LOCUS       NM_002938               2921 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens ring finger protein 4 (RNF4), transcript variant 2,
            mRNA.
ACCESSION   NM_002938
VERSION     NM_002938.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2921)
  AUTHORS   Fu,A., Luo,Z., Ziv,T., Bi,X., Lulu-Shimron,C., Cohen-Kaplan,V. and
            Ciechanover,A.
  TITLE     Nuclear p62 condensates stabilize the promyelocytic leukemia
            nuclear bodies by sequestering their ubiquitin ligase RNF4
  JOURNAL   Proc Natl Acad Sci U S A 121 (43), e2414377121 (2024)
   PUBMED   39418304
  REMARK    GeneRIF: Nuclear p62 condensates stabilize the promyelocytic
            leukemia nuclear bodies by sequestering their ubiquitin ligase
            RNF4.
REFERENCE   2  (bases 1 to 2921)
  AUTHORS   Her,J., Zheng,H. and Bunting,S.F.
  TITLE     RNF4 sustains Myc-driven tumorigenesis by facilitating DNA
            replication
  JOURNAL   J Clin Invest 134 (10), e167419 (2024)
   PUBMED   38530355
  REMARK    GeneRIF: RNF4 sustains Myc-driven tumorigenesis by facilitating DNA
            replication.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2921)
  AUTHORS   Oram,M.K., Baxley,R.M., Simon,E.M., Lin,K., Chang,Y.C., Wang,L.,
            Myers,C.L. and Bielinsky,A.K.
  TITLE     RNF4 prevents genomic instability caused by chronic DNA
            under-replication
  JOURNAL   DNA Repair (Amst) 135, 103646 (2024)
   PUBMED   38340377
  REMARK    GeneRIF: RNF4 prevents genomic instability caused by chronic DNA
            under-replication.
REFERENCE   4  (bases 1 to 2921)
  AUTHORS   Huang,J., Yang,W., Jiang,K., Liu,Y., Tan,X. and Luo,J.
  TITLE     RNF4 promotes tumorigenesis, therapy resistance of
            cholangiocarcinoma and affects cell cycle by regulating the
            ubiquitination degradation of p27kip1 in the nucleus
  JOURNAL   Exp Cell Res 419 (1), 113295 (2022)
   PUBMED   35926659
  REMARK    GeneRIF: RNF4 promotes tumorigenesis, therapy resistance of
            cholangiocarcinoma and affects cell cycle by regulating the
            ubiquitination degradation of p27kip1 in the nucleus.
REFERENCE   5  (bases 1 to 2921)
  AUTHORS   Novak,R., Ahmad,Y.A., Timaner,M., Bitman-Lotan,E.,
            Oknin-Vaisman,A., Horwitz,R., Hartmann,O., Reissland,M., Buck,V.,
            Rosenfeldt,M., Nikomarov,D., Diefenbacher,M.E., Shaked,Y. and
            Orian,A.
  TITLE     RNF4 RGMb BMP6 axis required for osteogenic differentiation and
            cancer cell survival
  JOURNAL   Cell Death Dis 13 (9), 820 (2022)
   PUBMED   36153321
  REMARK    GeneRIF: RNF4~RGMb~BMP6 axis required for osteogenic
            differentiation and cancer cell survival.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2921)
  AUTHORS   Fedele,M., Benvenuto,G., Pero,R., Majello,B., Battista,S.,
            Lembo,F., Vollono,E., Day,P.M., Santoro,M., Lania,L., Bruni,C.B.,
            Fusco,A. and Chiariotti,L.
  TITLE     A novel member of the BTB/POZ family, PATZ, associates with the
            RNF4 RING finger protein and acts as a transcriptional repressor
  JOURNAL   J Biol Chem 275 (11), 7894-7901 (2000)
   PUBMED   10713105
REFERENCE   7  (bases 1 to 2921)
  AUTHORS   Poukka,H., Aarnisalo,P., Santti,H., Janne,O.A. and Palvimo,J.J.
  TITLE     Coregulator small nuclear RING finger protein (SNURF) enhances Sp1-
            and steroid receptor-mediated transcription by different mechanisms
  JOURNAL   J Biol Chem 275 (1), 571-579 (2000)
   PUBMED   10617653
REFERENCE   8  (bases 1 to 2921)
  AUTHORS   Moilanen,A.M., Poukka,H., Karvonen,U., Hakli,M., Janne,O.A. and
            Palvimo,J.J.
