LOCUS       NM_025126               1986 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ring finger protein 34 (RNF34), transcript variant 2,
            mRNA.
ACCESSION   NM_025126
VERSION     NM_025126.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1986)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1986)
  AUTHORS   He,X., Zhu,Y., Zhang,Y., Geng,Y., Gong,J., Geng,J., Zhang,P.,
            Zhang,X., Liu,N., Peng,Y., Wang,C., Wang,Y., Liu,X., Wan,L.,
            Gong,F., Wei,C. and Zhong,H.
  TITLE     RNF34 functions in immunity and selective mitophagy by targeting
            MAVS for autophagic degradation
  JOURNAL   EMBO J 38 (14), e100978 (2019)
   PUBMED   31304625
  REMARK    GeneRIF: Study identified RNF34 as an important regulator of
            immunity and mitophagy by inducing the autophagic degradation of
            MAVS aggregates. RNF34 promoted the K63 to K27/K29 ubiquitination
            transition of MAVS and degraded activated MAVS oligomers. The loss
            of RNF34 led to defects in mitophagy. The RNF34-mediated
            mitochondrial quality control mechanism links the innate immune
            response, mitochondrial homeostasis, and infection.
REFERENCE   3  (bases 1 to 1986)
  AUTHORS   Zhang,R., Zhao,J., Song,Y., Wang,X., Wang,L., Xu,J., Song,C. and
            Liu,F.
  TITLE     The E3 ligase RNF34 is a novel negative regulator of the NOD1
            pathway
  JOURNAL   Cell Physiol Biochem 33 (6), 1954-1962 (2014)
   PUBMED   25012219
  REMARK    GeneRIF: Data indicate that E3 ligase RNF34 is associated with
            nucleotide-binding oligomerization domain-containing protein 1
            (NOD1).
REFERENCE   4  (bases 1 to 1986)
  AUTHORS   Wei,P., Pan,D., Mao,C. and Wang,Y.X.
  TITLE     RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1alpha and
            modulates brown fat cell metabolism
  JOURNAL   Mol Cell Biol 32 (2), 266-275 (2012)
   PUBMED   22064484
REFERENCE   5  (bases 1 to 1986)
  AUTHORS   Lin,M.L., Lu,Y.C., Su,H.L., Lin,H.T., Lee,C.C., Kang,S.E.,
            Lai,T.C., Chung,J.G. and Chen,S.S.
  TITLE     Destabilization of CARP mRNAs by aloe-emodin contributes to
            caspase-8-mediated p53-independent apoptosis of human carcinoma
            cells
  JOURNAL   J Cell Biochem 112 (4), 1176-1191 (2011)
   PUBMED   21308745
  REMARK    GeneRIF: Data indicate AE induces caspase-8-mediated activation of
            mitochondrial death pathways by decreasing the stability of CARP
            mRNAs in a p53-independent manner.
REFERENCE   6  (bases 1 to 1986)
  AUTHORS   Yang,W., Rozan,L.M., McDonald,E.R. 3rd, Navaraj,A., Liu,J.J.,
            Matthew,E.M., Wang,W., Dicker,D.T. and El-Deiry,W.S.
  TITLE     CARPs are ubiquitin ligases that promote MDM2-independent p53 and
            phospho-p53ser20 degradation
  JOURNAL   J Biol Chem 282 (5), 3273-3281 (2007)
   PUBMED   17121812
REFERENCE   7  (bases 1 to 1986)
  AUTHORS   Konishi,T., Sasaki,S., Watanabe,T., Kitayama,J. and Nagawa,H.
  TITLE     Overexpression of hRFI (human ring finger homologous to inhibitor
            of apoptosis protein type) inhibits death receptor-mediated
            apoptosis in colorectal cancer cells
  JOURNAL   Mol Cancer Ther 4 (5), 743-750 (2005)
   PUBMED   15897238
REFERENCE   8  (bases 1 to 1986)
  AUTHORS   Sasaki,S., Watanabe,T., Konishi,T., Kitayama,J. and Nagawa,H.
