LOCUS       NM_022781               5061 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens ring finger protein 38 (RNF38), transcript variant 1,
            mRNA.
ACCESSION   NM_022781
VERSION     NM_022781.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5061)
  AUTHORS   Wu,Z., Li,H., Liu,W., Huang,R. and Lin,B.
  TITLE     Hsa_circ_0097009 regulates proliferation, apoptosis, migration and
            invasion of hepatocellular carcinoma cells via miR-568/RNF38 axis
  JOURNAL   Bratisl Lek Listy 124 (3), 228-238 (2023)
   PUBMED   36598315
  REMARK    GeneRIF: Hsa_circ_0097009 regulates proliferation, apoptosis,
            migration and invasion of hepatocellular carcinoma cells via
            miR-568/RNF38 axis.
REFERENCE   2  (bases 1 to 5061)
  AUTHORS   Lin,C., Li,M., Lin,N., Zong,J., Pan,J. and Ye,Y.
  TITLE     RNF38 suppress growth and metastasis via ubiquitination of ACTN4 in
            nasopharyngeal carcinoma
  JOURNAL   BMC Cancer 22 (1), 549 (2022)
   PUBMED   35568845
  REMARK    GeneRIF: RNF38 suppress growth and metastasis via ubiquitination of
            ACTN4 in nasopharyngeal carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5061)
  AUTHORS   Zhou,J., Tang,Z.Y. and Sun,X.L.
  TITLE     RNF38 inhibits osteosarcoma cell proliferation by binding to CRY1
  JOURNAL   Biochem Cell Biol 99 (5), 629-635 (2021)
   PUBMED   34460347
  REMARK    GeneRIF: RNF38 inhibits osteosarcoma cell proliferation by binding
            to CRY1.
REFERENCE   4  (bases 1 to 5061)
  AUTHORS   Guo,W.L., Li,N., Ma,J.L., Chen,X.M. and Shi,F.Y.
  TITLE     Inhibiting microRNA-301b suppresses cell growth and targets RNF38
            in cervical carcinoma
  JOURNAL   Kaohsiung J Med Sci 36 (11), 878-884 (2020)
   PUBMED   32643846
  REMARK    GeneRIF: Inhibiting microRNA-301b suppresses cell growth and
            targets RNF38 in cervical carcinoma.
REFERENCE   5  (bases 1 to 5061)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5061)
  AUTHORS   Yonezawa,T., Takahashi,H., Shikata,S., Sawasaki,T., Kitamura,T. and
            Goyama,S.
  TITLE     The ubiquitin ligase RNF38 promotes RUNX1 ubiquitination and
            enhances RUNX1-mediated suppression of erythroid transcription
            program
  JOURNAL   Biochem Biophys Res Commun 505 (3), 905-909 (2018)
   PUBMED   30309654
  REMARK    GeneRIF: identified RNF38 as a novel E3 ligase that modifies RUNX1
            function without inducing its degradation
REFERENCE   7  (bases 1 to 5061)
  AUTHORS   Zhang,J., Wu,H., Yi,B., Zhou,J., Wei,L., Chen,Y. and Zhang,L.
  TITLE     RING finger protein 38 induces gastric cancer cell growth by
            decreasing the stability of the protein tyrosine phosphatase SHP-1
  JOURNAL   FEBS Lett 592 (18), 3092-3100 (2018)
   PUBMED   30112836
  REMARK    GeneRIF: Data show that E3 ubiquitin-protein ligase RNF38 (RNF38)
            interacts with the nonreceptor tyrosine phosphatase SH2-containing
            protein tyrosine phosphatase 1 (SHP-1) and induces the
            polyubiquitination of SHP-1, which leads to destabilization of
            SHP-1.
REFERENCE   8  (bases 1 to 5061)
  AUTHORS   Sheren,J.E. and Kassenbrock,C.K.
  TITLE     RNF38 encodes a nuclear ubiquitin protein ligase that modifies p53
  JOURNAL   Biochem Biophys Res Commun 440 (4), 473-478 (2013)
   PUBMED   23973461
  REMARK    GeneRIF: These results suggest RNF38 is an E3 ubiquitin ligase that
            may play a role in regulating p53.
REFERENCE   9  (bases 1 to 5061)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   10 (bases 1 to 5061)
  AUTHORS   Eisenberg,I., Hochner,H., Levi,T., Yelin,R., Kahan,T. and
            Mitrani-Rosenbaum,S.
