LOCUS       NM_014901               4122 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ring finger protein 44 (RNF44), mRNA.
ACCESSION   NM_014901
VERSION     NM_014901.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4122)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4122)
  AUTHORS   Stolk,L., Perry,J.R., Chasman,D.I., He,C., Mangino,M., Sulem,P.,
            Barbalic,M., Broer,L., Byrne,E.M., Ernst,F., Esko,T.,
            Franceschini,N., Gudbjartsson,D.F., Hottenga,J.J., Kraft,P.,
            McArdle,P.F., Porcu,E., Shin,S.Y., Smith,A.V., van Wingerden,S.,
            Zhai,G., Zhuang,W.V., Albrecht,E., Alizadeh,B.Z., Aspelund,T.,
            Bandinelli,S., Lauc,L.B., Beckmann,J.S., Boban,M., Boerwinkle,E.,
            Broekmans,F.J., Burri,A., Campbell,H., Chanock,S.J., Chen,C.,
            Cornelis,M.C., Corre,T., Coviello,A.D., d'Adamo,P., Davies,G., de
            Faire,U., de Geus,E.J., Deary,I.J., Dedoussis,G.V., Deloukas,P.,
            Ebrahim,S., Eiriksdottir,G., Emilsson,V., Eriksson,J.G.,
            Fauser,B.C., Ferreli,L., Ferrucci,L., Fischer,K., Folsom,A.R.,
            Garcia,M.E., Gasparini,P., Gieger,C., Glazer,N., Grobbee,D.E.,
            Hall,P., Haller,T., Hankinson,S.E., Hass,M., Hayward,C.,
            Heath,A.C., Hofman,A., Ingelsson,E., Janssens,A.C., Johnson,A.D.,
            Karasik,D., Kardia,S.L., Keyzer,J., Kiel,D.P., Kolcic,I.,
            Kutalik,Z., Lahti,J., Lai,S., Laisk,T., Laven,J.S., Lawlor,D.A.,
            Liu,J., Lopez,L.M., Louwers,Y.V., Magnusson,P.K., Marongiu,M.,
            Martin,N.G., Klaric,I.M., Masciullo,C., McKnight,B., Medland,S.E.,
            Melzer,D., Mooser,V., Navarro,P., Newman,A.B., Nyholt,D.R.,
            Onland-Moret,N.C., Palotie,A., Pare,G., Parker,A.N., Pedersen,N.L.,
            Peeters,P.H., Pistis,G., Plump,A.S., Polasek,O., Pop,V.J.,
            Psaty,B.M., Raikkonen,K., Rehnberg,E., Rotter,J.I., Rudan,I.,
            Sala,C., Salumets,A., Scuteri,A., Singleton,A., Smith,J.A.,
            Snieder,H., Soranzo,N., Stacey,S.N., Starr,J.M., Stathopoulou,M.G.,
            Stirrups,K., Stolk,R.P., Styrkarsdottir,U., Sun,Y.V., Tenesa,A.,
            Thorand,B., Toniolo,D., Tryggvadottir,L., Tsui,K., Ulivi,S., van
            Dam,R.M., van der Schouw,Y.T., van Gils,C.H., van Nierop,P.,
            Vink,J.M., Visscher,P.M., Voorhuis,M., Waeber,G., Wallaschofski,H.,
            Wichmann,H.E., Widen,E., Wijnands-van Gent,C.J., Willemsen,G.,
            Wilson,J.F., Wolffenbuttel,B.H., Wright,A.F.,
            Yerges-Armstrong,L.M., Zemunik,T., Zgaga,L., Zillikens,M.C.,
            Zygmunt,M., Arnold,A.M., Boomsma,D.I., Buring,J.E., Crisponi,L.,
            Demerath,E.W., Gudnason,V., Harris,T.B., Hu,F.B., Hunter,D.J.,
            Launer,L.J., Metspalu,A., Montgomery,G.W., Oostra,B.A.,
            Ridker,P.M., Sanna,S., Schlessinger,D., Spector,T.D.,
            Stefansson,K., Streeten,E.A., Thorsteinsdottir,U., Uda,M.,
            Uitterlinden,A.G., van Duijn,C.M., Volzke,H., Murray,A.,
            Murabito,J.M., Visser,J.A. and Lunetta,K.L.
