LOCUS       NM_030936               1679 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ring finger protein 32 (RNF32), transcript variant 3,
            mRNA.
ACCESSION   NM_030936
VERSION     NM_030936.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1679)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1679)
  AUTHORS   Wang,X.W., Wei,W., Wang,W.Q., Zhao,X.Y., Guo,H. and Fang,D.C.
  TITLE     RING finger proteins are involved in the progression of barrett
            esophagus to esophageal adenocarcinoma: a preliminary study
  JOURNAL   Gut Liver 8 (5), 487-494 (2014)
   PUBMED   25228972
REFERENCE   3  (bases 1 to 1679)
  AUTHORS   Li,H., Wang,C.Y., Wang,J.X., Wu,G.S., Yu,P., Yan,X.Y., Chen,Y.G.,
            Zhao,L.H. and Zhang,Y.P.
  TITLE     Mutation analysis of a large Chinese pedigree with congenital
            preaxial polydactyly
  JOURNAL   Eur J Hum Genet 17 (5), 604-610 (2009)
   PUBMED   19066618
REFERENCE   4  (bases 1 to 1679)
  AUTHORS   Wang,Z.Q., Tian,S.H., Shi,Y.Z., Zhou,P.T., Wang,Z.Y., Shu,R.Z.,
            Hu,L. and Kong,X.
  TITLE     A single C to T transition in intron 5 of LMBR1 gene is associated
            with triphalangeal thumb-polysyndactyly syndrome in a Chinese
            family
  JOURNAL   Biochem Biophys Res Commun 355 (2), 312-317 (2007)
   PUBMED   17300748
REFERENCE   5  (bases 1 to 1679)
  AUTHORS   von Bergh,A.R., van Drunen,E., van Wering,E.R., van Zutven,L.J.,
            Hainmann,I., Lonnerholm,G., Meijerink,J.P., Pieters,R. and
            Beverloo,H.B.
  TITLE     High incidence of t(7;12)(q36;p13) in infant AML but not in infant
            ALL, with a dismal outcome and ectopic expression of HLXB9
  JOURNAL   Genes Chromosomes Cancer 45 (8), 731-739 (2006)
   PUBMED   16646086
REFERENCE   6  (bases 1 to 1679)
  AUTHORS   van Baren,M.J., van der Linde,H.C., Breedveld,G.J., Baarends,W.M.,
            Rizzu,P., de Graaff,E., Oostra,B.A. and Heutink,P.
  TITLE     A double RING-H2 domain in RNF32, a gene expressed during sperm
            formation
  JOURNAL   Biochem Biophys Res Commun 292 (1), 58-65 (2002)
   PUBMED   11890671
  REMARK    GeneRIF: molecular cloning of a RING domain protein expressed
            during sperm formation
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB445126.1, BI460257.1 and
            AL136874.1.
            
            On May 21, 2020 this sequence version replaced NM_030936.3.
            
            Summary: The protein encoded by this gene contains two RING ring
            finger motifs. RING finger motifs are present in a variety of
            functionally distinct proteins and are known to be involved in
            protein-DNA or protein-protein interactions. This gene was found to
            be expressed during spermatogenesis, most likely in spermatocytes
            and/or in spermatids. Alternative splicing of this gene results in
            multiple transcript variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 all encode isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136874.1, SRR14038193.344707.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317955.10/ ENSP00000315950.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DB445126.1         116-118
            4-420               BI460257.1         122-538
            421-1679            AL136874.1         424-1682
FEATURES             Location/Qualifiers
     source          1..1679
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.3"
     gene            1..1679
                     /gene="RNF32"
                     /gene_synonym="FKSG33; HSD15; LMBR2"
                     /note="ring finger protein 32"
                     /db_xref="GeneID:140545"
                     /db_xref="HGNC:HGNC:17118"
                     /db_xref="MIM:610241"
     exon            1..38
                     /gene="RNF32"
                     /gene_synonym="FKSG33; HSD15; LMBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            39..130
                     /gene="RNF32"
                     /gene_synonym="FKSG33; HSD15; LMBR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1204
                     /gene="RNF32"
                     /gene_synonym="FKSG33; HSD15; LMBR2"
                     /note="isoform a is encoded by transcript variant 3"
                     /codon_start=1
                     /product="RING finger protein 32 isoform a"