  TITLE     Effects of expression of hRFI on adenoma formation and tumor
            progression in colorectal adenoma-carcinoma sequence
  JOURNAL   J Exp Clin Cancer Res 23 (3), 507-512 (2004)
   PUBMED   15595643
  REMARK    GeneRIF: hRFI may act as an oncogenic molecule affecting the
            apoptotic pathway
REFERENCE   9  (bases 1 to 1986)
  AUTHORS   McDonald,E.R. 3rd and El-Deiry,W.S.
  TITLE     Suppression of caspase-8- and -10-associated RING proteins results
            in sensitization to death ligands and inhibition of tumor cell
            growth
  JOURNAL   Proc Natl Acad Sci U S A 101 (16), 6170-6175 (2004)
   PUBMED   15069192
REFERENCE   10 (bases 1 to 1986)
  AUTHORS   Sasaki,S., Nakamura,T., Arakawa,H., Mori,M., Watanabe,T., Nagawa,H.
            and Croce,C.M.
  TITLE     Isolation and characterization of a novel gene, hRFI,
            preferentially expressed in esophageal cancer
  JOURNAL   Oncogene 21 (32), 5024-5030 (2002)
   PUBMED   12118383
  REMARK    GeneRIF: a novel gene, hRFI, preferentially expressed in esophageal
            cancer (hRFI)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF306709.1 and AK025439.1.
            
            On Aug 13, 2020 this sequence version replaced NM_025126.3.
            
            Summary: The protein encoded by this gene contains a RINF finger, a
            motif known to be involved in protein-protein and protein-DNA
            interactions. This protein interacts with DNAJA3/hTid-1, which is a
            DnaJ protein reported to function as a modulator of apoptosis.
            Overexpression of this gene in Hela cells was shown to confer the
            resistance to TNF-alpha induced apoptosis, suggesting an
            anti-apoptotic function of this protein. This protein can be
            cleaved by caspase-3 during the induction of apoptosis. This
            protein also targets p53 and phospho-p53 for degradation.
            Alternatively splicing results in multiple transcript variants
            encoding distinct isoforms. [provided by RefSeq, Feb 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007826.2, AK025439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361234.10/ ENSP00000355137.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1435              AF306709.1         78-1512
            1436-1986           AK025439.1         1436-1986
FEATURES             Location/Qualifiers
     source          1..1986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..1986
                     /gene="RNF34"
                     /gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
                     /note="ring finger protein 34"
                     /db_xref="GeneID:80196"
                     /db_xref="HGNC:HGNC:17297"
                     /db_xref="MIM:608299"
     exon            1..101
                     /gene="RNF34"
                     /gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1214
                     /gene="RNF34"
                     /gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2; RING
                     finger protein RIFF; FYVE-RING finger protein MOMO;
                     caspases-8 and -10-associated RING finger protein 1; E3
                     ubiquitin-protein ligase RNF34; caspase regulator CARP1;
                     human RING finger homologous to inhibitor of apoptosis
                     protein; ring finger protein 34, E3 ubiquitin protein
                     ligase; RING-type E3 ubiquitin transferase RNF34"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF34 isoform 2"
                     /protein_id="NP_079402.2"
                     /db_xref="CCDS:CCDS31915.1"
                     /db_xref="GeneID:80196"
                     /db_xref="HGNC:HGNC:17297"
                     /db_xref="MIM:608299"
                     /translation="MKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGPFRFTPN
                     PEFSTYPPAATEGPNIVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTC
                     HLLQETAFQRPQLMRLKVKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMD
                     TSSLNSSRSQTSSFFTRSFFSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQSEITS
                     ANTEDDDDDDDEDDDDEEENAEDRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEIL
                     ARNFVNYSGCCEKWELVEKVNRLYKENEENQKSYGERLQLQDEEDDSLCRICMDAVID
                     CVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS"
     exon            102..320
                     /gene="RNF34"
                     /gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
                     /inference="alignment:Splign:2.1.0"
     exon            321..728
                     /gene="RNF34"
                     /gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
                     /inference="alignment:Splign:2.1.0"
     exon            729..821
                     /gene="RNF34"
                     /gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1023
                     /gene="RNF34"
                     /gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1986
                     /gene="RNF34"
                     /gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1966..1971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF34"
                     /gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
                     /note="hexamer: AATAAA"
     polyA_site      1986
                     /gene="RNF34"
                     /gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
                     /note="major polyA site"
ORIGIN      
        1 aatcaccgcc cagagggaag gaggtcggca gtgtgaggag ctgctatggt gctgagtttc
       61 ctggtagagc cggccgagct gaggcggtcg cggccatgaa ggcgggtgcc acgtctatgt
      121 gggcttcgtg ctgtgggctg ctgaatgaag tcatgggaac tggagctgtc aggggccagc
      181 agtcagcatt tgcaggagcc accggtccat tcagatttac accaaaccct gagttttcca
      241 cctacccacc agcagctacg gaagggccca acatagtttg taaagcctgt gggctttcat
      301 tttcagtctt tagaaagaag catgtttgct gtgactgcaa gaaggatttt tgctccgttt
      361 gttcagtctt acaagaaaat ctccgtagat gttctacttg tcacttatta caagagacag
      421 catttcagcg ccctcagtta atgcgactga aggtgaagga cctgcggcag tatctcattc
      481 tgagaaatat acccatagat acttgtcgtg agaaagaaga cttggtggat ctagtactgt
      541 gccatcatgg actaggctct gaggacgaca tggacacaag cagtctgaat tcttcaaggt
      601 cccagacttc tagctttttt acacgttcgt ttttttcaaa ctatacagcc ccctctgcta
      661 ctatgtcttc gtttcaggga gagcttatgg atggagacca aacatccaga tctggagtgc
      721 cggcacaggt acaaagtgaa atcacttcag caaacacaga agatgatgat gacgacgatg
      781 atgaggatga tgatgatgaa gaagaaaacg cagaggatcg gaaccccggg ctctccaagg
      841 agagagtgag agcttcactg tctgacttgt caagccttga tgatgtggaa ggaatgagcg
      901 tgcgccagct gaaggaaatt ctggctcgga attttgtcaa ctattctggc tgttgtgaaa
      961 aatgggaact ggtagagaaa gtaaaccggt tatacaaaga gaatgaagaa aaccaaaagt
     1021 cctatggcga gcggctgcag ctgcaggatg aggaagacga cagcctgtgt cgcatctgca
     1081 tggatgccgt catcgactgt gtcctactgg agtgtgggca catggttacc tgcaccaagt
     1141 gcggcaagcg catgagtgag tgtcccatct gccggcagta tgtggtgcga gccgtgcacg
     1201 tgttcaagtc ctgaaacagg ctcccctcac caggacagtc acccccaaac ttgaccccca
     1261 acatttcaat gcacagaagg gactggaaag ttatgttcaa aggctgaagc tattttaaaa
     1321 cattattttg actactaagt ggggacagaa agatccatcc tgagttgtgg aaacattggt
     1381 ccatgccgtg agcctgtctg cctgtggaca cgtgagcttc ccgggctcag ctgggcttta
     1441 tcacacatcc cgtgaacact cattgaagtc agcctgtttg cgccatgtgg gcatcagcca
     1501 ctgctgtctt gggaggacac ttatcctgtt ctcttatttc cccttcatcc tatttttaac
     1561 ttaaactgct cagatgtttg aaacttctgt cctctttgga tgagatcagt gtccacaagt
     1621 ggccgacatg gaacatgctg agcagtggct cctctgaatg ttcactttat tagtcatgta
     1681 tattttaaat gctaacattt gatgaatgta agtttccaca ttgttgctgt ttctgcattt
     1741 aaacataatt gggaacaact gacattctct agtcgactgc cagggcctta gactccacat
     1801 gtccattttt gttcaggtat agctttttat agcaagggct gcatctagct tcttttatta
     1861 gaagtgtgtg tgctaaattc cttattaatg tgtaatcagt ttacattgtt ttgtatagtg
     1921 aaggtgtatt ttcagtgcta cccgctagct gattttaact ttaggaataa aattagtttt
     1981 aaaagc
//