  CONSRTM   LifeLines Cohort Study
  TITLE     Meta-analyses identify 13 loci associated with age at menopause and
            highlight DNA repair and immune pathways
  JOURNAL   Nat Genet 44 (3), 260-268 (2012)
   PUBMED   22267201
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4122)
  AUTHORS   Auffray,C., Behar,G., Bois,F., Bouchier,C., Da Silva,C.,
            Devignes,M.D., Duprat,S., Houlgatte,R., Jumeau,M.N., Lamy,B. et al.
  TITLE     [IMAGE: molecular integration of the analysis of the human genome
            and its expression]
  JOURNAL   C R Acad Sci III 318 (2), 263-272 (1995)
   PUBMED   7757816
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC063297.1 and BC039833.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014901.4.
            
            Summary: The protein encoded by this gene contains a RING finger, a
            motif present in a variety of functionally distinct proteins and
            known to be involved in protein-protein and protein-DNA
            interactions. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063297.1, AB029023.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274811.9/ ENSP00000274811.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               BC063297.1         19-401
            384-3616            BC063297.1         403-3635
            3617-4122           BC039833.1         3591-4096
FEATURES             Location/Qualifiers
     source          1..4122
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..4122
                     /gene="RNF44"
                     /note="ring finger protein 44"
                     /db_xref="GeneID:22838"
                     /db_xref="HGNC:HGNC:19180"
                     /db_xref="MIM:619283"
     exon            1..463
                     /gene="RNF44"
                     /inference="alignment:Splign:2.1.0"
     exon            464..614
                     /gene="RNF44"
                     /inference="alignment:Splign:2.1.0"
     CDS             508..1806
                     /gene="RNF44"
                     /codon_start=1
                     /product="RING finger protein 44"
                     /protein_id="NP_055716.1"
                     /db_xref="CCDS:CCDS4404.1"
                     /db_xref="GeneID:22838"
                     /db_xref="HGNC:HGNC:19180"
                     /db_xref="MIM:619283"
                     /translation="MRPWALAVTRWPPSAPVGQRRFSAGPGSTPGQLWGSPGLEGPLA
                     SPPARDERLPSQQPPSRPPHLPVEERRASAPAGGSPRMLHPATQQSPFMVDLHEQVHQ
                     GPVPLSYTVTTVTTQGFPLPTGQHIPGCSAQQLPACSVMFSGQHYPLCCLPPPLIQAC
                     TMQQLPVPYQAYPHLISSDHYILHPPPPAPPPQPTHMAPLGQFVSLQTQHPRMPLQRL
                     DNDVDLRGDQPSLGSFTYSTSAPGPALSPSVPLHYLPHDPLHQELSFGVPYSHMMPRR
                     LSTQRYRLQQPLPPPPPPPPPPPYYPSFLPYFLSMLPMSPTAMGPTISLDLDVDDVEM
                     ENYEALLNLAERLGDAKPRGLTKADIEQLPSYRFNPDSHQSEQTLCVVCFSDFEARQL
                     LRVLPCNHEFHTKCVDKWLKANRTCPICRADASEVPREAE"
     exon            615..804
                     /gene="RNF44"
                     /inference="alignment:Splign:2.1.0"
