LOCUS       NM_017999               3502 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens ring finger protein 31 (RNF31), transcript variant 1,
            mRNA.
ACCESSION   NM_017999
VERSION     NM_017999.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3502)
  AUTHORS   Hoshino,K., Nakazawa,S., Yokobori,T., Hagiwara,K., Ishii,N.,
            Tsukagoshi,M., Igarashi,T., Araki,K., Harimoto,N., Tokunaga,F. and
            Shirabe,K.
  TITLE     RNF31 promotes proliferation and invasion of hepatocellular
            carcinoma via nuclear factor kappaB activation
  JOURNAL   Sci Rep 14 (1), 346 (2024)
   PUBMED   38172174
  REMARK    GeneRIF: RNF31 promotes proliferation and invasion of
            hepatocellular carcinoma via nuclear factor kappaB activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3502)
  AUTHORS   Song,L., Zhong,F., Tu,X. and Zhang,J.
  TITLE     Resonance assignments of the PUB domain of the RNF31 protein
  JOURNAL   Biomol NMR Assign 17 (2), 189-192 (2023)
   PUBMED   37395936
  REMARK    GeneRIF: Resonance assignments of the PUB domain of the RNF31
            protein.
REFERENCE   3  (bases 1 to 3502)
  AUTHORS   Zhang,J., Tu,H., Zheng,Z., Zhao,X. and Lin,X.
  TITLE     RNF31 promotes tumorigenesis via inhibiting RIPK1 kinase-dependent
            apoptosis
  JOURNAL   Oncogene 42 (19), 1585-1596 (2023)
   PUBMED   36997719
  REMARK    GeneRIF: RNF31 promotes tumorigenesis via inhibiting RIPK1
            kinase-dependent apoptosis.
REFERENCE   4  (bases 1 to 3502)
  AUTHORS   Yang,H., Xue,M., Su,P., Zhou,Y., Li,X., Li,Z., Xia,Y., Zhang,C.,
            Fu,M., Zheng,X., Luo,G., Wei,T., Wang,X., Ding,Y., Zhu,J. and
            Zhuang,T.
  TITLE     RNF31 represses cell progression and immune evasion via YAP/PD-L1
            suppression in triple negative breast Cancer
  JOURNAL   J Exp Clin Cancer Res 41 (1), 364 (2022)
   PUBMED   36581998
  REMARK    GeneRIF: RNF31 represses cell progression and immune evasion via
            YAP/PD-L1 suppression in triple negative breast Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3502)
  AUTHORS   Ma,W., Lu,Y., Zuo,Y., Wang,C. and Liu,J.
  TITLE     Effects of removing a highly conserved disulfide bond in
            ubiquitin-associated domain of human HOIP on biochemical
            characteristics
  JOURNAL   Protein Expr Purif 190, 106005 (2022)
   PUBMED   34695570
  REMARK    GeneRIF: Effects of removing a highly conserved disulfide bond in
            ubiquitin-associated domain of human HOIP on biochemical
            characteristics.
REFERENCE   6  (bases 1 to 3502)
  AUTHORS   Thompson,H.G., Harris,J.W., Lin,L. and Brody,J.P.
  TITLE     Identification of the protein Zibra, its genomic organization,
            regulation, and expression in breast cancer cells
  JOURNAL   Exp Cell Res 295 (2), 448-459 (2004)
   PUBMED   15093743
  REMARK    GeneRIF: ZIBRA was identified and its genomic organization,
            regulation, and expression studied in breast cancer cells.
REFERENCE   7  (bases 1 to 3502)
  AUTHORS   Yamanaka,K., Ishikawa,H., Megumi,Y., Tokunaga,F., Kanie,M.,
            Rouault,T.A., Morishima,I., Minato,N., Ishimori,K. and Iwai,K.
  TITLE     Identification of the ubiquitin-protein ligase that recognizes
            oxidized IRP2
  JOURNAL   Nat Cell Biol 5 (4), 336-340 (2003)
   PUBMED   12629548
REFERENCE   8  (bases 1 to 3502)
  AUTHORS   Jikuya,H., Takano,J., Kikuno,R., Hirosawa,M., Nagase,T., Nomura,N.
            and Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen. II.
