LOCUS       NM_017763               4522 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens ring finger protein 43 (RNF43), transcript variant 1,
            mRNA.
ACCESSION   NM_017763
VERSION     NM_017763.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4522)
  AUTHORS   Nag,J.K., Appasamy,P., Malka,H., Sedley,S. and Bar-Shavit,R.
  TITLE     New Target(s) for RNF43 Regulation: Implications for Therapeutic
            Strategies
  JOURNAL   Int J Mol Sci 25 (15), 8083 (2024)
   PUBMED   39125653
  REMARK    GeneRIF: New Target(s) for RNF43 Regulation: Implications for
            Therapeutic Strategies.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4522)
  AUTHORS   Bugter,J.M., van Kerkhof,P., Jordens,I., Janssen,E., Tran Ngoc
            Minh,T., Iglesias van Montfort,D., Jamieson,C. and Maurice,M.M.
  TITLE     E3 ligases RNF43 and ZNRF3 display differential specificity for
            endocytosis of Frizzled receptors
  JOURNAL   Life Sci Alliance 7 (9), e202402575 (2024)
   PUBMED   38969364
  REMARK    GeneRIF: E3 ligases RNF43 and ZNRF3 display differential
            specificity for endocytosis of Frizzled receptors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4522)
  AUTHORS   Hsu,S.H., Tsai,Y.L., Wang,Y.T., Shen,C.H., Hung,Y.H., Chen,L.T. and
            Hung,W.C.
  TITLE     RNF43 Inactivation Enhances the B-RAF/MEK Signaling and Creates a
            Combinatory Therapeutic Target in Cancer Cells
  JOURNAL   Adv Sci (Weinh) 11 (12), e2304820 (2024)
   PUBMED   38225722
  REMARK    GeneRIF: RNF43 Inactivation Enhances the B-RAF/MEK Signaling and
            Creates a Combinatory Therapeutic Target in Cancer Cells.
REFERENCE   4  (bases 1 to 4522)
  AUTHORS   Chan,J.M., Clendenning,M., Joseland,S., Georgeson,P., Mahmood,K.,
            Joo,J.E., Walker,R., Como,J., Preston,S., Chai,S.M., Chu,Y.L.,
            Meyers,A.L., Pope,B.J., Duggan,D., Fink,J.L., Macrae,F.A.,
            Rosty,C., Winship,I.M., Jenkins,M.A. and Buchanan,D.D.
  TITLE     Inherited BRCA1 and RNF43 pathogenic variants in a familial
            colorectal cancer type X family
  JOURNAL   Fam Cancer 23 (1), 9-21 (2024)
   PUBMED   38063999
  REMARK    GeneRIF: Inherited BRCA1 and RNF43 pathogenic variants in a
            familial colorectal cancer type X family.
REFERENCE   5  (bases 1 to 4522)
  AUTHORS   Koo,B.K., Spit,M., Jordens,I., Low,T.Y., Stange,D.E., van de
            Wetering,M., van Es,J.H., Mohammed,S., Heck,A.J., Maurice,M.M. and
            Clevers,H.
  TITLE     Tumour suppressor RNF43 is a stem-cell E3 ligase that induces
            endocytosis of Wnt receptors
  JOURNAL   Nature 488 (7413), 665-669 (2012)
   PUBMED   22895187
  REMARK    GeneRIF: RNF43 and ZNRF3 reduce Wnt signals by selectively
            ubiquitinating frizzled receptors, thereby targeting these Wnt
            receptors for degradation
REFERENCE   6  (bases 1 to 4522)
  AUTHORS   Low,S.K., Kuchiba,A., Zembutsu,H., Saito,A., Takahashi,A., Kubo,M.,
            Daigo,Y., Kamatani,N., Chiku,S., Totsuka,H., Ohnami,S., Hirose,H.,
            Shimada,K., Okusaka,T., Yoshida,T., Nakamura,Y. and Sakamoto,H.