                     /protein_id="NP_112198.1"
                     /db_xref="CCDS:CCDS5944.1"
                     /db_xref="GeneID:140545"
                     /db_xref="HGNC:HGNC:17118"
                     /db_xref="MIM:610241"
                     /translation="MLKNKGHSSKKDNLAVNAVALQDHILHDLQLRNLSVADHSKTQV
                     QKKENKSLKRDTKAIIDTGLKKTTQCPKLEDSEKEYVLDPKPPPLTLAQKLGLIGPPP
                     PPLSSDEWEKVKQRSLLQGDSVQPCPICKEEFELRPQVLLSCSHVFHKACLQAFEKFT
                     NKKTCPLCRKNQYQTRVIHDGARLFRIKCVTRIQAYWRGCVVRKWYRNLRKTVPPTDA
                     KLRKKFFEKKFTEISHRILCSYNTNIEELFAEIDQCLAINRSVLQQLEEKCGHEITEE
                     EWEKIQVQALRRETHECSICLAPLSAAGGQRVGAGRRSREMALLSCSHVFHHACLLAL
                     EEFSVGDRPPFHACPLCRSCYQKKILEC"
     exon            131..389
                     /gene="RNF32"
                     /gene_synonym="FKSG33; HSD15; LMBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..532
                     /gene="RNF32"
                     /gene_synonym="FKSG33; HSD15; LMBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            533..565
                     /gene="RNF32"
                     /gene_synonym="FKSG33; HSD15; LMBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            566..690
                     /gene="RNF32"
                     /gene_synonym="FKSG33; HSD15; LMBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            691..799
                     /gene="RNF32"
                     /gene_synonym="FKSG33; HSD15; LMBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            800..967
                     /gene="RNF32"
                     /gene_synonym="FKSG33; HSD15; LMBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1679
                     /gene="RNF32"
                     /gene_synonym="FKSG33; HSD15; LMBR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1646..1651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF32"
                     /gene_synonym="FKSG33; HSD15; LMBR2"
                     /note="hexamer: AATAAA"
     polyA_site      1679
                     /gene="RNF32"
                     /gene_synonym="FKSG33; HSD15; LMBR2"
                     /note="major polyA site"
ORIGIN      
        1 agacgtccct gggttccggt gttcgcggag gagtcgagca gaagaataga aggaaggtga
       61 taggatgtga tgatagaatt tgtgatagcc aagcaacaac ttttcctaat tcggcatgtt
      121 aaaaaataag ggtcactcat ctaagaaaga taacttggca gtcaatgcag ttgctttaca
      181 agatcacatt ttacatgatc ttcaacttcg aaatctttca gttgcagatc attctaagac
      241 acaagtacaa aagaaagaga acaaatctct aaaaagagat acaaaggcaa taatagatac
      301 tggacttaaa aaaactacac agtgccccaa actagaagac tcagaaaaag aatatgttct
      361 tgatcccaaa ccgccgccgt tgactttggc acagaagttg ggcctcattg ggcctccacc
      421 acctccactg tcatcagatg aatgggagaa ggtgaaacag cgctctctcc tgcaagggga
      481 ctccgtgcaa ccatgcccca tctgtaaaga agaattcgag cttcgtcctc aggtgctgct
      541 ttcatgctcc catgtgttcc acaaagcatg tcttcaggct tttgaaaagt tcacaaataa
      601 gaaaacctgt cctctctgta gaaagaacca gtatcaaacc cgagtgatac acgatggggc
      661 ccgcctgttc agaatcaagt gtgtgaccag aatccaagcc tactggagag gatgtgttgt
      721 tagaaagtgg tacagaaacc tgaggaaaac agtacctccc acagatgcca agttaagaaa
      781 aaaattcttt gaaaaaaagt tcacagaaat cagccaccgc atcctgtgct catacaacac
      841 caacattgaa gagctctttg cagaaatcga tcagtgcttg gccataaatc gaagtgttct
      901 tcagcagttg gaagaaaaat gtggccatga gatcacagaa gaggaatggg agaaaatcca
      961 agtgcaggct ctgcgccggg agacccacga gtgctccatc tgcctggccc ctctctccgc
     1021 tgctggcggt cagcgcgtgg gtgcaggcag gcgttccaga gagatggccc tcctgtcctg
     1081 ctcacatgtg ttccaccatg cgtgtctgct ggcactagag gagttctccg tgggagacag
     1141 gcctcctttc catgcctgtc ctctctgccg ctcctgctac cagaagaaga ttcttgaatg
     1201 ttgaattcat agtcaaggaa agttaggtaa ttctgaggaa aaaagtttac catcattttg
     1261 gatgaactgc atgagttctg ggttaagtac tacaatgtaa tctgtttccc agggaaataa
     1321 gctattggta gttgtaggaa atcttagtat attttaaaag ctgacatccc acctaatttt
     1381 aatctttggt ctctaaaaag taaatttcaa atttatgagt ttaatcactt caaatatgaa
     1441 tagcaaaaaa tgagagcttg cttacttcta aaaattgagg ttaagatata gctagtgtct
     1501 gaacgacact ccttaaagta agttccaaat gtaaaacact ccttaagttc caaatgtttt
     1561 ccgctaatag tctgtcctaa agcctttgcc attcctaata ctcgttttgt aataattgct
     1621 gtatttctgt gtaataaaat ataaaaataa aatattcagt ggtattcaac atcaaaaaa
//