            The complete sequences of 81 cDNA clones
  JOURNAL   DNA Res 10 (1), 49-57 (2003)
   PUBMED   12693554
REFERENCE   9  (bases 1 to 3502)
  AUTHORS   van der Reijden,B.A., Erpelinck-Verschueren,C.A., Lowenberg,B. and
            Jansen,J.H.
  TITLE     TRIADs: a new class of proteins with a novel cysteine-rich
            signature
  JOURNAL   Protein Sci 8 (7), 1557-1561 (1999)
   PUBMED   10422847
REFERENCE   10 (bases 1 to 3502)
  AUTHORS   Saurin,A.J., Borden,K.L., Boddy,M.N. and Freemont,P.S.
  TITLE     Does this have a familiar RING?
  JOURNAL   Trends Biochem Sci 21 (6), 208-214 (1996)
   PUBMED   8744354
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN287790.1 and BC012077.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 20, 2018 this sequence version replaced NM_017999.4.
            
            Summary: The protein encoded by this gene contains a RING finger, a
            motif present in a variety of functionally distinct proteins and
            known to be involved in protein-DNA and protein-protein
            interactions. The encoded protein is the E3 ubiquitin-protein
            ligase component of the linear ubiquitin chain assembly complex.
            Two transcript variants encoding different isoforms have been found
            for this gene. [provided by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225832.1, AK291247.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324103.11/ ENSP00000315112.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                CN287790.1         479-510
            33-3502             BC012077.1         1-3470
FEATURES             Location/Qualifiers
     source          1..3502
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..3502
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /note="ring finger protein 31"
                     /db_xref="GeneID:55072"
                     /db_xref="HGNC:HGNC:16031"
                     /db_xref="MIM:612487"
     exon            1..393
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..3420
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /EC_number="2.3.2.31"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     in-between-RING-finger ubiquitin-associated domain
                     protein; HOIL-1-interacting protein; E3 ubiquitin-protein
                     ligase RNF31; RING-type E3 ubiquitin transferase RNF31"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF31 isoform 1"
                     /protein_id="NP_060469.4"
                     /db_xref="CCDS:CCDS41931.1"
                     /db_xref="GeneID:55072"
                     /db_xref="HGNC:HGNC:16031"
                     /db_xref="MIM:612487"
                     /translation="MPGEEEERAFLVAREELASALRRDSGQAFSLEQLRPLLASSLPL
                     AARYLQLDAARLVRCNAHGEPRNYLNTLSTALNILEKYGRNLLSPQRPRYWRGVKFNN
                     PVFRSTVDAVQGGRDVLRLYGYTEEQPDGLSFPEGQEEPDEHQVATVTLEVLLLRTEL
                     SLLLQNTHPRQQALEQLLEDKVEDDMLQLSEFDPLLREIAPGPLTTPSVPGSTPGPCF
                     LCGSAPGTLHCPSCKQALCPACDHLFHGHPSRAHHLRQTLPGVLQGTHLSPSLPASAQ
                     PRPQSTSLLALGDSSLSSPNPASAHLPWHCAACAMLNEPWAVLCVACDRPRGCKGLGL
                     GTEGPQGTGGLEPDLARGRWACQSCTFENEAAAVLCSICERPRLAQPPSLVVDSRDAG
                     ICLQPLQQGDALLASAQSQVWYCIHCTFCNSSPGWVCVMCNRTSSPIPAQHAPRPYAS
                     SLEKGPPKPGPPRRLSAPLPSSCGDPEKQRQDKMREEGLQLVSMIREGEAAGACPEEI