  TITLE     Cloning and characterization of a novel human gene RNF38 encoding a
            conserved putative protein with a RING finger domain
  JOURNAL   Biochem Biophys Res Commun 294 (5), 1169-1176 (2002)
   PUBMED   12074600
  REMARK    GeneRIF: Cloning and characterization of the RNF38 gene
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC033786.1, AL136817.1,
            AL120640.1, AF394047.1 and AL161792.29.
            
            On Nov 23, 2018 this sequence version replaced NM_022781.4.
            
            Summary: This gene encodes a protein with a coiled-coil motif and a
            RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a
            zinc-binding domain found in a large set of proteins playing roles
            in diverse cellular processes including oncogenesis, development,
            signal transduction, and apoptosis. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.237489.1, AL136817.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259605.11/ ENSP00000259605.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                BC033786.1         31-83
            54-374              AL136817.1         1-321
            375-1874            BC033786.1         255-1754
            1875-1883           AL136817.1         1824-1832
            1884-2484           AL120640.1         30-630
            2485-3865           AF394047.1         2637-4017
            3866-5059           AL161792.29        46569-47762         c
            5060-5061           AF394047.1         4680-4681
FEATURES             Location/Qualifiers
     source          1..5061
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.2"
     gene            1..5061
                     /gene="RNF38"
                     /note="ring finger protein 38"
                     /db_xref="GeneID:152006"
                     /db_xref="HGNC:HGNC:18052"
                     /db_xref="MIM:612488"
     exon            1..173
                     /gene="RNF38"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1709
                     /gene="RNF38"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase RNF38; RING-type E3 ubiquitin
                     transferase RNF38"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF38 isoform 1"
                     /protein_id="NP_073618.3"
                     /db_xref="CCDS:CCDS6603.1"
                     /db_xref="GeneID:152006"
                     /db_xref="HGNC:HGNC:18052"
                     /db_xref="MIM:612488"
                     /translation="MACKISPGANSASLPGHPNKVICERVRLQSLFPLLPSDQNTTVQ
                     EDAHFKAFFQSEDSPSPKRQRLSHSVFDYTSASPAPSPPMRPWEMTSNRQPPSVRPSQ
                     HHFSGERCNTPARNRRSPPVRRQRGRRDRLSRHNSISQDENYHHLPYAQQQAIEEPRA
                     FHPPNVSPRLLHPAAHPPQQNAVMVDIHDQLHQGTVPVSYTVTTVAPHGIPLCTGQHI
                     PACSTQQVPGCSVVFSGQHLPVCSVPPPMLQACSVQHLPVPYAAFPPLISSDPFLIHP
                     PHLSPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHLPVGGFTYPPSAHPPT
                     LPPSAPLQFLTHDPLHQEVSFGVPYPPFMPRRLTGRSRYRSQQPIPPPPYHPSLLPYV
                     LSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPSYR
                     FNPNNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKWLKANRTCPICRADAS
                     EVHRDSE"
     exon            174..323
                     /gene="RNF38"
                     /inference="alignment:Splign:2.1.0"
     exon            324..517
                     /gene="RNF38"
                     /inference="alignment:Splign:2.1.0"
     exon            518..731
                     /gene="RNF38"
                     /inference="alignment:Splign:2.1.0"
     exon            732..899