  TITLE     Genome-wide association study of pancreatic cancer in Japanese
            population
  JOURNAL   PLoS One 5 (7), e11824 (2010)
   PUBMED   20686608
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4522)
  AUTHORS   van Wijk,S.J., de Vries,S.J., Kemmeren,P., Huang,A., Boelens,R.,
            Bonvin,A.M. and Timmers,H.T.
  TITLE     A comprehensive framework of E2-RING E3 interactions of the human
            ubiquitin-proteasome system
  JOURNAL   Mol Syst Biol 5, 295 (2009)
   PUBMED   19690564
  REMARK    Erratum:[Mol Syst Biol. 2009;5:317]
REFERENCE   8  (bases 1 to 4522)
  AUTHORS   Sugiura,T., Yamaguchi,A. and Miyamoto,K.
  TITLE     A cancer-associated RING finger protein, RNF43, is a ubiquitin
            ligase that interacts with a nuclear protein, HAP95
  JOURNAL   Exp Cell Res 314 (7), 1519-1528 (2008)
   PUBMED   18313049
  REMARK    GeneRIF: These results infer that RNF43 is a resident protein of
            the ER and, at least partially, the nuclear membrane, with
            ubiquitin ligase activity and may be involved in cell growth
            control potentially through the interaction with HAP95.
REFERENCE   9  (bases 1 to 4522)
  AUTHORS   Uchida,N., Tsunoda,T., Wada,S., Furukawa,Y., Nakamura,Y. and
            Tahara,H.
  TITLE     Ring finger protein 43 as a new target for cancer immunotherapy
  JOURNAL   Clin Cancer Res 10 (24), 8577-8586 (2004)
   PUBMED   15623641
REFERENCE   10 (bases 1 to 4522)
  AUTHORS   Yagyu,R., Furukawa,Y., Lin,Y.M., Shimokawa,T., Yamamura,T. and
            Nakamura,Y.
  TITLE     A novel oncoprotein RNF43 functions in an autocrine manner in
            colorectal cancer
  JOURNAL   Int J Oncol 25 (5), 1343-1348 (2004)
   PUBMED   15492824
  REMARK    GeneRIF: RNF43 may exert its growth promoting effect in an
            antocrine manner and may be a novel diagnostic marker for
            colorectal cancer
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR627423.1, AK291027.1,
            BC109028.2 and AK000322.1.
            
            On Feb 5, 2020 this sequence version replaced NM_017763.5.
            
            Summary: The protein encoded by this gene is a RING-type E3
            ubiquitin ligase and is predicted to contain a transmembrane
            domain, a protease-associated domain, an ectodomain, and a
            cytoplasmic RING domain. This protein is thought to negatively
            regulate Wnt signaling, and expression of this gene results in an
            increase in ubiquitination of frizzled receptors, an alteration in
            their subcellular distribution, resulting in reduced surface levels
            of these receptors. Mutations in this gene have been reported in
            multiple tumor cells, including colorectal and endometrial cancers.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291027.1, SRR14038194.582040.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407977.7/ ENSP00000385328.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-518               CR627423.1         49-566
            519-835             AK291027.1         337-653
            836-3415            BC109028.2         130-2709
            3416-4522           AK000322.1         2681-3787
FEATURES             Location/Qualifiers