                     FSALQYSGTEVPLQWLRSELPYVLEMVAELAGQQDPGLGAFSCQEARRAWLDRHGNLD
                     EAVEECVRTRRRKVQELQSLGFGPEEGSLQALFQHGGDVSRALTELQRQRLEPFRQRL
                     WDSGPEPTPSWDGPDKQSLVRRLLAVYALPSWGRAELALSLLQETPRNYELGDVVEAV
                     RHSQDRAFLRRLLAQECAVCGWALPHNRMQALTSCECTICPDCFRQHFTIALKEKHIT
                     DMVCPACGRPDLTDDTQLLSYFSTLDIQLRESLEPDAYALFHKKLTEGVLMRDPKFLW
                     CAQCSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRMNDPEYQ
                     AQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPEP
                     NCRVKKSLHGHHPRDCLFYLRDWTALRLQKLLQDNNVMFNTEPPAGARAVPGGGCRVI
                     EQKEVPNGLRDEACGKETPAGYAGLCQAHYKEYLVSLINAHSLDPATLYEVEELETAT
                     ERYLHVRPQPLAGEDPPAYQARLLQKLTEEVPLGQSIPRRRK"
     exon            394..540
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            541..696
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            697..756
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            757..832
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1010
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1398
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1689
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1938
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2124
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2331
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2505
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2604
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2694
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2809
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2928
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3042
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3100
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3197
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3366
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..3502
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3483..3488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /note="hexamer: AATAAA"
     polyA_site      3502
                     /gene="RNF31"
                     /gene_synonym="HOIP; IMD115; Paul; ZIBRA"
                     /note="major polyA site"
ORIGIN      
        1 ctagtacttc ctgttctcgg ctaaccctgg cgctgggccg ggggctggag agtgaccgtg
       61 gtctgagtga cctggggcgg ctgcgtgggc cggggtgggc ctcaaagccg ggcaccagac
      121 gggaggggcg gcgctcgggc cgcgcgctgc ccgcgccggg tcctggcggg cggcgaggct
      181 ggggctgact cctgcctcag gatgccgggg gaggaagagg agcgggcctt cctggtggcc
      241 cgcgaggagc tggcgagcgc cctgaggagg gattccgggc aggcgttttc cctggagcag
      301 ctccggccgc tactagccag ctctctgccg ctagccgccc gctacctgca gctggacgcc
      361 gcacgccttg tccgctgcaa cgctcatggg gagccccgaa actacctcaa caccctgtcc
      421 acggctctga acatcctgga gaaatacggc cgcaaccttc tcagccctca gcggcctcgg
      481 tactggcgtg gtgtcaagtt taataaccct gtctttcgca gcacggtgga tgctgtgcag
      541 gggggccgag atgtgctgcg attatatggc tacacagagg agcaaccaga tgggttgagc
      601 ttccccgaag ggcaggagga gccagatgag caccaggttg ctacagtcac actggaagta
      661 ctgctgcttc ggacagagct cagcctgcta ttgcagaata ctcatccaag acagcaggca
      721 ctggagcagc tgttggaaga caaggttgaa gatgatatgc tgcagctttc agaatttgac
      781 cccctattga gagagattgc tcctggcccc ctcaccacac cctctgtccc aggctccact