  TITLE     Identification of a novel RING finger protein as a coregulator in
            steroid receptor-mediated gene transcription
  JOURNAL   Mol Cell Biol 18 (9), 5128-5139 (1998)
   PUBMED   9710597
REFERENCE   9  (bases 1 to 2921)
  AUTHORS   Hadano,S., Ishida,Y. and Ikeda,J.E.
  TITLE     The primary structure and genomic organization of five novel
            transcripts located close to the Huntington's disease gene on human
            chromosome 4p16.3
  JOURNAL   DNA Res 5 (3), 177-186 (1998)
   PUBMED   9734812
REFERENCE   10 (bases 1 to 2921)
  AUTHORS   Chiariotti,L., Benvenuto,G., Fedele,M., Santoro,M., Simeone,A.,
            Fusco,A. and Bruni,C.B.
  TITLE     Identification and characterization of a novel RING-finger gene
            (RNF4) mapping at 4p16.3
  JOURNAL   Genomics 47 (2), 258-265 (1998)
   PUBMED   9479498
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA342512.1, AB000468.1,
            U95140.1 and BX322586.11.
            
            On Nov 23, 2018 this sequence version replaced NM_002938.4.
            
            Summary: The protein encoded by this gene contains a RING finger
            motif and acts as a transcription regulator. This protein has been
            shown to interact with, and inhibit the activity of, TRPS1, a
            transcription suppressor of GATA-mediated transcription.
            Transcription repressor ZNF278/PATZ is found to interact with this
            protein, and thus reduce the enhancement of androgen
            receptor-dependent transcription mediated by this protein. Studies
            of the mouse and rat counterparts suggested a role of this protein
            in spermatogenesis. A pseudogene of this gene is found on
            chromosome 1.[provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1057758.1,
                                           SRR3476690.759234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314289.13/ ENSP00000315212.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA342512.1         39-51
            14-1458             AB000468.1         1-1445
            1459-2126           U95140.1           1419-2086
            2127-2921           BX322586.11        61456-62250         c
FEATURES             Location/Qualifiers
     source          1..2921
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..2921
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /note="ring finger protein 4"
                     /db_xref="GeneID:6047"
                     /db_xref="HGNC:HGNC:10067"
                     /db_xref="MIM:602850"
     exon            1..153
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            154..319
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..883
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 2; small
                     nuclear RING finger protein; E3 ubiquitin ligase RNF4; E3
                     ubiquitin-protein ligase RNF4; RING-type E3 ubiquitin
                     transferase RNF4"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF4 isoform 1"
                     /protein_id="NP_002929.1"
                     /db_xref="CCDS:CCDS47001.1"
                     /db_xref="GeneID:6047"
                     /db_xref="HGNC:HGNC:10067"
                     /db_xref="MIM:602850"
                     /translation="MSTRKRRGGAINSRQAQKRTREATSTPEISLEAEPIELVETAGD
                     EIVDLTCESLEPVVVDLTHNDSVVIVDERRRPRRNARRLPQDHADSCVVSSDDEELSR
                     DRDVYVTTHTPRNARDEGATGLRPSGTVSCPICMDGYSEIVQNGRLIVSTECGHVFCS
                     QCLRDSLKNANTCPTCRKKINHKRYHPIYI"
     exon            320..434
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            435..514
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            515..524
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            525..684
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            685..733
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            734..2921
