LOCUS       NM_001185010            2761 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens ring finger protein 4 (RNF4), transcript variant 3,
            mRNA.
ACCESSION   NM_001185010
VERSION     NM_001185010.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2761)
  AUTHORS   Fu,A., Luo,Z., Ziv,T., Bi,X., Lulu-Shimron,C., Cohen-Kaplan,V. and
            Ciechanover,A.
  TITLE     Nuclear p62 condensates stabilize the promyelocytic leukemia
            nuclear bodies by sequestering their ubiquitin ligase RNF4
  JOURNAL   Proc Natl Acad Sci U S A 121 (43), e2414377121 (2024)
   PUBMED   39418304
  REMARK    GeneRIF: Nuclear p62 condensates stabilize the promyelocytic
            leukemia nuclear bodies by sequestering their ubiquitin ligase
            RNF4.
REFERENCE   2  (bases 1 to 2761)
  AUTHORS   Her,J., Zheng,H. and Bunting,S.F.
  TITLE     RNF4 sustains Myc-driven tumorigenesis by facilitating DNA
            replication
  JOURNAL   J Clin Invest 134 (10), e167419 (2024)
   PUBMED   38530355
  REMARK    GeneRIF: RNF4 sustains Myc-driven tumorigenesis by facilitating DNA
            replication.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2761)
  AUTHORS   Oram,M.K., Baxley,R.M., Simon,E.M., Lin,K., Chang,Y.C., Wang,L.,
            Myers,C.L. and Bielinsky,A.K.
  TITLE     RNF4 prevents genomic instability caused by chronic DNA
            under-replication
  JOURNAL   DNA Repair (Amst) 135, 103646 (2024)
   PUBMED   38340377
  REMARK    GeneRIF: RNF4 prevents genomic instability caused by chronic DNA
            under-replication.
REFERENCE   4  (bases 1 to 2761)
  AUTHORS   Huang,J., Yang,W., Jiang,K., Liu,Y., Tan,X. and Luo,J.
  TITLE     RNF4 promotes tumorigenesis, therapy resistance of
            cholangiocarcinoma and affects cell cycle by regulating the
            ubiquitination degradation of p27kip1 in the nucleus
  JOURNAL   Exp Cell Res 419 (1), 113295 (2022)
   PUBMED   35926659
  REMARK    GeneRIF: RNF4 promotes tumorigenesis, therapy resistance of
            cholangiocarcinoma and affects cell cycle by regulating the
            ubiquitination degradation of p27kip1 in the nucleus.
REFERENCE   5  (bases 1 to 2761)
  AUTHORS   Novak,R., Ahmad,Y.A., Timaner,M., Bitman-Lotan,E.,
            Oknin-Vaisman,A., Horwitz,R., Hartmann,O., Reissland,M., Buck,V.,
            Rosenfeldt,M., Nikomarov,D., Diefenbacher,M.E., Shaked,Y. and
            Orian,A.
  TITLE     RNF4 RGMb BMP6 axis required for osteogenic differentiation and
            cancer cell survival
  JOURNAL   Cell Death Dis 13 (9), 820 (2022)
   PUBMED   36153321
  REMARK    GeneRIF: RNF4~RGMb~BMP6 axis required for osteogenic
            differentiation and cancer cell survival.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2761)
  AUTHORS   Fedele,M., Benvenuto,G., Pero,R., Majello,B., Battista,S.,
            Lembo,F., Vollono,E., Day,P.M., Santoro,M., Lania,L., Bruni,C.B.,
            Fusco,A. and Chiariotti,L.
  TITLE     A novel member of the BTB/POZ family, PATZ, associates with the
            RNF4 RING finger protein and acts as a transcriptional repressor
  JOURNAL   J Biol Chem 275 (11), 7894-7901 (2000)
   PUBMED   10713105
REFERENCE   7  (bases 1 to 2761)
  AUTHORS   Poukka,H., Aarnisalo,P., Santti,H., Janne,O.A. and Palvimo,J.J.
  TITLE     Coregulator small nuclear RING finger protein (SNURF) enhances Sp1-
            and steroid receptor-mediated transcription by different mechanisms
  JOURNAL   J Biol Chem 275 (1), 571-579 (2000)
   PUBMED   10617653
REFERENCE   8  (bases 1 to 2761)
  AUTHORS   Moilanen,A.M., Poukka,H., Karvonen,U., Hakli,M., Janne,O.A. and
            Palvimo,J.J.