      841 cctggtccct gcttcctctg tggttctgcc ccaggcacac tgcactgccc atcctgtaaa
      901 caggccctgt gtccagcctg tgaccacctg ttccatggac acccatcccg tgctcatcac
      961 ctccgccaga ccctgcctgg ggtcctgcag ggtacccacc tgagccccag tttacctgcc
     1021 tcagcccaac cacggcccca gtcgacctcc ctgctggccc tgggagacag ctctctttct
     1081 tcccctaatc ctgcaagtgc tcatttgccc tggcactgtg ctgcctgtgc catgctaaat
     1141 gagccttggg cagtgctctg tgtggcctgt gatcggcccc gaggctgtaa ggggttgggg
     1201 ttgggaactg agggtcccca aggaactgga ggcctagaac ctgatcttgc acggggtcgg
     1261 tgggcctgcc agagctgtac ctttgagaat gaggcagctg ctgtgctatg ttccatatgt
     1321 gagcgacctc ggctggccca gcctcccagc ttggtggtgg attcccgaga tgctggcatt
     1381 tgcctgcaac cccttcagca gggggatgct ttgctggcct ctgcccagag tcaagtctgg
     1441 tactgtattc actgtacctt ctgcaactcg agccctggct gggtgtgtgt tatgtgcaac
     1501 cggactagta gccccattcc agcacaacat gccccccggc cctatgccag ctctttggaa
     1561 aagggacccc ccaagcctgg gcccccacga cgccttagtg cccccctgcc cagttcctgt
     1621 ggagatcctg agaagcagcg ccaagacaag atgcgggaag aaggcctcca gctagtgagc
     1681 atgatccggg aaggggaagc cgcaggtgcc tgtccagagg agatcttctc ggctctgcag
     1741 tactcgggca ctgaggtgcc tctgcagtgg ttgcgctcag aactgcccta cgtcctggag
     1801 atggtggctg agctggctgg acagcaggac cctgggctgg gtgccttttc ctgtcaggag
     1861 gcccggagag cctggctgga tcgtcatggc aaccttgatg aagctgtgga ggagtgtgtg
     1921 aggaccaggc gaaggaaggt gcaggagctc cagtctctag gctttgggcc tgaggagggg
     1981 tctctccagg cattgttcca gcacggaggt gatgtgtcac gggccctgac tgagctacag
     2041 cgccaacgcc tagagccctt ccgccagcgc ctctgggaca gtggccctga gcccacccct
     2101 tcctgggatg ggccagacaa gcagagcctg gtcaggcggc ttttggcagt ctacgcactc
     2161 cccagctggg gccgggcaga gctggcactg tcactgctgc aggagacacc caggaactat
     2221 gagttggggg atgtggtaga agctgtgagg cacagccagg accgggcctt cctgcgccgc
     2281 ttgcttgccc aggagtgtgc cgtgtgtggc tgggccctgc cccacaaccg gatgcaggcc
     2341 ctgacttcct gtgagtgcac catctgtcct gactgcttcc gccagcactt caccatcgcc
     2401 ttgaaggaga agcacatcac agacatggtg tgccctgcct gtggccgccc cgacctcacc
     2461 gatgacacac agttgctcag ctacttctct acccttgaca tccagcttcg cgagagccta
     2521 gagccagatg cctatgcgtt gttccataag aagctgaccg agggtgtgct gatgcgggac
     2581 cccaagttct tgtggtgtgc ccagtgctcc tttggcttca tatatgagcg tgagcagctg
     2641 gaggcaactt gtccccagtg tcaccagacc ttctgtgtgc gctgcaagcg ccagtgggag
     2701 gagcagcacc gaggtcggag ctgtgaggac ttccagaact ggaaacgcat gaacgaccca
     2761 gaataccagg cccagggcct agcaatgtat cttcaggaaa acggcattga ctgccccaaa
     2821 tgcaagttct cgtacgccct ggcccgagga ggctgcatgc actttcactg tacccagtgc
     2881 cgccaccagt tctgcagcgg ctgctacaat gccttttacg ccaagaataa atgtccagag
     2941 cctaactgca gggtgaaaaa gtccctgcac ggccaccacc ctcgagactg cctcttctac
     3001 ctgcgggact ggactgctct ccggcttcag aagctgctac aggacaataa cgtcatgttt
     3061 aatacagagc ctccagctgg ggcccgggca gtccctggag gcggctgccg agtgatagag
     3121 cagaaggagg ttcccaatgg gctcagggac gaagcttgtg gcaaggaaac tccagctggc
     3181 tatgccggcc tgtgccaggc acactacaaa gagtatcttg tgagcctcat caatgcccac
     3241 tcgctggacc cagccacctt gtatgaggtg gaagagctgg agacggccac tgagcgctac
     3301 ctgcacgtac gcccccagcc tttggctgga gaggatcccc ctgcttacca ggcccgcttg
     3361 ttacagaagc tgacagaaga ggtacccttg ggacagagta tcccccgcag gcggaagtag
     3421 ctgagggcaa gggtcccgat gagggtccca tggcctgctc cctcaggaac agctccagca
     3481 ccaataaaga ggcatcttac ca
//
