LOCUS       NM_014771               5309 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ring finger protein 40 (RNF40), transcript variant 1,
            mRNA.
ACCESSION   NM_014771
VERSION     NM_014771.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5309)
  AUTHORS   Lyu,Y., Yang,Y., Talwar,V., Lu,H., Chen,C., Salman,S., Wicks,E.E.,
            Huang,T.Y., Drehmer,D., Wang,Y., Zuo,Q., Datan,E., Jackson,W. 3rd,
            Dordai,D., Wang,R. and Semenza,G.L.
  TITLE     Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate
            histone ubiquitination and transcriptional activation of target
            genes
  JOURNAL   Cell Rep 43 (4), 113972 (2024)
   PUBMED   38517892
  REMARK    GeneRIF: Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to
            mediate histone ubiquitination and transcriptional activation of
            target genes.
REFERENCE   2  (bases 1 to 5309)
  AUTHORS   Prokakis,E., Jansari,S., Boshnakovska,A., Wiese,M., Kusch,K.,
            Kramm,C., Dullin,C., Rehling,P., Glatzel,M., Pantel,K., Wikman,H.,
            Johnsen,S.A., Gallwas,J. and Wegwitz,F.
  TITLE     RNF40 epigenetically modulates glycolysis to support the
            aggressiveness of basal-like breast cancer
  JOURNAL   Cell Death Dis 14 (9), 641 (2023)
   PUBMED   37770435
  REMARK    GeneRIF: RNF40 epigenetically modulates glycolysis to support the
            aggressiveness of basal-like breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5309)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 5309)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5309)
  AUTHORS   Fu,J., Liao,L., Balaji,K.S., Wei,C., Kim,J. and Peng,J.
  TITLE     Epigenetic modification and a role for the E3 ligase RNF40 in
            cancer development and metastasis
  JOURNAL   Oncogene 40 (3), 465-474 (2021)
   PUBMED   33199825
  REMARK    GeneRIF: Epigenetic modification and a role for the E3 ligase RNF40
            in cancer development and metastasis.
            Review article
REFERENCE   6  (bases 1 to 5309)
  AUTHORS   Kim,J., Guermah,M., McGinty,R.K., Lee,J.S., Tang,Z., Milne,T.A.,
            Shilatifard,A., Muir,T.W. and Roeder,R.G.
  TITLE     RAD6-Mediated transcription-coupled H2B ubiquitylation directly
            stimulates H3K4 methylation in human cells
  JOURNAL   Cell 137 (3), 459-471 (2009)
   PUBMED   19410543
REFERENCE   7  (bases 1 to 5309)
  AUTHORS   Kaltenbach,L.S., Romero,E., Becklin,R.R., Chettier,R., Bell,R.,
            Phansalkar,A., Strand,A., Torcassi,C., Savage,J., Hurlburt,A.,
            Cha,G.H., Ukani,L., Chepanoske,C.L., Zhen,Y., Sahasrabudhe,S.,
            Olson,J., Kurschner,C., Ellerby,L.M., Peltier,J.M., Botas,J. and
            Hughes,R.E.
  TITLE     Huntingtin interacting proteins are genetic modifiers of
            neurodegeneration
  JOURNAL   PLoS Genet 3 (5), e82 (2007)
   PUBMED   17500595
REFERENCE   8  (bases 1 to 5309)
  AUTHORS   Zhu,B., Zheng,Y., Pham,A.D., Mandal,S.S., Erdjument-Bromage,H.,
            Tempst,P. and Reinberg,D.
  TITLE     Monoubiquitination of human histone H2B: the factors involved and
            their roles in HOX gene regulation
  JOURNAL   Mol Cell 20 (4), 601-611 (2005)
   PUBMED   16307923
  REMARK    GeneRIF: Formation of trimeric complex UbcH6 and RNF20/40 with PAF
            stimulates histone 2B monoubiquitination activity in vitro
REFERENCE   9  (bases 1 to 5309)
  AUTHORS   Chin,L.S., Vavalle,J.P. and Li,L.
  TITLE     Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin
            1 for degradation
  JOURNAL   J Biol Chem 277 (38), 35071-35079 (2002)
   PUBMED   12121982
  REMARK    GeneRIF: Functional Analysis of the rat counterpart
REFERENCE   10 (bases 1 to 5309)
  AUTHORS   Wen,H. and Ao,S.
  TITLE     RBP95, a novel leucine zipper protein, binds to the retinoblastoma
            protein
  JOURNAL   Biochem Biophys Res Commun 275 (1), 141-148 (2000)
   PUBMED   10944455
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106886.3 and KF456183.1.