     source          1..4522
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..4522
                     /gene="RNF43"
                     /gene_synonym="RNF124; SSPCS; URCC"
                     /note="ring finger protein 43"
                     /db_xref="GeneID:54894"
                     /db_xref="HGNC:HGNC:18505"
                     /db_xref="MIM:612482"
     exon            1..518
                     /gene="RNF43"
                     /gene_synonym="RNF124; SSPCS; URCC"
                     /inference="alignment:Splign:2.1.0"
     exon            519..1155
                     /gene="RNF43"
                     /gene_synonym="RNF124; SSPCS; URCC"
                     /inference="alignment:Splign:2.1.0"
     CDS             904..3255
                     /gene="RNF43"
                     /gene_synonym="RNF124; SSPCS; URCC"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; E3 ubiquitin-protein ligase RNF43; RING-type E3
                     ubiquitin transferase RNF43"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF43 isoform 1
                     precursor"
                     /protein_id="NP_060233.3"
                     /db_xref="CCDS:CCDS11607.1"
                     /db_xref="GeneID:54894"
                     /db_xref="HGNC:HGNC:18505"
                     /db_xref="MIM:612482"
                     /translation="MSGGHQLQLAALWPWLLMATLQAGFGRTGLVLAAAVESERSAEQ
                     KAIIRVIPLKMDPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPG
                     FISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWP
                     VVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWPDYDVWILMTVVGTIFVIILASVL
                     RIRCRPRHSRPDPLQQRTAWAISQLATRRYQASCRQARGEWPDSGSSCSSAPVCAICL
                     EEFSEGQELRVISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQE
                     PGRRLHLIRQHPGHAHYHLPAAYLLGPSRSAVARPPRPGPFLPSQEPGMGPRHHRFPR
                     AAHPRAPGEQQRLAGAQHPYAQGWGLSHLQSTSQHPAACPVPLRRARPPDSSGSGESY
                     CTERSGYLADGPASDSSSGPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPL
                     VYCSPKGDPQRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQWHG
                     RKPGPETGVPQSRPPIPRTQPQPEPPSPDQQVTRSNSAAPSGRLSNPQCPRALPEPAP
                     GPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGPSEPTPGSRPQDATVHPACQIFP
                     HYTPSVAYPWSPEAHPLICGPPGLDKRLLPETPGPCYSNSQPVWLCLTPRQPLEPHPP
                     GEGPSEWSSDTAEGRPCPYPHCQVLSAQPGSEEELEELCEQAV"
     exon            1156..1278
                     /gene="RNF43"
                     /gene_synonym="RNF124; SSPCS; URCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1353
                     /gene="RNF43"
                     /gene_synonym="RNF124; SSPCS; URCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1485
                     /gene="RNF43"
                     /gene_synonym="RNF124; SSPCS; URCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1590
                     /gene="RNF43"
                     /gene_synonym="RNF124; SSPCS; URCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1752
                     /gene="RNF43"
                     /gene_synonym="RNF124; SSPCS; URCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1855