                     /gene="RNF38"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1070
                     /gene="RNF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1232
                     /gene="RNF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1339
                     /gene="RNF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1424
                     /gene="RNF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1546
                     /gene="RNF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1646
                     /gene="RNF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..5061
                     /gene="RNF38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5036..5041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF38"
                     /note="hexamer: AATAAA"
     polyA_site      5061
                     /gene="RNF38"
                     /note="major polyA site"
ORIGIN      
        1 gtccttctgc ttccgtgggt ttctggatag gctgcgtttt gttctcaggg gatgcaagtt
       61 cttcctttca gggttgaagc gtgagagagg ttggtttttg aaacgggagt gtttcaggtt
      121 attgaggtcc aaaaagaaat aaagtttttg tttacgtctg tatggcttgt aagatatctc
      181 ccggggccaa ttcagcatct ctacctggcc atcctaacaa ggtgatttgt gaaagggtga
      241 gacttcagag cctgttccct ctcctcccaa gtgatcagaa cactaccgtt caagaggatg
      301 ctcacttcaa agctttcttc cagagtgaag atagtccaag tcctaagaga cagcgcctct
      361 ctcattcagt ctttgattat acatcagcat caccagctcc ctcaccacca atgcgaccat
      421 gggagatgac atcaaatagg cagccccctt cagttcgacc aagccaacat cacttctcag
      481 gggaacgatg caacacacct gcacgcaaca gaagaagtcc tcctgtcagg cgccagagag
      541 gaagaaggga tcgtctgtct cgacataatt ccattagtca agatgaaaac tatcaccatc
      601 tcccttacgc acagcagcaa gcaatagagg agcctcgagc cttccaccct ccgaatgtat
      661 ctccccgtct gctacatcct gctgctcatc caccccagca gaatgcagtc atggttgaca
      721 tacatgatca gctccatcaa ggaacagtcc ctgtttctta cacagtaaca acagtggcac
      781 cacatgggat tccactctgc acaggccagc acatccctgc ttgtagtaca cagcaggtcc
      841 caggatgctc tgtggttttc agtggacagc acctccctgt ctgtagtgtg cctcctccaa
      901 tgcttcaggc atgttcagtt cagcacttac cagtaccata tgctgcattc ccacccctta
      961 tttctagtga tccatttctt atacatcctc ctcacctttc tccccatcat cctcctcatt
     1021 tgccaccacc aggccagttt gtccctttcc aaacacagca atcacgatcg cctctgcaaa
     1081 ggatagaaaa tgaagtggaa ctcttaggag aacatcttcc agtaggaggt tttacttacc
     1141 ctccatcagc ccacccccca acattacctc catcagctcc cttgcagttc ttaacacatg
     1201 atcctttgca tcaggaggtg tcctttggag taccttatcc tccatttatg cctcggaggc
     1261 ttacaggacg tagtagatac cgatcccagc agccaatacc acctccccct tatcatccca
     1321 gcttactgcc atatgtgtta tcaatgcttc cagtgccacc tgcagtgggc ccaactttca
     1381 gctttgaatt agatgtagaa gatggagaag tagaaaatta cgaggccctg ttaaacctgg
     1441 cagagcgact gggagaggca aagcctcgtg gactgactaa agcagatatt gaacaacttc
     1501 cttcttatcg gttcaatcct aacaaccacc agtcagaaca gactttgtgt gtagtatgca
     1561 tgtgtgattt tgagtcaagg cagctactta gagtcttacc ctgtaaccac gagttccatg
     1621 ccaagtgtgt tgacaaatgg cttaaggcaa atcgtacttg cccaatttgc cgagctgatg
     1681 cttcagaagt gcatcgggat tcagaatgac caacctaaga agcacaaatt tagtttgggt
     1741 gttcctcatc acatgtatat acggactatc cattgaactt aatctgtgtg gcttccagcc
     1801 ctccctttac caaaagggtc aatggacctt tctttgcact gtgtgactta atcaactata
     1861 aaagcttaca attagtcttc acagttatgg gattgttata ctaaccgtgt gattggaact
     1921 ccaaagactt tttctttagc ttaattttgt gtgtgcacta acattccctg gtttttgtgt
     1981 gatcattccg agtgttgctg caagattaca gtggacgtga tcttttagca tgtgctttta
     2041 taaaaagtgg tagctacaga tgatatagca atctacctta tatagagcct tcagaaactg
     2101 tgagtggaaa tgaatgcgca gcgtatgact gttggtgata agtgtatctg tgtgagtgtg