            
            On Aug 14, 2019 this sequence version replaced NM_014771.3.
            
            Summary: The protein encoded by this gene contains a RING finger, a
            motif known to be involved in protein-protein and protein-DNA
            interactions. This protein was reported to interact with the tumor
            suppressor protein RB1. Studies of the rat counterpart suggested
            that this protein may function as an E3 ubiquitin-protein ligase,
            and facilitate the ubiquitination and degradation of syntaxin 1,
            which is an essential component of the neurotransmitter release
            machinery. Multiple alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1 and 4
            both encode the same isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011769.2, AB014561.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324685.11/ ENSP00000325677.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC106886.3         141255-141293
            40-242              AC106886.3         141408-141610
            243-410             AC106886.3         142051-142218
            411-552             AC106886.3         142351-142492
            553-759             AC106886.3         143112-143318
            760-881             AC106886.3         143871-143992
            882-1028            AC106886.3         144114-144260
            1029-1103           AC106886.3         144358-144432
            1104-1223           AC106886.3         145096-145215
            1224-1403           AC106886.3         145312-145491
            1404-1539           AC106886.3         145674-145809
            1540-1661           AC106886.3         146827-146948
            1662-1764           AC106886.3         147036-147138
            1765-2089           KF456183.1         1-325
            2090-2207           AC106886.3         147552-147669
            2208-2357           AC106886.3         147771-147920
            2358-2570           AC106886.3         148119-148331
            2571-2696           AC106886.3         148408-148533
            2697-2837           AC106886.3         150766-150906
            2838-2939           AC106886.3         151022-151123
            2940-5309           AC106886.3         152871-155240
FEATURES             Location/Qualifiers
     source          1..5309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..5309
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /note="ring finger protein 40"
                     /db_xref="GeneID:9810"
                     /db_xref="HGNC:HGNC:16867"
                     /db_xref="MIM:607700"
     exon            1..39
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            40..242
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..3116
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; BRE1
                     E3 ubiquitin ligase homolog B; 95 kDa retinoblastoma
                     protein binding protein; Rb-associated protein; E3
                     ubiquitin-protein ligase BRE1B; BRE1-B; ring finger
                     protein 40, E3 ubiquitin protein ligase; 95 kDa
                     retinoblastoma-associated protein; RING-type E3 ubiquitin
                     transferase BRE1B"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase BRE1B isoform 1"
                     /protein_id="NP_055586.1"
                     /db_xref="CCDS:CCDS10691.1"
                     /db_xref="GeneID:9810"
                     /db_xref="HGNC:HGNC:16867"
                     /db_xref="MIM:607700"
                     /translation="MSGPGNKRAAGDGGSGPPEKKLSREEKTTTTLIEPIRLGGISST
                     EEMDLKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLD
                     ETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSE
                     PALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGD
                     SEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEME
                     TTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEM
                     LNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQ
                     AQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLED
                     TLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKL
                     REVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAP
                     VPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGP
                     PPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKE
                     QRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHL
                     QRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQ
                     IHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQAL
                     ELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISR
                     LRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPCCNTRKKDAVLTKCFHVFCFECV
                     RGRYEARQRKCPKCNAAFGAHDFHRIYIS"
     exon            243..410
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            411..552
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            553..759
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            760..881
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1028
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1103
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1223
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1403
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1539
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1661
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..2089
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2207
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2357
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2570
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2696
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2837
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2939
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..5309
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4220
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /note="major polyA site"
     regulatory      5287..5292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
                     /note="hexamer: AATAAA"
     polyA_site      5309
                     /gene="RNF40"
                     /gene_synonym="BRE1B; RBP95; STARING"
ORIGIN      
        1 gaaatccaag atggcggcgc taggctgacc ctcctgctgg tgacggaagt accgcctcct
       61 cccgtttgac gcccctcagg ggaccctgca tcgctccagc cgccgcggcc atgtctgggc
      121 caggcaacaa acgcgccgcc ggcgacgggg gctcagggcc cccggaaaag aagctgagtc
      181 gtgaggagaa gaccaccacg actcttatcg agcccattcg tcttggaggc atctcttcca
      241 cggaggagat ggacctgaag gtactacagt tcaagaacaa gaaactggca gagcggctgg
      301 aacaacggca ggcttgtgaa gatgaactcc gagaacgaat tgagaagttg gagaagcggc
      361 aggccacaga tgatgccaca ctcctcatcg tcaatcgcta ctgggcccag ctggatgaaa
      421 ctgtggaagc ccttctccga tgccatgaga gccaggggga gctgtcttca gcgcctgagg
      481 cacctgggac ccaggagggg ccaacatgtg atgggactcc tctcccagag ccggggacat
      541 cagagctgag agaccccttg ctgatgcagc tgcggccccc tctcagtgag ccggccttgg
      601 cttttgtggt ggcactgggt gccagcagca gtgaggaggt ggagctggag ctgcaaggcc
      661 gaatggagtt ctccaaggca gctgtgtctc gtgtggtaga ggcctcagac cgcctacagc
      721 gccgggtgga ggaactctgt cagcgagtgt acagccgagg ggacagtgag cccctcagtg
      781 aggcggctca ggcacacacc cgagagctgg gccgtgagaa ccggcgactg caggacttgg
      841 ccactcagct gcaggagaaa caccaccgca tctcattgga gtactccgag ctccaggata
      901 aagtgacatc ggcagagacc aaggtgctgg agatggagac aacagtggag gacttgcagt
      961 gggacatcga gaagctgcgg aagcgagagc aaaagctcaa taagcacctg gcagaggcct
     1021 tagagcagct taactctggc tactatgtat ctgggagctc ctcaggcttc caggggggcc
     1081 agatcacact cagcatgcag aagtttgaga tgctgaatgc agagttagag gaaaaccagg
     1141 aactggccaa cagccgtatg gcagagctgg agaaactgca ggccgaactt cagggggctg
     1201 tgcggaccaa tgagcgcctc aaggtggccc tgcggagcct tcctgaggag gtagtgcggg
     1261 agacggggga gtaccgcatg ctgcaggccc aattctcact gctctacaac gagtctctgc
     1321 aagtgaagac ccagctagac gaggctcggg gcctgctgct ggccacaaag aactcccacc
     1381 tgcgacacat cgagcacatg gagagcgacg agctggggct gcagaagaag ctacgcacag
     1441 aggtcattca gctggaggac acgctggccc aggtacgcaa ggagtatgag atgctgcgca
     1501 tcgagtttga gcagaatctg gcggccaacg agcaggcggg gcccatcaac cgtgagatgc
     1561 gccacctgat tagtagtctt caaaaccaca accaccagct aaaaggggac gcccagcgat
     1621 acaagcggaa gcttcgagaa gtacaagctg agattggcaa gctccgggcc caggccagtg
     1681 gctctgccca ctccaccccc aacctgggcc acccagagga ttctggcgtc agtgccccag
     1741 ccccagggaa agaggagggt gggccaggcc ctgtcagtac ccccgacaac agaaaggaga
     1801 tggctccagt gcctggcacc accactacta ccacttcagt gaagaaggag gagctggtcc