  TITLE     Identification of a novel RING finger protein as a coregulator in
            steroid receptor-mediated gene transcription
  JOURNAL   Mol Cell Biol 18 (9), 5128-5139 (1998)
   PUBMED   9710597
REFERENCE   9  (bases 1 to 2761)
  AUTHORS   Hadano,S., Ishida,Y. and Ikeda,J.E.
  TITLE     The primary structure and genomic organization of five novel
            transcripts located close to the Huntington's disease gene on human
            chromosome 4p16.3
  JOURNAL   DNA Res 5 (3), 177-186 (1998)
   PUBMED   9734812
REFERENCE   10 (bases 1 to 2761)
  AUTHORS   Chiariotti,L., Benvenuto,G., Fedele,M., Santoro,M., Simeone,A.,
            Fusco,A. and Bruni,C.B.
  TITLE     Identification and characterization of a novel RING-finger gene
            (RNF4) mapping at 4p16.3
  JOURNAL   Genomics 47 (2), 258-265 (1998)
   PUBMED   9479498
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA342512.1, AK309509.1,
            AB000468.1, U95140.1 and BX322586.11.
            
            On May 31, 2019 this sequence version replaced NM_001185010.2.
            
            Summary: The protein encoded by this gene contains a RING finger
            motif and acts as a transcription regulator. This protein has been
            shown to interact with, and inhibit the activity of, TRPS1, a
            transcription suppressor of GATA-mediated transcription.
            Transcription repressor ZNF278/PATZ is found to interact with this
            protein, and thus reduce the enhancement of androgen
            receptor-dependent transcription mediated by this protein. Studies
            of the mouse and rat counterparts suggested a role of this protein
            in spermatogenesis. A pseudogene of this gene is found on
            chromosome 1.[provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            lacks an alternate exon in the 3' coding region which results in a
            frameshift, compared to variant 1. The resulting protein (isoform
            2) has a distinct C-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.229889.1,
                                           SRR6380200.125803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DA342512.1         39-72
            35-999              AK309509.1         1-965
            1000-1298           AB000468.1         1147-1445
            1299-1966           U95140.1           1419-2086
            1967-2761           BX322586.11        61456-62250         c
FEATURES             Location/Qualifiers
     source          1..2761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..2761
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /note="ring finger protein 4"
                     /db_xref="GeneID:6047"
                     /db_xref="HGNC:HGNC:10067"
                     /db_xref="MIM:602850"
     exon            1..153
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            154..319
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..652
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 3; small
                     nuclear RING finger protein; E3 ubiquitin ligase RNF4; E3
                     ubiquitin-protein ligase RNF4; RING-type E3 ubiquitin
                     transferase RNF4"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF4 isoform 2"
                     /protein_id="NP_001171939.1"
                     /db_xref="CCDS:CCDS54713.1"
                     /db_xref="GeneID:6047"
                     /db_xref="HGNC:HGNC:10067"
                     /db_xref="MIM:602850"
                     /translation="MSTRKRRGGAINSRQAQKRTREATSTPEISLEAEPIELVETAGD
                     EIVDLTCESLEPVVVDLTHNDSVVIVDGPQVLSVVPSAWTDTQRSCRMDVSSFPQNAA
                     MSSVASASVIP"
     exon            320..434
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            435..514
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            515..524
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            525..573