     exon            805..972
                     /gene="RNF44"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1146
                     /gene="RNF44"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1308
                     /gene="RNF44"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1433
                     /gene="RNF44"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1521
                     /gene="RNF44"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1643
                     /gene="RNF44"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1743
                     /gene="RNF44"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..4122
                     /gene="RNF44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4100..4105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF44"
                     /note="hexamer: AATAAA"
     polyA_site      4122
                     /gene="RNF44"
                     /note="major polyA site"
ORIGIN      
        1 gggcttgcag cgggctactg tttgccggag cctcccggcg cgcccccgcg agccccctcc
       61 cgtctggcgc gcgaccccgc cgcttcgaat gttgtgaatc aaatgtgggg tttgttacat
      121 tccgctgccg ccgcggacag ttcttaaagg gccagccgcc ggctgccgcg cagacccagc
      181 tgcgtcctgc gccgcctccc gctccctgag ggcctgggcc gagagagact gatcgcgcgt
      241 gggcctcgcg aggcagacgc cgtcgggcgg acaacaaaga gagaggcccc ggaaggagcc
      301 gggctgcccc cggacccggg ggtggggagg ggagcacatt gttccgcagg gcgggagctc
      361 ttaaaggatc cagacaggca ccccccccct cccccgcccc ctgcccagtt tggccgtcct
      421 agatcgggaa caaaggagtc aacgtgtggc cgggcggcca aagggttgtg agtcccggcc
      481 cagcccctcc acccccctgc ccccccgatg cgaccatggg ctctggcagt gactaggtgg
      541 ccaccctccg cccccgtggg ccagcggcga ttctctgcgg gacctggcag caccccgggc
      601 cagctctggg gaagccctgg cctcgagggc cccctggcca gcccgcctgc ccgggatgag
      661 cgcttaccct cccagcagcc gccgtcccga cctccacacc tccccgtaga ggagcgccga
      721 gcctcggctc ctgccggcgg gagcccccga atgctgcacc cagccaccca gcagagcccg
      781 ttcatggttg atctccacga gcaggtgcac cagggacctg tccctctgtc ctacacggtc
      841 accacagtga cgacccaagg cttccccttg cctacaggcc agcacatccc tggctgcagt
      901 gcccagcagc tcccagcatg ctccgtgatg ttcagtgggc agcattaccc cctctgctgc
      961 ctcccgcccc cgcttatcca ggcgtgcacc atgcagcagc tgcctgtgcc ctatcaggcc
     1021 tacccccacc tcatctccag tgaccactac atcctgcacc ccccaccacc ggccccaccc
     1081 ccccagccca cccacatggc gcccctgggg cagtttgtgt ctctgcagac ccagcaccct
     1141 cggatgcccc tccagcggct cgacaacgac gtggacctgc gtggggacca gccctccctg
     1201 ggcagcttca cctactccac ctctgcgcct ggcccagccc tttccccgtc ggtgcccctg
     1261 cactacctgc cccacgatcc gctgcaccag gagctgtcct ttggtgtgcc atattctcac
     1321 atgatgccac ggagactgag cacccagaga taccgcctgc agcagccact gcccccgccg
     1381 cccccacccc cacccccacc accctactac cccagcttcc tgccctactt cctctcgatg
     1441 ctgccaatgt caccaacagc aatggggccc accatcagcc tggacctgga cgtggatgat
     1501 gtggagatgg agaactatga ggccctcctg aacctggccg agcggctggg agatgccaag
     1561 ccccggggtc tcaccaaagc agacatagag cagctcccgt cgtaccgctt taacccggac
     1621 agccatcagt cggagcagac gctgtgtgtg gtctgcttca gtgacttcga ggcgcggcag