                     /gene="RNF43"
                     /gene_synonym="RNF124; SSPCS; URCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..3211
                     /gene="RNF43"
                     /gene_synonym="RNF124; SSPCS; URCC"
                     /inference="alignment:Splign:2.1.0"
     exon            3212..4522
                     /gene="RNF43"
                     /gene_synonym="RNF124; SSPCS; URCC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4505..4510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF43"
                     /gene_synonym="RNF124; SSPCS; URCC"
                     /note="hexamer: AATATA"
     polyA_site      4522
                     /gene="RNF43"
                     /gene_synonym="RNF124; SSPCS; URCC"
                     /note="major polyA site"
ORIGIN      
        1 gggagttgat ccagaattgt ctttctgaaa ggaagcactc ggaatccttc cgaactttcc
       61 aagtccatcc atgattcaga gatactgcct tctctctctc tgggatttta tgtgtttctg
      121 atagtgaatt gttgatgtat ttgctacttt gcttcttttc tctttcaaga cttgatcatt
      181 ttatatgctg tttggagaaa aaaagaactt ttgttagcaa ggaggtttca gaaatgattt
      241 tggattttct gtaagtgttt aatttagttc taggggacag catctctcat cccggagtaa
      301 atttctgcct ttgacctgca tggattattt tttcaggctg cggaatttct cggcacctac
      361 ctgtagtatg gggcacttgg tttggttgca gagtaagaag gtggaagaat gagctgtact
      421 tggttaagca gttgaaacct tttttgagca ggatctgtaa aagcataatt gaatttgttt
      481 cacccccgtg gattccagtg ggcccgacag cgcaacagtg cctggcaact tgatgcatat
      541 ggaagagcaa tgccaagtga tctgacataa tacaaattca cgaagtgaca ttcaatcaca
      601 agcaaagttg gaaattccaa agagaagtgg tgagatcttt actagtcaca gtgaagatgg
      661 gagaaaatga catacctgca gcagatgtgg gctgaaaata tcctcttctc tgcccaatca
      721 ggaatgctac ctgtttttgg gaataaactt tagagaaagg aagggccaaa actacgactt
      781 ggctttctga aacggaagca taaatgttct tttcctccat ttgtctggat ctgagaacct
      841 gcatttggta ttagctagtg gaagcagtat gtatggttga agtgcattgc tgcagctggt
      901 agcatgagtg gtggccacca gctgcagctg gctgccctct ggccctggct gctgatggct
      961 accctgcagg caggctttgg acgcacagga ctggtactgg cagcagcggt ggagtctgaa
     1021 agatcagcag aacagaaagc tattatcaga gtgatcccct tgaaaatgga ccccacagga
     1081 aaactgaatc tcactttgga aggtgtgttt gctggtgttg ctgaaataac tccagcagaa
     1141 ggaaaattaa tgcagtccca cccgctgtac ctgtgcaatg ccagtgatga cgacaatctg
     1201 gagcctggat tcatcagcat cgtcaagctg gagagtcctc gacgggcccc ccgcccctgc
     1261 ctgtcactgg ctagcaaggc tcggatggcg ggtgagcgag gagccagtgc tgtcctcttt
     1321 gacatcactg aggatcgagc tgctgctgag cagctgcagc agccgctggg gctgacctgg
     1381 ccagtggtgt tgatctgggg taatgacgct gagaagctga tggagtttgt gtacaagaac
     1441 caaaaggccc atgtgaggat tgagctgaag gagcccccgg cctggccaga ttatgatgtg
     1501 tggatcctaa tgacagtggt gggcaccatc tttgtgatca tcctggcttc ggtgctgcgc
     1561 atccggtgcc gcccccgcca cagcaggccg gatccgcttc agcagagaac agcctgggcc
     1621 atcagccagc tggccaccag gaggtaccag gccagctgca ggcaggcccg gggtgagtgg
     1681 ccagactcag ggagcagctg cagctcagcc cctgtgtgtg ccatctgtct ggaggagttc
     1741 tctgaggggc aggagctacg ggtcatttcc tgcctccatg agttccatcg taactgtgtg
     1801 gacccctggt tacatcagca tcggacttgc cccctctgca tgttcaacat cacagaggga
     1861 gattcatttt cccagtccct gggaccctct cgatcttacc aagaaccagg tcgaagactc
