 19 (1), e1011103 (2023)
   PUBMED   36656913
  REMARK    GeneRIF: Suppression of KSHV lytic replication and primary effusion
            lymphoma by selective RNF5 inhibition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1117)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1117)
  AUTHORS   Didier,C., Broday,L., Bhoumik,A., Israeli,S., Takahashi,S.,
            Nakayama,K., Thomas,S.M., Turner,C.E., Henderson,S., Sabe,H. and
            Ronai,Z.
  TITLE     RNF5, a RING finger protein that regulates cell motility by
            targeting paxillin ubiquitination and altered localization
  JOURNAL   Mol Cell Biol 23 (15), 5331-5345 (2003)
   PUBMED   12861019
  REMARK    GeneRIF: RNF5 regulates cell motility by targeting paxillin
            ubiquitination and altered localization
REFERENCE   7  (bases 1 to 1117)
  AUTHORS   Matsuda,N., Suzuki,T., Tanaka,K. and Nakano,A.
  TITLE     Rma1, a novel type of RING finger protein conserved from
            Arabidopsis to human, is a membrane-bound ubiquitin ligase
  JOURNAL   J Cell Sci 114 (Pt 10), 1949-1957 (2001)
   PUBMED   11329381
REFERENCE   8  (bases 1 to 1117)
  AUTHORS   Barritt,D.S., Pearn,M.T., Zisch,A.H., Lee,S.S., Javier,R.T.,
            Pasquale,E.B. and Stallcup,W.B.
  TITLE     The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the
            membrane-spanning proteoglycan NG2
  JOURNAL   J Cell Biochem 79 (2), 213-224 (2000)
   PUBMED   10967549
REFERENCE   9  (bases 1 to 1117)
  AUTHORS   Kyushiki,H., Kuga,Y., Suzuki,M., Takahashi,E. and Horie,M.
  TITLE     Cloning, expression and mapping of a novel RING-finger gene (RNF5),
            a human homologue of a putative zinc-finger gene from
            Caenorhabditis elegans
  JOURNAL   Cytogenet Cell Genet 79 (1-2), 114-117 (1997)
   PUBMED   9533025
REFERENCE   10 (bases 1 to 1117)
  AUTHORS   Kendall,E., Sargent,C.A. and Campbell,R.D.
  TITLE     Human major histocompatibility complex contains a new cluster of
            genes between the HLA-D and complement C4 loci
  JOURNAL   Nucleic Acids Res 18 (24), 7251-7257 (1990)
   PUBMED   2259622
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM712189.1, BC127652.1 and
            BC004155.2.
            
            On Nov 23, 2018 this sequence version replaced NM_006913.3.
            
            Summary: The protein encoded by this gene contains a RING finger,
            which is a motif known to be involved in protein-protein
            interactions. This protein is a membrane-bound ubiquitin ligase. It
            can regulate cell motility by targeting paxillin ubiquitination and
            altering the distribution and localization of paxillin in cytoplasm
            and cell focal adhesions. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111392.1, SRR5189667.389884.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375094.4/ ENSP00000364235.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                BM712189.1         342-421
            81-722              BC127652.1         1-642
            723-1117            BC004155.2         620-1014
FEATURES             Location/Qualifiers
     source          1..1117
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..1117
                     /gene="RNF5"
                     /gene_synonym="RING5; RMA1"
                     /note="ring finger protein 5"
                     /db_xref="GeneID:6048"
                     /db_xref="HGNC:HGNC:10068"
                     /db_xref="MIM:602677"
     exon            1..247
                     /gene="RNF5"
                     /gene_synonym="RING5; RMA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..650
                     /gene="RNF5"
                     /gene_synonym="RING5; RMA1"
                     /EC_number="2.3.2.27"
                     /note="protein G16; ram1 homolog; ring finger protein 5,
                     E3 ubiquitin protein ligase; RING-type E3 ubiquitin
                     transferase RNF5"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF5"
                     /protein_id="NP_008844.1"
                     /db_xref="CCDS:CCDS4745.1"
                     /db_xref="GeneID:6048"
                     /db_xref="HGNC:HGNC:10068"
                     /db_xref="MIM:602677"
                     /translation="MAAAEEEDGGPEGPNRERGGAGATFECNICLETAREAVVSVCGH
                     LYCWPCLHQWLETRPERQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQR
                     PAPESRGGFQPFGDTGGFHFSFGVGAFPFGFFTTVFNAHEPFRRGTGVDLGQGHPASS
                     WQDSLFLFLAIFFFFWLLSI"
     exon            248..266
                     /gene="RNF5"
                     /gene_synonym="RING5; RMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..379
                     /gene="RNF5"
                     /gene_synonym="RING5; RMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            380..434
                     /gene="RNF5"
                     /gene_synonym="RING5; RMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..552
                     /gene="RNF5"
                     /gene_synonym="RING5; RMA1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1117
                     /gene="RNF5"
                     /gene_synonym="RING5; RMA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1098..1103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF5"
                     /gene_synonym="RING5; RMA1"
                     /note="hexamer: AATAAA"
     polyA_site      1117
                     /gene="RNF5"
                     /gene_synonym="RING5; RMA1"
                     /note="major polyA site"
ORIGIN      
        1 gaagcctgcc caacgatcgt gggcaggagg tggtttctgg tttgttgggg cgtgtgtatg
       61 tgtatttggg gggactgaag ggtacgtggg gcgaaacaaa accggccatg gcagcagcgg
      121 aggaggagga cgggggcccc gaagggccaa atcgcgagcg gggcggggcg ggcgcgacct
      181 tcgaatgtaa tatatgtttg gagactgctc gggaagctgt ggtcagtgtg tgtggccacc
      241 tgtactgttg gccatgtctt catcagtggc tggagacacg gccagaacgg caagagtgtc
      301 cagtatgtaa agctgggatc agcagagaga aggttgtccc gctttatggg cgagggagcc
      361 agaagcccca ggatcccaga ttaaaaactc caccccgccc ccagggccag agaccagctc
      421 cggagagcag agggggattc cagccatttg gtgataccgg gggcttccac ttctcatttg
      481 gtgttggtgc ttttcccttt ggctttttca ccaccgtctt caatgcccat gagcctttcc
      541 gccggggtac aggtgtggat ctgggacagg gtcacccagc ctccagctgg caggattccc
      601 tcttcctgtt tctcgccatc ttcttctttt tttggctgct cagtatttga gctatgtctg
      661 cttcctgccc acctccagcc agagaagaat cagtattgag ggtccctgct gacccttccg
      721 tactcctgga cccccttgac ccctctattt ctgttggcta aggccagccc tggacattgt
      781 ccaggaaggc ctggggagga ggagtgaagt ctgtgcatag atgggagagc cttctgctca
      841 gaggctcact cagtaacgtt gtttaattct ctgccctggg gaaggaggat ggattgagag
      901 aatgtctttc tcctctccta agtctttgct ttccctgatt tcttgatttg atcttcaaag
      961 gtgggcaaag ttccctctga ctcttccccc actccccatc ttactgattt aatttaattt
     1021 ttcactcccc agagtctaat atggattctg actcttaagt gcttccgccc cctcactacc
     1081 tcctttaata caaattcaat aaaaaaggtg aaatata
//