     2161 tgcaactact tgtgtgaggg catggtagct aacgtgtgta tgagatccta tataccagca
     2221 tgtaccaaga atgtgtgtgt agttttaatt atgctgcaat gtataatctg gtgtgttatt
     2281 taaacagcac tagtactgta cactggtttt tttcccttgt gtttgctgtt gcacactgat
     2341 tgctgagggt gcatcaatta caagcattga atactccatc cccttccctc ccagtgaatg
     2401 gaatgagaaa agccttcttc ctttgcttca ggcagctgtc accttctctt tattggtggt
     2461 cctaagtggg tcacttaaga aaaaaaagtg taacaaattc tcgctccatg aacctggttt
     2521 ttttttattc tgttgtggaa atttttaaat ctccaacttg ctgtttccaa aaagaaggtg
     2581 caatatcata tatcatcagt tagcaatatt agcatttcaa tcagtgattt gaatgttgat
     2641 actttttttt cctttacatt tccagtaagt ttcttacaga aagtacctgt gatttttttt
     2701 aatgtttaga tttgtagtct agtctattct gaagatattt gattaatata tttctaagaa
     2761 gaccactagt cccatgaagt ctcaccttgt tgacttccac cagaacaaaa cctgttaatt
     2821 cagcttgact tctcatatgt gttctgtgtt caagctcctg tgggcaactc aattgtttta
     2881 agaaaactct atttctgttc atattaattc acttgccaga ctccaattct gaaagttgtc
     2941 tagttcttcc ttcatcacac gtgcttctca tcgaaaccct ggtttcagga tggatcaagt
     3001 gctgttacag ctcatgttcc ttagacctga tttgttttga tattttactg cctttccttt
     3061 taatttttgt ttgaatgaga aaagtttaat acaacaggtg tccagaatac ttgcagtata
     3121 aatgaagatt tggtttttgt ataaaaaaat aatgctgtta aacaggagtt gaccttcatt
     3181 tagttgatgt aatacatagc tgtatggggt tttttttagt aagttctttg agcataattc
     3241 actttaaagt catttttcca gcaatgttta aattactttc tcattctttt agtgtattca
     3301 acattgtctg cctcttcctg cagttgatgt aattgctttg tttgcaatag cacaagctgc
     3361 attattccag tcaggactgt gataacttgc tgccagcccc actcaacttt cagttggctc
     3421 tgtgtcagtt ttccattcag tgttaactac ttgttactgc catgctgctt gccctccctt
     3481 gaagtgtcta taagctcatc acagcctaga gttaagtaaa gtcaattcac agaagcacaa
     3541 ttttgccctt tgcgagacat tgttgcctct atctagtcct acaagtaggg ttttgcatac
     3601 tgtgtttgcc cctagggttg tcagtgcatc agaaatactt ctaaatagtg gtaaaaatgc
     3661 acatggttaa tgcacatgtt acttttaaat cattaggata tccctcacct gttcctgatg
     3721 aataaaaagt gtgttaaaga ccaaaattct tggcataata atcagctaca tacaaatcac
     3781 atatagttta atctttttta atgaaaaaaa atcatgttta aaatggcaaa agcccatctt
     3841 atacactttt atatagctgc aaaaaattta tatctgtaca gatctaacac tacgacactc
     3901 agtattcatt ttattgaagc atgcaagtaa agcacttttt ctaatttata tagaggtatc
     3961 taattaacac agcacattgt actaatgact aggagtagca gctttttctt ctctccctct
     4021 atgaattctt ataatgtccc tttttctgta agtttttgag aggcaattgg caatttagga
     4081 ggcagcaggg tctgttttgg tcaaatcttg aatttcgttg ttgcactcta gtgactgatc
     4141 tttgggaatg tcttgtcttt gcatggggct catagagatg tgtgcagact tgcttattgt
     4201 ggttagtgtg tatcaggaac acacacacag gtgttctgac cagctcaggc ttgccacagt
     4261 gagcaactct gtggctagca aaagagaagt ttatttgtgc ccagccattg gtcaccttgg
     4321 gtgatgcacc agatagcagg cagatgttgg ttcattggcc ttcgtcctct ttcctcctaa
     4381 aataatattg gctttaccat cttaactcag ctgtgggttt tttgtgggtt cttgtttgtt
     4441 ttttggcatg aattgtcatc tttggtgttt ttttaacccc cagcccctca aaaaaataag
     4501 gcctccaggt atcaagatct catattagga ttttctgtcc ttaatttttt gagcaaaatc
     4561 tggaaaatgt gaaagcatat ttagatttta tatactatct gaaatgtgat ttgttaagat
     4621 tcttaaattt gggcctctta gaataatttt gaatgagatc taccgactca cttgtgagaa
     4681 tatttttcac agattatctt tgggcctttt cattagaaag ctgtttgttt gtccccctgt
     4741 tggtacattt ggttacctca ttttgccgtt tcagattgtg aaagctcaca ggggtgtttt
     4801 ttggaatcat ttgctgagtc attttctcaa atcatattcc attgtatcag ttaacatata
     4861 gttttaaatg tatgtattat aaatatctgt aaccaaatca tttgaaggct tgataaattt
     4921 ttaacaaagt ttgtacattt tttatgaaag ttactagtaa tgctttacta agtagtgcaa
     4981 tgaattttta tttttaatcc ctgtgcccaa ttttggagtt gagagggttg ttggtaataa
     5041 atgtatgatg tacacttaaa a
//