     1921 cacctcattc gccagcatcc cggccatgcc cactaccacc tccctgctgc ctacctgttg
     1981 ggcccttccc ggagtgcagt ggctcggccc ccacgacctg gtcccttcct gccatcccag
     2041 gagccaggca tgggccctcg gcatcaccgc ttccccagag ctgcacatcc ccgggctcca
     2101 ggagagcagc agcgcctggc aggagcccag cacccctatg cacaaggctg gggactgagc
     2161 cacctccaat ccacctcaca gcaccctgct gcttgcccag tgcccctacg ccgggccagg
     2221 ccccctgaca gcagtggatc tggagaaagc tattgcacag aacgcagtgg gtacctggca
     2281 gatgggccag ccagtgactc cagctcaggg ccctgtcatg gctcttccag tgactctgtg
     2341 gtcaactgca cggacatcag cctacagggg gtccatggca gcagttctac tttctgcagc
     2401 tccctaagca gtgactttga ccccctagtg tactgcagcc ctaaagggga tccccagcga
     2461 gtggacatgc agcctagtgt gacctctcgg cctcgttcct tggactcggt ggtgcccaca
     2521 ggggaaaccc aggtttccag ccatgtccac taccaccgcc accggcacca ccactacaaa
     2581 aagcggttcc agtggcatgg caggaagcct ggcccagaaa ccggagtccc ccagtccagg
     2641 cctcctattc ctcggacaca gccccagcca gagccacctt ctcctgatca gcaagtcacc
     2701 agatccaact cagcagcccc ttcggggcgg ctctctaacc cacagtgccc cagggccctc
     2761 cctgagccag cccctggccc agttgacgcc tccagcatct gccccagtac cagcagtctg
     2821 ttcaacttgc aaaaatccag cctctctgcc cgacacccac agaggaaaag gcgggggggt
     2881 ccctccgagc ccacccctgg ctctcggccc caggatgcaa ctgtgcaccc agcttgccag
     2941 atttttcccc attacacccc cagtgtggca tatccttggt ccccagaggc acaccccttg
     3001 atctgtggac ctccaggcct ggacaagagg ctgctaccag aaaccccagg cccctgttac
     3061 tcaaattcac agccagtgtg gttgtgcctg actcctcgcc agcccctgga accacatcca
     3121 cctggggagg ggccttctga atggagttct gacaccgcag agggcaggcc atgcccttat
     3181 ccgcactgcc aggtgctgtc ggcccagcct ggctcagagg aggaactcga ggagctgtgt
     3241 gaacaggctg tgtgagatgt tcaggcctag ctccaaccaa gagtgtgctc cagatgtgtt
     3301 tgggccctac ctggcacaga gtcctgctcc tgggaaagga aaggaccaca gcaaacacca
     3361 ttctttttgc cgtacttcct agaagcactg gaagaggact ggtgatggtg gagggtgaga
     3421 gggtgccgtt tcctgctcca gctccagacc ttgtctgcag aaaacatctg cagtgcagca
     3481 aatccatgtc cagccaggca accagctgct gcctgtggcg tgtgtgggct ggatcccttg
     3541 aaggctgagt ttttgagggc agaaagctag ctatgggtag ccaggtgtta caaaggtgct
     3601 gctccttctc caacccctac ttggtttccc tcaccccaag cctcatgttc ataccagcca
     3661 gtgggttcag cagaacgcat gacaccttat cacctccctc cttgggtgag ctctgaacac
     3721 cagctttggc ccctccacag taaggctgct acatcagggg caaccctggc tctatcattt
     3781 tccttttttg ccaaaaggac cagtagcata ggtgagccct gagcactaaa aggaggggtc
     3841 cctgaagctt tcccactata gtgtggagtt ctgtccctga ggtgggtaca gcagccttgg
     3901 ttcctctggg ggttgagaat aagaatagtg gggagggaaa aactcctcct tgaagatttc
     3961 ctgtctcaga gtcccagaga ggtagaaagg aggaatttct gctggacttt atctgggcag
     4021 aggaaggatg gaatgaaggt agaaaaggca gaattacagc tgagcgggga caacaaagag
     4081 ttcttctctg ggaaaagttt tgtcttagag caaggatgga aaatggggac aacaaaggaa
     4141 aagcaaagtg tgacccttgg gtttggacag cccagaggcc cagctcccca gtataagcca
     4201 tacaggccag ggacccacag gagagtggat tagagcacaa gtctggcctc actgagtgga
     4261 caagagctga tgggcctcat cagggtgaca ttcaccccag ggcagcctga ccactcttgg
     4321 cccctcaggc attatcccat ttggaatgtg aatgtggtgg caaagtgggc agaggacccc
     4381 acctgggaac ctttttccct cagttagtgg ggagactagc acctaggtac ccacatgggt
     4441 atttatatct gaaccagaca gacgcttgaa tcaggcacta tgttaagaaa tatatttatt
     4501 tgctaatata tttatccaca aa
//