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /inference="alignment:Splign:2.1.0"
     exon            574..2761
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2737..2742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /note="hexamer: AATAAA"
     polyA_site      2761
                     /gene="RNF4"
                     /gene_synonym="RES4-26; SLX5; SNURF"
                     /note="major polyA site"
ORIGIN      
        1 agcggaagtg ggttgctgtt gaggcggcgg catctttctc gaggagctct cctgggcggc
       61 tgaagaagga gcttcttctc cggagtgcgc cggcggtggc gcctgcggac ctaactagct
      121 ccaggttagg ccgagctttg cgggaaagca gcggacttga aaatactgga aatctgtccg
      181 gatccaaatt attttgcaag ccagatgagt aaccagaggg catgaaaggt tgagaacatt
      241 tgacttccct gcaaaccttg gtatagatca cttccttttc tgtaggaaag gaaaggcacc
      301 aaagagcaca atgagtacaa gaaagcgtcg tggtggagca ataaattcta gacaagctca
      361 gaagcgaact cgggaagcaa cctccacccc cgagatctcc ttggaagcag aacccataga
      421 actcgtggaa actgctggag atgaaattgt ggacctcact tgtgaatctt tagagcctgt
      481 ggtggttgat ctgactcaca atgactctgt tgtgattgtt gacggccctc aggtactgtc
      541 agttgtccca tctgcatgga cggatactca gagatcgtgc agaatggacg tctcatcgtt
      601 tccacagaat gcggccatgt cttctgtagc cagtgcctcc gtgattccct gaagaatgct
      661 aatacttgcc caacttgtag gaaaaagatc aaccacaaac ggtaccaccc catttatata
      721 tgaagtattc agagcccccc aggagagacg gatggacaga cagacagcca ggttctccag
      781 tggtatctgc ctccattttc ctgagatcaa aaagactgtt tcgaaaccaa catctgatat
      841 gtaaactgct cttttgtttc caaccccttc cttttgttat ctccagtttg atgctatggc
      901 gctggaccca gggccctccc aggccatctc tgttcctctg gggtggtcca gttctagagt
      961 gggagaaagg gagtcaggcg cattgggaat cgtggttcca gtctggttgc agaatctgca
     1021 catttgccaa gaaattttcc ctgtttggaa agtttgcccc agctttcccg ggcacaccac
     1081 cttttgtccc aagtgtctgc cggtcgacca atctgcctgc cacacattga ccaagccaga
     1141 cccggttcac ccagctcgag gatcccaggt tgaagagtgg ccccttgagg ccctggaaag
     1201 accaatcact ggacttcttc ccttgagagt cagaggtcac ccgtgattct gcctgcacct
     1261 tatcattgat ctgcagtgat ttctgcaaat caagagaaac tctgcagggc actcccctgt
     1321 ttcctaagaa cgaaaaagtg caataaaggc cattcgttac ctacttttca gcagcccaca
     1381 agatgtagca ctattagtgt ccccctcaga ggcttaatgt tgcctgtgga gcagtgccca
     1441 tcccagcccg tttctgccca ccagttgttc tcaggaacct tacccatgct ccagcgtcct
     1501 tcacctggca caggacatgc aagataaata gggcaggcac gtgtttgggt gtcctctctt
     1561 ttctgataaa atccatcccg tgtttgccac acgccctcca gtcctcagtt cccactgcct
     1621 aacgtctgcc cccgtgtaga tactgagagg tggtggcagt aattgtggcc ttatcagccg
     1681 ctcagttcca ggcttttgcc caggtcactg ttgccccatg ttcggagaac ctggcccacc
     1741 tgtcttggct ttctcatcct tcccaaccca gtgccgttta tttcagaagc ttcctggcca
     1801 ctgggcttgg atgcttcggg cttctgactg ctccataggt tttgactggt gaaacagggg
     1861 cccagatgac aacctctcct tcgctccaca ggtacgcggg agcctcaggt tctctcaggg
     1921 gcagcaaagt ggcccaagct gcccctgaca gcacagggcc tggggggtgg ctaacgagag
     1981 aggccttaca gtgccggcat gcctcctctt ccactgtcgt ccttcctcag agggcctcac
     2041 gccaaacaaa cggccttttc gtgtgaaaca tcttcagggc gggaaagggg ccacttctgg
     2101 ctttgttagc aataactgac cttcagttta cccttctgaa ggagcaggga ctcagcacag
     2161 aattcacttt agacggggct gaaggagtgt ccctcctcta tgtgaaaaga aaattgtttt
     2221 attcttcatt ctgacttttt aactgtttgg ctcacttcca gttagtttga atgaaaataa
     2281 taattttcta cttggagttg aagagggcag aatccgcagc tctcatcatt gtgatgtgta
     2341 gcatgtctgc cctctgactg gacatcattg ccattaactt tcttctgggc atcacggcaa
     2401 tgtcacgatg cccagacttg gagcaaggca accttggagt cagtccactc ataaaatatg
     2461 gtaacaccca ttttaaaatt taagttttgt ccttaaagac aacttcagtg gttaattata
     2521 aaagttgtgt tacttcgtcc taaattaaat tgatagaaag atttaaaaat gtgttttgtt
     2581 tctactattc agaaactgcg aactagggaa aggttggtat gaagaaatgt ctttcctttt
     2641 ttcaatgtac atagttcaac tctttctttg ttacatttaa actatatcca tggatatcag
     2701 tctgctttgg actcctctgc tagtgttaca gatggaaata aaaccattaa tttgaaccaa
     2761 a
//