     1861 cctctgaaga ggacttccag ggtataaccc ctggggccca gggcccttcc tcccggggcc
     1921 gagaacctga ggccaggccc aagcgggagc ttcgggaacg ggaaggtccc agcctaggac
     1981 ctccacctgt agcctccgct ctctcaaggg ctgatcggga gaaggccaag gtggaagaaa
     2041 ccaagcggaa ggaatcagaa ctcctcaagg gtctccgagc agagctcaag aaggcccagg
     2101 agagccagaa ggagatgaaa ctgctgctgg atatgtacaa gtcagcgccc aaggagcagc
     2161 gggataaggt gcagctcatg gcagcggaac gcaaggctaa ggccgaggtt gatgagctgc
     2221 ggagccgcat ccgggaattg gaggagaggg atcgaaggga gagcaagaag atcgcggatg
     2281 aggatgccct gcggcgcatt cggcaggcag aggagcagat agaacacctg cagcgcaagc
     2341 tgggtgccac caagcaggag gaggaggctc tgctctcaga gatggatgtg acaggtcagg
     2401 cttttgagga catgcaggaa cagaacgggc ggctgctaca gcagttgcgg gaaaaggatg
     2461 atgccaactt taagctaatg tcagagcgga tcaaggccaa ccagattcac aagctgctgc
     2521 gggaggagaa ggatgagttg ggcgagcagg tccttggcct caagtcccag gtggatgccc
     2581 agctgctgac tgtgcagaag ctagaggaga aggagcgagc cttgcagggc agcctcgggg
     2641 gtgtggagaa ggagctgacg ctgcgcagcc aagccctgga gctcaacaag cggaaggctg
     2701 tagaagccgc ccagctggcc gaggacctga aggtgcagct ggagcacgtg cagactcggc
     2761 tgcgggagat ccagccctgc ctggcagaga gccgggctgc tcgtgagaaa gagagcttca
     2821 acctcaagag ggctcaggag gacatctcac ggctgcggcg caagctggaa aagcagagga
     2881 aggtggaggt ctacgcagat gccgacgaaa tcctccagga ggagatcaag gagtacaagg
     2941 cgcggttgac ctgcccctgc tgtaacaccc gcaagaagga tgcagtcctt accaagtgct
     3001 tccacgtttt ctgcttcgag tgcgtgcggg gccgctatga ggcccgccag aggaagtgcc
     3061 ccaagtgcaa cgcggccttt ggtgcccacg acttccatcg tatctacatc agctgaacct
     3121 gaaactcagg ggactctgga acaccatgga ccctgggggc tgtgccccca tctcctcccc
     3181 accccaggtc tagtggcccc accctccatt ccggacccca tgggcccagc ccctgcccat
     3241 ctagttggtt tggggaccct ggtgcatgct agtgggcatg ggatcagcca agcttcgttc
     3301 catcttttcc taaaggtcag agctgcagcc tagggggcac tgccctacag aaaaggtctg
     3361 cctgagaggc ctgaggagcc cagagcactt gactgagctt cccggaaact ggccctaacc
     3421 tgtctgtctc cgtggatgca tcctaaccct aaggaaaatt ccccaggctg tgatctaccc
     3481 tagagaaggc tcgctccctg cctactggct cacaaatgag gaccagtgag ccatgtcctt
     3541 gttccttgtt tgagactggg ctgcaggccc caggaagact ttccttcacc caccatcccc
     3601 ctaacctcgg cagggcttct gtcctgtgga gttccctgga caccttggtc tggctcttgt
     3661 gccaagggct gaaggaggta ccctcttggc agatgggggc atcacttgct tcctttggga
     3721 agctctaagg ttgctgcagt caccttcctc atcttgcagg tgctgaacca acatcatcag
     3781 tttctattct aatcaggccc cttcccaatc tccatttctc tgccaagccc atttaccccc
     3841 acctcatgca tcccaaggct ctactgggtc cctggaccta accctgcttt catcctggtg
     3901 gccttaacta cagtggaggt ggaacttccc aggaggggaa gggacagacc agccccagcc
     3961 gctgggccaa cttccaatca ttccagctag aagagcttcc ccctgacacc ctgtgactga
     4021 gcctgtgtcc tgtctgcctg cccagccatg ctccatcggc tgtgagggca gtgcccggag
     4081 aggccagagg gttggagctg cagggacccg tttggaccca cagcctctgt tctagagatg
     4141 cttgtatagg ctgttaattg tgatgaataa acgttcaacc ctcggcctgc agccagagta
     4201 gccaggccgc gcaccccaaa tgtagtcccc cgattttagc tgcagcagct gagcagcact
     4261 ttgctggctt ggtgtgagcc tgggagggct cagacttaac ggccggcagg gatcccggac
     4321 tgggcctgaa ggggagagcg tggtggtcgt cgcggagccg cctgtcctgc tcccaccgac
     4381 cccggtctga ccacgtcctt ggctgtcatg gccgggggat gccgggactc ctcgggctgc
     4441 atcctgggaa gtgtagttcc tggtccgcac atggttagga ggttctcgga gagagagcta
     4501 gtttcccggt tgcgctggcc aaaggccggc ctgaactgga tcctgcggac cgcttctcag
     4561 cggcttcacc cccacaccac tcgaatgcac agatcgggac acctcagctg ggtgacttcc
     4621 ctcgttgcaa tcggcctcgg gagcggtgcg gcgtgtaccg agcggcgccc ctgggctcag
     4681 cgcgctgcag gcgccccggg cggatccttc accgaggcag gactggggct ggcgccagag
     4741 ccggtgcgga gcggtgttgg ttcaggcgct ggcgacagtg ctatggccac ggcaggggcc
     4801 gcgtgcgtct cagcggtggc gccttcggac cctattggcg cccgggactt aagcggggcc
     4861 gccgctgctg gaccaggacg aactggagaa ggagacgcgg gccgccacgg tgacctcggg
     4921 cgtagggccg gcggcggcgg gcacgctggt ggaagcgcgg gccgcggcag gggaggacat
     4981 cgggccgcag agaaagtgcc gatggcctgg ggcagcggtg cgagggtggg aaaaacgcag
     5041 gatattgcat catagagacg cggccacctt cgcccctgga gagcgccagt ctcaggagcg
     5101 ccgcaccggt cacgggtgga ggtcagccag gcctccgtaa gcgcggtccc cttccaggag
     5161 tagccttcgc ctgggctctt gagtagatgc caagtaattc cgcatcgtct ctctagatat
     5221 ctgcgctaaa ggccacccgg tctccttatc agaggggcaa aactctcctc gtgggtcttc
     5281 atacctaata aaagtcggca tcaaaccac
//