     1681 ctgctccgag tcctcccctg caaccatgag ttccacacca agtgtgttga caagtggttg
     1741 aaggccaacc ggacgtgtcc catctgccgg gccgacgcct ccgaggtgcc cagggaggct
     1801 gagtgaggcc acgcagccgc ctgcccggga gaaccctgcc tgaagctctg gaaacttgtg
     1861 ggtggggccc agggaggatg gggagggagt ggcccaggcc tgccccttcg ctcctgcctg
     1921 catttccaga gctggtgcca gggtcagccc agcgaggagt ccctgcaata agcccctgca
     1981 tttgccaagc tccaaagact ccctccctag tctgcctgcc tgcccgcccg ccacggagct
     2041 gcctgagtgt ccctgatcgg gtctccctcc tgtgcaccct caggtccctc cttttcctgc
     2101 tggcactgag tgccaggggt ccgctccctc agtggggccg gtggagatcc ttggccccag
     2161 gatgggcaga cagagcacca tcctgggtca gaaggtctca tgctctgaaa tggcgtgccc
     2221 tctgcccagg tggcactgcc aggtgcgtag acagacggtg tcacgagcca tttcctgagc
     2281 cccagggctg aatcccccct ccttgacccc gaacagtgaa ctcaggcagc tggctctgtg
     2341 ttggctgctg tgagggctga gtctggttcc ctaggggacc ctcatcccag gaacaacatt
     2401 ccagccccac cctcaggctg gagggcgtcc cagcctaatc ccgagctggg gcacacgtat
     2461 cctgaggggc ttgggccata cggggagagg gagccctgtg ttcccggtgg ttgtccctcc
     2521 cagggatgca gccagacccg tgcccaatct cctctccctc tgttgttttg catgaacgtg
     2581 aggagcagca gtttttgttc attcatttgg cccaaaatca cgtgtaggat ttggggatgt
     2641 ggatatttaa gacaatttct tttttctttt ggtttaatag gggcgggtat agggaccaac
     2701 tgggaccgag tgcccagggg gccgagcacg gtcatgctgg ccggcctgca tgcatgcgtg
     2761 tgccgggctg ggctgggcgg ccggcggtcg tggggcaggg ttgggggtct gtgctcagct
     2821 gataactgcc atgcactgta ctgcacacgt ccctagagcc taccgggacc cgacgctttt
     2881 cagggcattt ctccctccag ccagggccca actcccacct gcctgggcga atctcctcca
     2941 aggaagtccc aggaggatgg ggaccaggaa ggctgtggac ccccatctcc agggggcctt
     3001 cccagcctga tccctgtcct ccaagttctg gaggaggccg ctgtagggtc tggctgagct
     3061 tcccacccac tttccctggt cccaatcctt tcttgtccta tacccagctg gggttgctgc
     3121 cctgaacgaa ctgcgtgtgg ggccggcaca tcctagcagg cagcccctgg cgcctgctgc
     3181 ctcagggatg ctccaaccac cctcgttctc ctcgcagtgg ccctggctcc cacctcccgc
     3241 cccagcctgc cgtggggccc gtcagcctgg tcccaccccc atggagaacc caaagtctta
     3301 ctgtatataa ctccaggtga cgtttctata tttatagcag tgttgaaaac ccacgtgttt
     3361 tacacagaac caccctctcc aacccctccc ttcccgaccc caacaaaacg ttttcaaacc
     3421 ccttacagtt cctggggcag gcggaaacag gctcacagat tgtgtgtcgg ctgcagcagt
     3481 gattccaaca agcagctatt gggggggaaa cacagcattt aaaaagatca tcattaaaaa
     3541 acaagattta tacaacaatt acttaggatg tttgtgatct gccgaccttg ctatagatgc
     3601 catgttacca atgatttcct gtggtggggg cttgccattg tttactctct tatttaccaa
     3661 cttctggcct aggcatgaca gtgggcacct tcccccagcc ctggctgggc ccagcgcctg
     3721 tgttctgtgt tagaaaggtt ttatatatat ataaaattac atatatatgt agaaatatat
     3781 gtaattttgg gggccctgtt ccttgcacat tttacagtta cctcattttt cccatgtatg
     3841 tatttgagaa aatgctaata tatagagaaa aaaatggttc ttaaagctta aatgtgtggt
     3901 tttttccatt ccatgggatt cacattggtt tgtagcattt aacataacta gtatgttgta
     3961 ttatatatat gtgtatactg attgaaattt ttaacagatt tgtacttttt ttaaaatgaa
     4021 agttgctagt tctgcttgac caagtagtgc aatcattatt ttttttaata ttgttgctga
     4081 tttcagaggg atattcacta ataaatgtat gatgtatacc aa
//