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2897..2902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /note="hexamer: AATAAA"
     polyA_site      2921
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /note="major polyA site"
ORIGIN      
        1 agcggaagtg ggttgctgtt gaggcggcgg catctttctc gaggagctct cctgggcggc
       61 tgaagaagga gcttcttctc cggagtgcgc cggcggtggc gcctgcggac ctaactagct
      121 ccaggttagg ccgagctttg cgggaaagca gcggacttga aaatactgga aatctgtccg
      181 gatccaaatt attttgcaag ccagatgagt aaccagaggg catgaaaggt tgagaacatt
      241 tgacttccct gcaaaccttg gtatagatca cttccttttc tgtaggaaag gaaaggcacc
      301 aaagagcaca atgagtacaa gaaagcgtcg tggtggagca ataaattcta gacaagctca
      361 gaagcgaact cgggaagcaa cctccacccc cgagatctcc ttggaagcag aacccataga
      421 actcgtggaa actgctggag atgaaattgt ggacctcact tgtgaatctt tagagcctgt
      481 ggtggttgat ctgactcaca atgactctgt tgtgattgtt gacgaaagaa gaagaccaag
      541 gaggaatgct aggaggctgc cccaggacca tgctgacagc tgtgtggtga gcagtgacga
      601 tgaggagttg tccagggaca gagacgtata tgtgactacc catactccca gaaacgccag
      661 ggatgagggc gctacaggcc tcaggccctc aggtactgtc agttgtccca tctgcatgga
      721 cggatactca gagatcgtgc agaatggacg tctcatcgtt tccacagaat gcggccatgt
      781 cttctgtagc cagtgcctcc gtgattccct gaagaatgct aatacttgcc caacttgtag
      841 gaaaaagatc aaccacaaac ggtaccaccc catttatata tgaagtattc agagcccccc
      901 aggagagacg gatggacaga cagacagcca ggttctccag tggtatctgc ctccattttc
      961 ctgagatcaa aaagactgtt tcgaaaccaa catctgatat gtaaactgct cttttgtttc
     1021 caaccccttc cttttgttat ctccagtttg atgctatggc gctggaccca gggccctccc
     1081 aggccatctc tgttcctctg gggtggtcca gttctagagt gggagaaagg gagtcaggcg
     1141 cattgggaat cgtggttcca gtctggttgc agaatctgca catttgccaa gaaattttcc
     1201 ctgtttggaa agtttgcccc agctttcccg ggcacaccac cttttgtccc aagtgtctgc
     1261 cggtcgacca atctgcctgc cacacattga ccaagccaga cccggttcac ccagctcgag
     1321 gatcccaggt tgaagagtgg ccccttgagg ccctggaaag accaatcact ggacttcttc
     1381 ccttgagagt cagaggtcac ccgtgattct gcctgcacct tatcattgat ctgcagtgat
     1441 ttctgcaaat caagagaaac tctgcagggc actcccctgt ttcctaagaa cgaaaaagtg
     1501 caataaaggc cattcgttac ctacttttca gcagcccaca agatgtagca ctattagtgt
     1561 ccccctcaga ggcttaatgt tgcctgtgga gcagtgccca tcccagcccg tttctgccca
     1621 ccagttgttc tcaggaacct tacccatgct ccagcgtcct tcacctggca caggacatgc
     1681 aagataaata gggcaggcac gtgtttgggt gtcctctctt ttctgataaa atccatcccg
     1741 tgtttgccac acgccctcca gtcctcagtt cccactgcct aacgtctgcc cccgtgtaga
     1801 tactgagagg tggtggcagt aattgtggcc ttatcagccg ctcagttcca ggcttttgcc
     1861 caggtcactg ttgccccatg ttcggagaac ctggcccacc tgtcttggct ttctcatcct
     1921 tcccaaccca gtgccgttta tttcagaagc ttcctggcca ctgggcttgg atgcttcggg
     1981 cttctgactg ctccataggt tttgactggt gaaacagggg cccagatgac aacctctcct
     2041 tcgctccaca ggtacgcggg agcctcaggt tctctcaggg gcagcaaagt ggcccaagct
     2101 gcccctgaca gcacagggcc tggggggtgg ctaacgagag aggccttaca gtgccggcat
     2161 gcctcctctt ccactgtcgt ccttcctcag agggcctcac gccaaacaaa cggccttttc
     2221 gtgtgaaaca tcttcagggc gggaaagggg ccacttctgg ctttgttagc aataactgac
     2281 cttcagttta cccttctgaa ggagcaggga ctcagcacag aattcacttt agacggggct
     2341 gaaggagtgt ccctcctcta tgtgaaaaga aaattgtttt attcttcatt ctgacttttt
     2401 aactgtttgg ctcacttcca gttagtttga atgaaaataa taattttcta cttggagttg
     2461 aagagggcag aatccgcagc tctcatcatt gtgatgtgta gcatgtctgc cctctgactg
     2521 gacatcattg ccattaactt tcttctgggc atcacggcaa tgtcacgatg cccagacttg
     2581 gagcaaggca accttggagt cagtccactc ataaaatatg gtaacaccca ttttaaaatt
     2641 taagttttgt ccttaaagac aacttcagtg gttaattata aaagttgtgt tacttcgtcc
     2701 taaattaaat tgatagaaag atttaaaaat gtgttttgtt tctactattc agaaactgcg
     2761 aactagggaa aggttggtat gaagaaatgt ctttcctttt ttcaatgtac atagttcaac
     2821 tctttctttg ttacatttaa actatatcca tggatatcag tctgctttgg actcctctgc
     2881 tagtgttaca gatggaaata aaaccattaa tttgaaccaa a
//
